Effects of the PREMEN-CALM ® in the Management of the Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
J Diet Suppl. 2024 Jan 11:1-17. doi: 10.1080/19390211.2023.2301398. Online ahead of print.ABSTRACTPremenstrual syndrome is a common disorder in women of reproductive age characterized by a variety of cyclical symptoms with a great impact on their lifestyle. Available pharmacological options include both antidepressants and oral contraceptives, both of which have side effects, are expensive and not always effective. Vitamins, minerals and plant extracts have been proven to alleviate the symptomatology of the premenstrual syndrome. For this reason, the purpose of this study was to test the effectiveness of a commercial phyto...
Source: Journal of Dietary Supplements - January 12, 2024 Category: Nutrition Authors: Andrea Herrera Miriam Al Adib Ana Beatriz Rodr íguez Cristina Carrasco Source Type: research

Evaluation of the therapeutic efficacy of < em > Vitex agnus-castus < /em > extract on cisplatin-induced hematotoxicity in female Wistar rats
CONCLUSION: Our findings showed that VACE can mitigate CP-induced damage to peripheral blood cells at lower doses.PMID:38152275 | PMC:PMC10750742 | DOI:10.14202/vetworld.2023.2186-2191 (Source: Cancer Control)
Source: Cancer Control - December 28, 2023 Category: Cancer & Oncology Authors: Aparna Tripathy Archana Parampalli Raghavendra Babi Dutta Sudarshan Surendran Source Type: research

Evaluation of the therapeutic efficacy of < em > Vitex agnus-castus < /em > extract on cisplatin-induced hematotoxicity in female Wistar rats
CONCLUSION: Our findings showed that VACE can mitigate CP-induced damage to peripheral blood cells at lower doses.PMID:38152275 | PMC:PMC10750742 | DOI:10.14202/vetworld.2023.2186-2191 (Source: Cancer Control)
Source: Cancer Control - December 28, 2023 Category: Cancer & Oncology Authors: Aparna Tripathy Archana Parampalli Raghavendra Babi Dutta Sudarshan Surendran Source Type: research

Vitex agnus castus effects on hyperprolactinaemia
ConclusionIt appears that VAC may represent a potentially useful and safe phytotherapic option for the management of selected patients with mild hyperprolactinaemia who wish to be treated with phytotherapy. However, larger studies of high quality are needed to corroborate it. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - November 21, 2023 Category: Endocrinology Source Type: research

Efficacy and Tolerability Evaluation of a Nutraceutical Composition Containing Vitex agnus-castus Extract (EVX40 ™), Pyridoxine, and Magnesium in Premenstrual Syndrome: A Real-World, Interventional, Comparative Study
Conclusion The results of the current study conclude that the nutraceutical composition of Vitex agnus-castus extract, vitamin B6, and magnesium is effective in reducing the severity of PMS symptoms and improving the quality of life of PMS subjects. The nutraceutical therapy provided greater relief from PMS symptoms compared to standard therapy alone, and this effect was augmented when the nutraceutical therapy was provided in combination with standard therapies. Similarly, the improvement in quality-of-life parameters was greater in subjects treated with nutraceuticals alone or in combination therapy. Despite the limitati...
Source: Pain Physician - September 4, 2023 Category: Anesthesiology Authors: Varun P Sureja Dharmeshkumar B Kheni Vishal P Dubey Jignesh Kansagra Zeel K Soni Sandipkumar P Bhatt Akash Mathuria Shrikalp S Deshpande Source Type: research

Efficacy and Tolerability Evaluation of a Nutraceutical Composition Containing Vitex agnus-castus Extract (EVX40 ™), Pyridoxine, and Magnesium in Premenstrual Syndrome: A Real-World, Interventional, Comparative Study
Conclusion The results of the current study conclude that the nutraceutical composition of Vitex agnus-castus extract, vitamin B6, and magnesium is effective in reducing the severity of PMS symptoms and improving the quality of life of PMS subjects. The nutraceutical therapy provided greater relief from PMS symptoms compared to standard therapy alone, and this effect was augmented when the nutraceutical therapy was provided in combination with standard therapies. Similarly, the improvement in quality-of-life parameters was greater in subjects treated with nutraceuticals alone or in combination therapy. Despite the limitati...
Source: Pain Physician - September 4, 2023 Category: Anesthesiology Authors: Varun P Sureja Dharmeshkumar B Kheni Vishal P Dubey Jignesh Kansagra Zeel K Soni Sandipkumar P Bhatt Akash Mathuria Shrikalp S Deshpande Source Type: research

Molecules, Vol. 28, Pages 5096: Wild Vitex agnus-castus L.: Phytochemical Characterization, Acute Toxicity, and Bioactive Properties
This study aimed to validate, for the first time, the beneficial use of VAC fruits and fruit decoctions (VFDs) through in vitro and in vivo trials. Forty-one volatile components were detected in VAC fruits, with 1,8-cineole (30.3%) comprising the majority. The antioxidant activity of VFD was measured by using different in vitro methods (EC50 of 0.16 mg/mL by &amp;beta;-carotene bleaching inhibition assay) and by measuring the DNA protection power. Using the disc diffusion assay, the antimicrobial activity of VFD was evaluated, and it exhibited a noticeable anticandidal activity. VFD did not cause any toxicity or mortal...
Source: Molecules - June 29, 2023 Category: Chemistry Authors: Mohamed Ali Boujbiha Hassiba Chahdoura Khaoula Adouni Borhane Eddine Cherif Ziani Mejdi Snoussi Yasmine Chakroun Mar ía Ciudad-Mulero Virginia Fern ández-Ruiz Lotfi Achour Boulbaba Selmi Patricia Morales Guido Flamini Habib Mosbah Tags: Article Source Type: research

Evaluation of Anti- < em > Candida albicans < /em > Activities of Herbal Preparations Sold at the Kumasi Central Market in the Ashanti Region of Ghana
This study, therefore, evaluated the anti-C. albicans activities of five selected herbal preparations indicated for treating candidiasis sold at the Kumasi Central Market in the Ashanti Region of Ghana. The market was divided into five clusters, and one herbal preparation was randomly selected from each cluster. Using the Kirby Bauer disc diffusion antimicrobial susceptibility test, the herbal preparations were tested against clinically isolated C. albicans. Fluconazole, a standard antifungal drug, was included in the evaluation as a positive control. The experiments were performed on three different days and each in tripl...
Source: Evidence-based Complementary and Alternative Medicine - April 21, 2023 Category: Complementary Medicine Authors: Seth A Domfeh Godfred Kyeremeh Mark Belifini Source Type: research

Polyphenol content and antioxidant activity of phytoestrogen containing food and dietary supplements: DPPH free radical scavenging activity by HPLC
This study is aimed to evaluate the total polyphenolic content and antioxidant activity of phytoestrogen-containing food and formulated dietary supplements. The HPLC-DPPH method was applied for DPPH free radical scavenging activity testing of various phytoestrogen-containing samples. Polyphenol content and antioxidant activity in dietary supplements were higher than in functional food samples; multiple-botanical-source preparations showed higher polyphenol content and antioxidant activity than the mono-botanical counterparts. Furthermore, the correlation between polyphenol content and anti-oxidant activity was strongly sta...
Source: Acta Pharmaceutica - January 18, 2023 Category: Drugs & Pharmacology Authors: Daniela Amid žić Klarić Ana Mornar Jelena Kova čić Mario-Livio Jeli čić Edvin Brusa č Iva Brleti ć Ilija Klari ć Source Type: research

Polyphenol content and antioxidant activity of phytoestrogen containing food and dietary supplements: DPPH free radical scavenging activity by HPLC
This study is aimed to evaluate the total polyphenolic content and antioxidant activity of phytoestrogen-containing food and formulated dietary supplements. The HPLC-DPPH method was applied for DPPH free radical scavenging activity testing of various phytoestrogen-containing samples. Polyphenol content and antioxidant activity in dietary supplements were higher than in functional food samples; multiple-botanical-source preparations showed higher polyphenol content and antioxidant activity than the mono-botanical counterparts. Furthermore, the correlation between polyphenol content and anti-oxidant activity was strongly sta...
Source: Acta Pharmaceutica - January 18, 2023 Category: Drugs & Pharmacology Authors: Daniela Amid žić Klarić Ana Mornar Jelena Kova čić Mario-Livio Jeli čić Edvin Brusa č Iva Brleti ć Ilija Klari ć Source Type: research

Polyphenol content and antioxidant activity of phytoestrogen containing food and dietary supplements: DPPH free radical scavenging activity by HPLC
This study is aimed to evaluate the total polyphenolic content and antioxidant activity of phytoestrogen-containing food and formulated dietary supplements. The HPLC-DPPH method was applied for DPPH free radical scavenging activity testing of various phytoestrogen-containing samples. Polyphenol content and antioxidant activity in dietary supplements were higher than in functional food samples; multiple-botanical-source preparations showed higher polyphenol content and antioxidant activity than the mono-botanical counterparts. Furthermore, the correlation between polyphenol content and anti-oxidant activity was strongly sta...
Source: Acta Pharmaceutica - January 18, 2023 Category: Drugs & Pharmacology Authors: Daniela Amid žić Klarić Ana Mornar Jelena Kova čić Mario-Livio Jeli čić Edvin Brusa č Iva Brleti ć Ilija Klari ć Source Type: research

Polyphenol content and antioxidant activity of phytoestrogen containing food and dietary supplements: DPPH free radical scavenging activity by HPLC
This study is aimed to evaluate the total polyphenolic content and antioxidant activity of phytoestrogen-containing food and formulated dietary supplements. The HPLC-DPPH method was applied for DPPH free radical scavenging activity testing of various phytoestrogen-containing samples. Polyphenol content and antioxidant activity in dietary supplements were higher than in functional food samples; multiple-botanical-source preparations showed higher polyphenol content and antioxidant activity than the mono-botanical counterparts. Furthermore, the correlation between polyphenol content and anti-oxidant activity was strongly sta...
Source: Acta Pharmaceutica - January 18, 2023 Category: Drugs & Pharmacology Authors: Daniela Amid žić Klarić Ana Mornar Jelena Kova čić Mario-Livio Jeli čić Edvin Brusa č Iva Brleti ć Ilija Klari ć Source Type: research

Polyphenol content and antioxidant activity of phytoestrogen containing food and dietary supplements: DPPH free radical scavenging activity by HPLC
This study is aimed to evaluate the total polyphenolic content and antioxidant activity of phytoestrogen-containing food and formulated dietary supplements. The HPLC-DPPH method was applied for DPPH free radical scavenging activity testing of various phytoestrogen-containing samples. Polyphenol content and antioxidant activity in dietary supplements were higher than in functional food samples; multiple-botanical-source preparations showed higher polyphenol content and antioxidant activity than the mono-botanical counterparts. Furthermore, the correlation between polyphenol content and anti-oxidant activity was strongly sta...
Source: Acta Pharmaceutica - January 18, 2023 Category: Drugs & Pharmacology Authors: Daniela Amid žić Klarić Ana Mornar Jelena Kova čić Mario-Livio Jeli čić Edvin Brusa č Iva Brleti ć Ilija Klari ć Source Type: research

Green Synthesis of Silver Nanoparticles Using the Plant Extracts of Vitex Agnus Castus L: An Ecofriendly Approach to Overcome Antibiotic Resistance
Conclusions: It can be stated that the biosynthesis of Ag NPs using fruit extract of this plant is an environmentally friendly, economic and harmless method without any use of poisonous substances and no side effects. These Ag NPs can be considered as suitable antibacterial agents and replacements for antibiotics. (Source: International Journal of Preventive Medicine)
Source: International Journal of Preventive Medicine - November 23, 2022 Category: International Medicine & Public Health Source Type: research

Anticholinergic, antioxidant, and antibacterial properties of Vitex agnus-castus L. seed extract : Assessment of its phenolic content by LC-MS/MS
Chem Biodivers. 2022 Sep 8. doi: 10.1002/cbdv.202200143. Online ahead of print.ABSTRACTIn this current study, Vitex agnus-castus seed ethanol extracts were analyzed for their phytochemical component content, anticholinergic and antioxidant activities, and antibacterial properties. The phenolic compound composition of these seeds was determined by using LC-MS/MS. Antioxidant activity of the seeds was examined by the DPPH, ABTS, Fe 3+ -Fe 2+ reducing, and CUPRAC. Also, the anticholinergic activity was measured by the inhibition of acetylcholinesterase (AChE). The antibacterial activity was performed by disc diffusion and min...
Source: Chemistry and Biodiversity - September 8, 2022 Category: Biochemistry Authors: Arzu Kavaz Mesut I şık Emrah Dikici Mehmet Y üksel Source Type: research