Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration
Neuropharmacology. 2024 Jan 3;246:109834. doi: 10.1016/j.neuropharm.2023.109834. Online ahead of print.ABSTRACTProtein L-isoaspartyl methyltransferase (PIMT/PCMT1) could repair l-isoaspartate (L-isoAsp) residues formed by deamidation of asparaginyl (Asn) residues or isomerization of aspartyl (Asp) residues in peptides and proteins during aging. Aside from abnormal accumulation of L-isoAsp, PIMT knockout (KO) mice mirrors some neuropathological hallmarks such as anxiety-like behaviors, impaired spatial memory and aberrant synaptic plasticity in the hippocampus of neurodegenerative diseases (NDs), including Alzheimer's disea...
Source: Neuropharmacology - January 5, 2024 Category: Drugs & Pharmacology Authors: Zicheng Ling Sirui Zhou Yancheng Zhou Wanyu Zhong Zhonghao Su Zhenxia Qin Source Type: research

Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration
Neuropharmacology. 2024 Jan 3:109834. doi: 10.1016/j.neuropharm.2023.109834. Online ahead of print.ABSTRACTProtein L-isoaspartyl methyltransferase (PIMT/PCMT1) could repair l-isoaspartate (L-isoAsp) residues formed by deamidation of asparaginyl (Asn) residues or isomerization of aspartyl (Asp) residues in peptides and proteins during aging. Aside from abnormal accumulation of L-isoAsp, PIMT knockout (KO) mice mirrors some neuropathological hallmarks such as anxiety-like behaviors, impaired spatial memory and aberrant synaptic plasticity in the hippocampus of neurodegenerative diseases (NDs), including Alzheimer's disease (...
Source: Neuropharmacology - January 5, 2024 Category: Drugs & Pharmacology Authors: Zicheng Ling Sirui Zhou Yancheng Zhou Wanyu Zhong Zhonghao Su Zhenxia Qin Source Type: research

Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research

Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research

Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research

Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research

Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research

Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research

Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research

Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research

Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research

Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research

Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research

Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research

Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators
In this study, the researchers used LED light to increase the productivity of Edelweiss EVs and confirmed that productivity was enhanced by LED exposure. Additionally, improvements in skin anti-aging indicators were observed. Notably, M-LED significantly elevated callus fresh and dry weight, with a DW/FW ratio of 4.11%, indicating enhanced proliferation. Furthermore, M-LED boosted secondary metabolite production, including a 20% increase in total flavonoids and phenolics. The study explores the influence of M-LED on EV production, revealing a 2.6-fold increase in concentration compared to darkness. This effect is consisten...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Mi-Jung Kim Hoon Ko Ji-Young Kim Hye-Jin Kim Hwi-Yeob Kim Hang-Eui Cho Hyun-Dae Cho Won-Sang Seo Hee-Cheol Kang Source Type: research