Efficacy of Wearable low-intensity pulsed Ultrasound treatment in the Movement disorder in Parkinson ’s disease (the SWUMP trial): protocol for a single-site, double-blind, randomized controlled trial
This study represents the clinical investigation into the efficacy of therapeutic LIPUS in the treatment of PD for the first time. If LIPUS is determined to be effective, it could offer a practical and innovative means of expanding the accessibility of ultrasound therapy by using a wearable LIPUS device within a home setting.Trial registrationChinese Clinical Trial Registry ChiCTR2100052093. Registered on 17 October 2021. (Source: Trials)
Source: Trials - April 22, 2024 Category: Research Source Type: clinical trials
Dopamine, Reward Learning and Sex Hormones
Conditions: Hormonal Changes; Menstrual Cycle Interventions: Drug: Levodopa administration; Drug: Placebo administration Sponsors: University Hospital Tuebingen; German Research Foundation; Uppsala University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
DBS and Levodopa for Treating Freezing of Gait in Parkinson's Disease
Conditions: Freezing of Gait; Parkinson Disease Interventions: Device: STIM ON plus; Drug: MED ON plus Sponsors: IRCCS Istituto delle Scienze Neurologiche di Bologna; Azienda Ospedaliera Citt à della Salute e della Scienza di Torino Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 18, 2024 Category: Research Source Type: clinical trials
Electroencephalographic Signatures of Neuropsychiatric Fluctuations in Parkinson's Disease
Conditions: Parkinson Disease Interventions: Behavioral: assessment during the transition between OFF-levodopa (i.e. withdrawal of levodopa phase) and ON-levodopa (i.e. effect of Levodopa phase)states Sponsors: University Hospital, Geneva Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 8, 2024 Category: Research Source Type: clinical trials
Behavioural Profiling of Disease-related Cognitive and Motor Impairment in PD
Conditions: Parkinson Disease; Medication; UPDRS; Motor Function; Cognitive Impairment; Depression; Impulsive; Levodopa Interventions: Drug: Levodopa Sponsors: University Hospital Bispebjerg and Frederiksberg Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 23, 2024 Category: Research Source Type: clinical trials
Dynamic Brain Mapping of the Functional Effects of Levodopa on Multiple Cortex-basal Ganglia Circuits in Parkinson ́s Disease
Conditions: Levodopa-induced Dyskinesia in Parkinson ' s Disease Interventions: Other: No intervention Sponsors: Danish Research Centre for Magnetic Resonance; Bispebjerg Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 5, 2024 Category: Research Source Type: clinical trials
A multicenter double-blind randomized crossover study comparing the impact of dorsal subthalamic nucleus deep brain stimulation versus standard care on apathy in Parkinson ’s disease: a study protocol
AbstractBackgroundNeuroimaging studies suggest an association between apathy after deep brain stimulation (DBS) and stimulation of the ventral part of the subthalamic nucleus (STN) due to the associative fibers connected to the non-motor limbic circuits that are involved in emotion regulation and motivation. We have previously described three patients with severe apathy that could be fully treated after switching stimulation from a ventral electrode contact point to a more dorsal contact point.ObjectivesTo determine whether more dorsal stimulation of the STN decreases apathy compared to standard care in a multicenter rando...
Source: Trials - February 3, 2024 Category: Research Source Type: clinical trials
Basic and Clinical Studies of Levodopa/Carbidopa/Entacapone in the Treatment of Early Parkinson's Disease
Conditions: Parkinson Disease Interventions: Drug: levodopa/carbidopa/entacapone Sponsors: Second Affiliated Hospital of Soochow University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 1, 2024 Category: Research Source Type: clinical trials
Cortical Electrophysiology of Response Inhibition in Parkinson's Disease
Conditions: Parkinson Disease Interventions: Drug: Levodopa; Device: Clinical DBS Setting; Device: Sham DBS; Device: DBS Setting Maximizing Prefrontal Activation; Device: DBS Setting Minimizing Prefrontal Activation Sponsors: Emory University; National Institute of Neurological Disorders and Stroke (NINDS) Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 31, 2024 Category: Research Source Type: clinical trials
Effect of Dopamine on Specific Processing of Shame and Embarrassment in Parkinson's Disease
Conditions: Parkinson Disease Interventions: Behavioral: Assessments in ON and OFF levodopa state Sponsors: University Hospital, Geneva Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 26, 2024 Category: Research Source Type: clinical trials
Neurobiological Drivers of Mobility Resilience: The Dopaminergic System - Placebo-Controlled Arm
Conditions: Parkinsonian Signs in Older Persons Interventions: Drug: Carbidopa 25 mg; Drug: Carbidopa-Levodopa 25/100 mg; Drug: Placebo 1; Drug: Placebo 2 Sponsors: University of Michigan; National Institute on Aging (NIA) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 23, 2024 Category: Research Source Type: clinical trials
Bioequivalence Study of Entacapone,Levodopa and Carbidopa Tablets in the Postprandial State in Healthy Chinese Subjects
Conditions: Healthy Interventions: Drug: Test (T) Entacapone,Levodopa and Carbidopa Tablets (II); Drug: Reference (R) Entacapone,Levodopa and Carbidopa Tablets (II) Sponsors: The Affiliated Hospital of Qingdao University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 22, 2023 Category: Research Source Type: clinical trials
A TQT Study to Evaluate the Electrocardiographic Effects of Carbidopa in Healthy Subjects
Conditions: Cardiac Repolarization in Healthy Subjects Interventions: Drug: Carbidopa capsule; Drug: Moxifloxacin Tablets, USP; Drug: Placebo Sponsors: Impax Laboratories, LLC Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 7, 2023 Category: Research Source Type: clinical trials
Comparison of Dopamin Level in Idiopathic Parkinson's Patients
Conditions: Parkinson Disease; Treatment Adherence Interventions: Drug: Levodopa Sponsors: Ankara Ataturk Sanatorium Training and Research Hospital Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 3, 2023 Category: Research Source Type: clinical trials
Montelukast in Parkinson Disease
Conditions: Parkinson Disease Interventions: Drug: levodopa-carbidopa; Drug: Montelukast Sponsors: Mostafa Bahaa Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 2, 2023 Category: Research Source Type: clinical trials
