Keloidal penile fibrosis: improvements with Centellicum ® (Centella asiatica) and Pycnogenol® supplementation: a pilot registry.
Keloidal penile fibrosis: improvements with Centellicum® (Centella asiatica) and Pycnogenol® supplementation: a pilot registry. Panminerva Med. 2020 Mar;62(1):13-18 Authors: Ledda A, Cornelli U, Belcaro G, Dugall M, Feragalli B, Cotellese R, Hu S, Corsi M Abstract BACKGROUND: The aim of this pilot study was to evaluate the effects of Pycnogenol® and CA (Centellicum®) on penile fibrosis and on associated signs and symptoms. METHODS: A group of 82 subjects with penile nodules and plaques was included in this registry study and followed up for 3 months; 32 were managed with standard ma...
Source: Panminerva Medica - March 24, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Expression of Escherichia coli heat-labile enterotoxin B subunit in centella (Centella asiatica (L.) Urban) via biolistic transformation.
CONCLUSION: The s-ltb gene that was successfully transformated into centella plants by biolistic method has produced a relatively high amount of plant LTB protein in the pentameric quaternary structure that has GM1-ganglioside binding affinity, a receptor on the intestinal epithelial membrane. PMID: 32101119 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 25, 2020 Category: Biotechnology Authors: Loc NH, Tung NV, A Kim PT, Yang MS Tags: Curr Pharm Biotechnol Source Type: research

Molecules, Vol. 25, Pages 892: Inhibitory Effects of Raw-Extract Centella asiatica (RECA) on Acetylcholinesterase, Inflammations, and Oxidative Stress Activities via In Vitro and In Vivo
eh Adenan Centella asiatica (C. asiatica) is one of the medicinal plants that has been reported to exert comprehensive neuroprotection in vitro and in vivo. In view of this, the present study was performed to investigate the effect of ethanolic extract of C. asiatica, designated as raw-extract of C. asiatica (RECA) in reducing the acetylcholinesterase (AChE), inflammations, and oxidative stress activities via both in vitro (SH-SY5Y and RAW 264.7 cells) and in vivo (Sprague Dawley rats). Quantitative high-performance liquid chromatography analysis reveals that RECA contains a significantly high proportion of glycosid...
Source: Molecules - February 17, 2020 Category: Chemistry Authors: Hafiz Mohd Amin Johari James Teh Salleh Adenan Tags: Article Source Type: research

Optimization of solvent-free microwave extraction of Centella asiatica using Taguchi method
In this study, the process parameters (microwave power, extraction time, vacuum and stirrer) affecting SFME of asiaticoside from C. asiatica were optimized by the Taguchi method. Here, the vacuum was identified as the primary factor that contributes to the level of yield followed by microwave power, extraction time and stirrer. The highest amount of asiaticoside detected in the C. asiatica extract was 158.8 µg ml-1. The extraction carried out at optimized conditions for the confirmatory study was found to produce 0.38 % of more extract yield than the highest yield obtained in the test runs of Taguchi design, t...
Source: Journal of Environmental Chemical Engineering - February 11, 2020 Category: Chemistry Source Type: research

Centella asiatica (L.)-Neurodifferentiated Mesenchymal Stem Cells Promote the Regeneration of Peripheral Nerve
CONCLUSION:NC showed promising effects on nerve regeneration and functional restoration similar to those of RA. These findings revealed the neuroregenerative properties ofC. asiatica and its potential as an alternative strategy for the treatment of critical size nerve defect. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - February 8, 2020 Category: Biotechnology Source Type: research

Asiaticoside Alleviates Cerebral Ischemia-Reperfusion Injury via NOD2/Mitogen-Activated Protein Kinase (MAPK)/Nuclear Factor kappa B (NF- κB) Signaling Pathway.
CONCLUSIONS Asiaticoside showed a protective effect against cerebral ischemia-reperfusion injury via the NOD2/MAPK/NF-kappaB signaling pathway. These findings are vital for future research on use of asiaticoside in CIRI, providing a new avenue for alleviating CIRI. PMID: 32006420 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

In vivo and in vitro antimicrobial activity of phytol, a diterpene molecule, isolated and characterized from Adhatoda vasica Nees. (Acanthaceae), to control severe bacterial disease of ornamental fish, Carassius auratus, caused by Bacillus licheniformis PKBMS16
Publication date: Available online 15 January 2020Source: Microbial PathogenesisAuthor(s): Mandira Saha, P.K. BandyopadhyayAbstractBacillus licheniformis, a pathogenic new strain of bacteria is considered as the main cause of high mortalities and economic losses among the ornamental fish farms of India. The present study aimed to investigate the anti-bacterial and Immunostimulant activity of three selected Indian medicinal plants, Allium sativum, Adhatoda vasica and Centella asiatica for treating Bacillus licheniformis PKBMS16 by subsequent experimental and clinical trials using different organic polar and non-polar solven...
Source: Microbial Pathogenesis - January 16, 2020 Category: Infectious Diseases Source Type: research

Corrigendum to “Piriformospora indica cell wall extract as the best elicitor for asiaticoside production in Centella asiatica (L.) Urban, evidenced by morphological, physiological and molecular analyses” [125 (2018) 106–115]
Publication date: March 2020Source: Plant Physiology and Biochemistry, Volume 148Author(s): S. Jisha, P.R. Gouri, K.N. Anith, K.K. Sabu (Source: Plant Physiology and Biochemistry)
Source: Plant Physiology and Biochemistry - January 10, 2020 Category: Biochemistry Source Type: research

Study on Trace Elements Concentration in Medicinal Plants Using EDXRF Technique.
Abstract Ten medicinal plants used as ingredients of folklore and Ayurvedic medicine belonging to the Malnad Kerala region of South India, were analysed for concentrations of trace elements Fe, Cr, Mn, Co, Ni, Cu, Zn, As, and Pb using the Energy Dispersive X-ray Fluorescence (EDXRF) technique. The soil from the root area of these medicinal plants was also analysed, and the soil to plant transfer factor (TF) of the elements was estimated. Iron (Fe) recorded higher concentration than the other trace elements estimated in the medicinal plants, followed by manganese (Mn) and zinc (Zn). The mean TF was found to be high...
Source: Biological Trace Element Research - January 10, 2020 Category: Biology Authors: Kulal C, Padhi RK, Venkatraj K, Satpathy KK, Mallaya SH Tags: Biol Trace Elem Res Source Type: research

Corrigendum to "Piriformospora indica cell wall extract as the best elicitor for asiaticoside production in Centella asiatica (L.) Urban, evidenced by morphological, physiological and molecular analyses" [125 (2018) 106-115].
Corrigendum to "Piriformospora indica cell wall extract as the best elicitor for asiaticoside production in Centella asiatica (L.) Urban, evidenced by morphological, physiological and molecular analyses" [125 (2018) 106-115]. Plant Physiol Biochem. 2020 Jan 10;148:62 Authors: Jisha S, Gouri PR, Anith KN, Sabu KK PMID: 31931393 [PubMed - as supplied by publisher] (Source: Physiological Research)
Source: Physiological Research - January 10, 2020 Category: Physiology Authors: Jisha S, Gouri PR, Anith KN, Sabu KK Tags: Plant Physiol Biochem Source Type: research

Medicinal plants for gastrointestinal diseases among the Kuki-Chin ethnolinguistic groups across Bangladesh, India, and Myanmar: A comparative and network analysis study
ConclusionOverall, this study revealed an astonishingly rich diversity of medicinal plants used to treat digestive diseases among the Kuki-Chin. A comparative analysis showed variations and remarkable distinctions in medicinal plant knowledge among country-affiliated groups, as likely influenced by external sociocultural factors and geopolitical barriers, as well as the availability of ethnobotanical data. The use of network analysis reflected not only shared common affinities and patterns of plant use based on the taxonomic composition and species selection, but also disease prevalence and distribution patterns. The infor...
Source: Journal of Ethnopharmacology - January 7, 2020 Category: Drugs & Pharmacology Source Type: research

Hexokinase II Upregulation Contributes to Asiaticoside-Induced Protection of H9c2 Cardioblasts During Oxygen–Glucose Deprivation/Reoxygenation
In conclusion, the protective effects of AS on cardiomyocytes from OGD/R-induced injury were mediated at least partly by upregulating HK2. (Source: Journal of Cardiovascular Pharmacology)
Source: Journal of Cardiovascular Pharmacology - December 31, 2019 Category: Cardiology Tags: Original Article Source Type: research

Raft-forming gastro-retentive formulations based on Centella asiatica extract-solid dispersions for gastric ulcer treatment.
Abstract Liquid raft-forming formulations comprising solid dispersions of glycoside-rich Centella asiatica extract and Eudragit® EPO (GR-SD) were developed to achieve prolonged delivery of the glycosides, asiaticoside (AS) and madecassoside (MS) in the stomach and thus increase the effectiveness of gastric ulcer treatment. Solid dispersions of GR extract and Eudragit® EPO (GR-SD, weight ratio 1:0.5) resulted in the highest solubility of AS (41.7 mg/mL) and MS (29.3 mg/mL) and completed dissolution of both glycosides occurred in SGF within 10 min. The optimized raft-forming formulation was composed of algin...
Source: European Journal of Pharmaceutical Sciences - December 20, 2019 Category: Drugs & Pharmacology Authors: Wannasarit S, Mahattanadul S, Issarachot O, Puttarak P, Wiwattanapatapee R Tags: Eur J Pharm Sci Source Type: research

Asiaticoside nitric oxide gel accelerates diabetic cutaneous ulcers healing by activating Wnt/ β-catenin signaling pathway.
In this study we considered gels of AC and NO, and evaluated the effects of the gel on DCU healing. Based on our study, it was found that the combined effect of asiaticoside and NO could accelerate the healing rate of DCU wounds. The asiaticoside NO gel can inhibit the growth of bacteria in the wound surface, alleviate the inflammatory reaction of wound, and increase the expression of VEGF, iNOS, eNOS and CD34. Our research shows that asiaticoside NO gel may promote DCU wound healing by regulating Wnt/β-Catenin signaling pathway. It will provide new targets and strategies for the diagnosis and treatment of DCU. P...
Source: International Immunopharmacology - December 19, 2019 Category: Allergy & Immunology Authors: Nie X, Zhang H, Shi X, Zhao J, Chen Y, Wu F, Yang J, Li X Tags: Int Immunopharmacol Source Type: research

Molecules, Vol. 24, Pages 4587: Kleeb Bua Daeng, a Thai Traditional Herbal Formula, Ameliorated Unpredictable Chronic Mild Stress-Induced Cognitive Impairment in ICR Mice
it Anake Kijjoa Thai traditional herbal formula ‘’Kleeb Bua Daeng (KBD)’’consists of a 1:1:1 ratio (dry weight) of three medicinal plants: Piper nigrum fruit, the aerial part of Centella asiatica and the petals of Nelumbo nucifera. Oral administration of KBD to unpredictable chronic mild stress (UCMS) mice significantly improved their cognitive function caused by chronic mild stress. Daily administration of KBD significantly decreased the serum corticosterone (CORT) and malondialdehyde (MDA) levels but increased the catalase and superoxide dismutase activities i...
Source: Molecules - December 14, 2019 Category: Chemistry Authors: Juthamart Maneenet Supawadee Daodee Orawan Monthakantirat Chantana Boonyarat Charinya Khamphukdee Pakakrong Kwankhao Supaporn Pitiporn Suresh Awale Yaowared Chulikhit Anake Kijjoa Tags: Article Source Type: research

Preparation and evaluation of PEGylated Asiatic Acid Nanostructured Lipid Carriers on anti-fibrosis effects.
In this study, AA loading PEGylated nanostructured lipid carriers (P-AA-NLC) were prepared. P-AA-NLC were characterized for particle size distribution, polydispersity index, entrapment efficiency, X-ray powder diffraction pattern (XRD), differential scanning colorimeter (DSC) and transmission electron microscopy (TEM). The intestinal absorption, in vivo distribution, pharmacokinetics and anti-fibrosis effects of P-AA-NLC were studied compared with that of AA-NLC. In situ single-pass intestinal perfusion model shown that there are significant differences in absorption between the free and NLCs formulation. The Peff values o...
Source: Drug Development and Industrial Pharmacy - December 11, 2019 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Centella asiatica (L.) extract attenuates inflammation and improve insulin sensitivity in a coculture of lipopolysaccharide (LPS)-induced 3T3-L1 adipocytes and RAW 264.7 macrophages.
Authors: Kusumastuti SA, Nugrahaningsih DAA, Wahyuningsih MSH Abstract Insulin resistance in obese condition is related to chronic low-grade inflammation which leads to insulin signaling impairment. Centella asiatica (L.) is an herb that exhibits anti-inflammatory and blood sugar-lowering activity (hypoglycemia). The study aims to investigate the molecular mechanism of C. asiatica extract in insulin sensitivity improvement in a coculture of lipopolysaccharide (LPS)-induced 3T3-L1 adipocytes and RAW 264.7 macrophages. A coculture of 3T3-L1 adipocytes and RAW 264.7 macrophages were incubated with LPS to induce insuli...
Source: Drug Discoveries and Therapeutics - November 16, 2019 Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research

Combined Liquid Chromatography-mass Spectrometry and Next-generation DNA Sequencing Detection of Adulterants and Contaminants in Analgesic and Anti-inflammatory Herbal Medicines
ConclusionThe high level of contamination and substitution of herbal medicine preparations sourced from Australian dispensaries supports the need for more stringent pharmacovigilance measures in Australia and abroad. (Source: Pharmaceutical Medicine)
Source: Pharmaceutical Medicine - November 16, 2019 Category: Drugs & Pharmacology Source Type: research

Neurotransmitter, antioxidant and anti-neuroinflammatory mechanistic potentials of herbal medicines in ameliorating autism spectrum disorder.
CONCLUSIONS: Consequently, these herbs, in theory at least, appear to be suitable candidates within an overall management strategy for those on the autism spectrum. PMID: 31721693 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 12, 2019 Category: Drugs & Pharmacology Authors: Kardani A, Soltani A, Sewell RDE, Shahrani M, Rafieian-Kopaei M Tags: Curr Pharm Des Source Type: research

Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR- γ.
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ. Acta Pharmacol Sin. 2019 Nov 08;: Authors: Zhang ZH, He JQ, Zhao YY, Chen HC, Tan NH Abstract Renal fibrosis is an inevitable outcome of all kinds of progressive chronic kidney disease (CKD). Recently, asiatic acid (AA), a triterpenoid compound from Chinese medicine Centella asiatica, has been found to attenuate renal fibrosis. In the current study, we explored the mechanisms underlying antifibrotic effect of AA on UUO model. SD rats and ICR mice were subjected to unilateral...
Source: Acta Pharmacologica Sinica - November 8, 2019 Category: Drugs & Pharmacology Authors: Zhang ZH, He JQ, Zhao YY, Chen HC, Tan NH Tags: Acta Pharmacol Sin Source Type: research

Asiatic acid, an active substance of Centella asiatica, presynaptically depresses glutamate release in the rat hippocampus.
In this study, by using isolated nerve terminal (synaptosome) and slice preparations, we investigated the effect of asiatic acid, a triterpene isolated from Centella asiatica with antiepileptic activity, on glutamate release in the hippocampus of rats. In hippocampal synaptosomes, application of asiatic acid resulted in a concentration-dependent inhibition of 4-aminopyridine-evoked glutamate release. This inhibitory action was dependent on extracellular calcium, blocked by inhibiting the vesicular transporter, but was unaffected by inhibiting the glutamate transporter. In addition, asiatic acid decreased the 4-aminopyridin...
Source: European Journal of Pharmacology - November 7, 2019 Category: Drugs & Pharmacology Authors: Lu CW, Lin TY, Wang SJ, Huang SK Tags: Eur J Pharmacol Source Type: research

Wound Healing and the Use of Medicinal Plants.
We describe the active ingredients, bioactivities, clinical uses, formulations, methods of preparation, and clinical value of 36 medical plant species. Several species stand out, including Centella asiatica, Curcuma longa, and Paeonia suffruticosa, which are popular wound healing products used by several cultures and ethnic groups. The popularity and evidence of continued use clearly indicates that there are still lessons to be learned from traditional practices. Hidden in the myriad of natural products and derivatives from natural products are undescribed reagents, unexplored combinations, and adjunct compounds that could...
Source: Evidence-based Complementary and Alternative Medicine - November 1, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Central cardiovascular calcifications: supplementtion with Pycnogenol ® and Centellicum®: variations in 12 months.
Central cardiovascular calcifications: supplementtion with Pycnogenol® and Centellicum®: variations in 12 months. Minerva Cardioangiol. 2019 Oct 15;: Authors: Hu S, Belcaro G, Cesarone MR, Feragalli B, Cotellese R, Dugall M, Scipione C, Scipione V, Maione C Abstract BACKGROUND: This 'concept' registry evaluated the efficacy of Pycnogenol® and the combination Pycnogenol® and Centella Asiatica (Centellicum®) in controlling the increasing number of arterial/cardiac calcifications in subjects with asymptomatic atherosclerosis. METHODS: The study included 3 groups of 30 males with as...
Source: Minerva Cardioangiologica - October 23, 2019 Category: Cardiology Tags: Minerva Cardioangiol Source Type: research

Factors associated with perioperative mortality in children and adolescents operated for tetralogy of Fallot: A sub ‐Saharan experience
We examined perioperative outcomes, primarily focusing on factors associated with perioperative mortality.ResultsDuring this period, 62 patients underwent surgery. Fifty ‐seven (91.9%) underwent primary repair, while 5 (6.5%) underwent palliative shunt surgery. Of the five patients with shunt surgery, four ultimately underwent total repair. Eight (12.9%) patients died during the perioperative period. Factors associated with perioperative mortality include repeated preoperative phlebotomy procedures (P 
Source: Journal of Cardiac Surgery - October 10, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Endale Tefera, Etsegenet Gedlu, Berhanu Nega, Birkneh T. Tadesse, Yilkal Chanie, Ali Dawoud, Fekadesilassie H. Moges, Abebe Bezabih, Tamirat Moges, Tomasa Centella, Stefano Marianeschi, Ana Coca, Raquel Collado, Mamo W. Kassa, Sune Johansson Tags: ORIGINAL ARTICLE Source Type: research

Pumpkin seeds, Centella asiatica, Boswellia, Helichrysum, acetate vitamin E, Melaleuca alternifolia and hyaluronic acid phytocomplex monotherapy effects in patients with chronic pelvic pain syndrome.
Authors: Di Vico T, Durante J, Polito C, Tognarelli A, Canale D, Caglieresi C, Morelli G, Bartoletti R Abstract BACKGROUND: Proxelan® and antibiotics combined therapy was successfully previously used in the treatment of symptoms of patients with chronic prostatitis. Aim of the present study was to investigate the effects of Proxelan® monotherapy on pain symptoms of patients with chronic prostatitis (CP) or chronic pelvic pain syndrome (CPPS) in a prospective pilot study. METHODS: Thirty consecutive patients with CP/CPPS symptoms younger than 50, without urinary obstruction, total prostate-specific antigen (PSA)
Source: Minerva Urologica e Nefrologica - September 28, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Cardiovascular Protective Effects of Centella asiatica and Its Triterpenes: A Review
In conclusion, more clinical and pharmacokinetic studies are needed to support the use of C. asiatica and its triterpenes as therapeutic agents for cardiovascular diseases. Besides, elucidation of the molecular pathways modulated by C. asiatica and its active constituents will help to understand the mechanisms underlying the cardioprotective action of C. asiatica. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Planta Medica)
Source: Planta Medica - September 20, 2019 Category: Drugs & Pharmacology Authors: Razali, Nur Nadia Mohd Ng, Chin Theng Fong, Lai Yen Tags: Reviews Source Type: research

Facile green synthesis of silver oxide nanoparticles and their electrochemical, photocatalytic and biological studies
Publication date: Available online 13 September 2019Source: Inorganic Chemistry CommunicationsAuthor(s): B.N. Rashmi, Sujatha F. Harlapur, B. Avinash, C.R. Ravikumar, H.P. Nagaswarupa, M.R. Anil Kumar, K. Gurushantha, M.S. SantoshAbstractIn the recent times, cost-effective and eco-friendly processes of synthesizing nanoparticles (NPs) have emerged as a substitute to conventional synthetic methods. Several research groups in the past have synthesized silver oxide (Ag2O) nanoparticles from various plant extracts and have been extensively reported. A first of its kind facile green combustion method has been adopted here to sy...
Source: Inorganic Chemistry Communications - September 15, 2019 Category: Chemistry Source Type: research

Karyological investigation of Calotropis gigantea (L.) W. T. Aiton and Centella asiatica (L.) Urban: Two important medicinal plants of Bangladesh
In this study, karyotypic features of these two species were studied with orcein staining and banding with two base specific fluorochromes such as chromomycine A3 (CMA) and 4´, 6 diamidino-2-phenylindole (DAPI) for authentic cytogenetical characterization. 2n = 22 and 2n = 18 somatic chromosomes were found in C. gigantea and C. asiatica, respectively. The total chromosome length of C. gigantea and C. asiatica were 45.35 ± 2.64 µm and 63.63 ± 3.19 µm, respectively. The total form percent (TF%), karyotype asymmetry index (As...
Source: Journal of Applied Research on Medicinal and Aromatic Plants - September 9, 2019 Category: Complementary Medicine Source Type: research

Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives.
This study aimed to investigate the effect of natural compounds on telomerase activity in human peripheral blood mononuclear cells (PBMCs). The tested compounds included Centella asiatica extract formulation (08AGTLF), Astragalus extract formulation (Nutrient 4), TA‑65 (containing Astragalus membranaceus extract), oleanolic acid (OA), maslinic acid (MA), and 3 multi‑nutrient formulas (Nutrients 1, 2 and 3) at various concentrations. The mean absorbance values of telomerase activity measured following treatment with some of the above‑mentioned formulations were statistically signific...
Source: Molecular Medicine Reports - September 7, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Evaluation of the efficacy and tolerance of a facial treatment on subjects with self-perceived sensitive skin
Introduction: Sensitive skin is commonly associated with compromised skin barrier function and may be exacerbated by environmental, topical and internal factors. Further, it is often characterized by sensorial and visual signs such as discomfort and red, blotchy appearance. Studies have shown that sensitive skin is associated with higher transepidermal water loss (TEWL). The present studies were conducted to evaluate the efficacy and tolerance of a facial moisturizer with D-Panthenol and centella asiatica derived madecassoside on subjects with self-perceived sensitive skin. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits
Various extracts of Centella asiatica (Apiaceae) and its active constituent, asiaticoside, have been reported to possess wound healing property when assessed using various in vivo and in vitro models. In an attem... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - August 14, 2019 Category: Complementary Medicine Authors: Afnan Sh. Ahmed, Muhammad Taher, Uttam Kumar Mandal, Juliana Md Jaffri, Deny Susanti, Syed Mahmood and Zainul Amiruddin Zakaria Tags: Research article Source Type: research

Strategies for Improving Healing of the Gastric Epithelium Using Oral Solid Dispersions Loaded with Pentacyclic Triterpene-Rich Centella Extract.
In this study, pentacyclic triterpene-rich centella extract (PRE) was combined with Eudragit® EPO as a hydrophilic polymer using solvent evaporation to produce a solid dispersion (PRE-ESD). The optimum PRE/Eudragit ratio of 1:2 enhanced the solubility and dissolution of glycosides (AS> 3.5 folds, MS> 2 folds) and aglycones (AA> 65 folds and MA> 56 folds) in 0.1 N hydrochloric acid (pH 1.2). DSC, XRD, and FT-IR analysis showed that the four pentacyclic triterpenes in PRE existed in the amorphous state in the solid dispersion. Moreover, almost 100% of the compounds were r...
Source: AAPS PharmSciTech - August 8, 2019 Category: Drugs & Pharmacology Authors: Wannasarit S, Puttarak P, Kaewkroek K, Wiwattanapatapee R Tags: AAPS PharmSciTech Source Type: research

ECa 233 Suppresses LPS-Induced Proinflammatory Responses in Macrophages via Suppressing ERK1/2, p38 MAPK and Akt Pathways.
This study aimed to investigate its anti-inflammatory effect and mechanisms of ECa 233 in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, nitric oxide (NO) assay, reactive oxygen species (ROS) production assay, enzyme-linked immunosorbent assay (ELISA) and Western blot analysis. Our results found that ECa 233 significantly inhibited LPS-stimulated pro-inflammatory mediators production including ROS, NO and prostaglandin E2 (PGE2), and pro-inflammatory cytokines, including tumor necrosis factor (TNF)-α and interleukin (IL)-1&be...
Source: Biological and Pharmaceutical Bulletin - August 3, 2019 Category: Drugs & Pharmacology Authors: Sukketsiri W, Tanasawet S, Moolsap F, Tantisira MH, Hutamekalin P, Tipmanee V Tags: Biol Pharm Bull Source Type: research

The effects of Centella asiatica (L.) Urban on neural differentiation of human mesenchymal stem cells in vitro
Centella asiatica (L.) Urban, known as Indian Pennywort, is a tropical medicinal plant from Apiaceae family native to Southeast Asian countries. It has been widely used as a nerve tonic in Ayuverdic medicine sinc... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - July 8, 2019 Category: Complementary Medicine Authors: Norazzila Omar, Yogeswaran Lokanathan, Zainul Rashid Mohd Razi and Ruszymah Bt Haji Idrus Tags: Research article Source Type: research

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited
AbstractTraumatic brain injury (TBI) is the most prevalent health problem affecting all age groups, and leads to many secondary problems in other organs especially kidneys, gastrointestinal tract, and heart function. In this review, the search terms were TBI, fluid percussion injury, cold injury, weight drop impact acceleration injury, lateral fluid percussion, cortical impact injury, and blast injury. Studies withActaea racemosa,Artemisia annua,Aframomum melegueta,Carthamus tinctorius,Cinnamomum zeylanicum,Crocus sativus,Cnidium monnieri,Curcuma longa,Gastrodia elata,Malva sylvestris, Da Chuanxiong Formula,Erigeron brevis...
Source: BioFactors - June 17, 2019 Category: Biochemistry Authors: Zakieh Keshavarzi, Farzaneh Shakeri, George E. Barreto, Bahram Bibak, Thozhukat Sathyapalan, Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research

Combination Effect of Titrated Extract of Centella asiatica and Astaxanthin in a Mouse Model of Phthalic Anhydride-Induced Atopic Dermatitis.
CONCLUSIONS: Our results demonstrate that the combination of TECA and AST could be a promising therapeutic agent for AD by inhibiting NF-κB signaling. PMID: 31172723 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - June 8, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

An optimization approach of dynamic maceration of Centella asiatica to obtain the highest content of four centelloids by response surface methodology
ABSTRACT Centella asiatica (L.) Urb., Apiaceae, is commonly used as food, food supplement, and medicine. Development of the extraction process to obtain the high extent of the active compound is necessary. So, the response surface methodology was used in this work to optimize the dynamic maceration of C. asiatica to obtain the highest content of the four centelloids including asiatic acid, madecassic acid, asiaticoside, and madecassoside. Two factors: extraction temperature and extraction time, were studied. The content of four centelloids was observed. After the extraction of C. asiatica using ethanol, the content of four...
Source: Revista Brasileira de Farmacognosia - May 27, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of asiatic acid, an active constituent in Centella asiatica (L.): restorative perspectives of streptozotocin-nicotinamide induced changes on lipid profile and lipid metabolic enzymes in diabetic rats
AbstractThe present study was aimed to evaluate the restorative efficacy of asiatic acid (AA), an active constituent inCentella asiatica (L.) in streptozotocin (STZ)-nicotinamide (NAD)-induced diabetic rats. Male Wistar albino rats were made diabetic with STZ-NAD administration and assessed the effect of AA (20, 30, and 40  mg/kg body weight per day, for 45 days) on body weight, glucose, insulin, insulin resistance, lipid metabolic parameters in plasma and tissue (liver and kidney), and histopathology of liver in control and experimental diabetic rats. A significant (p 
Source: Comparative Clinical Pathology - May 24, 2019 Category: Pathology Source Type: research

Protective effects of Asiatic acid against pelvic inflammatory disease in rats.
Authors: Kong D, Fu P, Zhang Q, Ma X, Jiang P Abstract Asiatic acid (AA) is one of the major components of the Chinese herb Centella asiatica and exerts a variety of pharmacological activities. However, the pharmacological effects of AA on pelvic inflammatory disease (PID) remain unknown. The purpose of the present study was to investigate the therapeutic efficacy and potential mechanisms of AA on PID in rats. A total of 75 female Sprague Dawley rats were randomly divided into the following five groups: A control group; a PID group; a PID + AA 5 mg/kg group; a PID + AA 35 mg/kg group; and a PID + AA 75 mg/kg group....
Source: Experimental and Therapeutic Medicine - May 17, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Effect of asiatic acid on epithelial-mesenchymal transition of human alveolar epithelium A549 cells induced by TGF- β1.
In conclusion, these results suggested that AA may inhibit TGF-β1-induced EMT in lung cancer through increased expression of E-cadherin, and inhibition of Snail, N-cadherin and vimentin expression. PMID: 30988806 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Centella asiatica Prevents Increase of Hippocampal Tumor Necrosis Factor- α Independently of Its Effect on Brain-Derived Neurotrophic Factor in Rat Model of Chronic Stress.
In conclusion, lower TNF-α and higher BDNF in the hippocampus support the hypothesis that these factors independently contribute to Centella asiatica's neuroprotective effect in chronically stressed rats. PMID: 30956976 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - April 10, 2019 Category: Research Authors: Ar Rochmah M, Harini IM, Septyaningtrias DE, Sari DCR, Susilowati R Tags: Biomed Res Int Source Type: research

Effects of Asiaticoside Treatment on the Survival of Random Skin Flaps in Rats.
CONCLUSIONS: AS exhibits promise as a therapeutic option due to its effects on the viability and function of random skin flaps in rats. PMID: 30898065 [PubMed - as supplied by publisher] (Source: Journal of Investigative Surgery)
Source: Journal of Investigative Surgery - March 23, 2019 Category: Surgery Tags: J Invest Surg Source Type: research

The novel phytocomponent asiaticoside-D isolated from Centella asiatica exhibits monoamine oxidase-B inhibiting potential in the rotenone degenerated cerebral ganglions of Lumbricus terrestris
Publication date: May 2019Source: Phytomedicine, Volume 58Author(s): Mamangam Subaraja, Arambakkam Janardhanam VanisreeAbstractBackground: Centella asiatica (CA) is one of the most valuable herbal medicines widely being used for the treatment of various neurological ailments that are challenging for health-care providers and also is deemed to be safe and effective.Purpose: Monoamines (MAs) are neurotransmitters and neuromodulators that play a significant role in the neural communication, regulation of motor and cognitive functions in the brain. Neurodegeneration is associated with elevated levels of MAO-B that can lead to ...
Source: Phytomedicine - March 22, 2019 Category: Drugs & Pharmacology Source Type: research

Role of age and comorbidities in mortality of patients with infective endocarditis.
al L, Gálvez-Acebal J, Martínez Marcos FJ, Fariñas MC, Spanish Collaboration on Endocarditis — Grupo de Apoyo al Manejo de la Endocarditis Infecciosa en Espana Study Group, Fernández Sánchez F, Noureddine M, Rosas G, de la Torre Lima J, Aramendi J, Bereciartua E, Blanco MJ, Blanco R, Boado MV, Campaña Lázaro M, Crespo A, Goikoetxea J, Iruretagoyena JR, Irurzun Zuazabal J, López-Soria L, Montejo M, Nieto J, Rodrigo D, Rodríguez D, Rodríguez R, Vitoria Y, Voces R, García López MV, Georgieva RI, Ojeda G, Rodríguez Bailón I,...
Source: European Journal of Internal Medicine - March 20, 2019 Category: Internal Medicine Authors: Armiñanzas C, Fariñas-Alvarez C, Zarauza J, Muñoz P, González Ramallo V, Martínez Sellés M, Miró Meda JM, Pericás JM, Goenaga MÁ, Ojeda Burgos G, Rodríguez Álvarez R, Castelo Corral L, Gálvez-Acebal J, Martínez Marcos FJ, Fariñas MC, Spanish Tags: Eur J Intern Med Source Type: research

The protective role of Piriformospora indica colonization in Centella asiatica (L.) in vitro under phosphate stress
Publication date: Available online 18 March 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): S. Jisha, K.N. Anith, K.K. SabuAbstractThe core of present study was to determine potential role of Piriformospora indica, mutualistic Basidiomycete endosymbiont on co-cultivation with Centella asiatica (L.) Urb., a neutraceutical plant. The analysis of major secondary metabolite asiaticoside and differential expression of key genes involved in pathway under varying phosphate (P) concentrations maintained in vitro were carried out. Maximum asiaticoside content was documented in plants maintained in MS medium contai...
Source: Biocatalysis and Agricultural Biotechnology - March 18, 2019 Category: Biotechnology Source Type: research

Protection of mouse brain from paracetamol-induced stress by Centella asiatica methanol extract
ConclusionsCAM showed antioxidant and anti-inflammatory effects (which were pronounced at higher doses) against Paracetamol-induced oxidative stress associated inflammation in mouse brain. The underlying mechanisms may be mediated by inhibiting the pro-inflammatory cytokines TNF β, IL 1 and MCP 1 via regulation of the antioxidant mediated INF γ and MAPK 14 gene signalling pathways. The major bioactive constituents in CAM are the triterpenoid saponins, asiaticoside and madecassoside. The present results provide pharmacological evidence that CAM acts as an antioxidant and anti-inflammatory agent. Furthermore, this...
Source: Journal of Ethnopharmacology - March 12, 2019 Category: Drugs & Pharmacology Source Type: research

Identification of annotated metabolites in the extract of Centella asiatica
Plants contribute to 75% of molecular medicines (MM) either directly or indirectly. Centella asiatica (CA) is being extensively used in experimental and clinical studies. However, its scientific approval is not forthcoming. It is well known that every plant contains useful as well as some harmful compounds. Subjecting whole plant extracts containing harmful compounds to modern pharmacologica... (Source: Journal of Medicinal Plants Research)
Source: Journal of Medicinal Plants Research - March 10, 2019 Category: Complementary Medicine Source Type: research

Effects of Centella asiatica on skeletal muscle structure and key enzymes of glucose and glycogen metabolism in type 2 diabetic rats
ConclusionOur findings strongly suggest that the anti-diabetic effects of CA in part target muscle glucose and glycogen metabolism and hence supporting its folkloric medical use as an anti-diabetic remedy.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Ethnobotany of medicinal plants used by the Zeliangrong ethnic group of Manipur, northeast India
ConclusionThe medicinal plants with higher use reports can be evaluated for validation pharmacological activities and their toxicity. The Indigenous Knowledge System of Zeliangrong community for herbal remedies may be of immense value in pharmacological experimentation particularly for the uses like malaria, health tonic, cancer, jaundice, hypertension and diabetes.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 7, 2019 Category: Drugs & Pharmacology Source Type: research