Biomarker triterpenoids of Centella asiatica as potential antidepressant agents: Combining in vivo and in silico studies
This study aims to explore the antidepressant-like effects of the major constituents found in C. asiatica, i.e., asiatic acid, asiaticoside, madecassic acid, and madecassoside at three doses (1.25, 2.5, and 5mg/kg, i.p), on the behavioural and cortisol level of unpredictable chronic stress (UCS) zebrafish model. Based on the findings from the behavioural study, the cortisol levels in the zebrafish body after treatment with the two most effective compounds were measured using enzyme-linked immunosorbent assay (ELISA). Furthermore, a molecular docking study was conducted to predict the inhibitory impact of the triterpenoid c...
Source: Brain Research - April 10, 2024 Category: Neurology Authors: Zaynab Mando Huda Mando Adlin Afzan Khozirah Shaari Zurina Hassan Mohamad Nurul Azmi Fauziahanim Zakaria Source Type: research

Biomarker triterpenoids of Centella asiatica as potential antidepressant agents: Combining in vivo and in silico studies
This study aims to explore the antidepressant-like effects of the major constituents found in C. asiatica, i.e., asiatic acid, asiaticoside, madecassic acid, and madecassoside at three doses (1.25, 2.5, and 5mg/kg, i.p), on the behavioural and cortisol level of unpredictable chronic stress (UCS) zebrafish model. Based on the findings from the behavioural study, the cortisol levels in the zebrafish body after treatment with the two most effective compounds were measured using enzyme-linked immunosorbent assay (ELISA). Furthermore, a molecular docking study was conducted to predict the inhibitory impact of the triterpenoid c...
Source: Behavioural Brain Research - April 10, 2024 Category: Neurology Authors: Zaynab Mando Huda Mando Adlin Afzan Khozirah Shaari Zurina Hassan Mohamad Nurul Azmi Fauziahanim Zakaria Source Type: research

Biomarker triterpenoids of Centella asiatica as potential antidepressant agents: Combining in vivo and in silico studies
This study aims to explore the antidepressant-like effects of the major constituents found in C. asiatica, i.e., asiatic acid, asiaticoside, madecassic acid, and madecassoside at three doses (1.25, 2.5, and 5mg/kg, i.p), on the behavioural and cortisol level of unpredictable chronic stress (UCS) zebrafish model. Based on the findings from the behavioural study, the cortisol levels in the zebrafish body after treatment with the two most effective compounds were measured using enzyme-linked immunosorbent assay (ELISA). Furthermore, a molecular docking study was conducted to predict the inhibitory impact of the triterpenoid c...
Source: Brain Research - April 10, 2024 Category: Neurology Authors: Zaynab Mando Huda Mando Adlin Afzan Khozirah Shaari Zurina Hassan Mohamad Nurul Azmi Fauziahanim Zakaria Source Type: research

Biomarker triterpenoids of Centella asiatica as potential antidepressant agents: Combining in vivo and in silico studies
This study aims to explore the antidepressant-like effects of the major constituents found in C. asiatica, i.e., asiatic acid, asiaticoside, madecassic acid, and madecassoside at three doses (1.25, 2.5, and 5mg/kg, i.p), on the behavioural and cortisol level of unpredictable chronic stress (UCS) zebrafish model. Based on the findings from the behavioural study, the cortisol levels in the zebrafish body after treatment with the two most effective compounds were measured using enzyme-linked immunosorbent assay (ELISA). Furthermore, a molecular docking study was conducted to predict the inhibitory impact of the triterpenoid c...
Source: Behavioural Brain Research - April 10, 2024 Category: Neurology Authors: Zaynab Mando Huda Mando Adlin Afzan Khozirah Shaari Zurina Hassan Mohamad Nurul Azmi Fauziahanim Zakaria Source Type: research

Cancers, Vol. 16, Pages 1317: Can Asiatic Acid from Centella asiatica Be a Potential Remedy in Cancer Therapy? & mdash;A Review
Cancers, Vol. 16, Pages 1317: Can Asiatic Acid from Centella asiatica Be a Potential Remedy in Cancer Therapy?—A Review Cancers doi: 10.3390/cancers16071317 Authors: Michał Wiciński Anna Fajkiel-Madajczyk Zuzanna Kurant Sandra Gajewska Dominik Kurant Marcin Kurant Masaoud Sousak Centella asiatica has been recognized for centuries in Eastern medicine for its pharmacological properties. Due to the increasing prevalence of oncological diseases worldwide, natural substances that could qualify as anticancer therapeutics are becoming increasingly important subjects of research. This review aims to...
Source: Cancers - March 28, 2024 Category: Cancer & Oncology Authors: Micha ł Wiciński Anna Fajkiel-Madajczyk Zuzanna Kurant Sandra Gajewska Dominik Kurant Marcin Kurant Masaoud Sousak Tags: Review Source Type: research

Asiatic acid and madecassic acid cause cardiotoxicity via inflammation and production of excessive reactive oxygen species in zebrafish
In this study, sample quantification was done using liquid chromatography –tandem mass spectrometry. The cardiotoxicity of Centella total glycosides, asiaticoside, madecassoside, asiatic acid, and madecassic acid was evaluated using zebrafish and cell models. The zebrafish oxidative stress model and myocarditis model were used to explore further the mechanisms through w hich cardiotoxicity is achieved. Asiatic acid and madecassic acid caused zebrafish cardiotoxicity and H9C2 cell death. However, no toxicity effects were observed for asiaticoside and madecassoside in zebrafish, until the solution was saturated. The result...
Source: Journal of Applied Toxicology - March 26, 2024 Category: Toxicology Authors: Qingquan Guo, Qiuru Li, Wenyao Liang, Yudong Zhang, Chenyang Jiang, Yihan Zhang, Jianhua Tan, Haishan Zhao Tags: RESEARCH ARTICLE Source Type: research

Dietary agents in the prevention of radiation-induced nausea and vomiting (RINV): review addressing the scientific observations, benefits, lacunae and future direction
CONCLUSIONS: Results indicate that Indian pennywort, Sea buckthorn, Spearmint oil and ginger are beneficial in mitigating RINV. Also, of the four plants investigated in preclinical models of study, mint oil and ginger seem to be more useful and merit structured systematic translational studies to ascertain the benefit of these two agents.PMID:38506659 | DOI:10.1080/09553002.2024.2309899 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 20, 2024 Category: Radiology Authors: Princy Louis Palatty Dhanya Sacheendran Shamprasad Varija Raghu Rajesh Arora Suresh Rao Manjeshwar Shrinath Baliga Source Type: research

Intermittent fasting along with hydroalcoholic extract of Centella-asiatica ameliorates sub-acute hypoxia-induced ischemic stroke in adult zebrafish
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Feb 29;279:109871. doi: 10.1016/j.cbpc.2024.109871. Online ahead of print.ABSTRACTReduced blood flow (hypoxia) to the brain is thought to be the main cause of strokes because it deprives the brain of oxygen and nutrients. An increasing amount of evidence indicates that the Centella-Asiatica (HA-CA) hydroalcoholic extract has a variety of pharmacological benefits, such as antioxidant activity, neuroprotection, anti-inflammatory qualities, and angiogenesis promotion. Intermittent fasting (IF) has neurological benefits such as anti-inflammatory properties, neuroprotective effects...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 1, 2024 Category: Biochemistry Authors: Priya Bindal Kaunava Roy Biplob Sarkar Natasha Rana Lakshay Kapil Charan Singh Arti Singh Source Type: research

Intermittent fasting along with hydroalcoholic extract of Centella-asiatica ameliorates sub-acute hypoxia-induced ischemic stroke in adult zebrafish
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Feb 29;279:109871. doi: 10.1016/j.cbpc.2024.109871. Online ahead of print.ABSTRACTReduced blood flow (hypoxia) to the brain is thought to be the main cause of strokes because it deprives the brain of oxygen and nutrients. An increasing amount of evidence indicates that the Centella-Asiatica (HA-CA) hydroalcoholic extract has a variety of pharmacological benefits, such as antioxidant activity, neuroprotection, anti-inflammatory qualities, and angiogenesis promotion. Intermittent fasting (IF) has neurological benefits such as anti-inflammatory properties, neuroprotective effects...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 1, 2024 Category: Biochemistry Authors: Priya Bindal Kaunava Roy Biplob Sarkar Natasha Rana Lakshay Kapil Charan Singh Arti Singh Source Type: research

Intermittent fasting along with hydroalcoholic extract of Centella-asiatica ameliorates sub-acute hypoxia-induced ischemic stroke in adult zebrafish
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Feb 28:109871. doi: 10.1016/j.cbpc.2024.109871. Online ahead of print.ABSTRACTReduced blood flow (hypoxia) to the brain is thought to be the main cause of strokes because it deprives the brain of oxygen and nutrients. An increasing amount of evidence indicates that the Centella-Asiatica (HA-CA) hydroalcoholic extract has a variety of pharmacological benefits, such as antioxidant activity, neuroprotection, anti-inflammatory qualities, and angiogenesis promotion. Intermittent fasting (IF) has neurological benefits such as anti-inflammatory properties, neuroprotective effects, an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 1, 2024 Category: Biochemistry Authors: Priya Bindal Kaunava Roy Biplob Sarkar Natasha Rana Lakshay Kapil Charan Singh Arti Singh Source Type: research