Targeting immune cell metabolism with a view to altering disease outcome
By training I am an immunologist with expertise in infection biology. Over time, the research focus of my laboratory has remained immunology-based, but has evolved to encompass an interest in autoimmunity and cancer. Over the last 15 years we have increasingly focused on understanding the relationship between basic aspects of cell-intrinsic metabolism and cell function and fate in immune cells. In general, immune cells are responsive to stimulation through receptors that recognize signals from pathogens, other immune cells and stromal cells. Responses to these signals encompass marked changes in cellular metabolism that se...
Source: Videocast - All Events - November 22, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Virtual National Cancer Advisory Board (NCAB) Subcommittee Meetings
The Virtual NCAB Cancer Centers Subcommittee meeting will be held from 1:00 p.m. to 2:00 p.m., EDT. The Virtual NCAB Experimental Therapeutics Subcommittee meeting will be held from 2:05 p.m. to 3:05 p.m., EDT.Air date: 11/29/2023 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 20, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Grand Rounds - Dr. Jordan Meier
CCR Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians.Air date: 12/8/2023 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 20, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Virtual National Cancer Advisory Board (NCAB) Cancer Centers Subcommittee Meeting
The Virtual NCAB Cancer Centers Subcommittee meeting will be held from 1:00 p.m. to 2:00 p.m., EDT.Air date: 11/29/2023 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 15, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
8th Virtual Joint Meeting of the NCI Board of Scientific Advisors and the National Cancer Advisory Board
The 8th Virtual Joint Meeting of the NCI Board of Scientific Advisors (BSA) and the National Cancer Advisory Board (NCAB) will be held from 1:15 p.m. to 5:00 p.m., EDT.Air date: 11/30/2023 1:15:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 15, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Immune evasion of stem cells in health and cancer
The Agudo lab is focused on the study of immune evasion of stem cells in both autoimmunity and cancer. Our goal is to identify targets to protect tissues for regeneration as well as mechanisms to ensure effective responses to immunotherapy in cancer patients. Dr. Agudo has recently discovered a population of quiescent cancer stem cells in breast cancer that survive during T cell attack and lead to resistance to immunotherapy.Air date: 11/29/2023 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 14, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
8th Virtual Joint Meeting of the NCI Board of Scientific Advisors and the National Cancer Advisory Board
There will be two Virtual NCAB Subcommittee Meetings prior to the start of the Virtual Joint Meeting of the NCI Board of Scientific Advisors and the National Cancer Advisory Board. The NCAB Clinical Investigations Subcommittee meeting will be held from 11:15 a.m. to 12:15 p.m. At this point, there is a 5-minute break. Then the NCAB Cancer Centers Subcommittee meeting will be held from 12:20 p.m. to 1:20 p.m. At this point there is a 10-minute break. Then the Virtual Joint Meeting of the NCI Board of Scientific Advisors and the National Cancer Advisory Board will be held from 1:30 p.m. to 5:30 p.m.Air date: 11/29/2023 11:15...
Source: Videocast - All Events - November 9, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Clinicopathologic Grand Rounds - Clinical Cases from the NIH Clinical Center: Hyperphosphatemic Familial Tumoral Calcinosis: Defining Pathomechanisms to Inform Treatment
Kelly L Roszko MD, PhDResearch Physician, Skeletal Disorders and Mineral Homeostasis SectionFaculty, Interinstitute Endocrine Training ProgramNational Institute of Dental and Craniofacial ResearchMichael Collins, MDSenior InvestigatorSkeletal Disorders& Mineral Homeostasis SectionSkeletal, Matrix,& MechanobiologyMechanisms of Development& Stem Cell FateNational Institute of Dental and Craniofacial ResearchBabak Saboury, MDPhysician-ScientistRadiology and Imaging SciencesClinical CenterDavid Kleiner, MD, PhDHead, Histopathology and Autopsy PathologySenior Research PhysicianLaboratory of PathologyCenter for Cance...
Source: Videocast - All Events - October 31, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
40 Years of Cancer Epigenetics Symposium
Forty years ago, Drs. Andrew Feinberg and Bert Vogelstein observed that levels of DNA methylation, an epigenetic modification now known as a critical modulator of gene expression, were significantly reduced in cancer cells when compared to normal cells. This landmark discovery is considered by many to be the birth of the field of cancer epigenetics. Since that time, this transformational research area has exploded and there no doubt regarding the importance of these phenomena. There have been foundational studies leading to groundbreaking discoveries that span benchtop to bedside. Cancer therapeutics that target epigenetic...
Source: Videocast - All Events - October 16, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Grand Rounds: Melanoma Control by its Cross Talk with the Microenvironment
CCR Grand Rounds “ Melanoma Control by its Cross Talk with the Microenvironment ” Ze'ev Ronai, Ph.D.Jeanne and Gary Herberger Leadership Chair in Cancer ResearchProfessor, Tumor Initiation and Maintenance ProgramSanford Burnham Prebys Medical Discovery InstituteDirector, NCI-Designated Cancer CenterFriday, October 27, 202312:00 – 1:00 p.m.Lipsett AmphitheaterAir date: 10/27/2023 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 13, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Grand Rounds: A Garden of Forking Paths: Branching, Switching, and Reversing in Homologous Recombination
CCR Grand Rounds “ A Garden of Forking Paths: Branching, Switching, and Reversing in Homologous Recombination ” Michael Lichten, Ph.D.NIH Scientist EmeritusLaboratory of Biochemistry and Molecular BiologyCenter for Cancer Research, NCI Friday, October 20, 202312:00 – 1:00 p.m.Lipsett AmphitheaterAir date: 10/20/2023 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 11, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS Lecture: Laura Niedernhofer Ph.D.
Laura Niedernhofer joined the University of Minnesota in July 2018 to direct the new Institute on the Biology of Aging& Metabolism ;(external link)(iBAM) and Medical Discovery Team on the Biology of Aging. She is also a Professor in the Department of Biochemistry, Molecular Biology and Biophysics at UMN. Dr. Niedernhofer ’ s expertise is in DNA damage and repair, genome instability disorders, cellular senescence and aging. Her research program is centered on studying fundamental mechanisms of aging and developing therapeutics to target them. Her research program implements a murine model of a human progeroid syndrome...
Source: Videocast - All Events - October 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Advancing Health Equity Through Culture-Centered Dietary Interventions to Address Chronic Diseases Virtual Workshop (Day 2)
Goals and Key Audience: Objectives: 1. Identify gaps and opportunities for research on the cultural adaptation of evidence-based dietary approaches (e.g., DASH and Mediterranean Diet) to address diet-related diseases in racial/ethnic populations; 2. Understand dietary acculturation and its influence on the development and effectiveness of dietary interventions among diverse immigrant populations; 3. Interrogate the influence of dietary acculturation on the gut microbiome, and understand gut microbiome response to traditional and evidence-based diets. Need and Justification: Adherence to evidence-based dietary approaches, s...
Source: Videocast - All Events - September 26, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Advancing Health Equity Through Culture-Centered Dietary Interventions to Address Chronic Diseases Virtual Workshop (Day 1)
Goals and Key Audience: Objectives: 1. Identify gaps and opportunities for research on the cultural adaptation of evidence-based dietary approaches (e.g., DASH and Mediterranean Diet) to address diet-related diseases in racial/ethnic populations; 2. Understand dietary acculturation and its influence on the development and effectiveness of dietary interventions among diverse immigrant populations; 3. Interrogate the influence of dietary acculturation on the gut microbiome, and understand gut microbiome response to traditional and evidence-based diets. Need and Justification: Adherence to evidence-based dietary approaches, s...
Source: Videocast - All Events - September 26, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Grand Rounds: Big Data Approaches to Study Intercellular Signaling During Tumor Immune Evasion
CCR Grand Rounds “ Big Data Approaches to Study Intercellular Signaling During Tumor Immune Evasion ”
Peng Jiang, Ph.D.
Stadtman Investigator
Cancer Data Science Laboratory
Center for Cancer Research, NCI
Friday, September 29, 2023
12:00 – 1:00 p.m.
Lipsett Amphitheater
Dr. Peng Jiang started his research program at the National Cancer Institute (NCI) in July 2019. His lab focuses on developing big data and artificial intelligence frameworks to identify biomarkers and new therapeutic approaches for cancer immunotherapies in solid tumors. Before joining NCI, he fi nished his postdoctoral training at the Dana Far...
Source: Videocast - All Events - September 19, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
