Impulse Control Disorders in Parkinson ’s Disease: An Overview of Risk Factors, Pathogenesis and Pharmacological Management
AbstractImpulse control disorders in Parkinson ’s disease are relatively common drug-induced addictive behaviours that are usually triggered by the dopamine agonists pramipexole, ropinirole and rotigotine. This narrative review aimed to provide a comprehensive overview of the current knowledge of impulse control disorders in Parkinson’s dise ase. We summarised the prevalence, clinical features, risk factors and potential underlying mechanisms of impulse control disorders in Parkinson’s disease. Moreover, recent advances in behavioural and imaging characteristics and management strategies are discussed. Early detectio...
Source: CNS Drugs - April 13, 2024 Category: Neurology Source Type: research
Effects of dopaminergic therapy on sleep quality in fluctuating Parkinson ’s disease patients
ConclusionOur study highlights the positive influence of DA add-on treatment on sleep quality in this group of advanced fluctuating PD patients. (Source: Journal of Neurology)
Source: Journal of Neurology - April 12, 2024 Category: Neurology Source Type: research
Metabolite profiling of foslevodopa/foscarbidopa in plasma of healthy human participants by LC ‐HRMS indicates no major differences compared to administration of levodopa/carbidopa intestinal gel
Extracted ion chromatograms of drug-related material from pooled plasma after administration of LCIG and foslevodopa/foscarbidopa to healthy human participants AbstractAnalysis was conducted to compare levodopa/carbidopa pharmacokinetics and drug-related material in plasma of healthy participants after receiving a continuous infusion of Levodopa/Carbidopa Intestinal Gel (LCIG) to a continuous subcutaneous infusion of foslevodopa/foscarbidopa. Study samples were from a randomized, open-label, 2-period crossover study in 20 healthy participants. Participants received either 24-h foslevodopa/foscarbidopa SC infusion to the ab...
Source: Pharmacology Research and Perspectives - April 11, 2024 Category: Drugs & Pharmacology Authors: John P. Savaryn,
Richard L. Smith,
Matthew Rosebraugh,
Melina Neenan,
Richard Burton,
Kennan Marsh,
David Wagner Tags: ORIGINAL ARTICLE Source Type: research
Levodopa-Carbidopa: An Unusual Case of Voluntary Drug Intoxication
Acta Med Port. 2024 Apr 10. doi: 10.20344/amp.21161. Online ahead of print.NO ABSTRACTPMID:38598320 | DOI:10.20344/amp.21161 (Source: Acta Medica Portuguesa)
Source: Acta Medica Portuguesa - April 10, 2024 Category: General Medicine Authors: Sara Aleixo Duarte Catarina Jorge Miguel Varela Rui Almeida Tatjana Mihailovic Source Type: research
OFF-Times Before, During, and After Nighttime Sleep Periods in Parkinson ’s Disease Patients with Motor Fluctuations and the Effects of Opicapone: A Post Hoc Analysis of Diary Data from BIPARK-1 and -2
In BIPARK-1 and BIPARK-2, addition of once-daily opicapone to levodopa/carbidopa significantly reduced daily “OFF”-time relative to placebo in adults with Parkinson’s disease (PD) and motor fluctuations. Diary data from these studies were pooled and analyzed post hoc to characterize “OFF”-times around nighttime sleep and to explore the effects of opicapone 50 mg. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 8, 2024 Category: Neurology Authors: Robert A. Hauser, Aleksandar Videnovic, Patr ício Soares-da-Silva, Grace S. Liang, Kurt Olson, Eric Jen, José-Francisco Rocha, Olga Klepitskaya Source Type: research
Compound heterozygous mutations in three Chinese patients of Segawa syndrome and their treatment outcomes
Int J Dev Neurosci. 2024 Apr 2. doi: 10.1002/jdn.10328. Online ahead of print.ABSTRACTSegawa syndrome is a rare autosomal recessive form of dopa-responsive dystonia resulting from TH gene dysfunction. Patients typically exhibit symptoms such as generalized dystonia, rigidity, tremors, infantile Parkinsonism, and pseudo-spastic paraplegia. Levodopa is often an effective treatment. Due to its rarity, high heterogeneity, and poorly understood pathological mutation and phenotype spectrums, as well as genotype-phenotype and genotype-treatment outcome correlations, Segawa syndrome poses diagnostic and therapeutic challenges. In ...
Source: International Journal of Developmental Neuroscience - April 3, 2024 Category: Neuroscience Authors: Jie Zhang Yaxin Huang Yulei Hu Bing Bai Source Type: research
Compound heterozygous mutations in three Chinese patients of Segawa syndrome and their treatment outcomes
Int J Dev Neurosci. 2024 Apr 2. doi: 10.1002/jdn.10328. Online ahead of print.ABSTRACTSegawa syndrome is a rare autosomal recessive form of dopa-responsive dystonia resulting from TH gene dysfunction. Patients typically exhibit symptoms such as generalized dystonia, rigidity, tremors, infantile Parkinsonism, and pseudo-spastic paraplegia. Levodopa is often an effective treatment. Due to its rarity, high heterogeneity, and poorly understood pathological mutation and phenotype spectrums, as well as genotype-phenotype and genotype-treatment outcome correlations, Segawa syndrome poses diagnostic and therapeutic challenges. In ...
Source: International Journal of Developmental Neuroscience - April 3, 2024 Category: Neuroscience Authors: Jie Zhang Yaxin Huang Yulei Hu Bing Bai Source Type: research
Compound heterozygous mutations in three Chinese patients of Segawa syndrome and their treatment outcomes
Int J Dev Neurosci. 2024 Apr 2. doi: 10.1002/jdn.10328. Online ahead of print.ABSTRACTSegawa syndrome is a rare autosomal recessive form of dopa-responsive dystonia resulting from TH gene dysfunction. Patients typically exhibit symptoms such as generalized dystonia, rigidity, tremors, infantile Parkinsonism, and pseudo-spastic paraplegia. Levodopa is often an effective treatment. Due to its rarity, high heterogeneity, and poorly understood pathological mutation and phenotype spectrums, as well as genotype-phenotype and genotype-treatment outcome correlations, Segawa syndrome poses diagnostic and therapeutic challenges. In ...
Source: International Journal of Developmental Neuroscience - April 3, 2024 Category: Neuroscience Authors: Jie Zhang Yaxin Huang Yulei Hu Bing Bai Source Type: research
Compound heterozygous mutations in three Chinese patients of Segawa syndrome and their treatment outcomes
Int J Dev Neurosci. 2024 Apr 2. doi: 10.1002/jdn.10328. Online ahead of print.ABSTRACTSegawa syndrome is a rare autosomal recessive form of dopa-responsive dystonia resulting from TH gene dysfunction. Patients typically exhibit symptoms such as generalized dystonia, rigidity, tremors, infantile Parkinsonism, and pseudo-spastic paraplegia. Levodopa is often an effective treatment. Due to its rarity, high heterogeneity, and poorly understood pathological mutation and phenotype spectrums, as well as genotype-phenotype and genotype-treatment outcome correlations, Segawa syndrome poses diagnostic and therapeutic challenges. In ...
Source: International Journal of Developmental Neuroscience - April 3, 2024 Category: Neuroscience Authors: Jie Zhang Yaxin Huang Yulei Hu Bing Bai Source Type: research
Compound heterozygous mutations in three Chinese patients of Segawa syndrome and their treatment outcomes
Int J Dev Neurosci. 2024 Apr 2. doi: 10.1002/jdn.10328. Online ahead of print.ABSTRACTSegawa syndrome is a rare autosomal recessive form of dopa-responsive dystonia resulting from TH gene dysfunction. Patients typically exhibit symptoms such as generalized dystonia, rigidity, tremors, infantile Parkinsonism, and pseudo-spastic paraplegia. Levodopa is often an effective treatment. Due to its rarity, high heterogeneity, and poorly understood pathological mutation and phenotype spectrums, as well as genotype-phenotype and genotype-treatment outcome correlations, Segawa syndrome poses diagnostic and therapeutic challenges. In ...
Source: International Journal of Developmental Neuroscience - April 3, 2024 Category: Neuroscience Authors: Jie Zhang Yaxin Huang Yulei Hu Bing Bai Source Type: research
Early-onset levodopa responsive parkinsonism in PPP2R5D mutation
The gene PPP2R5D encodes the regulatory subunit B56 of PP2A, a serine-threonine phosphatase that plays an important regulatory role in cellular processes, including proliferation, apoptosis, and signal transduction, and is primarily expressed in the brain. The de novo missense variants in the gene PPP2R5D are reported to be associated with neurodevelopmental delay, intellectual disability, macrocephaly, motor and coordination deficits, epilepsy, visual impairment, and autism spectrum disorders [1]. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 3, 2024 Category: Neurology Authors: Rohan Mahale, Gautham Arunachal, Deepak Chadha, Hansashree Padmanabha, Pooja M, Mathuranath Pavagada Tags: Correspondence Source Type: research
Synthesis of Novel Plant-Derived Encapsulated Radiolabeled Compounds for the Diagnosis of Parkinson ’s Disease and the Evaluation of Biological Effects with In Vitro/In Vivo Methods
This study contributes to the advancement of drug delivery agents in the field of brain research. (Source: Molecular Neurobiology)
Source: Molecular Neurobiology - April 3, 2024 Category: Neurology Source Type: research
The prevalence of non-troublesome dyskinesia in Parkinson's disease
This study investigated prevalence and severity of dyskinesia, particularly non-troublesome dyskinesia, to provide insights into its significance for long-term PD management. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 3, 2024 Category: Neurology Authors: Hee Jin Chang, Mihee Jang, Kyung Ah Woo, Jung Hwan Shin, Han-Joon Kim, Beomseok Jeon Tags: Short communication Source Type: research
The Gut Microbiota in Parkinson Disease: Interactions with Drugs and Potential for Therapeutic Applications
This article summarises the most up-to-date knowledge in pharmacomicrobiomics in PD, and discusses how the manipulation of gut microbiota represents a potential new therapeutic avenue for PD. (Source: CNS Drugs)
Source: CNS Drugs - April 3, 2024 Category: Neurology Source Type: research
