Cardiac Resynchronization Therapy Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Right Heart in Congenital Heart Disease
AbstractPurpose of ReviewTo analyze the pathophysiologic importance of the right heart in different types of congenital heart disease (CHD), summarize current diagnostic modalities, and discuss treatment options.Recent FindingsThe right ventricle (RV) plays a key role in disease progression and prognosis, either as the subpulmonary or as the systemic ventricle. Volume and/or pressure overload as well as intrinsic myocardial disease are the main factors for RV remodeling. Echocardiography and cardiac magnetic resonance imaging are important noninvasive modalities for assessing anatomy, size, and function of the right heart....
Source: Current Heart Failure Reports - September 29, 2023 Category: Cardiology Source Type: research

Effectiveness of conduction system pacing for cardiac resynchronization therapy: A systematic review and network meta ‐analysis
ConclusionThis study found that CSP-CRT is associated with greater improvements in QRSd, echocardiographic, and clinical response. LBB-CRT was associated with lower pacing thresholds. Future randomized trials are needed to determine CSP-CRT efficacy. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - September 28, 2023 Category: Cardiology Authors: Hamed Tavolinejad, Sina Kazemian, Ali Bozorgi, Roman Michalski, Daniel Hoyer, Daniel Sedding, Arash Arya Tags: REVIEW Source Type: research

Circulating microRNAs and cardiomyocyte proliferation in heart failure patients related to 10 years survival
ConclusionsThis study proposes that generating regenerative signals observed during PICSO intervention relate to patient outcomes. Morphogenetic pathways induced by periods of flow reversal in cardiac veins in a domino-like pattern transform embryonic into regenerative signals. Studies supporting the conversion of mechanochemical signals into regenerative molecules during PICSO are warranted to substantiate predictive power on patient longevity, opening new therapeutic avenues in otherwise untreatable heart failure. (Source: ESC Heart Failure)
Source: ESC Heart Failure - September 27, 2023 Category: Cardiology Authors: Vilas Wagh, Filomain Nguemo, Zlata Kiseleva, Robert M. Mader, Juergen Hescheler, Werner Mohl Tags: Original Article Source Type: research

PRecision Event Monitoring for PatienTs with Heart Failure using HeartLogic (PREEMPT ‐HF) study design and enrolment
ConclusionsThe PREEMPT study will provide clinical data and blinded sensor trends for the characterization of sensor changes with HF readmission, tachyarrhythmias, and event subgroups. These data may help to refine the clinical use of HeartLogic and to improve patient outcomes. (Source: ESC Heart Failure)
Source: ESC Heart Failure - September 23, 2023 Category: Cardiology Authors: John Boehmer, Andrew J. Sauer, Roy Gardner, Craig M. Stolen, Brian Kwan, Ramesh Wariar, Stephen Ruble Tags: Study Design Source Type: research

Impact of sacubitril/valsartan and gliflozins on cardiac resynchronization therapy response in ischemic and non-ischemic heart failure patients
This study investigated whether ARNi and SGLT2i 1) improve the rate of clinical and echocardiographic CRT response and 2) have different impact based on the ischemic or non-ischemic etiology. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 23, 2023 Category: Cardiology Authors: Celeste Fonderico, Valerio Pergola, Daniele Faccenda, Alfonsomaria Salucci, Gianluigi Comparone, Aldo Marrese, Giuseppe Ammirati, Luigi Cocchiara, Alfonso Varriale, Giovanni Esposito, Antonio Rapacciuolo, Teresa Strisciuglio Source Type: research

In Search of the “True” Left Bundle Branch Block: The art of asking research questions.
Conduction system pacing (CSP) is a promising new approach for delivering pacing therapy.1 The CSP offers an elegant treatment solution to the challenging problem of heart failure (HF) caused by electrical dyssynchrony due to the left bundle branch block (LBBB). Pacing therapy of LBBB-caused electrical dyssynchrony has a long and successful history. Cardiac resynchronization therapy (CRT) improves survival and quality of life and reduces HF hospitalizations in HF patients with LBBB.1 Striving to improve patient outcomes, the field opened the quest for the “true” LBBB. (Source: Heart Rhythm)
Source: Heart Rhythm - September 21, 2023 Category: Cardiology Authors: Larisa G. Tereshchenko Source Type: research

In search of the “true” left bundle branch block: The art of asking research questions
Conduction system pacing (CSP) is a promising new approach for delivering pacing therapy.1 CSP offers an elegant treatment solution to the challenging problem of heart failure (HF) caused by electrical dyssynchrony due to left bundle branch block (LBBB). Pacing therapy of LBBB-caused electrical dyssynchrony has a long and successful history. Cardiac resynchronization therapy improves survival and quality of life and reduces HF hospitalizations in HF patients with LBBB.1 Striving to improve patient outcomes, the field opened the quest for the “true” LBBB. (Source: Heart Rhythm)
Source: Heart Rhythm - September 21, 2023 Category: Cardiology Authors: Larisa G. Tereshchenko Tags: Editorial Commentary Source Type: research

Implications of Ventricular Arrhythmia After Cardiac Resynchronization Therapy
Conflicting data are available on whether ventricular arrhythmia (VA) or shock therapy increases mortality. Though cardiac resynchronization therapy (CRT) reduces the risk of VA, little is known about the prognostic value of VA among patients with CRT devices. (Source: Heart Rhythm)
Source: Heart Rhythm - September 20, 2023 Category: Cardiology Authors: Nobuhiko Ueda, Kohei Ishibashi, Takashi Noda, Satoshi Oka, Yuichiro Miyazaki, Keiko Shimamoto, Akinori Wakamiya, Kenzaburo Nakajima, Tsukasa Kamakura, Mitsuru Wada, Yuko Inoue, Koji Miyamoto, Satoshi Nagase, Takeshi Aiba, Hideaki Kanzaki, Chisato Izumi, T Source Type: research

Coronary artery complications with left bundle branch area pacing: A review of literature
AbstractLeft bundle branch area pacing (LBBAP) is an emerging technique in cardiac resynchronization therapy that shows promise in improving ventricular synchrony and clinical outcomes in patients with heart failure. However, the potential risk of coronary artery complications with LBBAP necessitates careful attention and management. This literature review explores the mechanisms, acute coronary events, and clinical implications associated with coronary artery complications in LBBAP. The mechanism of coronary injury with LBBAP involves mechanical trauma, altered coronary blood flow dynamics, and endothelial damage. Acute c...
Source: Pacing and Clinical Electrophysiology : PACE - September 14, 2023 Category: Cardiology Authors: Muhammad Hassan Raza, Muhammad Usama Maqbool, Sunil Kumar, Jahanzeb Malik, Sameer Ali, Zahoor Aslam Khan Tags: REVIEW Source Type: research

Situs inversus totalis: A challenge for cardiac resynchronization therapy
We present a challenging cardiac resynchronization therapy (CRT) implantation in a 60-year-old man with SIT-DXC, heart failure, extreme bradycardia, wide QRS, and left ventricular (LV) dysfunction. The procedure was complex due to the mirror-image anatomy and the tortuous origin of the coronary sinus (CS) branches that required a subselection catheter for adequate lead implantation. (Source: Pacing and Clinical Electrophysiology : PACE)
Source: Pacing and Clinical Electrophysiology : PACE - September 12, 2023 Category: Cardiology Authors: Sebasti án Peñaloza, Marcelo Godoy, Rodrigo Miranda Tags: CASE REPORT Source Type: research

Addressing Barriers for Women with Advanced Heart Failure
AbstractPurpose of ReviewDescribe disparities in diagnosis and management between men and women with advanced heart failure (HF). Our goal is to identify barriers and suggest solutions.Recent FindingsWomen with advanced HF are less likely to undergo diagnostic testing and procedures (i.e., revascularization, implantable cardioverter defibrillators, cardiac resynchronization therapy, mechanical circulatory support, and orthotopic heart transplantation).SummaryDisparities related to gender create less favorable outcomes for women with advanced HF. The issues arise from access to care, paucity of knowledge, enrollment in clin...
Source: Current Cardiology Reports - September 12, 2023 Category: Cardiology Source Type: research

Perspectives on Secondary Mitral Regurgitation in Heart Failure
AbstractPurpose of the ReviewThis review focuses on broader perspectives of mitral regurgitation (MR) in patients with heart failure.Recent FindingsThe ratio of regurgitant volume to end-diastolic volume appears to help identify patients who may benefit from valve interventions. Secondary MR is not only attributed to geometric changes of the LV but also related to the structural changes in the mitral valve that include fibrosis of the mitral leaflets and changes in the extracellular matrix. The transition from mild to severe secondary MR can occur at different rates, from a slow LV remodeling process to a more abrupt proce...
Source: Current Heart Failure Reports - September 11, 2023 Category: Cardiology Source Type: research

Comorbidities and Clinical Response to Cardiac Resynchronization Therapy: Patient ‐Level Meta‐analysis From Eight Clinical Trials
ConclusionIn a meta-analysis of patient-level data from eight major trials, the totality of evidence suggests that CRT reduces HFH and/or all-cause mortality even when several comorbid diseases are present.This article is protected by copyright. All rights reserved. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - September 6, 2023 Category: Cardiology Authors: Marat Fudim, Frederik Dalgaard, Daniel J. Friedman, William T. Abraham, John G. F. Cleland, Anne B. Curtis, Michael R. Gold, Valentina Kutyifa, Cecilia Linde, Fatima Ali ‐Ahmed, Anthony Tang, Antonio Olivas‐Martinez, Lurdes Y.T. Inoue, Sa Tags: Research Article Source Type: research