Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway
CONCLUSION: AC alleviates t-BHP-induced oxidative injury and apoptosis in HUVECs through the ROS-dependent p53/Bcl-2/Caspase-3 signaling pathway. It may be a potential antioxidant applied in metabolic disorders and pharmaceutical products.PMID:36284389 | DOI:10.2174/1566524023666221024120825 (Source: Molecular Medicine)
Source: Molecular Medicine - October 26, 2022 Category: Molecular Biology Authors: Zhenwen Liang Yu Chen Rifang Gu Qi Guo Xuqiang Nie Source Type: research
Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway
CONCLUSION: AC alleviates t-BHP-induced oxidative injury and apoptosis in HUVECs through the ROS-dependent p53/Bcl-2/Caspase-3 signaling pathway. It may be a potential antioxidant applied in metabolic disorders and pharmaceutical products.PMID:36284389 | DOI:10.2174/1566524023666221024120825 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 26, 2022 Category: Molecular Biology Authors: Zhenwen Liang Yu Chen Rifang Gu Qi Guo Xuqiang Nie Source Type: research
Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway
CONCLUSION: AC alleviates t-BHP-induced oxidative injury and apoptosis in HUVECs through the ROS-dependent p53/Bcl-2/Caspase-3 signaling pathway. It may be a potential antioxidant applied in metabolic disorders and pharmaceutical products.PMID:36284389 | DOI:10.2174/1566524023666221024120825 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 26, 2022 Category: Molecular Biology Authors: Zhenwen Liang Yu Chen Rifang Gu Qi Guo Xuqiang Nie Source Type: research
Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway
CONCLUSION: AC alleviates t-BHP-induced oxidative injury and apoptosis in HUVECs through the ROS-dependent p53/Bcl-2/Caspase-3 signaling pathway. It may be a potential antioxidant applied in metabolic disorders and pharmaceutical products.PMID:36284389 | DOI:10.2174/1566524023666221024120825 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 26, 2022 Category: Molecular Biology Authors: Zhenwen Liang Yu Chen Rifang Gu Qi Guo Xuqiang Nie Source Type: research
Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway
CONCLUSION: AC alleviates t-BHP-induced oxidative injury and apoptosis in HUVECs through the ROS-dependent p53/Bcl-2/Caspase-3 signaling pathway. It may be a potential antioxidant applied in metabolic disorders and pharmaceutical products.PMID:36284389 | DOI:10.2174/1566524023666221024120825 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 26, 2022 Category: Molecular Biology Authors: Zhenwen Liang Yu Chen Rifang Gu Qi Guo Xuqiang Nie Source Type: research
Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway
CONCLUSION: AC alleviates t-BHP-induced oxidative injury and apoptosis in HUVECs through the ROS-dependent p53/Bcl-2/Caspase-3 signaling pathway. It may be a potential antioxidant applied in metabolic disorders and pharmaceutical products.PMID:36284389 | DOI:10.2174/1566524023666221024120825 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 26, 2022 Category: Molecular Biology Authors: Zhenwen Liang Yu Chen Rifang Gu Qi Guo Xuqiang Nie Source Type: research
Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway
CONCLUSION: AC alleviates t-BHP-induced oxidative injury and apoptosis in HUVECs through the ROS-dependent p53/Bcl-2/Caspase-3 signaling pathway. It may be a potential antioxidant applied in metabolic disorders and pharmaceutical products.PMID:36284389 | DOI:10.2174/1566524023666221024120825 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 26, 2022 Category: Molecular Biology Authors: Zhenwen Liang Yu Chen Rifang Gu Qi Guo Xuqiang Nie Source Type: research
Centella asiatica extract-SiO < sub > 2 < /sub > nanocomposite: More than a drug-delivery system for skin protection from oxidative damage
J Biomed Mater Res A. 2022 Oct 24. doi: 10.1002/jbm.a.37462. Online ahead of print.ABSTRACTAn innovative nanotechnology-based approach was used for the preparation of Centella asiatica (C. asiatica) extract-SiO2 nanocomposites, specifically tailored for skin protection from oxidative damage. Different amounts of C. asiatica glycolic extract (1.0, 3.0, 5.0, and 10.0 wt %) and fumed silica were used to prepare the nanocomposites by means of ball milling method. The influence of both composition of the starting mixture and milling time on the final products was evaluated by different techniques such as X-ray powder diffractio...
Source: Biomed Res - October 24, 2022 Category: Research Authors: Federico Ebau Alessandra Scano Maria Letizia Manca Maria Manconi Valentina Cabras Martina Pilloni Guido Ennas Source Type: research
Centella asiatica extract-SiO < sub > 2 < /sub > nanocomposite: More than a drug-delivery system for skin protection from oxidative damage
J Biomed Mater Res A. 2022 Oct 24. doi: 10.1002/jbm.a.37462. Online ahead of print.ABSTRACTAn innovative nanotechnology-based approach was used for the preparation of Centella asiatica (C. asiatica) extract-SiO2 nanocomposites, specifically tailored for skin protection from oxidative damage. Different amounts of C. asiatica glycolic extract (1.0, 3.0, 5.0, and 10.0 wt %) and fumed silica were used to prepare the nanocomposites by means of ball milling method. The influence of both composition of the starting mixture and milling time on the final products was evaluated by different techniques such as X-ray powder diffractio...
Source: Biomed Res - October 24, 2022 Category: Research Authors: Federico Ebau Alessandra Scano Maria Letizia Manca Maria Manconi Valentina Cabras Martina Pilloni Guido Ennas Source Type: research
Asiatic acid alleviates LPS-induced acute kidney injury in broilers by inhibiting oxidative stress and ferroptosis via activation of the Nrf2 pathway
Food Chem Toxicol. 2022 Oct 13:113468. doi: 10.1016/j.fct.2022.113468. Online ahead of print.ABSTRACTAsiatic acid (AA), a triterpenoid compound isolated from Centella asiatica, has anti-inflammatory, antioxidant and anticancer biological characteristics. To explore the effect of AA on LPS-induced acute kidney injury (AKI) in broilers, a total of 60 one-day-old broilers were randomly divided into 6 groups, including the normal group, AKI model group, AKI + AA 15 mg/kg group, AKI + AA 30 mg/kg group, AKI + AA 60 mg/kg group and normal + AA 60 mg/kg group. Hematoxylin-eosin staining was used to observe the histopathology in k...
Source: Food and Chemical Toxicology - October 16, 2022 Category: Food Science Authors: Wenyue Qiu Xinting Zhang Xiaoyue Pang Jianjia Huang Shuilian Zhou Rongmei Wang Zhaoxin Tang Rongsheng Su Source Type: research
Asiaticoside delays senescence and attenuate generation of ROS in UV ‑exposure cells through regulates TGF‑β1/Smad pathway
Exp Ther Med. 2022 Sep 8;24(5):667. doi: 10.3892/etm.2022.11603. eCollection 2022 Nov.ABSTRACTAsiaticoside, isolated from Centella asiatica, shows great improvement on wound healing and anti-oxidation function in vitro and in vivo. From previous research, asiaticoside possesses the potential capability to delay skin aging and reduce wrinkles clinically, but its underlying mechanism to regulate aging have not well-investigated. The present study found that asiaticoside could improve the viability and maintains a normal morphology in ultraviolet (UV)-exposure cells. In addition, β-galactosidase release was inhibited by trea...
Source: Experimental and Therapeutic Medicine - October 14, 2022 Category: General Medicine Authors: Honghao Jiang Xiaoyong Zhou Liuqing Chen Source Type: research
