Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research
Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research
Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research
Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research
Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research
Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research
Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research
Exploring aryl hydrocarbon receptor (AhR) as a target for Bisphenol-A (BPA)-induced pancreatic islet toxicity and impaired glucose homeostasis: protective efficacy of ethanol extract of Centella asiatica
Toxicology. 2023 Nov 30:153693. doi: 10.1016/j.tox.2023.153693. Online ahead of print.ABSTRACTThe estrogenic impact of Bisphenol-A (BPA), a widely recognized endocrine disruptor, causes disruption of pancreatic β-cell function through estrogen receptors (ERs). While BPA's binding affinity for ERs is significantly lower than that of its natural counterpart, estrogen, recent observations of BPA's affinity for aryl hydrocarbon receptor (AhR) in specific cellular contexts have sparked a specific question: does AhR play a role in BPA's toxicological effects within the endocrine pancreas? To explore this question, we investigat...
Source: Toxicology - December 2, 2023 Category: Toxicology Authors: Oly Banerjee Siddhartha Singh Shilpi Kumari Prasad Ankita Bhattacharjee Tapan Seal Jayanta Mandal Sangram Sinha Anindita Banerjee Bithin Kumar Maji Sandip Mukherjee Source Type: research
Exploring aryl hydrocarbon receptor (AhR) as a target for Bisphenol-A (BPA)-induced pancreatic islet toxicity and impaired glucose homeostasis: protective efficacy of ethanol extract of Centella asiatica
Toxicology. 2023 Nov 30:153693. doi: 10.1016/j.tox.2023.153693. Online ahead of print.ABSTRACTThe estrogenic impact of Bisphenol-A (BPA), a widely recognized endocrine disruptor, causes disruption of pancreatic β-cell function through estrogen receptors (ERs). While BPA's binding affinity for ERs is significantly lower than that of its natural counterpart, estrogen, recent observations of BPA's affinity for aryl hydrocarbon receptor (AhR) in specific cellular contexts have sparked a specific question: does AhR play a role in BPA's toxicological effects within the endocrine pancreas? To explore this question, we investigat...
Source: Toxicology - December 2, 2023 Category: Toxicology Authors: Oly Banerjee Siddhartha Singh Shilpi Kumari Prasad Ankita Bhattacharjee Tapan Seal Jayanta Mandal Sangram Sinha Anindita Banerjee Bithin Kumar Maji Sandip Mukherjee Source Type: research
In-silico and in-vitro screening of Asiatic acid and Asiaticoside A against Cathepsin S enzyme
CONCLUSION: This clearly shows that asiaticoside will be a better drug candidate than asiatic acid in inhibiting the CatS enzyme for the purpose of improving the outcome of atherosclerosis. However, certain modifications need to be made to the structural make-up of asiaticoside A to improve its pharmacokinetics properties.PMID:38007481 | DOI:10.1186/s40360-023-00701-x (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - November 25, 2023 Category: Drugs & Pharmacology Authors: Temitope Akinwumi Ajani Kenechukwu Obikeze Zandisiwe E Magwebu Samuel Egieyeh Chesa G Chauke Source Type: research
In-silico and in-vitro screening of Asiatic acid and Asiaticoside A against Cathepsin S enzyme
CONCLUSION: This clearly shows that asiaticoside will be a better drug candidate than asiatic acid in inhibiting the CatS enzyme for the purpose of improving the outcome of atherosclerosis. However, certain modifications need to be made to the structural make-up of asiaticoside A to improve its pharmacokinetics properties.PMID:38007481 | PMC:PMC10676574 | DOI:10.1186/s40360-023-00701-x (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - November 25, 2023 Category: Drugs & Pharmacology Authors: Temitope Akinwumi Ajani Kenechukwu Obikeze Zandisiwe E Magwebu Samuel Egieyeh Chesa G Chauke Source Type: research
In-silico and in-vitro screening of Asiatic acid and Asiaticoside A against Cathepsin S enzyme
CONCLUSION: This clearly shows that asiaticoside will be a better drug candidate than asiatic acid in inhibiting the CatS enzyme for the purpose of improving the outcome of atherosclerosis. However, certain modifications need to be made to the structural make-up of asiaticoside A to improve its pharmacokinetics properties.PMID:38007481 | PMC:PMC10676574 | DOI:10.1186/s40360-023-00701-x (Source: Atherosclerosis)
Source: Atherosclerosis - November 25, 2023 Category: Cardiology Authors: Temitope Akinwumi Ajani Kenechukwu Obikeze Zandisiwe E Magwebu Samuel Egieyeh Chesa G Chauke Source Type: research
In-silico and in-vitro screening of Asiatic acid and Asiaticoside A against Cathepsin S enzyme
CONCLUSION: This clearly shows that asiaticoside will be a better drug candidate than asiatic acid in inhibiting the CatS enzyme for the purpose of improving the outcome of atherosclerosis. However, certain modifications need to be made to the structural make-up of asiaticoside A to improve its pharmacokinetics properties.PMID:38007481 | PMC:PMC10676574 | DOI:10.1186/s40360-023-00701-x (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - November 25, 2023 Category: Drugs & Pharmacology Authors: Temitope Akinwumi Ajani Kenechukwu Obikeze Zandisiwe E Magwebu Samuel Egieyeh Chesa G Chauke Source Type: research
Molecular cloning and heterologous expression analysis of 1-Deoxy-D-Xylulose-5-Phosphate Synthase gene in Centella asiatica L
Gene. 2023 Nov 18:148015. doi: 10.1016/j.gene.2023.148015. Online ahead of print.ABSTRACTMany genes involved in triterpenoid saponins in plants control isoprenoid flux and constitute the precursor pool, which is channeled into various downstream pathways leading to the synthesis of triterpenoid saponins in C. asiatica. Full-length 1-Deoxy-D-Xylulose-5-Phosphate-Synthase (CaDXS) gene was isolated for the study from the previously annotated Centella asiatica leaves transcriptomic data. The CaDXS gene sequence was submitted to the NCBI databases with GenBank accession number MZ997832. The full-length CaDXS gene contained a 22...
Source: Gene - November 20, 2023 Category: Genetics & Stem Cells Authors: Shama Afroz Kahkashan Khatoon Zafar Warsi Zakir Husain Sanjeet Kumar Verma Laiq Ur Rahman Source Type: research
Molecular cloning and heterologous expression analysis of 1-Deoxy-D-Xylulose-5-Phosphate Synthase gene in Centella asiatica L
Gene. 2023 Nov 19;895:148015. doi: 10.1016/j.gene.2023.148015. Online ahead of print.ABSTRACTMany genes involved in triterpenoid saponins in plants control isoprenoid flux and constitute the precursor pool, which is channeled into various downstream pathways leading to the synthesis of triterpenoid saponins in C. asiatica. Full-length 1-Deoxy-D-Xylulose-5-Phosphate-Synthase (CaDXS) gene was isolated for the study from the previously annotated Centella asiatica leaves transcriptomic data. The CaDXS gene sequence was submitted to the NCBI databases with GenBank accession number MZ997832. The full-length CaDXS gene contained ...
Source: Gene - November 20, 2023 Category: Genetics & Stem Cells Authors: Shama Afroz Kahkashan Khatoon Zafar Warsi Zakir Husain Sanjeet Kumar Verma Laiq Ur Rahman Source Type: research
