Synthesis of some novel 1H-phenanthro [9,10-d]imidazole derivatives and their Antibacterial and Molecular docking investigation
In this study, several imidazole derivatives in one pot multicomponent reaction from various aldehydes (1(a-z)), 9,10-phenanthrenequinone, or benzyl (2), and ammonium acetate (3) were synthesized in the presence of acetic acid (AcOH) under reflux conditions at 120°C. Also, the photochromic properties of synthesized compounds were investigated in AcOH as a solvent under laboratory conditions at a temperature of 120°C. Moreover, the antibacterial and antioxidant activity of the synthesized compounds was investigated. The structure of the products was confirmed using FT-IR, UV-Vis, 1HNMR, and 13CNMR spectroscopy. The antimi...
Source: Chemistry and Biodiversity - April 18, 2024 Category: Biochemistry Authors: Nosrat O Mahmoodi Anahita Rajabi Hadiseh Yazdani Nyaki Hossein Taherpour Nahzomi Source Type: research
Flavonoids from the Aerial Parts of Sophora tonkinensis and Their Potential Anti-inflammatory Activities
Chem Biodivers. 2024 Apr 18:e202400399. doi: 10.1002/cbdv.202400399. Online ahead of print.ABSTRACTFour undescribed prenylated flavonoids, sophoratones A-D (1-4), and 17 known flavonoids, were obtained from the aerial parts of Sophora tonkinensis. Their structures with absolute configurations were elucidated by detailed interpretation of NMR spectroscopy, mass spectrometry, and ECD calculations. Meanwhile, the ability of these compounds to inhibit the release of nitric oxide (NO) by a lipopolysaccharide induced mouse in RAW 264.7 cells was assayed. The results indicated that some compounds exhibited clear inhibitory effect...
Source: Chemistry and Biodiversity - April 18, 2024 Category: Biochemistry Authors: Qing-Qing Yang Yan-Fei Yang Xuan-Qin Chen Rong-Tao Li Zhi-Jun Zhang Source Type: research
Two New Phenylpropanoid Compounds from Lilium Brownii and Their Anti-monoamine Oxidase Activity
Chem Biodivers. 2024 Apr 18:e202400524. doi: 10.1002/cbdv.202400524. Online ahead of print.ABSTRACTBaihe is a commonly used Chinese medicine for the treatment of neurological disorders. Clinically, the bulbs of Lilium brownii are used to act as Baihe. In the study, two new phenylpropanoid compounds including 3-O-acetyl-1-O-caffeoylglycerol (1) and 3-O-acetyl-1-O-p-coumaroylglycerol (2) were isolated from the bulbs of L. brownii. Their structures were identified by spectroscopic method and the effect on monoamine oxidase activity was determined using an enzyme labeling method. The results show 1 and 2 have anti-monoamine ox...
Source: Chemistry and Biodiversity - April 18, 2024 Category: Biochemistry Authors: Chengcheng Hui Shuaibo He Mengshan Ji Yuhang Zhang Haibo Wang Xiaowei Wang Tao Guo Source Type: research
Phytochemical Composition, Antioxidant and Antimicrobial Activity of Three Monarda Species: M. bradburiana L. C. Beck, M. × media Willd., and M. punctata L
This study aimed to evaluate the differences in chemical characteristics and biological activity among different organs of plants representing three underinvestigated species of this genus: Monarda bradburiana L. C. Beck, Monarda × media Willd., and Monarda punctata L. The content of phenolic compounds and the antioxidant activity of leaves, stems, and inflorescences were determined. Essential oil (EO) content, composition, and antimicrobial activity were also examined. M. punctata leaves and inflorescences had the highest EO content (4.43% and 5.59%, respectively), with carvacrol as a dominant constituent. Leaf EO was al...
Source: Chemistry and Biodiversity - April 18, 2024 Category: Biochemistry Authors: Łukasz Gontar Anna Geszprych And żelika Drutowska Ewa Osi ńska Source Type: research
Synergistic Inhibitions of Gram-negative Bacteria by Combination Treatment with Ciprofloxacin and a Novel Glucolipid
Chem Biodivers. 2024 Apr 17:e202400578. doi: 10.1002/cbdv.202400578. Online ahead of print.ABSTRACTPsychrophilic fungus Pseudogymnoascus sp. OUCMDZ-4032 derived from Antarctica was cultivated under 16 ℃ to produce a new glucolipid compound (1). Its structure was elucidated by analysis of detailed spectroscopic data, acid hydrolysis and 1-phenyl-3-methyl-5-pyrazolone precolumn derivatization, and 13C NMR quantum chemical calculations. Though compound 1 did not show inhibitory activity against bacteria, it can reduce the minimum inhibitory concentration (MIC) of ciprofloxacin against Gram-negative bacteria Pseudomonas aeru...
Source: Chemistry and Biodiversity - April 18, 2024 Category: Biochemistry Authors: Liyuan Yang Qingqing Zhang Deng Yu Weiming Zhu Yi Wang Source Type: research
Keratin 5 Basal Cells are Temporally Regulated Developmental and Tissue Repair Progenitors in Bladder Urothelium
Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00378.2023. Online ahead of print.ABSTRACTUrothelium forms a distensible yet impermeable barrier, senses and transduces stimuli, and defends the urinary tract from mechanical, chemical and bacterial injuries. Biochemical and genetic labeling studies support the existence of one or more progenitor populations with the capacity to rapidly regenerate the urothelium following injury, but slow turnover, a low mitotic index, and inconsistent methodologies obscure progenitor identity. The progenitor properties of basal Keratin 5 urothelial cells (K5-UC) have been prev...
Source: American Journal of Physiology. Renal Physiology - April 18, 2024 Category: Physiology Authors: Brian Becknell Mohammad El-Harakeh Felipe Rodriguez-Tirado Kelly M Grounds Birong Li Macie Kercsmar Xin Wang Ashley R Jackson Source Type: research
Molecular-level insight into the chlorofluorocarbons adsorption by defective covalent organic polymers
Chemphyschem. 2024 Apr 17:e202400283. doi: 10.1002/cphc.202400283. Online ahead of print.ABSTRACTHalocarbons have important industrial applications, however they contribute to global warming and the fact that they can cause ozone depletion. Hence, the techniques that can capture and recover the used halocarbons with energy efficiency methods have recently received greater attention. In this contribution, we report the capture of dichlorodifluoromethane (R12), which has high global warming and ozone depletion potential, using covalent organic polymers (COPs). The defect-engineered COPs were synthesized and demonstrated outs...
Source: Chemphyschem - April 18, 2024 Category: Chemistry Authors: Jian Shen Mohammad Wahiduzzaman Abhishek Kumar Dushyant Barpaga B Peter McGrail Praveen Thallapally Guillaume Maurin Radha Kishan Motkuri Source Type: research
Gas-Phase Preparation of the 14 π Hückel Polycyclic Aromatic Anthracene and Phenanthrene Isomers (C14H10) via the Propargyl Addition-BenzAnnulation (PABA) Mechanism
Chemphyschem. 2024 Apr 18:e202400151. doi: 10.1002/cphc.202400151. Online ahead of print.ABSTRACTPolycyclic aromatic hydrocarbons (PAHs) imply the missing link between resonantly stabilized free radicals and carbonaceous nanoparticles, commonly referred to as soot particles in combustion systems and interstellar grains in deep space. Whereas gas phase formation pathways to the simplest PAH - naphthalene (C10H8) - are beginning to emerge, reaction pathways leading to the synthesis of the 14π Hückel aromatic PAHs anthracene and phenanthrene (C14H10) are still incomplete. Here, by utilizing a chemical microreactor in conjun...
Source: Chemphyschem - April 18, 2024 Category: Chemistry Authors: ChangYang Wang Long Zhao Ralf I Kaiser Source Type: research
Disentangling the Conformational Space and Structural Preferences of Tetrahydrofurfuryl Alcohol Using Rotational Spectroscopy and Computational Chemistry
Chemphyschem. 2024 Apr 18:e202400298. doi: 10.1002/cphc.202400298. Online ahead of print.ABSTRACTThe influence of the hydroxymethyl (CH2OH) group on the tetrahydrofuran (THF) ring structure was investigated by disentangling the gas phase conformational landscape of the sugar analogue tetrahydrofurfuryl alcohol (THFA). By combining rotational spectroscopy (6-20 GHz) and quantum chemical calculations, transitions corresponding to two stable conformers of THFA and their 13C isotopologues were observed and assigned in the rotational spectrum. The positions of the C atoms were precisely determined to unambiguously distinguish b...
Source: Chemphyschem - April 18, 2024 Category: Chemistry Authors: Weslley Silva Jennifer van Wijngaarden Source Type: research
Update to RIFM fragrance ingredient safety assessment, hexanoic acid, 4-methyl-, CAS Registry Number 1561-11-1
Food Chem Toxicol. 2024 Apr 16:114661. doi: 10.1016/j.fct.2024.114661. Online ahead of print.NO ABSTRACTPMID:38636594 | DOI:10.1016/j.fct.2024.114661 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 18, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Update to RIFM fragrance ingredient safety assessment, 4-ethyloctanoic acid, CAS Registry Number 16493-80-4
Food Chem Toxicol. 2024 Apr 16:114662. doi: 10.1016/j.fct.2024.114662. Online ahead of print.NO ABSTRACTPMID:38636595 | DOI:10.1016/j.fct.2024.114662 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 18, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
RIFM fragrance ingredient safety assessment, butyl 2-methylvalerate, CAS Registry Number 6297-41-2
Food Chem Toxicol. 2024 Apr 16:114658. doi: 10.1016/j.fct.2024.114658. Online ahead of print.NO ABSTRACTPMID:38636596 | DOI:10.1016/j.fct.2024.114658 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 18, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Multi-Elemental Composition of Botanical Preparations and Probabilistic Evaluation of Toxic Metals and Metalloids Intake Upon Dietary Exposure
Food Chem Toxicol. 2024 Apr 16:114664. doi: 10.1016/j.fct.2024.114664. Online ahead of print.ABSTRACTThe aim of this study was to evaluate the inorganic elemental composition (49 elements) of 29 botanical preparations obtained from fruits, leaves, peels, seeds, roots, fungi, and spirulina by using inductively coupled-mass spectrometry and a mercury analyzer. Simultaneously, the risk associated with the chronic dietary exposure to 12 toxic metals and metalloids among the European population was evaluated by using a probabilistic approach based on Monte Carlo simulations. The analysis revealed worrying intake levels of Al, A...
Source: Food and Chemical Toxicology - April 18, 2024 Category: Food Science Authors: Maria Olga Varr à Lenka Hus áková Giovanni Tommaso Lanza Martina Piroutkov á Jan Pato čka Sergio Ghidini Emanuela Zanardi Source Type: research
Update to RIFM fragrance ingredient safety assessment, 2-methylhexanoic acid, CAS Registry Number 4536-23-6
Food Chem Toxicol. 2024 Apr 16:114660. doi: 10.1016/j.fct.2024.114660. Online ahead of print.NO ABSTRACTPMID:38636598 | DOI:10.1016/j.fct.2024.114660 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 18, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Update to RIFM fragrance ingredient safety assessment, 2-methylheptanoic acid, CAS Registry Number 1188-02-9
Food Chem Toxicol. 2024 Apr 16:114659. doi: 10.1016/j.fct.2024.114659. Online ahead of print.NO ABSTRACTPMID:38636599 | DOI:10.1016/j.fct.2024.114659 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 18, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
