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Standardized Extract of < em > Centella asiatica < /em > Prevents Fear Memory Deficit in 3xTg-AD Mice
In this study, we orally administered ECa 233 (doses: 10, 30, and 100[Formula: see text]mg/kg) to 3xTg-AD mice, who were five months old, for 30 consecutive days. We found that ECa 233 prevented a cued fear memory deficit and enhanced hippocampal long-term potentiation (LTP) in 3xTg-AD mice. Subsequent proteomic and western blot analyses revealed increased expression levels of the molecules related to LTP induction and maintenance, including brain-derived neurotrophic factor (BDNF), tyrosine receptor kinase B (TrkB) and its network proteins, and extracellular signal-regulated kinase 1 and 2 (ERK1 and 2) in the hippocampi a...
Source: The American Journal of Chinese Medicine - January 25, 2023 Category: Complementary Medicine Authors: Tanita Pairojana Sarayut Phasuk Mayuree H Tantisira Kai-Chi Liang Sittiruk Roytrakul Narawut Pakaprot Supin Chompoopong Sutisa Nudmamud-Thanoi Yang Ming Ingrid Y Liu Source Type: research

Molecules, Vol. 28, Pages 311: Effect of Acidic Electrolysed Water and Pulsed Light Technology on the Sensory, Morphology and Bioactive Compounds of Pennywort (Centella asiatica L.) Leaves
In conclusion, the combination of acidic electrolysed water and pulsed light treatment is beneficial in retaining the sensory quality and bioactive compounds in the leaves of Pennywort during storage at 4 &plusmn; 1 &deg;C. (Source: Molecules)
Source: Molecules - December 30, 2022 Category: Chemistry Authors: Siti Rosli Zaharah Noranizan Mohd Adzahan Roselina Karim Nor-Khaizura Mahmud Ab Rashid Tags: Article Source Type: research

Biotechnological and endophytic-mediated production of centellosides in Centella asiatica
Appl Microbiol Biotechnol. 2022 Dec 9. doi: 10.1007/s00253-022-12316-z. Online ahead of print.NO ABSTRACTPMID:36481800 | DOI:10.1007/s00253-022-12316-z (Source: Applied Microbiology and Biotechnology)
Source: Applied Microbiology and Biotechnology - December 9, 2022 Category: Microbiology Authors: Sujata Mandal Tuyelee Das Samapika Nandy Mimosa Ghorai Suchismita Chatterjee Saha Abilash Valsala Gopalakrishnan Manoj Kumar None Radha Arabinda Ghosh Nobendu Mukerjee Mahipal S Shekhawat Devendra Kumar Pandey Abhijit Dey Source Type: research

Neuroprotective Potential of Hydroalcoholic Extract of Centella asiatica Against 3-Nitropropionic Acid-Induced Huntington's Like Symptoms in Adult Zebrafish
Rejuvenation Research, Ahead of Print. (Source: Rejuvenation Research)
Source: Rejuvenation Research - November 29, 2022 Category: Genetics & Stem Cells Authors: Vishal Kumar Charan Singh Arti Singh Source Type: research

Molecules, Vol. 27, Pages 8101: In Vitro Determination of the Skin Anti-Aging Potential of Four-Component Plant-Based Ingredient
Caturla The beauty industry is actively searching for solutions to prevent skin aging. Some of the crucial elements protecting cells from the aging process are telomere shortening, telomerase expression, cell senescence, and homeostasis of the redox system. Modification of these factors using natural antioxidants is an appealing way to support healthy skin aging. Therefore, in this study, we sought to investigate the antiaging efficacy of a specific combination of four botanical extracts (pomegranate, sweet orange, Cistanche and Centella asiatica) with proven antioxidant properties. To this end, normal human dermal fi...
Source: Molecules - November 21, 2022 Category: Chemistry Authors: Jos é Quiles Maria Cabrera Jonathan Jones Menelaos Tsapekos Nuria Caturla Tags: Article Source Type: research

608 The historical efficacy of Centella asiatica on stretchmarks demonstrated
Commonly associated with pregnancy, stretchmarks appear whenever the body experience a rapid growth. Into the dermis, collagen fibres are altered associated with a loss of orientation and the elastic network is disrupted leading to a fibrotic organisation. This results to epidermal tearing which produce skin lesions. Centella asiatica is one of the most well-known medicinal plants rich in triterpenic actives molecules and traditionally used to treat wounds and help skin repair. The aim of this study was to evaluate Centella asiatica extract as a natural way to solve stretchmarks concern. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - November 18, 2022 Category: Dermatology Authors: C. Boira, M. Meunier, M. Bracq, G. Maramaldi, A. Scandolera, R. Reynaud Source Type: research

Centella asiatica (L.) Urb. Extract ameliorates branched-chain amino acid (BCAA) metabolism in acute reserpine-induced stress zebrafish model via < sup > 1 < /sup > H Nuclear Magnetic Resonance (NMR)-based metabolomics approach
Comp Biochem Physiol C Toxicol Pharmacol. 2022 Nov 3:109501. doi: 10.1016/j.cbpc.2022.109501. Online ahead of print.ABSTRACTDepression is a common mental disorder that can adversely affect psychosocial function and quality of life. However, the exact aetiology and pathogenesis of depression are still unclear. Stress plays a major role in the pathogenesis of depression. The use of currently prescribed antidepressants has many side effects. Centella asiatica (C. asiatica) has shown promising antidepressant activity in rodent models. Here, we developed a reserpine-induced zebrafish stress-like model and performed behavioural ...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - November 6, 2022 Category: Biochemistry Authors: Fauziahanim Zakaria Muhammad Tayyab Akhtar Wan Norhamidah Wan Ibrahim Noraini Abu Bakar Azira Muhamad Shamarina Shohaimi None Maulidiani Hafandi Ahmad Intan Safinar Ismail Nor Hadiani Ismail Khozirah Shaari Source Type: research

Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway
CONCLUSION: AC alleviates t-BHP-induced oxidative injury and apoptosis in HUVECs through the ROS-dependent p53/Bcl-2/Caspase-3 signaling pathway. It may be a potential antioxidant applied in metabolic disorders and pharmaceutical products.PMID:36284389 | DOI:10.2174/1566524023666221024120825 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 26, 2022 Category: Molecular Biology Authors: Zhenwen Liang Yu Chen Rifang Gu Qi Guo Xuqiang Nie Source Type: research

Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway
CONCLUSION: AC alleviates t-BHP-induced oxidative injury and apoptosis in HUVECs through the ROS-dependent p53/Bcl-2/Caspase-3 signaling pathway. It may be a potential antioxidant applied in metabolic disorders and pharmaceutical products.PMID:36284389 | DOI:10.2174/1566524023666221024120825 (Source: Molecular Medicine)
Source: Molecular Medicine - October 26, 2022 Category: Molecular Biology Authors: Zhenwen Liang Yu Chen Rifang Gu Qi Guo Xuqiang Nie Source Type: research