A portal for RNA exit
Virus particles are metastable: they must be highly stable, to protect the nucleic acid while traveling from host to host or cell to cell, and then come apart to liberate the genome into the cell. New insight into this uncoating process comes from beautiful images of feline calicivirus showing formation of a portal on the […] (Source: virology blog)
Source: virology blog - February 15, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information calicivirus cell receptor conformational changes fJAM-A hydrophobic peptide portal viral viruses VP1 VP2 Source Type: blogs
TWiV 534: Portal to the METTL
The TWiV crew reveal a unique portal on the calcivirus capsid formed upon receptor engagement, and the regulation of interferon responses in virus-infected cells by methylation of mRNA. Click arrow to play Download TWiV 534 (57 MB .mp3, 95 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - February 10, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology calicivirus cryoEM cytomegalovirus endocytosis HCMV herpesvirus IFN ISG m6A methylation methyl eraser methyl reader methyl writer METTL mRNA stability portal receptor uncoating viral viruses Source Type: blogs
Science publishing has a Zika problem
Science publishing has a problem. I agree with Nobel Laureate Randy Schekman, who wrote that prestigious science journals like Cell, Nature, and Science – which he calls ‘luxury journals’ – are damaging science. The succession of articles on Zika virus nicely illustrates this problem.
The big three in science publishing – Science, Nature, and Cell – have published many papers on Zika virus since the beginning of 2016. Many of these have had a turnaround time of a week or two – the time between when the papers were submitted, and when they were published online. A rapid turnaround time is...
Source: virology blog - May 19, 2016 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Commentary Information cell luxury journal nature science science publishing viral virus viruses zika virus Source Type: blogs
TWiV 312: She sells B cells
On episode #312 of the science show This Week in Virology, the TWiVbolans discuss the finding that human noroviruses, major causes of gastroenteritis, can for the first time be propagated in B cell cultures, with the help of enteric bacteria.
You can find TWiV #312 at www.twiv.tv. (Source: virology blog)
Source: virology blog - November 23, 2014 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology B cell calicivirus cell culture diarrhea Ebola ebolavirus gastroenteritis hemorrhagic fever norovirus plaque assay semen sexual transmission two bucket disease viral vomiting Source Type: blogs
