Drug-drug interaction between tacrolimus and caspofungin in Chinese kidney transplant patients with different < em > CYP3A5 < /em > genotypes
CONCLUSION: Co-administration of caspofungin reduced tacrolimus blood levels and elevated the required daily dose of tacrolimus. In CYP3A5 non-expressers, co-administration of caspofungin had a significant effect on tacrolimus C0/D values. An approximate 10% increase in the weight-adjusted daily dose of tacrolimus in CYP3A5 non-expressers is recommended to ensure the safety of tacrolimus administration.PMID:38646424 | PMC:PMC11027596 | DOI:10.1177/20420986241243165 (Source: Adv Data)
Source: Adv Data - April 22, 2024 Category: Epidemiology Authors: Yundi Zhang Bowen Shen Yue Li Huiying Zong Xiaoming Zhang Xiaohong Cao Fengxi Liu Yan Li Source Type: research
Niche-specific microevolution of Candida glabrata (Nakaseomyces glabrata) during an infection
Fungal Genet Biol. 2024 Apr 13:103891. doi: 10.1016/j.fgb.2024.103891. Online ahead of print.ABSTRACTCandida glabrata (Nakaseomyces glabrata) is an emergent and opportunistic fungal pathogen that colonizes and persists in different niches within its human host. In this work, we studied five clinical isolates from one patient (P7), that have a clonal origin, and all of which come from blood cultures except one, P7-3, obtained from a urine culture. We found phenotypic variation such as sensitivity to high temperature, oxidative stress, susceptibility to two classes of antifungal agents, and cell wall porosity. Only isolate P...
Source: Fungal Genetics and Biology - April 15, 2024 Category: Biology Authors: Ana L L ópez-Marmolejo Marco J Hern ández-Chávez Guadalupe Guti érrez-Escobedo M Selene Herrera-Basurto H éctor M Mora-Montes Alejandro De Las Pe ñas Irene Casta ño Source Type: research
Niche-specific microevolution of Candida glabrata (Nakaseomyces glabrata) during an infection
Fungal Genet Biol. 2024 Apr 13:103891. doi: 10.1016/j.fgb.2024.103891. Online ahead of print.ABSTRACTCandida glabrata (Nakaseomyces glabrata) is an emergent and opportunistic fungal pathogen that colonizes and persists in different niches within its human host. In this work, we studied five clinical isolates from one patient (P7), that have a clonal origin, and all of which come from blood cultures except one, P7-3, obtained from a urine culture. We found phenotypic variation such as sensitivity to high temperature, oxidative stress, susceptibility to two classes of antifungal agents, and cell wall porosity. Only isolate P...
Source: Fungal Genetics and Biology - April 15, 2024 Category: Biology Authors: Ana L L ópez-Marmolejo Marco J Hern ández-Chávez Guadalupe Guti érrez-Escobedo M Selene Herrera-Basurto H éctor M Mora-Montes Alejandro De Las Pe ñas Irene Casta ño Source Type: research
Niche-specific microevolution of Candida glabrata (Nakaseomyces glabrata) during an infection
Fungal Genet Biol. 2024 Apr 13:103891. doi: 10.1016/j.fgb.2024.103891. Online ahead of print.ABSTRACTCandida glabrata (Nakaseomyces glabrata) is an emergent and opportunistic fungal pathogen that colonizes and persists in different niches within its human host. In this work, we studied five clinical isolates from one patient (P7), that have a clonal origin, and all of which come from blood cultures except one, P7-3, obtained from a urine culture. We found phenotypic variation such as sensitivity to high temperature, oxidative stress, susceptibility to two classes of antifungal agents, and cell wall porosity. Only isolate P...
Source: Fungal Genetics and Biology - April 15, 2024 Category: Biology Authors: Ana L L ópez-Marmolejo Marco J Hern ández-Chávez Guadalupe Guti érrez-Escobedo M Selene Herrera-Basurto H éctor M Mora-Montes Alejandro De Las Pe ñas Irene Casta ño Source Type: research
Microevolution of Candida glabrata (Nakaseomyces glabrata) during an infection
Fungal Genet Biol. 2024 Apr 14;172:103891. doi: 10.1016/j.fgb.2024.103891. Online ahead of print.ABSTRACTCandida glabrata (Nakaseomyces glabrata) is an emergent and opportunistic fungal pathogen that colonizes and persists in different niches within its human host. In this work, we studied five clinical isolates from one patient (P7), that have a clonal origin, and all of which come from blood cultures except one, P7-3, obtained from a urine culture. We found phenotypic variation such as sensitivity to high temperature, oxidative stress, susceptibility to two classes of antifungal agents, and cell wall porosity. Only isola...
Source: Fungal Genetics and Biology - April 15, 2024 Category: Biology Authors: Ana L L ópez-Marmolejo Marco J Hern ández-Chávez Guadalupe Guti érrez-Escobedo M Selene Herrera-Basurto H éctor M Mora-Montes Alejandro De Las Pe ñas Irene Casta ño Source Type: research
Successful Treatment of Severe Aplastic Anemia with Hematopoietic Stem Cell Transplantation in the Setting of Active Mucormycosis
AbstractSevere aplastic anemia (SAA) is a life-threatening hematological disease characterized by the suppression of the bone marrow. Patients with SAA are predisposed to recurrent bacterial infections and invasive fungal infections (IFI) due to profound and persistent neutropenia. Mucorales are the second most common cause of IFI encountered in SAA. Here we present a pediatric case of SAA with active mucormycosis infection of the paranasal sinuses. In the first step, surgical debridement was performed and combined antifungal therapy (liposomal amphotericin B, posaconazole, caspofungin) was started. Due to severe neutropen...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 4, 2024 Category: ENT & OMF Source Type: research
Analysis of candidemia cases in a city hospital during the COVID-19 pandemic
CONCLUSIONS: As our study observed, the COVID-19 pandemic brought increasing numbers of immunosuppressed patients, widespread use of antibacterials, and central venous catheters, increasing the frequency and mortality of candidemia cases. All health institutions should be prepared for the diagnosis and treatment of candidemia. In addition, C. auris, the frequency of which has increased in recent years, is a new factor that should be considered in candidemia cases.PMID:38567615 | DOI:10.26355/eurrev_202403_35762 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 3, 2024 Category: Drugs & Pharmacology Authors: O Ozalp S Komec M Unsel A Gunduz O Altuntas Aydin Source Type: research
Analysis of candidemia cases in a city hospital during the COVID-19 pandemic
CONCLUSIONS: As our study observed, the COVID-19 pandemic brought increasing numbers of immunosuppressed patients, widespread use of antibacterials, and central venous catheters, increasing the frequency and mortality of candidemia cases. All health institutions should be prepared for the diagnosis and treatment of candidemia. In addition, C. auris, the frequency of which has increased in recent years, is a new factor that should be considered in candidemia cases.PMID:38567615 | DOI:10.26355/eurrev_202403_35762 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: O Ozalp S Komec M Unsel A Gunduz O Altuntas Aydin Source Type: research
Analysis of candidemia cases in a city hospital during the COVID-19 pandemic
CONCLUSIONS: As our study observed, the COVID-19 pandemic brought increasing numbers of immunosuppressed patients, widespread use of antibacterials, and central venous catheters, increasing the frequency and mortality of candidemia cases. All health institutions should be prepared for the diagnosis and treatment of candidemia. In addition, C. auris, the frequency of which has increased in recent years, is a new factor that should be considered in candidemia cases.PMID:38567615 | DOI:10.26355/eurrev_202403_35762 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 3, 2024 Category: Drugs & Pharmacology Authors: O Ozalp S Komec M Unsel A Gunduz O Altuntas Aydin Source Type: research
Analysis of candidemia cases in a city hospital during the COVID-19 pandemic
CONCLUSIONS: As our study observed, the COVID-19 pandemic brought increasing numbers of immunosuppressed patients, widespread use of antibacterials, and central venous catheters, increasing the frequency and mortality of candidemia cases. All health institutions should be prepared for the diagnosis and treatment of candidemia. In addition, C. auris, the frequency of which has increased in recent years, is a new factor that should be considered in candidemia cases.PMID:38567615 | DOI:10.26355/eurrev_202403_35762 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: O Ozalp S Komec M Unsel A Gunduz O Altuntas Aydin Source Type: research
