Nontargeted mass-spectral detection of chloroperfluoropolyether carboxylates in New Jersey soils
The toxicity and environmental persistence of anthropogenic per- and poly-fluoroalkyl substances (PFAS) are of global concern. To address legacy PFAS concerns in the United States, industry developed numerous replacement PFAS that commonly are treated as confidential information. To investigate the distribution of PFAS in New Jersey, soils collected from across the state were subjected to nontargeted mass-spectral analyses. Ten chloroperfluoropolyether carboxylates were tentatively identified, with at least three congeners in all samples. Nine congeners are ≥(CF2)7. Distinct chemical formulas and structures, as well as ...
Source: ScienceNOW - June 4, 2020 Category: Science Authors: Washington, J. W., Rosal, C. G., McCord, J. P., Strynar, M. J., Lindstrom, A. B., Bergman, E. L., Goodrow, S. M., Tadesse, H. K., Pilant, A. N., Washington, B. J., Davis, M. J., Stuart, B. G., Jenkins, T. M. Tags: Chemistry reports Source Type: news

The link between electrolytes and metals
(Source: ScienceNOW)
Source: ScienceNOW - June 4, 2020 Category: Science Authors: Isborn, C. M. Tags: Chemistry perspective Source Type: news

Perfluorocarbons' path into soils
(Source: ScienceNOW)
Source: ScienceNOW - June 4, 2020 Category: Science Authors: Yeston, J. Tags: Chemistry twis Source Type: news

Watching electrons swarm ammonia
(Source: ScienceNOW)
Source: ScienceNOW - June 4, 2020 Category: Science Authors: Yeston, J. Tags: Chemistry twis Source Type: news

Hydrogenations that tolerate N-O bonds
(Source: ScienceNOW)
Source: ScienceNOW - June 4, 2020 Category: Science Authors: Yeston, J. Tags: Chemistry twis Source Type: news

Photoelectron spectra of alkali metal-ammonia microjets: From blue electrolyte to bronze metal
Experimental studies of the electronic structure of excess electrons in liquids—archetypal quantum solutes—have been largely restricted to very dilute electron concentrations. We overcame this limitation by applying soft x-ray photoelectron spectroscopy to characterize excess electrons originating from steadily increasing amounts of alkali metals dissolved in refrigerated liquid ammonia microjets. As concentration rises, a narrow peak at ~2 electron volts, corresponding to vertical photodetachment of localized solvated electrons and dielectrons, transforms continuously into a band with a sharp Fermi edge accomp...
Source: ScienceNOW - June 4, 2020 Category: Science Authors: Buttersack, T., Mason, P. E., McMullen, R. S., Schewe, H. C., Martinek, T., Brezina, K., Crhan, M., Gomez, A., Hein, D., Wartner, G., Seidel, R., Ali, H., Thürmer, S., Marsalek, O., Winter, B., Bradforth, S. E., Jungwirth, P. Tags: Chemistry r-articles Source Type: news

Iridium-catalyzed acid-assisted asymmetric hydrogenation of oximes to hydroxylamines
We report a robust cyclometalated iridium(III) complex bearing a chiral cyclopentadienyl ligand as an efficient catalyst for this reaction operating under highly acidic conditions. Valuable N-alkoxy amines can be accessed at room temperature with nondetected overreduction of the N-O bond. Catalyst turnover numbers up to 4000 and enantiomeric ratios up to 98:2 are observed. The findings serve as a blueprint for the development of metal-catalyzed enantioselective hydrogenations of challenging substrates. (Source: ScienceNOW)
Source: ScienceNOW - June 4, 2020 Category: Science Authors: Mas-Rosello, J., Smejkal, T., Cramer, N. Tags: Chemistry reports Source Type: news

Community participation effects on preparedness behaviour through risk perception: impirical data of hazardous chemicals from China - Li X, Liu T.
This study explores the relationship among community participation, risk perception and preparedness behaviour in the context of hazardous chemicals risk. Community participation is divided into top-down community participation and bottom-up community part... (Source: SafetyLit)
Source: SafetyLit - June 3, 2020 Category: International Medicine & Public Health Tags: Community-Based Prevention Source Type: news

Exploring the neurological impact of air pollution
(American Chemical Society) Air pollution has become a fact of modern life, with a majority of the global population facing chronic exposure. Although the impact of inhaling polluted air on the lungs is well known, scientists are just now beginning to understand how it affects the brain. A new article in Chemical& Engineering News, the weekly newsmagazine of the American Chemical Society, details how researchers are connecting air pollution to dementia, autism and other neurological diseases. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 3, 2020 Category: Biology Source Type: news

Synthetic red blood cells mimic natural ones, and have new abilities
(American Chemical Society) Scientists have tried to develop synthetic red blood cells that mimic the favorable properties of natural ones, such as flexibility, oxygen transport and long circulation times. But so far, most artificial red blood cells have had one or a few, but not all, key features of the natural versions. Now, researchers reporting in ACS Nano have made synthetic red blood cells that have all of the cells' natural abilities, plus a few new ones. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 3, 2020 Category: Biology Source Type: news

Birmingham biotech company creates new division
A local biotech company has created a new unit of its contract research organization services business. DiscoveryBioMed launched Sentirix, a unit based on the company’s continuing five-year collaboration with the Philadelphia-based Monell Chemical Senses Center. The unit will be located in Birmingham. According to the company, future labs for studies and chemistry are envisioned but details are no t available yet. According to DiscoveryBioMed CEO Dr. Erik Schwiebert, the name Sentirix is derived… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - June 2, 2020 Category: Biotechnology Authors: Tyler Patchen Source Type: news

Birmingham biotech company creates new division
A local biotech company has created a new unit of its contract research organization services business. DiscoveryBioMed launched Sentirix, a unit based on the company’s continuing five-year collaboration with the Philadelphia-based Monell Chemical Senses Center. The unit will be located in Birmingham. According to the company, future labs for studies and chemistry are envisioned but details are no t available yet. According to DiscoveryBioMed CEO Dr. Erik Schwiebert, the name Sentirix is derived… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - June 2, 2020 Category: Pharmaceuticals Authors: Tyler Patchen Source Type: news

Organic contaminants formed during fire extinguishing using different firefighting methods assessed by nontarget analysis - Dubocq F, Bjurlid F, Ydst ål D, Titaley IA, Reiner E, Wang T, Almirall XO, Kärrman A.
During a fire event, potentially hazardous chemicals are formed from the combustion of burning materials and are released to the surrounding environment, both via gas and soot particles. The aim of this investigation was to study if firefighting techniques... (Source: SafetyLit)
Source: SafetyLit - June 2, 2020 Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news

Health Experts Criticize EPA ’s Asbestos Draft Risk Evaluation
Doctors, scientists and occupational health experts from across the country are openly criticizing the U.S. Environmental Protection Agency’s recent asbestos draft risk evaluation. At a virtual press conference arranged by the Asbestos Disease Awareness Organization last week, speakers labeled the asbestos evaluation inadequate and in need of serious revision. The year-long evaluation was required as part of the Frank R. Lautenberg Chemical Safety for the 21st Century Act, which was passed in 2016. It amended the original Toxic Substances Control Act, the country’s primary chemicals management law. “I am...
Source: Asbestos and Mesothelioma News - June 2, 2020 Category: Environmental Health Authors: Fran Mannino Source Type: news

Genetic study reveals similarities and differences of COVID-19 and SARS viruses
(University of Tokyo) Researchers have identified specific portions of the genetic codes of the COVID-19 and SARS viruses that may promote the viruses' lifecycles. The new technique is researchers' first tool for determining what genetic sequences stored as RNA -- DNA's chemical cousin -- are more stable. The research team named their technique Fate-seq because it aims to determine the fate of a genetic sequence, whether it will persist or degrade based on its stability. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 2, 2020 Category: International Medicine & Public Health Source Type: news

Understanding the role of cardiorespiratory fitness and body composition in brain health
(Beckman Institute for Advanced Science and Technology) Researchers at the Beckman Institute at the University of Illinois at Urbana-Champaign have demonstrated that brain chemistry is sensitive to fitness and body composition. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 2, 2020 Category: International Medicine & Public Health Source Type: news

Antibiotic-destroying genes widespread in bacteria in soil and on people
(Washington University School of Medicine) Researchers at Washington University in St. Louis and the National Institutes of Health (NIH) have found that genes that confer the power to destroy tetracycline antibiotics are widespread in bacteria. But the researchers have also created a chemical compound that shields tetracyclines from destruction, restoring the antibiotics lethality. The findings indicate an emerging threat to one of the most widely used classes of antibiotics -- but also a promising way to protect against that threat. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 2, 2020 Category: Infectious Diseases Source Type: news

Study reveals continuous pathway to building blocks of life
(Institute for Advanced Study) A new study conducted by scientists at the Institute for Advanced Study, the Earth-Life Science Institute (ELSI), and the University of New South Wales, among other participating institutions, marks an important step forward in the effort to understand the chemical origins of life. The findings of this study demonstrate how 'continuous reaction networks' are capable of producing RNA precursors and possibly ultimately RNA itself--a critical bridge to life. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 2, 2020 Category: Biology Source Type: news

The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells
The dysregulation of multiple signaling pathways, including those through endosomal Toll-like receptors (TLRs), Fc gamma receptors (FcR), and antigen receptors in B cells (BCR), promote an autoinflammatory loop in systemic lupus erythematosus (SLE). Here, we used selective small-molecule inhibitors to assess the regulatory roles of interleukin-1 receptor (IL-1R)–associated kinase 4 (IRAK4) and Bruton’s tyrosine kinase (BTK) in these pathways. The inhibition of IRAK4 repressed SLE immune complex– and TLR7-mediated activation of human plasmacytoid dendritic cells (pDCs). Correspondingly, the expression of i...
Source: Signal Transduction Knowledge Environment - June 2, 2020 Category: Science Authors: Corzo, C. A., Varfolomeev, E., Setiadi, A. F., Francis, R., Klabunde, S., Senger, K., Sujatha-Bhaskar, S., Drobnick, J., Do, S., Suto, E., Huang, Z., Eastham-Anderson, J., Katewa, A., Pang, J., Domeyer, M., Dela Cruz, C., Paler-Martinez, A., Lau, V. W. C. Tags: STKE Research Articles Source Type: news

Metformin Recalled for Possible Cancerous Chemical
The recall for all lots of metformin hydrochloride extended-release tablets 500 mg from Apotex comes after one lot tested by the U.S. Food and Drug Administration had higher NDMA levels than allowed by the FDA. (Source: WebMD Health)
Source: WebMD Health - June 1, 2020 Category: Consumer Health News Source Type: news

Lessening water quality problems caused by hurricane-related flooding
(American Chemical Society) June 1 is the start of hurricane season in the Atlantic, and with 2020 predicted to be particularly active, residents in coastal regions are keeping watchful eyes on the weather. Flooding is often the most damaging effect of tropical storms, and it can disproportionately affect vulnerable people and ecosystems. Now, in ACS'Environmental Science& Technology, researchers study water quality impacts of two recent hurricanes in North Carolina and suggest interventions to protect susceptible areas. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 1, 2020 Category: Biology Source Type: news

Nitrogen-efficient fertilizer research could have lasting impact
(Lehigh University) Jonas Baltrusaitis, an associate professor of chemical and biomolecular engineering at Lehigh University, has been awarded a four-year, nearly $435,000 grant through the USDA's National Institute of Food and Agriculture (NIFA). His team has developed a dry mechanochemical synthesis method of a family of urea ionic cocrystals that can serve as functional fertilizers that significantly slow down urea hydrolysis in soil, reduce ammonia emissions, and extend availability of nitrogen to plants. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 1, 2020 Category: Biology Source Type: news

Monitoring environmental exposures in dogs could be early warning system for human health
(North Carolina State University) Man's best friend may also be man's best bet for figuring out how environmental chemicals could impact our health. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 1, 2020 Category: International Medicine & Public Health Source Type: news

Solubilizer Captisol enables body to absorb authorized COVID-19 drug therapy
(University of Kansas) Remdesivir's formulation includes the solubilizer Captisol, developed at the University of Kansas, which allows remdesivir be administered to the patient. Captisol was invented and patented by Valentino Stella, University Distinguished Professor Emeritus, and Roger Rajewski, research professor in the Department of Pharmaceutical Chemistry. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 1, 2020 Category: International Medicine & Public Health Source Type: news

What is Dry Needling?
Discussion Myofascial pain is pain from muscle or fascia, and usually associated with myofascial trigger points which are “…a highly localized, hyperirritable spot in a palpable, taut band of skeletal muscle fibers.” Trigger points are common reasons people, especially adults, seek relief in primary care or pain clinic settings. Athletes may also complain of pain caused by them. They are treated in a variety of ways, none of which used as a single method is successful for all individuals. Muscle “…stretching, massage, ischemic compression, laser therapy, transcutaneous electrical nerve stimu...
Source: PediatricEducation.org - June 1, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Government to divest stake in some pharma PSUs: Goyal
The government had in 2016 decided to close Indian Drugs and Pharmaceutical Ltd and Rajasthan Drugs and Pharmaceuticals Ltd. It had also announced strategic sale of Hindustan Antibiotics Ltd and Bengal Chemicals and Pharmaceutical Ltd. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - June 1, 2020 Category: Pharmaceuticals Source Type: news

Patterns, associated factors, and clinical outcomes of poisoning among poisoning cases presented to selected hospitals in Western Ethiopia: hospital-based study - Woyessa AH, Palanichamy T.
RESULTS: The broad types of poisoning were identified in about 193 (91.47%) cases of poisoning in this study. Pesticides exposure and food poisoning have, respectively, contributed for 32.70% and 20.91% of the poisoning incidence. On the other hand, chemic... (Source: SafetyLit)
Source: SafetyLit - May 30, 2020 Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news

Metformin Recalled Due to Potential Cancer-Causing Chemical
FRIDAY, May 29, 2020 -- A recall of the widely used diabetes drug metformin was announced by drug maker Apotex due to possible high levels of N-Nitrosodimethylamine (NDMA), which is believed to cause cancer in people. The recall for all lots of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 29, 2020 Category: Pharmaceuticals Source Type: news

Hidden Cause of Cancer?
When you’re tearing off a sheet of aluminum foil to cook with — or wrap your leftovers before you put them in the fridge — you probably never consider aluminum is a dangerous toxin. Truth is, aluminum is a heavy metal… just like lead, mercury and arsenic. It’s in our food… our cookware… even in the water we drink. Exposure to aluminum is a risk factor for cancer, Alzheimer’s, Parkinson’s, and bone disease, just to name a few. Our lungs, liver, and kidneys are able to eliminate a majority of the small amounts of aluminum we ingest through eating, drinking or breath...
Source: Al Sears, MD Natural Remedies - May 29, 2020 Category: Complementary Medicine Authors: Dr.A.Sears Tags: Health Source Type: news

Scientists develop sorbent for purifying water from radioactive elements
(Far Eastern Federal University) Scientists from Far Eastern Federal University (FEFU) in collaboration with colleagues from the Institute of Chemistry FEB RAS come up with a smart technology for the synthesis of sorbent based on a " tungsten bronze " compound powder (Na2WO4) aimed to purify industrial and drinking water from hazardous radionuclides cesium (137Cs), and strontium (90Sr), as well as for effective processing of liquid radioactive waste. A related article appears in the Journal of Materials Science. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 29, 2020 Category: Biology Source Type: news

A hormone -- plant style
(Bielefeld University) Researchers from the Faculties of Chemistry and Biology at Bielefeld University have now found a method that might make the production of a biologically significant precursor of jasmonic acid more efficient and cheaper. Their innovation: they imitate how plants produce the hormone. The result is 12-OPDA, a central precursor of jasmonic acid. In the long term, it could also be a potential precur-sor for high-quality perfume. The researchers present their method today (29.05.2020) in the re-search journal Advanced Science. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 29, 2020 Category: Biology Source Type: news

The New Normal of Workplace Safety
Just a couple of short months ago, workplace safety was a familiar concept. The potential hazards — exposure to chemicals, proximity to machinery, ladders, and so forth — and the preventive measures implemented by employers were straightforward and well-understood. What does that look like in the COVID-19 era? Social distancing . . . temperature checks . . . obsessive hand washing . . . face masks and shields . . . double and triple shifts to comply with strict capacity requirements. And that bulletin board where the company proudly touted the number of days without a workplace injury? N...
Source: MDDI - May 28, 2020 Category: Medical Devices Tags: Business Source Type: news

Babies developed blisters, swelling after touching disinfected shopping carts, Manitoba moms say
Three Manitoba mothers are warning other parents not to let their children near shopping carts that have been sanitized with disinfecting chemicals, after they say their children developed blisters, rashes and swelling from touching carts. (Source: CBC | Health)
Source: CBC | Health - May 28, 2020 Category: Consumer Health News Tags: News/Canada/Manitoba Source Type: news

Unique 'home built' device provides fast disease analysis in kidneys affected by diabetes
(Georgetown University Medical Center) The amount of scarring in damaged kidneys as a result of diabetes or acute injury, is a key factor in determining treatment. But it has not been possible, using traditional techniques, to quickly and accurately assess how widespread this kind of wounding extends within the organ. Now, however, a physicist and chemist at Georgetown University Medical Center has shown that a microscope he began developing with colleagues at University of California-Irvine can provide an immediate answer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 28, 2020 Category: International Medicine & Public Health Source Type: news

Not sure if you've already had coronavirus? This test can (maybe) tell you (video)
(American Chemical Society) Many people are wondering if that bad cold they had back in February or March was actually the new coronavirus. In principle, an antibody test could tell you that, but most of the tests out there right now aren't very good. We chatted with David Kroll to learn how these tests work, where they go wrong and why a test that's 96% accurate is actually pretty bad: https://youtu.be/jqudyDnnvJo. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 28, 2020 Category: Infectious Diseases Source Type: news

Balancing the economy while saving the planet
(Technical University of Denmark) A new research-based framework lets companies make informed decisions balancing economic and sustainability factors when producing bio-chemicals. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - May 28, 2020 Category: International Medicine & Public Health Source Type: news

UNH researchers find wildfires can alter arctic watersheds for 50 years
(University of New Hampshire) Climate change has contributed to the increase in the number of wildfires in the Arctic and can dramatically shift stream chemistry. Researchers at the University of New Hampshire have found that some of the aftereffects, like decreased carbon and increased nitrogen, can last up to five decades and could have major implications on vital waterways like the Yenisei River and the Arctic Ocean (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 28, 2020 Category: Biology Source Type: news

Synthesis of proteins by automated flow chemistry
Ribosomes can produce proteins in minutes and are largely constrained to proteinogenic amino acids. Here, we report highly efficient chemistry matched with an automated fast-flow instrument for the direct manufacturing of peptide chains up to 164 amino acids long over 327 consecutive reactions. The machine is rapid: Peptide chain elongation is complete in hours. We demonstrate the utility of this approach by the chemical synthesis of nine different protein chains that represent enzymes, structural units, and regulatory factors. After purification and folding, the synthetic materials display biophysical and enzymatic proper...
Source: ScienceNOW - May 28, 2020 Category: Science Authors: Hartrampf, N., Saebi, A., Poskus, M., Gates, Z. P., Callahan, A. J., Cowfer, A. E., Hanna, S., Antilla, S., Schissel, C. K., Quartararo, A. J., Ye, X., Mijalis, A. J., Simon, M. D., Loas, A., Liu, S., Jessen, C., Nielsen, T. E., Pentelute, B. L. Tags: Chemistry r-articles Source Type: news

Comment on "High-surface-area corundum by mechanochemically induced phase transformation of boehmite"
Amrute et al. (Reports, 25 October 2019, p. 485) claimed that no methods were able to produce high-purity α-Al2O3 with surface areas greater than 100 m2 g–1, even though much higher surface areas up to 253 m2 g–1 have been reported. Moreover, the materials they obtained could be porous aggregates and may not be 13-nm nanoparticles, as claimed. (Source: ScienceNOW)
Source: ScienceNOW - May 28, 2020 Category: Science Authors: Li, J., Pu, S., Cao, W., Li, L., Guo, R. Tags: Chemistry, Materials Science t-comment Source Type: news

Catching up to nature's ribosomes
(Source: ScienceNOW)
Source: ScienceNOW - May 28, 2020 Category: Science Authors: Proulx, C. Tags: Chemistry perspective Source Type: news

Response to Comment on "High-surface-area corundum by mechanochemically induced phase transformation of boehmite"
Li et al. commented that our report claims that methods reported thus far cannot enable the production of high-purity corundum with surface areas greater than 100 m2 g–1, and that our obtained material could be porous aggregates rather than nanoparticles. We disagree with both of these suggestions. (Source: ScienceNOW)
Source: ScienceNOW - May 28, 2020 Category: Science Authors: Amrute, A. P., Łodziana, Z., Schreyer, H., Weidenthaler, C., Schüth, F. Tags: Chemistry, Materials Science t-comment Source Type: news

Zeolites that prefer alkynes
(Source: ScienceNOW)
Source: ScienceNOW - May 28, 2020 Category: Science Authors: Szuromi, P. Tags: Chemistry, Materials Science twis Source Type: news

Stitching alkynes into bryostatin 3
(Source: ScienceNOW)
Source: ScienceNOW - May 28, 2020 Category: Science Authors: Yeston, J. Tags: Chemistry twis Source Type: news

Fully synthetic whole proteins in reach
(Source: ScienceNOW)
Source: ScienceNOW - May 28, 2020 Category: Science Authors: Funk, M. A. Tags: Chemistry twis Source Type: news

Control of zeolite pore interior for chemoselective alkyne/olefin separations
We report a strategy to control the pore interior of faujasite (FAU) zeolites by the confinement of isolated open nickel(II) sites in their six-membered rings. Under ambient conditions, Ni@FAU showed remarkable adsorption of alkynes and efficient separations of acetylene/ethylene, propyne/propylene, and butyne/1,3-butadiene mixtures, with unprecedented dynamic separation selectivities of 100, 92, and 83, respectively. In situ neutron diffraction and inelastic neutron scattering revealed that confined nickel(II) sites enabled chemoselective and reversible binding to acetylene through the formation of metastable [Ni(II)(C2H2...
Source: ScienceNOW - May 28, 2020 Category: Science Authors: Chai, Y., Han, X., Li, W., Liu, S., Yao, S., Wang, C., Shi, W., da-Silva, I., Manuel, P., Cheng, Y., Daemen, L. D., Ramirez-Cuesta, A. J., Tang, C. C., Jiang, L., Yang, S., Guan, N., Li, L. Tags: Chemistry, Materials Science reports Source Type: news

Total synthesis of bryostatin 3
Bryostatins are a family of 21 complex marine natural products with a wide range of potent biological activities. Among all the 21 bryostatins, bryostatin 3 is structurally the most complex. Whereas nine total syntheses of bryostatins have been achieved to date, bryostatin 3 has only been targeted once and required the highest number of steps to synthesize (43 steps in the longest linear sequence and 88 total steps). Here, we report a concise total synthesis of bryostatin 3 using 22 steps in the longest linear sequence and 31 total steps through a highly convergent synthetic plan by the use of highly atom-economical and ch...
Source: ScienceNOW - May 28, 2020 Category: Science Authors: Trost, B. M., Wang, Y., Buckl, A. K., Huang, Z., Nguyen, M. H., Kuzmina, O. Tags: Chemistry reports Source Type: news

Evaluation of chemical disinfection and microwave irradiation on denture base materials: An in vitro study
This study evaluated the effect of chemical disinfection and microwave irradiation on the surface hardness and roughness of two commercially available hard relining materials (Ufi Gel hard, GC Kooliner) and one denture base resin (Trevalon). Materials and Methods: A total of 72 specimens (n = 24) were divided into four groups. C: Not disinfected, Cl: disinfected with 4% chlorhexidine solution, Gl: disinfected with 2% glutaraldehyde solution, Mw: disinfected with microwave irradiation (650 W; 6 min). Hardness and roughness measurements were made after polymerisation, 1st day, 14th day and 28th day.Results: Ufi Gel hard...
Source: Dental Technology Blog - May 27, 2020 Category: Dentistry Source Type: news

New antiviral, antibacterial surface could reduce spread of infections in hospitals
(American Chemical Society) The novel coronavirus pandemic has caused an increased demand for antimicrobial treatments that can keep surfaces clean, particularly in health care settings. Although some surfaces have been developed that can combat bacteria, what's been lacking is a surface that can also kill off viruses. Now, researchers have found a way to impart durable antiviral and antibacterial properties to an aluminum alloy used in hospitals, according to a report inACS Biomaterials Science& Engineering. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 27, 2020 Category: Biology Source Type: news

Superworms digest plastic, with help from their bacterial sidekicks
(American Chemical Society) Resembling giant mealworms, superworms (Zophobas atratus) are beetle larvae that are often sold in pet stores as feed for reptiles, fish and birds. In addition to their relatively large size (about 2 inches long), these worms have another superpower: They can degrade polystyrene plastic. Now, researchers reporting in ACS'Environmental Science& Technology have linked this ability to a strain of bacteria that lives in the larvae's gut. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 27, 2020 Category: Biology Source Type: news

Multifunctional e-glasses monitor health, protect eyes, control video game
(American Chemical Society) Fitness tracker bracelets and watches provide useful information, such as step count and heart rate, but they usually can't provide more detailed data about the wearer's health. Now, researchers reporting in ACS Applied Materials& Interfaces have developed smart electronic glasses (e-glasses) that not only monitor a person's brain waves and body movements, but also can function as sunglasses and allow users to control a video game with eye motions. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 27, 2020 Category: Biology Source Type: news