Stimulatory effect of dietary chasteberry (Vitex agnus-castus) extract on immunity, some immune-related gene expression, and resistance against Aeromonas hydrophila infection in goldfish (Carassius auratus)
Publication date: December 2020Source: Fish & Shellfish Immunology, Volume 107, Part AAuthor(s): Maedeh Rashmeei, Seyed Pezhman Hosseini Shekarabi, Mehdi Shamsaie Mehrgan, Hamed Paknejad (Source: Fish and Shellfish Immunology)
Source: Fish and Shellfish Immunology - October 14, 2020 Category: Biology Source Type: research

Buckwheat, rooibos, and vitex extracts can mitigate adverse effects of xylene on ovarian cells in vitro.
This study examines whether selected functional food and medicinal plants can mitigate the adverse effects of xylene on ovarian cells. The influences of xylene (0, 10, 100, or 1000 ng/mL), buckwheat (Fagopyrum esculentum), rooibos (Aspalathus linearis), vitex (Vitex agnus-castus), extracts (10 μg/mL each), and a combination of xylene with these plant additives on cultured porcine ovarian granulosa cells are compared. Cell viability, proliferation (PCNA accumulation), apoptosis (accumulation of bax), and release of progesterone (P4) and estradiol (E2) were analyzed by the trypan blue tests, quantitative immunoc...
Source: Environmental Science and Pollution Research International - October 8, 2020 Category: Environmental Health Authors: Sirotkin AV, Macejková M, Tarko A, Fabova Z, Alwasel S, Harrath AH Tags: Environ Sci Pollut Res Int Source Type: research

Essential Oils from Vitex agnus castus L. Leaves Induces Caspase-Dependent Apoptosis of Human Multidrug-Resistant Lung Carcinoma Cells through Intrinsic and Extrinsic Pathways.
This study revealed that VAC EOs may be a promising candidate in the development of novel therapeutic agents for multi-drug resistant lung cancer treatment. PMID: 32972249 [PubMed - as supplied by publisher] (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - September 24, 2020 Category: Cancer & Oncology Authors: Ilhan S Tags: Nutr Cancer Source Type: research

Essential Oils from Vitex agnus castus L. Leaves Induces Caspase-Dependent Apoptosis of Human Multidrug-Resistant Lung Carcinoma Cells through Intrinsic and Extrinsic Pathways
. (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - September 24, 2020 Category: Cancer & Oncology Authors: Suleyman Ilhan Source Type: research

Effects of benzene on gilts ovarian cell functions alone and in combination with buckwheat, rooibos, and vitex.
th AH Abstract We aimed to examine the influence of benzene and of three dimethyl sulfoxide (DMSO) plant extracts-buckwheat (Fagopyrum Esculentum), rooibos (Aspalathus linearis), and vitex, (Vitex Agnus-Castus), and the combination of benzene with these three plant extracts on basic ovarian cell functions. Specifically, the study investigated the influence of benzene (0, 10, 100, or 1000 ng/mL) with and without these three plant additives on porcine ovarian granulosa cells cultured during 2 days with and without these additives. Cell viability, proliferation (accumulation of proliferating cell nuclear antigen, PCN...
Source: Environmental Science and Pollution Research International - September 10, 2020 Category: Environmental Health Authors: Sirotkin AV, Macejková M, Tarko A, Fabova Z, Alrezaki A, Alwasel S, Harrath AH Tags: Environ Sci Pollut Res Int Source Type: research

Chemical composition and biological activities of the essential oils from Vitex-agnus castus, Ocimum campechianum and Ocimum carnosum.
o GMP Abstract The essential oils obtained by hydrodistillation from fresh leaves of Vitex agnus-castus and Ocimum campechianum, and from fresh inflorescences of Ocimum carnosum were analysed by GC-FID and GC-MS. The major components of V. agnus-castus essential oil were identified as 1,8-cineole (47.9%), terpinyl α-acetate (11.6%), sabinene (11.2%) and caryophyllene oxide (9.7%), while in the O. campechianum essential oil were eugenol (72.1%), β-elemene (6.8%), (E)-caryophyllene (6.4%) and bicyclogermacrene (5.2%). Linalool (79.0%), α-epi-cadinol (5.4%), terpinen-4-ol (3.2%) and 1,8-cineole (2.8%...
Source: An Acad Bras Cienc - April 23, 2020 Category: Science Authors: Ricarte LP, Bezerra GP, Romero NR, Silva HCD, Lemos TLG, Arriaga AMC, Alves PB, Santos MBD, Militão GCG, Silva TDS, Braz-Filho R, Santiago GMP Tags: An Acad Bras Cienc Source Type: research

Photocatalytic-degradation of organic dye and removal of heavy metal ions using synthesized SnO2 nanoparticles by Vitex agnus-castus fruit via a green route
Publication date: Available online 26 December 2019Source: Materials LettersAuthor(s): J. Ebrahimian, M. Mohsennia, M. KhayatkashaniAbstractThe SnO2 nanoparticles (NPs) have been successfully synthesized by green synthesis method using Vitex agnus-castus fruit extract. The structural properties of prepared NPs were investigated, indicating homogeneous size distribution of spherically shaped NPs with an average particle size of 8 nm. The photocatalytic activity of the SnO2 NPs for degradation of rhodamine B (RhB) dye in aqueous solution under UV irradiation has been investigated. According the results, the dye degradation e...
Source: Materials Letters - December 26, 2019 Category: Materials Science Source Type: research

Facile synthesis of trimetallic nanoparticles Au/CuO/ZnO using Vitex agnus-castus extract and their activity in degradation of organic dyes
. (Source: International Journal of Environmental Analytical Chemistry)
Source: International Journal of Environmental Analytical Chemistry - December 20, 2019 Category: Chemistry Authors: Renata Dobrucka Source Type: research

Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials.
te;s I, Szentesi A, Matuz M Abstract Although chasteberry (Vitex agnus-castus, VAC) has been studied in several clinical trials and available as medicine for the alleviation of premenstrual syndrome (PMS) symptoms, the efficacy of properly characterised preparations has not been assessed in meta-analyses. The aim of our work was to evaluate the efficacy of VAC in PMS. The meta-analysis was performed following the PRISMA guidelines using the PICOS format, taking into account the CONSORT recommendations. PubMed, Embase, the Cochrane Central Register of Controlled Trials and Web of Science were searched for studies o...
Source: Complementary Therapies in Medicine - November 30, 2019 Category: Complementary Medicine Authors: Csupor D, Lantos T, Hegyi P, Benkő R, Viola R, Gyöngyi Z, Csécsei P, Tóth B, Vasas A, Márta K, Rostás I, Szentesi A, Matuz M Tags: Complement Ther Med Source Type: research

Facile synthesis of trimetallic nanoparticles Au/CuO/ZnO using Vitex agnus-castus extract and their activity in degradation of organic dyes
. (Source: International Journal of Environmental Analytical Chemistry)
Source: International Journal of Environmental Analytical Chemistry - November 13, 2019 Category: Chemistry Authors: Renata Dobrucka Source Type: research

Vitex Agnus-Castus for the Treatment of Cyclic Mastalgia: A Systematic Review and Meta-Analysis
Journal of Women's Health, Ahead of Print. (Source: Journal of Women)
Source: Journal of Women - August 28, 2019 Category: OBGYN Authors: Soo Liang Ooi Stephanie Watts Rhett McClean Sok Cheon Pak Source Type: research

The effects of Vitex agnus-castus on menstrual bleeding: A systematic review and meta-analysis
Authors: Mollazadeh, Sanaz / Mirghafourvand, Mojgan / Abdollahi, Nafiseh Ghassab (Source: Journal of Complementary and Integrative Medicine)
Source: Journal of Complementary and Integrative Medicine - July 30, 2019 Category: Complementary Medicine Source Type: research

Drug-induced psychotic disorder after administration of Vitex agnus castus (chasteberry) medication to treat premenstrual syndrome: a case report
Discussion The standardization of the diagnostic criteria for MCI, as well as the tests used in the cognitive evaluation, could allow the comparison between the studies and would be an important step in the researches of this area. (Source: Revista de Psiquiatria Clinica)
Source: Revista de Psiquiatria Clinica - July 30, 2019 Category: Psychiatry Source Type: research

Quality Assessment of Medicinal Product and Dietary Supplements Containing Vitex agnus-castus by HPLC Fingerprint and Quantitative Analyses.
In this study, we aimed to evaluate the quality of 11 products sold in Japan (one medicinal product and 10 dietary supplements) containing/claiming to contain chasteberry extract (fruit of Vitex agnus-castus L.) using HPLC fingerprint (15 characteristic peaks), quantitative determination of chemical marker compounds, and a disintegration test. The HPLC profile of the medicinal product was similar to that of the reference standard of V. agnus-castus fruit dry extract obtained from European Directive for the Quality of Medicines (EDQM), whereas the profiles of some dietary supplements showed great variability, such as differ...
Source: Chemical and Pharmaceutical Bulletin - June 4, 2019 Category: Drugs & Pharmacology Authors: Sogame M, Naraki Y, Sasaki T, Seki M, Yokota K, Masada S, Hakamatsuka T Tags: Chem Pharm Bull (Tokyo) Source Type: research

Designing an Au/reduced graphene oxide modified carbon paste electrode for the electrochemical quantification of agnuside
This study reported a good linearity in the range of 0.050-250.0 nM and a low detection limit of 0.016 nM. The relative standard deviations (RSDs) for 10.0 nM and 100.0 nM of agnuside were obtained 3.3% and 1.2%, respectively. The sensor was successfully applied to determine agnuside in Vitex agnus castus fruit and urine sample.Graphical abstract (Source: Sensors and Actuators B: Chemical)
Source: Sensors and Actuators B: Chemical - April 2, 2019 Category: Chemistry Source Type: research

The LC/ESI-MSMS Profiles and Biological Potentials of Vitex agnus castus Extracts.
Authors: Ağalar HG, Çiftçi GA, Yιldιrιm SU, Göger F, Kιrιmer N Abstract The chemical profile, cytotoxic and apoptotic effect, and antioxidant activity were determined of ethanolic extracts of Vitex agnus-castus L. (chaste tree). Ripened fruits and fruitless aerial parts were extracted with ethanol, and the chemical characterization of the extracts was determined by LC/ESI-MS-MS. Twelve compounds were tentatively identified in the extracts. The dose-dependent cytotoxic effects of the extracts were tested on C6, A549 and MCF-7 cells by using MT7 assay; inhibition of DNA sy...
Source: Natural Product Communications - January 2, 2019 Category: Biochemistry Tags: Nat Prod Commun Source Type: research

Optimizing a recombinant estrogen receptor binding assay for analysis of herbal extracts
Publication date: Available online 10 December 2018Source: Journal of Herbal MedicineAuthor(s): Sandra L. Gray, Brett R. LackeyAbstractPhytoestrogens may directly or indirectly affect the function of estrogen receptors. A method using human recombinant estrogen receptors alpha and beta (ERα and ERβ) was adapted for pure isoflavone compounds: glycitein, glycitin, biochanin A and formononetin; and extracts from chaste tree, Queen-Anne’s lace, Cyperus rhizome, dong quai, flaxseed, black cohosh, Siberian ginseng, saw palmetto, hops, licorice, red clover and alfalfa. Estrogen binding equivalents (EBE) for extra...
Source: Journal of Herbal Medicine - December 11, 2018 Category: Complementary Medicine Source Type: research

Efficacy of a Herbal Formulation Based on Foeniculum Vulgare in Oligo/Amenorrhea: A Randomized Clinical Trial.
Abstract BACKGROUND: The aim of this study was to evaluate the efficacy of the herbal tea based on Foeniculum vulgare, on inducing regular bleeding in women with oligomenorrhea and secondary amenorrhea(oligo/amenorrhea). METHODS: Forty women aged 18- 40 with oligo/amenorrhea were enrolled in this randomized controlled clinical trial and were allocated to two groups equally. The women in the first group were treated by Fomentex (Foeniculum vulgare / Mentha longifolia / Vitex agnus-castus) herbal tea 11.2 g/day in 2 divided doses for 2 weeks and the second group were treated by medroxy progesterone acetate (MP)...
Source: Current Drug Discovery Technologies - October 29, 2018 Category: Drugs & Pharmacology Authors: Falahat F, Ayatiafin S, Jarahi L, Mokaberinejad R, Rakhshandeh H, Feyzabadi Z, Tavakkoli M Tags: Curr Drug Discov Technol Source Type: research

Vitex negundo and its medicinal value.
Abstract Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Several bioactive compounds have been extracted from leaves, seeds, roots in form of volatile oils, flavonoids, lignans, iridoids, terpenes, and steroids. These bioactive compounds exhibit anti-inflammatory, antioxidant, antidiabetic, anticanc...
Source: Molecular Biology Reports - October 11, 2018 Category: Molecular Biology Authors: Gill BS, Mehra R, Navgeet, Kumar S Tags: Mol Biol Rep Source Type: research

Effects of a combination of Nigella sativa and Vitex agnus-castus with citalopram on healthy menopausal women with hot flashes: results from a subpopulation analysis
. (Source: Gynecological Endocrinology)
Source: Gynecological Endocrinology - August 21, 2018 Category: Endocrinology Authors: Maryam Molaie Behrad Darvishi Zahra Jafari Azar Mahboobeh Shirazi Gholamreza Amin Shima Afshar Source Type: research

Integrated in silico-in vitro strategy for screening of some traditional Egyptian plants for human aromatase inhibitors
ConclusionThe suggested strategy provides a reliable means of prospecting in-silico screening of natural products databases in the search for new dug leads as aromatase inhibitors. The hits so obtained can then be subjected to further phytochemical studies, to isolate and identify suitable compounds for further in-vitro testing.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of Vitex agnus-castus extract on the secretory function of pituitary-gonadal axis and pregnancy rate in patients with premature ovarian aging (POA)
ConclusionVAC extract as a fertility-promoting plant appears to be a safe and effective herb for medicinal applications in women with POA when used within the established dosage guidelines. (Source: Journal of Herbal Medicine)
Source: Journal of Herbal Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research

Integrated in silico-in vitro strategy for screening of some traditional Egyptian plants for human aromatase inhibitors
ConclusionThe suggested strategy provides a reliable means of prospecting in-silico screening of natural products databases in the search for new dug leads as aromatase inhibitors. The hits so obtained can then be subjected to further phytochemical studies, to isolate and identify suitable compounds for further in-vitro testing.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of Vitex agnus-castus extract on the secretory function of pituitary-gonadal axis and pregnancy rate in patients with premature ovarian aging (POA)
ConclusionVAC extract as a fertility-promoting plant appears to be a safe and effective herb for medicinal applications in women with POA when used within the established dosage guidelines. (Source: Journal of Herbal Medicine)
Source: Journal of Herbal Medicine - July 5, 2018 Category: Complementary Medicine Source Type: research

Integrated in silico-in vitro strategy for screening of some traditional Egyptian plants for human aromatase inhibitors
Conclusion The suggested strategy provides a reliable means of prospecting in-silico screening of natural products databases in the search for new dug leads as aromatase inhibitors. The hits so obtained can then be subjected to further phytochemical studies, to isolate and identify suitable compounds for further in-vitro testing. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - June 20, 2018 Category: Drugs & Pharmacology Source Type: research

Herbal Medicine for Oligomenorrhea and Amenorrhea: A Systematic Review of Ancient and Conventional Medicine.
Conclusion. Traditional Persian medicine has proposed many different medicinal plants for treatment of oligomenorrhea and amenorrhea. Although just few plants have been proven to be effective for treatment of menstrual irregularities, the results and the classification in present study can be used as an outline for future studies and treatment. PMID: 29744355 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 11, 2018 Category: Research Authors: Moini Jazani A, Hamdi K, Tansaz M, Nazemiyeh H, Sadeghi Bazargani H, Fazljou SMB, Nasimi Doost Azgomi R Tags: Biomed Res Int Source Type: research

Effects of Vitex agnus-castus extract on the secretory function of pituitary-gonadal axis and pregnancy rate in patients with premature ovarian aging (POA)
Conclusion VAC extract as a fertility-promoting plant appears to be a safe and effective herb for medicinal applications in women with POA when used within the established dosage guidelines. (Source: Journal of Herbal Medicine)
Source: Journal of Herbal Medicine - October 28, 2017 Category: Complementary Medicine Source Type: research

IJERPH, Vol. 14, Pages 1209: Toxic Elements in Different Medicinal Plants and the Impact on Human Health
a Local medicinal plants from Madina, Saudi Arabia, are used to cure various diseases. However, some can cause adverse health effects. Five different medicinal plants were collected in the city of Madina: mahareeb (Cymbopogon), sheeh (Artemisia), harjal (Cynanchum argel delile), nabipoot (Equisetum), and kafmariam (Vitex agnus-castus). In total, four toxic elements including Al, Pb, As, and Cd were analyzed using inductively coupled plasma mass spectrometry (ICP-MS). The range of recoveries fell between 86.1 and 90.6% for all measured elements. Al levels were the highest of any of the studied elements in all plant samp...
Source: International Journal of Environmental Research and Public Health - October 11, 2017 Category: Environmental Health Authors: Eid Brima Tags: Article Source Type: research

Assessment of in vitro dopamine-neuroblastoma cell interactions with a bioelectric biosensor: perspective for a novel in vitro functional assay for dopamine agonist/antagonist activity.
Abstract Current receptor-binding assays for dopamine do not measure the in vitro whole cellular response against dopamine or potential agonist/antagonist molecules. We herewith report the development of a novel functional assay concept for studying the in vitro interaction of the neurotransmitter dopamine with neural cells bearing dopamine receptors. The concept is based on the ultra-rapid measurement of changes in the electric properties of cultured N2a mouse neuroblastoma cells (corresponding to cumulative changes of the cell membrane potential). A close relationship between cumulative cell membrane potential a...
Source: Talanta - May 15, 2017 Category: Chemistry Authors: Apostolou T, Moschopoulou G, Kolotourou E, Kintzios S Tags: Talanta Source Type: research

The treatment of premenstrual syndrome with  preparations of Vitex agnus castus: a systematic review and meta-analysis
Our objective was to determine the efficacy, tolerability, and acceptability of Vitex agnus castus preparations for treatment of premenstrual syndrome. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 22, 2017 Category: OBGYN Authors: Saskia Verkaik, Astrid M. Kamperman, Roos van Westrhenen, Peter F.J. Schulte Tags: Systematic Review Source Type: research

The treatment of premenstrual syndrome with preparations of Vitex agnus castus: A systematic review and meta-analysis
A high risk of bias and the heterogeneity of the included studies preclude a definite conclusion about the effectiveness of treatment of PMS with Vitex agnus castus (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 22, 2017 Category: OBGYN Authors: Saskia Verkaik, Astrid M. Kamperman, Roos van Westrhenen, Peter F.J. Schulte Tags: Systematic Review Source Type: research

Nanoemulsion for improving solubility and permeability of Vitex agnus-castus extract: formulation and in vitro evaluation using PAMPA and Caco-2 approaches.
Authors: Piazzini V, Monteforte E, Luceri C, Bigagli E, Bilia AR, Bergonzi MC Abstract The purpose of this study was to develop new formulation for an improved oral delivery of Vitex agnus-castus (VAC) extract. After the optimization and validation of analytical method for quali-quantitative characterization of extract, nanoemulsion (NE) was selected as lipid-based nanocarrier. The composition of extract-loaded NE resulted in triacetin as oil phase, labrasol as surfactant, cremophor EL as co-surfactant and water. NE contains until 60 mg/mL of extract. It was characterized by DLS and TEM analyses and its drop...
Source: Drug Delivery - February 8, 2017 Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research

Report on the Medicinal Use of Eleven Lamiaceae Species in Lebanon and Rationalization of Their Antimicrobial Potential by Examination of the Chemical Composition and Antimicrobial Activity of Their Essential Oils.
Authors: Khoury M, Stien D, Eparvier V, Ouaini N, El Beyrouthy M Abstract Many Lamiaceae species are consumed in the Lebanese cuisine as food or condiment and are largely used in the traditional medicine of Lebanon to treat various diseases, including microbial infections. In this article we report the traditional medicinal uses of eleven Lamiaceae species: Coridothymus capitatus L., Lavandula stoechas L., Lavandula angustifolia Mill., Mentha spicata L. subsp. condensata, Origanum syriacum L., Rosmarinus officinalis, Salvia fruticosa Miller., Satureja cuneifolia Ten., Satureja thymbra L., Thymbra spicata L., and Vi...
Source: Evidence-based Complementary and Alternative Medicine - January 7, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

SC-CO2 extraction of Vitex agnus-castus L. fruits: The influence of pressure, temperature and water presoaking on the yield and GC –MS profiles of the extracts in comparison to the essential oil composition
The objectives were trifold: 1) to investigate the impact of pressure, temperature and water presoaking on SC-CO2 extraction of Vitex agnus-castus L. fruits with respect to the yield and GC–MS profiles of the extracts; 2) to find optimal extraction conditions by response surface methodology (RSM); 3) to compare GC–MS profiles of the extracts and essential oil. SC-CO2 extraction was performed at different pressures (8.4–36.6MPa) and temperatures (35.8–64.1°C) determined by central composite rotatable design. The essential oil was obtained by hydrodistillation. The extracts and oil were analyzed b...
Source: The Journal of Supercritical Fluids - December 31, 2016 Category: Chemistry Source Type: research

Nanoemulsions to enhance oral bioavailability of Vitex Agnus-castus extract
Planta Med 2016; 81: S1-S381 DOI: 10.1055/s-0036-1596925 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Planta Medica)
Source: Planta Medica - December 13, 2016 Category: Drugs & Pharmacology Authors: Piazzini, V Monteforte, E Luceri, C Bigagli, E Guccione, C Bilia, AR Bergonzi, MC Tags: Abstracts Source Type: research

Botanicals and Their Bioactive Phytochemicals for Women's Health.
Abstract Botanical dietary supplements are increasingly popular for women's health, particularly for older women. The specific botanicals women take vary as a function of age. Younger women will use botanicals for urinary tract infections, especially Vaccinium macrocarpon (cranberry), where there is evidence for efficacy. Botanical dietary supplements for premenstrual syndrome (PMS) are less commonly used, and rigorous clinical trials have not been done. Some examples include Vitex agnus-castus (chasteberry), Angelica sinensis (dong quai), Viburnum opulus/prunifolium (cramp bark and black haw), and Zingiber offici...
Source: Pharmacological Reviews - September 30, 2016 Category: Drugs & Pharmacology Authors: Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL Tags: Pharmacol Rev Source Type: research

Effects of Vitex agnus-castus fruit on sex hormones and antioxidant indices in a d-galactose-induced aging female mouse model
Conclusion Vitex improved some aging events in the reproductive system of female mice. Therefore, because of its apparent antiaging effects, Vitex can be suitable for some aging problems such as oxidative stress, female sex hormone deficiency, and an atrophic endometrium. (Source: Journal of the Chinese Medical Association)
Source: Journal of the Chinese Medical Association - August 29, 2016 Category: Journals (General) Source Type: research

Chemical composition and acaricidal activity of the essential oils from Vitex agnus-castus L. (Verbenaceae) and selected monoterpenes.
Abstract Tetranychus urticae is considered one of the main plagues in the world. Its occurrence in Pernambuco was registered for the first time in 1985 and it has caused considerable damage to the farmers, attacking different cultures of agricultural interest. The essential oils from different parts of Vitex agnus-castus harvested in the Atlantic forest in the state of Pernambuco, Brazil, were obtained by hydrodistillation and the acaricidal potential was evaluated against Tetranychus urticae using two methods under laboratory conditions. Gas chromatography-mass spectrometry revealed the presence of 47 components ...
Source: An Acad Bras Cienc - August 3, 2016 Category: Science Authors: Neves RC, Camara CA Tags: An Acad Bras Cienc Source Type: research

Functional morphology of pituitary -thyroid and -adrenocortical axes in middle-aged male rats treated with Vitex agnus castus essential oil.
lošević V Abstract We previously reported that Vitex agnus-castus L. essential oil (VACEO), when administered to middle-aged males, exerts a bone-protective effect, induces silencing of locomotor activities and decreases pituitary prolactin immunopositivity. To further assess the putative endocrine effects of VACEO, we examined the pituitary-thyroid and -adrenocortical axes in our model. Sixteen-month-old Wistar rats were subcutaneously administered 60mg/kg of VACEO dissolved in sterile olive oil, while the control group received the same amount of vehicle alone for three weeks. Pituitaries, thyroids and a...
Source: Acta Histochemica - July 27, 2016 Category: Biochemistry Authors: Šošić-Jurjević B, Ajdžanović V, Filipović B, Trifunović S, Jarić I, Ristić N, Milošević V Tags: Acta Histochem Source Type: research

Induction of apoptosis in HepG2 by Vitex agnus-castus L. leaves extracts and identification of their active chemical constituents by LC-ESI-MS
Conclusions The butanolic fraction has higher contents of secondary metabolites than the defatted methanolic extract. The cytotoxic activities, apoptotic changes, and caspase-3 activation may be due to the presence of these bioactive secondary metabolites (iridoids, flavonoid, and phenolic acids) in these extracts. These results would suggest V. agnus-castus to be used as an adjuvant in cancer therapy. (Source: Asian Pacific Journal of Tropical Disease)
Source: Asian Pacific Journal of Tropical Disease - July 9, 2016 Category: Tropical Medicine Source Type: research

Authentication of the botanical origin of Western herbal products using Cimicifuga and Vitex products as examples
Abstract Various herbal medicines have been developed and used in various parts of the world for thousands of years. Although locally grown indigenous plants were originally used for traditional herbal preparations, Western herbal products are now becoming popular in Japan with the increasing interest in health. At the same time, there are growing concerns about the substitution of ingredients and adulteration of herbal products, highlighting the need for the authentication of the origin of plants used in herbal products. This review describes studies on Cimicifuga and Vitex products developed in Europe and Japan,...
Source: Journal of Natural Medicines - May 16, 2016 Category: Drugs & Pharmacology Source Type: research

A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies
Systematic reviews and meta‐analyses represent the uppermost ladders in the hierarchy of evidence. Systematic reviews/meta‐analyses suggest preliminary or satisfactory clinical evidence for agnus castus (Vitex agnus castus) for premenstrual complaints, flaxseed (Linum usitatissimum) for hypertension, feverfew (Tanacetum partenium) for migraine prevention, ginger (Zingiber officinalis) for pregnancy‐induced nausea, ginseng (Panax ginseng) for improving fasting glucose levels as well as phytoestrogens and St John's wort (Hypericum perforatum) for the relief of some symptoms in menopause. However, firm conclusions of ef...
Source: Phytotherapy Research - February 17, 2016 Category: Biochemistry Authors: Angelo A. Izzo, Sung Hoon‐Kim, Rajan Radhakrishnan, Elizabeth M. Williamson Tags: Review Source Type: research

Phytopharmacological Review on Vitex agnus-castus: A Potential Medicinal Plant
Publication date: January 2016 Source:Chinese Herbal Medicines, Volume 8, Issue 1 Author(s): Hina Zahid, Ghazala H. Rizwani, Sumaira Ishaqe Vitex agnus-castus is a small tree or shrub, belonging to the family Verbenaceae. It is a deciduous shrub native to European, Mediterranean, and Central Asian countries. V. agnus castus has a long tradition as a herbal remedy and was used in ancient times not only as an anaphrodisiac but also against diverse disturbances of the female genital system. The major constituents in V. agnus-castus are flavonoids, essential oils, diterpenes, and glycosides. The flavonoids (casticin, quer...
Source: Chinese Herbal Medicines - February 2, 2016 Category: Complementary Medicine Source Type: research

Determination and identification of a specific marker compound for discriminating Shrub Chaste Tree Fruit from Agnus Castus Fruit based on LC/MS metabolic analysis.
Abstract Shrub Chaste Tree Fruit (SCTF) is defined as the fruits of Vitex rotundifolia L. f. and V. trifolia L. and has been used as a component of some traditional Japanese medicines (Kampo formulations). Agnus Castus Fruit (ACF) is defined as the dried ripe fruits of V. agnus-castus L.; it is used in traditional European medicines, but is becoming popular in Japan as both an over-the-counter drug and as an ingredient in health foods for treating premenstrual syndrome (PMS). To ensure the efficacy and safety of both SCTF and ACF products, it is important to precisely authenticate their botanical origins and to cl...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2016 Category: Drugs & Pharmacology Authors: Yahagi T, Masada S, Oshima N, Suzuki R, Matsufuji H, Takahashi Y, Watanabe M, Yahara S, Iida O, Kawahara N, Maruyama T, Goda Y, Hakamatsuka T Tags: Chem Pharm Bull (Tokyo) Source Type: research

[Evaluation of the efficacy of a new nutraceutical product in the treatment of postmenopausal symptoms].
In conclusion, it can be stated that the supplement evaluated in the present study is able to reduce moderate/severe menopause symptoms. PMID: 26788874 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - January 22, 2016 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Identification of New Diterpenes as Putative Marker Compounds Distinguishing Agnus Castus Fruit (Chaste Tree) from Shrub Chaste Tree Fruit (Viticis Fructus)
Planta Med 2016; 82: 147-153DOI: 10.1055/s-0035-1558089Agnus Castus Fruit is defined in the European Pharmacopoeia as the dried ripe fruit of Vitex agnus-castus. In Europe it is used as a medicine targeting premenstrual syndrome and climacteric disorder. In Japan, Agnus Castus Fruit is becoming popular as a raw material for over-the-counter drugs and health food products, though its congenic species, Vitex rotundifolia and Vitex trifolia, have been used as Shrub Chaste Tree Fruit in traditional medicines. Therefore, it is important to discriminate these Vitex plants from the viewpoint of regulatory science. Here we tried t...
Source: Planta Medica - January 12, 2016 Category: Drugs & Pharmacology Authors: Oshima, NaohiroMasada, SayakaSuzuki, RyutaYagi, KanaeMatsufuji, HiroshiSuenaga, EmiTakahashi, YutakaYahagi, TadahiroWatanabe, MasatoYahara, ShojiIida, OsamuKawahara, NobuoMaruyama, TakuroGoda, YukihiroHakamatsuka, Takashi Tags: Natural Product Chemistry Source Type: research

Study on chemical analysis, antioxidant and in vitro antifungal activities of essential oil from wild Vitex agnus-castus L. seeds growing in area of Argan Tree of Morocco against clinical strains of Candida responsible for nosocomial infections
Conclusion Results of this study indicated that the oils of plant origin could be used as potential anti-Candida species causative agents of nosocomial infections. These oils exhibited a noticeable antifungal activity against the selected fungi. The natural antifungal substances are inexpensive and have fewer side effects, they may represent alternative therapies for candidiasis. (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - November 22, 2015 Category: Biology Source Type: research

Casticin, an active compound isolated from Vitex Fructus, ameliorates the cigarette smoke-induced acute lung inflammatory response in a murine model.
Abstract The aim of this study was to determine of the effect of casticin, as an anti-inflammatory agent, on an acute lung inflammation in vivo model established through exposure to cigarette smoke (CS). Casticin is a phytochemical from Vitex species such as Vitex rotundifolia and Vitex agnus-castus that was recently shown to exert an anti-inflammatory effect in vivo. To demonstrate the effects of casticin, C57BL/6 mice were whole-body exposed to mainstream CS or fresh air for two weeks and treated with 1, 2, and 10mg/kg casticin via an i.p. injection. Immune cell infiltrations and cytokine productions were assess...
Source: International Immunopharmacology - August 25, 2015 Category: Allergy & Immunology Authors: Lee H, Jung KH, Lee H, Park S, Choi W, Bae H Tags: Int Immunopharmacol Source Type: research

Vitex agnus-castus L. (Verbenaceae) Improves the Liver Lipid Metabolism and Redox State of Ovariectomized Rats.
Authors: Moreno FN, Campos-Shimada LB, da Costa SC, Garcia RF, Cecchini AL, Natali MR, Vitoriano Ade S, Ishii-Iwamoto EL, Salgueiro-Pagadigorria CL Abstract Vitex agnus-castus (VAC) is a plant that has recently been used to treat the symptoms of menopause, by its actions on the central nervous system. However, little is known about its actions on disturbances in lipid metabolism and nonalcoholic fat liver disease (NAFLD), frequently associated with menopause. Ovariectomized (OVX) rats exhibit increased adiposity and NAFLD 13 weeks after ovary removal and were used as animal models of estrogen deficiency. The rats w...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research