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News in Brief: Week of March 9-13
This roundup includes the following news briefs: FDA: Use Caution Mixing Chantix, Alcohol; VA Accelerates Deployment of Nationwide Opioid Therapy Tool; FDA Backs WHO Recommendations for 2015-16 Flu Vaccine Composition; Join HHS Network, Help Move Health Care Toward Value-based Payments; and Harvard Medical School Announces Inaugural InciteHealth Fellows. (Source: AAFP News)
Source: AAFP News - March 12, 2015 Category: Primary Care Source Type: news

Largest review of clinical trials to assess risk of patients using Champix
(University of Bristol) Findings from the largest review of clinical trials to date to determine whether patients prescribed the smoking cessation drug Varenicline (brand name Champix in the UK) are at an increased risk of neuropsychiatric events are published online in the British Medical Journal today. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 12, 2015 Category: Global & Universal Source Type: news

FDA Warns of Seizure, Alcohol Risk With Chantix
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - March 11, 2015 Category: Journals (General) Source Type: news

FDA Warns of Seizure, Alcohol Risk With Chantix
Title: FDA Warns of Seizure, Alcohol Risk With ChantixCategory: Health NewsCreated: 3/11/2015 12:00:00 AMLast Editorial Review: 3/11/2015 12:00:00 AM (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - March 11, 2015 Category: Respiratory Medicine Source Type: news

New FDA warning for anti-smoking drug Chantix
Drug already comes with a warning of suicidal or violent behavior, and now there's something else to be wary of (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - March 11, 2015 Category: Consumer Health News Source Type: news

FDA: Chantix Carries Potential Alcohol Interaction and Seizure Risk (FREE)
By Kristin J. Kelley Edited by Lorenzo Di Francesco, MD, FACP, FHM The FDA has approved a label change to varenicline (Chantix) to warn that the smoking cessation drug could "change the way people react to alcohol." Additionally, the label … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - March 11, 2015 Category: Primary Care Source Type: news

Quitting smoking? FDA flags alcohol, seizure risks for Chantix users
The U.S. Food and Drug Administration is warning smokers who are trying to quit that they may have trouble tolerating alcohol if they are taking Chantix. (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - March 10, 2015 Category: Science Source Type: news

FDA Warns of Seizure, Alcohol Risk With Chantix
The FDA has changed the labeling on the quit-smoking drug Chantix to reflect concerns that it may lower your tolerance to alcohol and is linked to a rare risk of seizures. (Source: WebMD Health)
Source: WebMD Health - March 10, 2015 Category: Consumer Health News Source Type: news

Morning Break: No Reprieve for Chantix; Rx Spending Spike
(MedPage Today) -- Health news and commentary from around the Web, gathered by the MedPage Today staff. (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - March 10, 2015 Category: American Health Source Type: news

U.S. FDA warns of seizure, alcohol risk with Pfizer's Chantix
(Reuters) - The U.S. Food and Drug Administration warned on Monday that Pfizer Inc's quit-smoking drug, Chantix, has been associated with seizures and that some patients who drink while taking the drug may become aggressive or black out. (Source: Reuters: Health)
Source: Reuters: Health - March 9, 2015 Category: Consumer Health News Tags: healthNews Source Type: news

Chantix (varenicline): Drug Safety Communication - FDA Updates Label to Include Potential Alcohol Interaction
Rare risk of seizures, and studies of side effects on mood, behavior, or thinking. Posted 03/09/2015 (Source: FDA MedWatch)
Source: FDA MedWatch - March 9, 2015 Category: American Health Source Type: news

Chantix May Lower Alcohol Tolerance, Up Seizure Risk: FDAChantix May Lower Alcohol Tolerance, Up Seizure Risk: FDA
The FDA has changed the labeling on the smoking cessation medication Chantix to reflect concerns that the drug may lower alcohol tolerance and boost seizure risk. News Alerts (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 9, 2015 Category: Consumer Health News Tags: Psychiatry News Source Type: news

Stop-Smoking Drug Helps HIV Patients Kick Habit (CME/CE)
(MedPage Today) -- But success rates with varenicline were still low. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - March 1, 2015 Category: Cardiology Source Type: news

Cardiac Regeneration/Stop-Smoking Drug/Juicing: Mayo Clinic Radio
On this week’s Mayo Clinic Radio: fixing a broken heart. Cardiac regeneration uses the body’s own stem cells to repair damage done by heart disease, Mayo Clinic cardiologist Dr. Atta Behfar explains. Also, Mayo Clinic registered dietitian Katherine Zeratsky explains the risks of juice-only diets. Plus, nicotine dependency expert Dr. Richard Hurt joins the program to discuss results of a new study about the stop-smoking drug varenicline (Chantix). Click here [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - February 23, 2015 Category: Databases & Libraries Source Type: news

Mayo clinic radio
On this week’s Mayo Clinic Radio: fixing a broken heart. Cardiac regeneration uses the body’s own stem cells to repair damage done by heart disease, Mayo Clinic cardiologist Dr. Atta Behfar explains. Also, Mayo Clinic registered dietitian Katherine Zeratsky explains the risks of juice-only diets. Plus, nicotine dependency expert Dr. Richard Hurt joins the program to discuss results of a new study about the stop-smoking drug varenicline (Chantix).  Myth or [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - February 20, 2015 Category: Databases & Libraries Source Type: news

Drug may help people gradually quit smoking
Anti-smoking drug Chantix can help smokers cut back, but "its success comes with a cost" -- serious side effects (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - February 18, 2015 Category: Consumer Health News Source Type: news

Chantix Linked to Higher Quit Rates in Certain Smokers: Study
Title: Chantix Linked to Higher Quit Rates in Certain Smokers: StudyCategory: Health NewsCreated: 2/17/2015 12:00:00 AMLast Editorial Review: 2/18/2015 12:00:00 AM (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - February 18, 2015 Category: Respiratory Medicine Source Type: news

Varenicline May Be an Option for Smokers Who Aren't Willing to Quit Just Yet (FREE)
By Kelly Young Edited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM Varenicline (Chantix) leads to higher smoking cessation rates among smokers who say they're not quite ready to quit, according to an industry-funded study in … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - February 18, 2015 Category: Primary Care Source Type: news

Chantix Linked to Higher Quit Rates in Certain Smokers: Study
But drug's side effects still worry some doctors (Source: WebMD Health)
Source: WebMD Health - February 17, 2015 Category: Consumer Health News Source Type: news

Chantix Linked to Higher Quit Rates in Certain Smokers
But drug's side effects still worry some doctors Source: HealthDay Related MedlinePlus Pages: Medicines, Quitting Smoking (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - February 17, 2015 Category: Consumer Health News Source Type: news

Medicine Given Even Before Smokers Are Ready to Quit Is Found to Help Them
A study has found that even for people who are not ready to stop smoking immediately, medicine taken over time can improve their chances of eventually quitting. (Source: NYT Health)
Source: NYT Health - February 17, 2015 Category: Consumer Health News Authors: By SABRINA TAVERNISE Tags: Nicotine Chantix Smoking and Tobacco Medicine and Health Pfizer Inc Source Type: news

Medication Therapy Can Increase Long-Term Success For Smokers Who Cut Back First
https://www.youtube.com/watch?v=1Dg5bncTJsg ROCHESTER, Minn. — A study of more than 1,500 cigarette smokers who were not ready to quit smoking but were willing to cut back on cigarette consumption and combine their approach with varenicline (Chantix) increased their long-term success of quitting smoking. The multinational study is published in the February issue of the Journal of [...] (Source: Mayo Clinic Rochester News)
Source: Mayo Clinic Rochester News - February 17, 2015 Category: Hospital Management Source Type: news

Mayo Clinic Radio: Cardiac Regeneration/Stop-Smoking Drug/Juicing
On this week’s Mayo Clinic Radio, fixing a broken heart. Cardiac regeneration uses the body’s own stem cells to repair damage done by heart disease. Mayo Clinic cardiologist Dr. Atta Behfar explains. Also on the program, nicotine dependency expert Dr. Richard Hurt discusses results of a new study about the stop-smoking drug varenicline (Chantix). And Mayo [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - February 16, 2015 Category: Databases & Libraries Source Type: news

Varenicline as a cause of suicidal outcomes - Hughes JR.
This article reviews post-marketing analyses, case reports, clinical trials, uncontrolled observational studies, controlled observational studies, ... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - January 23, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Blood test may tell you the 'best' way to quit smoking
Conclusion This is a well-conducted randomised controlled trial, which found that use of the nicotine-metabolite ratio (NMR) may be helpful in indicating which stop smoking treatment may be best for different people. For those with a normal NMR, varenicline was more effective than a nicotine patch. For slower metabolisers, there was no significant difference in the effectiveness of the two treatments, but they tended to get more side effects with varenicline. The study benefits from its large size, double-blind design and high follow-up rates. However, there are still questions to be answered. For example, the difference ...
Source: NHS News Feed - January 12, 2015 Category: Consumer Health News Tags: Heart/lungs Medication Medical practice Cancer Source Type: news

Varenicline May Affect Normal and Slow Metabolizers of Nicotine Differently (FREE)
By Kelly Young Edited by Susan Sadoughi, MD, and André Sofair, MD, MPH Varenicline is associated with higher cessation rates in smokers who metabolize nicotine normally but with more side effects in slow metabolizers, according to a Lancet … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - January 12, 2015 Category: Primary Care Source Type: news

Nicotine metabolism rates may impact success of smoking cessation treatments
A randomized clinical trial of smokers trying to quit found that the effectiveness of particular smoking cessation therapies might relate to how quickly their body metabolizes nicotine. The study compared success rates of the nicotine patch versus the prescription medication varenicline. Among... (Source: NIDA News)
Source: NIDA News - January 12, 2015 Category: Addiction Tags: Health and Medical Professionals, Researchers, Tobacco, Treatment Research Source Type: news

Nicotine metabolism rates may impact success of smoking cessation treatments
A randomized clinical trial of smokers trying to quit found that the effectiveness of particular smoking cessation therapies might relate to how quickly their body metabolizes nicotine. The study compared success rates of the nicotine patch versus the prescription medication varenicline. Among... (Source: NIDA News)
Source: NIDA News - January 12, 2015 Category: Addiction Tags: Health and Medical Professionals, Researchers, Tobacco, Treatment Research Source Type: news

Increasing Varenicline Dose Unlikely to Help in NonrespondersIncreasing Varenicline Dose Unlikely to Help in Nonresponders
Don't bother raising the dose of varenicline (Chantix) when smokers don't respond to the standard dose; it won't help, according to a new study. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 30, 2014 Category: Consumer Health News Tags: Psychiatry News Source Type: news

Varenicline poisoning for a suicidal purpose - Sørup FH, Neumann AB, Holst H.
We report a history of a 45-year-old woman who ingested 40-50 mg varenicline. She... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - October 31, 2014 Category: Global & Universal Tags: Poisoning Source Type: news

FDA Advisers Vote to Keep Black-Box Warning on Chantix (FREE)
By Amy Orciari Herman Edited by Susan Sadoughi, MD An FDA advisory panel voted late last week to keep the black-box warning on the smoking cessation drug varenicline … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - October 20, 2014 Category: Primary Care Source Type: news

FDA panel supports retaining Chantix boxed warning for now
Read the full story on MD Consult: FDA panel supports retaining Chantix boxed warning for now (Source: MD Consult: News: Top Stories)
Source: MD Consult: News: Top Stories - October 20, 2014 Category: Journals (General) Source Type: news

FDA Advisers Vote to Keep Black-Box Warning on Chantix (FREE)
By Amy Orciari Herman Edited by Susan Sadoughi, MD An FDA advisory panel voted late last week to keep the black-box warning on the smoking cessation drug varenicline … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - October 20, 2014 Category: Primary Care Source Type: news

D.C. Week: Of Travel Bans and Chantix
(MedPage Today) -- Recess notwithstanding, Congress had advice on Ebola. (Source: MedPage Today Pulmonary)
Source: MedPage Today Pulmonary - October 18, 2014 Category: Respiratory Medicine Source Type: news

Black Box Warning Should Remain on Chantix: FDA Panel
(Source: WebMD Health)
Source: WebMD Health - October 17, 2014 Category: Consumer Health News Source Type: news

Keep Chantix Black Box Warning, FDA Panel SaysKeep Chantix Black Box Warning, FDA Panel Says
An FDA panel recommends waiting for data from an ongoing study designed to capture serious neuropsychiatric adverse events related to Chantix before making a final decision on the black box warning. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 17, 2014 Category: Consumer Health News Tags: Psychiatry News Source Type: news

FDA Panel: Chantix Boxed Warning Should Stay (CME/CE)
(MedPage Today) -- Some panelists said it doesn't go far enough. (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - October 16, 2014 Category: Geriatrics Source Type: news

FDA panel votes to keep severe warning on Pfizer anti-smoking drug
(Reuters) - Pfizer Inc failed to convince the U.S. Food and Drug Administration to remove a black box warning on its controversial quit-smoking drug Chantix, with an advisory panel to the agency voting against the removal on Thursday. (Source: Reuters: Health)
Source: Reuters: Health - October 16, 2014 Category: Consumer Health News Tags: healthNews Source Type: news

Pfizer, FDA Square Off on Chantix Psych Risk
(MedPage Today) -- Agency staff say black-box warning on smoking-cessation aid should stay. (Source: MedPage Today Pulmonary)
Source: MedPage Today Pulmonary - October 15, 2014 Category: Respiratory Medicine Source Type: news

FDA Staff: Chantix Should Keep Neuropsychiatric Warning on Label (FREE)
By Kelly Young Edited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM FDA officials are recommending that the smoking … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - October 15, 2014 Category: Primary Care Source Type: news

FDA staff recommend Pfizer keep black box warning on anti-smoking drug
(Reuters) - Pfizer Inc's quit-smoking drug Chantix received its latest setback on Tuesday after U.S. Food and Drug Administration staff recommended that the drugmaker keep a severe warning on the treatment's label. (Source: Reuters: Health)
Source: Reuters: Health - October 14, 2014 Category: Consumer Health News Tags: healthNews Source Type: news

Morning Break: Ebola Scares, Chantix Faceoff
(MedPage Today) -- Health news and commentary from around the Web, gathered by the MedPage Today staff. (Source: MedPage Today Pulmonary)
Source: MedPage Today Pulmonary - October 14, 2014 Category: Respiratory Medicine Source Type: news

Smoking rates fall 1% in past year
18.7% of adults in UK now smoke, says ONSRelated items from OnMedicaSmoking cessationCombining varenicline with nicotine patch boosts quit rates11 million working days lost to smokingHelp smokers cut down if they can’t quitE-cigarettes may not help smokers quit (Source: OnMedica Latest News)
Source: OnMedica Latest News - October 7, 2014 Category: UK Health Source Type: news

11 million working days lost to smoking
235,000 smokers sign up to Stoptober campaign to quitRelated items from OnMedicaE-cigarettes may not help smokers quitSmoking cessationCombining varenicline with nicotine patch boosts quit ratesPublic must own responsibility for their healthRoll-ups worse than factory-made cigarettes (Source: OnMedica Latest News)
Source: OnMedica Latest News - October 3, 2014 Category: UK Health Source Type: news

Varenicline Label Changes Downplay Suicide RiskVarenicline Label Changes Downplay Suicide Risk
New data suggest lower neuropsychiatric risks with the smoking cessation drug varenicline. The FDA is set to review these new safety data at an upcoming meeting. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 30, 2014 Category: Consumer Health News Tags: Psychiatry News Source Type: news

New FDA Label Touts Chantix Safety; Pfizer Pushes to Remove Black Box
The FDA updated the label of Pfizer's anti-smoking drug Chantix to include data from a number of recent studies that found little to no evidence of psychiatric problems or suicidal tendencies in patients taking the drug. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - September 25, 2014 Category: Pharmaceuticals Source Type: news

Chantix Label Revision Casts Doubt on Link to Suicidality (FREE)
By Amy Orciari Herman Edited by Susan Sadoughi, MD, and Richard Saitz, MD, MPH, FACP, FASAM The addition of new data to the varenicline (Chantix) label suggests that the smoking-cessation drug may be safer … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - September 25, 2014 Category: Primary Care Source Type: news

Varenicline and Cardiovascular Adverse EventsVarenicline and Cardiovascular Adverse Events
How strong is the evidence suggesting that varenicline is cardiotoxic? Read this review to find out. Therapeutic Advances in Drug Safety (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 22, 2014 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news

PodMed: A Medical News Roundup From Johns Hopkins (with audio)
(MedPage Today) -- This week's topics include a look at neuropathic pain treatment, infusion pumps for hard to control diabetes, screening for carotid artery stenosis, and varenicline and nicotine replacement for smoking cessation. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - July 11, 2014 Category: Cardiology Source Type: news

Study: combination of varenicline and nicotine patch best way to quit smoking
Brooks HaysWASHINGTON, July 9 (UPI) -- The best way to quit smoking, researchers say, is a combination of a drug called varenicline and the use of nicotine patches. (Source: Health News - UPI.com)
Source: Health News - UPI.com - July 9, 2014 Category: Consumer Health News Source Type: news