The antifungal activity of caspofungin in combination with antifungals or non-antifungals against < em > Candida < /em > species < em > in vitro < /em > and in clinical therapy
Expert Rev Anti Infect Ther. 2021 Jun 15. doi: 10.1080/14787210.2021.1941868. Online ahead of print.ABSTRACTINTRODUCTION: Candida species have been regarded as global health threats due to their ability to cause invasive infections. It is challenging to treat Candida bloodstream infections, which are associated with high mortality levels. Monotherapy with antifungals is sometimes not effective against severe Candida infections, and combination therapy is needed in clinical practice.AREAS COVERED: This review was undertaken based on data from a PubMed search for English language reports published before March 2021 by using ...
Source: Expert Review of Anti-Infective Therapy - June 15, 2021 Category: Infectious Diseases Authors: Shan Su Haiying Yan Li Min Hongmei Wang Xueqi Chen Jinyi Shi Shujuan Sun Source Type: research

In vitro activity of anidulafungin, caspofungin, fluconazole and amphotericin B against biofilms and planktonic forms of Candida species isolated from blood culture in patients with hematological malignancies
Publication date: Available online 2 June 2021Source: Journal of Medical MycologyAuthor(s): Anna Olegovna Malchikova, Galina Aleksandrovna Klyasova (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - June 3, 2021 Category: Biology Source Type: research

Pharmacokinetics and antifungal activity of echinocandins in ascites fluid of critically ill patients
Antimicrob Agents Chemother. 2021 May 10:AAC.02565-20. doi: 10.1128/AAC.02565-20. Online ahead of print.ABSTRACTPharmacokinetics and antifungal activity of the echinocandins anidulafungin (AFG), micafungin (MFG) and caspofungin (CAS) were assessed in ascites fluid and plasma of critically ill adults treated for suspected or proven invasive candidiasis. Ascites fluid was obtained from ascites drains or during paracentesis. The antifungal activity of the echinocandins in ascites fluid was assessed by incubation of Candida (C.) albicans and C. glabrata at concentrations of 0.03 to 16.00 μg/ml. In addition, ascites fluid sa...
Source: Antimicrobial Agents and Chemotherapy - May 11, 2021 Category: Microbiology Authors: Ren é Welte Herbert Oberacher Tiziana Gasperetti Hartwig Pfisterer Andrea Griesmacher Tobias Santner Cornelia Lass-Fl örl Caroline H örtnagl Sandra Leitner-Rupprich Maria Aigner Ingo Lorenz Stefan Schmid Michael Edlinger Philipp Eller Daniel Dankl Mich Source Type: research

Pharmacokinetics and antifungal activity of echinocandins in ascites fluid of critically ill patients
Antimicrob Agents Chemother. 2021 May 10:AAC.02565-20. doi: 10.1128/AAC.02565-20. Online ahead of print.ABSTRACTPharmacokinetics and antifungal activity of the echinocandins anidulafungin (AFG), micafungin (MFG) and caspofungin (CAS) were assessed in ascites fluid and plasma of critically ill adults treated for suspected or proven invasive candidiasis. Ascites fluid was obtained from ascites drains or during paracentesis. The antifungal activity of the echinocandins in ascites fluid was assessed by incubation of Candida (C.) albicans and C. glabrata at concentrations of 0.03 to 16.00 μg/ml. In addition, ascites fluid sa...
Source: Antimicrobial Agents and Chemotherapy - May 11, 2021 Category: Microbiology Authors: Ren é Welte Herbert Oberacher Tiziana Gasperetti Hartwig Pfisterer Andrea Griesmacher Tobias Santner Cornelia Lass-Fl örl Caroline H örtnagl Sandra Leitner-Rupprich Maria Aigner Ingo Lorenz Stefan Schmid Michael Edlinger Philipp Eller Daniel Dankl Mich Source Type: research

Pharmacokinetics and antifungal activity of echinocandins in ascites fluid of critically ill patients
Antimicrob Agents Chemother. 2021 May 10:AAC.02565-20. doi: 10.1128/AAC.02565-20. Online ahead of print.ABSTRACTPharmacokinetics and antifungal activity of the echinocandins anidulafungin (AFG), micafungin (MFG) and caspofungin (CAS) were assessed in ascites fluid and plasma of critically ill adults treated for suspected or proven invasive candidiasis. Ascites fluid was obtained from ascites drains or during paracentesis. The antifungal activity of the echinocandins in ascites fluid was assessed by incubation of Candida (C.) albicans and C. glabrata at concentrations of 0.03 to 16.00 μg/ml. In addition, ascites fluid sa...
Source: Antimicrobial Agents and Chemotherapy - May 11, 2021 Category: Microbiology Authors: Ren é Welte Herbert Oberacher Tiziana Gasperetti Hartwig Pfisterer Andrea Griesmacher Tobias Santner Cornelia Lass-Fl örl Caroline H örtnagl Sandra Leitner-Rupprich Maria Aigner Ingo Lorenz Stefan Schmid Michael Edlinger Philipp Eller Daniel Dankl Mich Source Type: research

Pharmacokinetics and antifungal activity of echinocandins in ascites fluid of critically ill patients
Antimicrob Agents Chemother. 2021 May 10:AAC.02565-20. doi: 10.1128/AAC.02565-20. Online ahead of print.ABSTRACTPharmacokinetics and antifungal activity of the echinocandins anidulafungin (AFG), micafungin (MFG) and caspofungin (CAS) were assessed in ascites fluid and plasma of critically ill adults treated for suspected or proven invasive candidiasis. Ascites fluid was obtained from ascites drains or during paracentesis. The antifungal activity of the echinocandins in ascites fluid was assessed by incubation of Candida (C.) albicans and C. glabrata at concentrations of 0.03 to 16.00 μg/ml. In addition, ascites fluid sa...
Source: Antimicrobial Agents and Chemotherapy - May 11, 2021 Category: Microbiology Authors: Ren é Welte Herbert Oberacher Tiziana Gasperetti Hartwig Pfisterer Andrea Griesmacher Tobias Santner Cornelia Lass-Fl örl Caroline H örtnagl Sandra Leitner-Rupprich Maria Aigner Ingo Lorenz Stefan Schmid Michael Edlinger Philipp Eller Daniel Dankl Mich Source Type: research

Pharmacokinetics and antifungal activity of echinocandins in ascites fluid of critically ill patients
Antimicrob Agents Chemother. 2021 May 10:AAC.02565-20. doi: 10.1128/AAC.02565-20. Online ahead of print.ABSTRACTPharmacokinetics and antifungal activity of the echinocandins anidulafungin (AFG), micafungin (MFG) and caspofungin (CAS) were assessed in ascites fluid and plasma of critically ill adults treated for suspected or proven invasive candidiasis. Ascites fluid was obtained from ascites drains or during paracentesis. The antifungal activity of the echinocandins in ascites fluid was assessed by incubation of Candida (C.) albicans and C. glabrata at concentrations of 0.03 to 16.00 μg/ml. In addition, ascites fluid sa...
Source: Antimicrobial Agents and Chemotherapy - May 11, 2021 Category: Microbiology Authors: Ren é Welte Herbert Oberacher Tiziana Gasperetti Hartwig Pfisterer Andrea Griesmacher Tobias Santner Cornelia Lass-Fl örl Caroline H örtnagl Sandra Leitner-Rupprich Maria Aigner Ingo Lorenz Stefan Schmid Michael Edlinger Philipp Eller Daniel Dankl Mich Source Type: research

Pharmacokinetics and antifungal activity of echinocandins in ascites fluid of critically ill patients
Antimicrob Agents Chemother. 2021 May 10:AAC.02565-20. doi: 10.1128/AAC.02565-20. Online ahead of print.ABSTRACTPharmacokinetics and antifungal activity of the echinocandins anidulafungin (AFG), micafungin (MFG) and caspofungin (CAS) were assessed in ascites fluid and plasma of critically ill adults treated for suspected or proven invasive candidiasis. Ascites fluid was obtained from ascites drains or during paracentesis. The antifungal activity of the echinocandins in ascites fluid was assessed by incubation of Candida (C.) albicans and C. glabrata at concentrations of 0.03 to 16.00 μg/ml. In addition, ascites fluid sa...
Source: Antimicrobial Agents and Chemotherapy - May 11, 2021 Category: Microbiology Authors: Ren é Welte Herbert Oberacher Tiziana Gasperetti Hartwig Pfisterer Andrea Griesmacher Tobias Santner Cornelia Lass-Fl örl Caroline H örtnagl Sandra Leitner-Rupprich Maria Aigner Ingo Lorenz Stefan Schmid Michael Edlinger Philipp Eller Daniel Dankl Mich Source Type: research

Pharmacokinetics and antifungal activity of echinocandins in ascites fluid of critically ill patients
Antimicrob Agents Chemother. 2021 May 10:AAC.02565-20. doi: 10.1128/AAC.02565-20. Online ahead of print.ABSTRACTPharmacokinetics and antifungal activity of the echinocandins anidulafungin (AFG), micafungin (MFG) and caspofungin (CAS) were assessed in ascites fluid and plasma of critically ill adults treated for suspected or proven invasive candidiasis. Ascites fluid was obtained from ascites drains or during paracentesis. The antifungal activity of the echinocandins in ascites fluid was assessed by incubation of Candida (C.) albicans and C. glabrata at concentrations of 0.03 to 16.00 μg/ml. In addition, ascites fluid sa...
Source: Antimicrobial Agents and Chemotherapy - May 11, 2021 Category: Microbiology Authors: Ren é Welte Herbert Oberacher Tiziana Gasperetti Hartwig Pfisterer Andrea Griesmacher Tobias Santner Cornelia Lass-Fl örl Caroline H örtnagl Sandra Leitner-Rupprich Maria Aigner Ingo Lorenz Stefan Schmid Michael Edlinger Philipp Eller Daniel Dankl Mich Source Type: research

Effects of calcineurin inhibitors, cyclosporine A and tacrolimus (FK506), on the activity of antifungal drugs against < em > Candida < /em > spp
Conclusion. Synergistic interactions in the combinations of TAC or CsA with antifungal drugs, except for AMB, in many concentrations was found to be promising in terms of the treatment of patients with fungal infections.PMID:33915075 | DOI:10.1099/jmm.0.001354 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 29, 2021 Category: Microbiology Authors: S ümeyye Şen Kaya Nuri Kiraz Ay şe Bariş Deniz Turan Yasemin Öz İlknur Dağ G ökhan Aygün Source Type: research

Effects of calcineurin inhibitors, cyclosporine A and tacrolimus (FK506), on the activity of antifungal drugs against < em > Candida < /em > spp
Conclusion. Synergistic interactions in the combinations of TAC or CsA with antifungal drugs, except for AMB, in many concentrations was found to be promising in terms of the treatment of patients with fungal infections.PMID:33915075 | DOI:10.1099/jmm.0.001354 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 29, 2021 Category: Microbiology Authors: S ümeyye Şen Kaya Nuri Kiraz Ay şe Bariş Deniz Turan Yasemin Öz İlknur Dağ G ökhan Aygün Source Type: research

Effects of calcineurin inhibitors, cyclosporine A and tacrolimus (FK506), on the activity of antifungal drugs against < em > Candida < /em > spp
Conclusion. Synergistic interactions in the combinations of TAC or CsA with antifungal drugs, except for AMB, in many concentrations was found to be promising in terms of the treatment of patients with fungal infections.PMID:33915075 | DOI:10.1099/jmm.0.001354 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 29, 2021 Category: Microbiology Authors: S ümeyye Şen Kaya Nuri Kiraz Ay şe Bariş Deniz Turan Yasemin Öz İlknur Dağ G ökhan Aygün Source Type: research

Effects of calcineurin inhibitors, cyclosporine A and tacrolimus (FK506), on the activity of antifungal drugs against < em > Candida < /em > spp
Conclusion. Synergistic interactions in the combinations of TAC or CsA with antifungal drugs, except for AMB, in many concentrations was found to be promising in terms of the treatment of patients with fungal infections.PMID:33915075 | DOI:10.1099/jmm.0.001354 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 29, 2021 Category: Microbiology Authors: S ümeyye Şen Kaya Nuri Kiraz Ay şe Bariş Deniz Turan Yasemin Öz İlknur Dağ G ökhan Aygün Source Type: research

Effects of calcineurin inhibitors, cyclosporine A and tacrolimus (FK506), on the activity of antifungal drugs against < em > Candida < /em > spp
Conclusion. Synergistic interactions in the combinations of TAC or CsA with antifungal drugs, except for AMB, in many concentrations was found to be promising in terms of the treatment of patients with fungal infections.PMID:33915075 | DOI:10.1099/jmm.0.001354 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 29, 2021 Category: Microbiology Authors: S ümeyye Şen Kaya Nuri Kiraz Ay şe Bariş Deniz Turan Yasemin Öz İlknur Dağ G ökhan Aygün Source Type: research

ALS3 Expression as an Indicator for Candida albicans Biofilm Formation and Drug Resistance
In this study, C. albicans samples were selected from C. albicans septicemia that were sensitive to common antifungal agents. It was found that the agglutinin-like sequence 3 (ALS3) gene was differentially expressed in free, antifungal, drug-sensitive C. albicans. The average ALS3 gene expression was higher in the C. albicans strains with biofilm formation than that in the C. albicans strains without biofilm formation. Then, it was further confirmed that the rate of biofilm formation was higher in the high ALS3 gene expression group than that in the low ALS3 gene expression group. It was found that C. albicans with biofilm...
Source: Frontiers in Microbiology - April 29, 2021 Category: Microbiology Source Type: research

Breakthrough fungal infections after allogeneic hematopoietic cell transplant: Improved understanding and new strategic approach with sargramostim
Clin Immunol. 2021 Apr 20:108731. doi: 10.1016/j.clim.2021.108731. Online ahead of print.ABSTRACTIn hosts with damaged or impaired immune systems such as those undergoing hematopoietic cell transplant (HCT) or intensive chemotherapy, breakthrough fungal infections can be fatal. Risk factors for breakthrough infections include severe neutropenia, use of corticosteroids, extended use of broad-spectrum antibiotics, and intensive care unit admission. An individual's cumulative state of immunosuppression directly contributes to the likelihood of experiencing increased infection risk. Incidence of invasive fungal infection (IFI)...
Source: Clinical Immunology - April 23, 2021 Category: Allergy & Immunology Authors: Sherman Chu Thomas S McCormick Hillard M Lazarus Luis O Leal Mahmoud A Ghannoum Source Type: research

Breakthrough fungal infections after allogeneic hematopoietic cell transplant: Improved understanding and new strategic approach with sargramostim
Clin Immunol. 2021 Apr 20:108731. doi: 10.1016/j.clim.2021.108731. Online ahead of print.ABSTRACTIn hosts with damaged or impaired immune systems such as those undergoing hematopoietic cell transplant (HCT) or intensive chemotherapy, breakthrough fungal infections can be fatal. Risk factors for breakthrough infections include severe neutropenia, use of corticosteroids, extended use of broad-spectrum antibiotics, and intensive care unit admission. An individual's cumulative state of immunosuppression directly contributes to the likelihood of experiencing increased infection risk. Incidence of invasive fungal infection (IFI)...
Source: Clinical Immunology - April 23, 2021 Category: Allergy & Immunology Authors: Sherman Chu Thomas S McCormick Hillard M Lazarus Luis O Leal Mahmoud A Ghannoum Source Type: research

The Importance of Mycological Diagnosis: A Scedosporium apiospermum Complex Mycetoma Case Neglected For 20 Years
In this report, we aimed to present a case of mycetoma caused by Scedosporium apiospermum complex that developed in a 40-year-old female patient with immunocompetent system and diagnosed by fungal culture. In the anamnesis of the patient who admitted in 2015 with the complaint of more than one fistulized discharge wound, pain and swelling in the dorsal of the right hand and wrist; it was learned that her complaints started about 20 years ago with a slight swelling on the back of the wrist, and when it worsened, the abscess was drained and antibiotic treatment was initiated in a private surgical center. However, it was lear...
Source: Mikrobiyoloji Bulteni - April 22, 2021 Category: Microbiology Authors: Ay şe Barış Ahsen Öncül Kahraman Öztürk Alican Bar ış Serkan Aykut Elif Akta ş Source Type: research