Monitoring the utilization and effectiveness of Iron and Vitamin D supplementations program and its predictive factors in high schools ’ girls in Qom, Iran
Conclusion:The inadequate and incomplete rate of IVDSP in Qom was high and more than 60% of distributed supplementations have been wasted. Our results showed that students who were participated in educational orientation classes were more successful and eager in iron and vitamin D3 consumption. Therefore, it is recommended to increase interventions at individual, interpersonal, intra-organizational and inter-organizational levels in order to fully support the program and ultimately increase the efficiency of the program. (Source: Journal of Preventive Medicine and Hygiene)
Source: Journal of Preventive Medicine and Hygiene - April 15, 2024 Category: International Medicine & Public Health Authors: Abolfazl Mohammadbeigi, Dr Source Type: research
Relationships of serum FGF23 and α-klotho with atherosclerosis in patients with type 2 diabetes mellitus
Compelling evidence suggests that calcium/phosphorus homeostasis-related parameters may be linked to diabetes mellitus and cardiovascular events. However, few studies have investigated the association of fibro... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 15, 2024 Category: Cardiology Authors: Jiao Bi, Mei Zheng, Ke Li, Siwei Sun, Zihang Zhang, Nana Yan and Xueping Li Tags: Research Source Type: research
CaMK4: Structure, physiological functions, and therapeutic potential
Biochem Pharmacol. 2024 Apr 12:116204. doi: 10.1016/j.bcp.2024.116204. Online ahead of print.ABSTRACTCalcium/calmodulin-dependent protein kinase IV (CaMK4) is a versatile serine/threonine kinase involved in various cellular functions. It regulates T-cell differentiation, podocyte function, tumor cell proliferation/apoptosis, β cell mass, and insulin sensitivity. However, the underlying molecular mechanisms are complex and remain incompletely understood. The aims of this review are to highlight the latest advances in the regulatory mechanisms of CaMK4 underlying T-cell imbalance and parenchymal cell mass in multiple diseas...
Source: Biochemical Pharmacology - April 14, 2024 Category: Drugs & Pharmacology Authors: Hao Xu Liang Yong Xianxian Gao Yandong Chen Yixuan Wang Fuyan Wang Xin Hou Source Type: research
Design, synthesis, and biological activity of D-bishomo-1 α,25-dihydroxyvitamin D < sub > 3 < /sub > analogs and their crystal structures with the vitamin D nuclear receptor
In this study, we present the synthesis of vitamin D derivatives characterized by an enlarged (seven-membered) ring D. Preparation of the designed vitamin D compounds required separate syntheses of crucial building blocks (C/D-rings fragments with side chain and rings A) which were combined by different methods, including Wittig-Horner reaction and Suzuki coupling. Biological activities of the target vitamin D analogs were assessed both in vitro and in vivo, demonstrating their significant potency compared to the natural hormone. Furthermore, the successful crystallization of these compounds with the vitamin D receptor (VD...
Source: European Journal of Medicinal Chemistry - April 14, 2024 Category: Chemistry Authors: Adrian Fabisiak Pawel Brzeminski Rafal R Sicinski Natacha Rochel Ewa Maj Beata Filip-Psurska Joanna Wietrzyk Lori A Plum Hector F DeLuca Source Type: research
Effect of incorporating modified pinh ão starch in alginate-based hydrogel beads for encapsulation of bioactive compounds by hydrodynamic electrospray ionization jetting
Int J Biol Macromol. 2024 Apr 12:131555. doi: 10.1016/j.ijbiomac.2024.131555. Online ahead of print.ABSTRACTKnown for its antioxidant properties, Araucaria angustifolia bracts extract was encapsulated using hydrodynamic electrospray ionization jetting within calcium alginate cross-linked hydrogel beads with varying contents of modified pinhão starch. The rheological properties of the dispersions and analysis of the physicochemical and digestive properties of encapsulated beads were studied. The results demonstrated that dispersions containing starch exhibited higher viscosity and reduced compliance values, indicating samp...
Source: International Journal of Biological Macromolecules - April 14, 2024 Category: Biochemistry Authors: Mariane Santos Dorneles Eduarda Silva de Azevedo Caciano Pelayo Zapata Nore ña Source Type: research
Neuroplastin splice variants Np55 and Np65: Who is doing the job in macrophages?
Mol Immunol. 2024 Apr 13;170:57-59. doi: 10.1016/j.molimm.2024.03.008. Online ahead of print.ABSTRACTNeuroplastin, a paralog of CD147/Basigin, is known as a neuronal cell adhesion molecule and as an auxiliary subunit of plasma membrane calcium ATPases in both neurons and adaptive immune cells. Recently, an interesting study by Ren et al. (2022) provided evidence for an important role of neuroplastin in macrophages during bacterial infection. Here, we critically discuss one aspect of this study, the assignment of this role to Np65 as one of two prominent splice variants of neuroplastin.PMID:38615628 | DOI:10.1016/j.molimm.2...
Source: Molecular Medicine - April 14, 2024 Category: Molecular Biology Authors: Kristina Langnaese Nikhil Tiwari Klaus-Dieter Fischer Ulrich Thomas Mark Korthals Source Type: research
Quercetin alleviates chronic unpredictable mild stress-induced depression-like behavior by inhibiting NMDAR1 with α2δ-1 in rats
CONCLUSIONS: Que has a good antidepressant effect and can significantly improve the depression-like behavior caused by CUMS. It exerts antidepressant effects by inhibiting the expression level of α2δ-1, interfering with the interaction between α2δ-1 and NMDAR, and then reducing the excitability of the HPA axis.PMID:38615365 | PMC:PMC11016343 | DOI:10.1111/cns.14724 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Mingyan Wang Xin Wei Yugai Jia Chaonan Wang Xinliu Wang Xin Zhang Depei Li Yuanyuan Wang Yonggang Gao Source Type: research
CaMK4: Structure, physiological functions, and therapeutic potential
Biochem Pharmacol. 2024 Apr 12:116204. doi: 10.1016/j.bcp.2024.116204. Online ahead of print.ABSTRACTCalcium/calmodulin-dependent protein kinase IV (CaMK4) is a versatile serine/threonine kinase involved in various cellular functions. It regulates T-cell differentiation, podocyte function, tumor cell proliferation/apoptosis, β cell mass, and insulin sensitivity. However, the underlying molecular mechanisms are complex and remain incompletely understood. The aims of this review are to highlight the latest advances in the regulatory mechanisms of CaMK4 underlying T-cell imbalance and parenchymal cell mass in multiple diseas...
Source: Biochemical Pharmacology - April 14, 2024 Category: Drugs & Pharmacology Authors: Hao Xu Liang Yong Xianxian Gao Yandong Chen Yixuan Wang Fuyan Wang Xin Hou Source Type: research
Quercetin alleviates chronic unpredictable mild stress-induced depression-like behavior by inhibiting NMDAR1 with α2δ-1 in rats
CONCLUSIONS: Que has a good antidepressant effect and can significantly improve the depression-like behavior caused by CUMS. It exerts antidepressant effects by inhibiting the expression level of α2δ-1, interfering with the interaction between α2δ-1 and NMDAR, and then reducing the excitability of the HPA axis.PMID:38615365 | PMC:PMC11016343 | DOI:10.1111/cns.14724 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 14, 2024 Category: Neuroscience Authors: Mingyan Wang Xin Wei Yugai Jia Chaonan Wang Xinliu Wang Xin Zhang Depei Li Yuanyuan Wang Yonggang Gao Source Type: research
Systematic Review Article: New Drug Strategies for Treating Resistant Hypertension —the Importance of a Mechanistic, Personalized Approach
AbstractResistant hypertension (RHT) is characterized by persistently high blood pressure (BP) levels above the widely recommended therapeutic targets of less than 140/90 mmHg office BP, despite life-style measures and optimal medical therapies, including at least three antihypertensive drug classes at maximum tolerated dose (one should be a diuretic). This condition is strongly related to hypertension-mediated organ damage and, mostly, high risk of hospitalization due to hypertension emergencies or acute cardiovascular events. Hypertension guidelines proposed a triple combination therapy based on renin angiotensin system ...
Source: High Blood Pressure and Cardiovascular Prevention - April 14, 2024 Category: Cardiology Source Type: research
Coronary Plaque in Athletes
J Clin Med. 2024 Apr 1;13(7):2044. doi: 10.3390/jcm13072044.ABSTRACTThe relationship between vigorous physical activity (PA) and the development of coronary atherosclerosis has remained less explored for many years. Recently, literature data have focused on coronary atherosclerosis in athletes showing that prevalence is not trivial, that there are differences among various types of sport, and that there are some peculiar features. As a matter of fact, plaque composition in athletes seems to be characterized by calcium rather than soft components. Specific mechanisms through which vigorous PA influences coronary artery dise...
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Elisabetta Tonet Matteo Arzenton Marco De Pietri Luca Canovi Davide Lapolla Alberto Sarti Veronica Amantea Andrea Raisi Gianni Mazzoni Gianluca Campo Giovanni Grazzi Source Type: research
Sens-ocular model: Cell-based assay to evaluate eye stinging potential of chemicals and baby cosmetic formulations
In this study, HEK-293 cells with high TRPV1 expression were utilized to evaluate calcium influx related to receptor activation triggered by chemicals and cosmetic formulations. The cells were exposed to increasing concentrations of substances to cause or not some aggression to the eye, and TRPV1 activity was assessed by measuring intracellular FURA-2 AM fluorescence signal. To confirm TRPV1 channel activation, capsazepine, a capsaicin antagonist, was employed in addition to using capsaicin as a positive control. The study's results indicate that this novel model can identify compounds known to cause some aggression to the...
Source: Toxicology in Vitro - April 13, 2024 Category: Toxicology Authors: Lara Barroso Brito Carolina Motter Catarino Maria Claudia Passos Artur C Garcia Silva Desiree Cigaran Schuck Andrezza Di Pietro Micali Canavez Marize Campos Valadares Source Type: research
Sens-ocular model: Cell-based assay to evaluate eye stinging potential of chemicals and baby cosmetic formulations
In this study, HEK-293 cells with high TRPV1 expression were utilized to evaluate calcium influx related to receptor activation triggered by chemicals and cosmetic formulations. The cells were exposed to increasing concentrations of substances to cause or not some aggression to the eye, and TRPV1 activity was assessed by measuring intracellular FURA-2 AM fluorescence signal. To confirm TRPV1 channel activation, capsazepine, a capsaicin antagonist, was employed in addition to using capsaicin as a positive control. The study's results indicate that this novel model can identify compounds known to cause some aggression to the...
Source: Toxicology in Vitro - April 13, 2024 Category: Toxicology Authors: Lara Barroso Brito Carolina Motter Catarino Maria Claudia Passos Artur C Garcia Silva Desiree Cigaran Schuck Andrezza Di Pietro Micali Canavez Marize Campos Valadares Source Type: research
Intravenous Administration of Recombinant Ph α1β: Antinociceptive Properties and Morphine Tolerance Reversal in a Cancer-Associated Pain Model
This study aims to assess the antinociceptive effects resulting from intravenous administration of the recombinant form of Phα1β (r-Phα1β) in an experimental model of cancer-related pain in mice, tolerant or not to morphine. The model of cancer-induced pain was used to evaluate these effects, with the injection of B16F10 cells, followed by the administration of the r-Phα1β, and evaluation of the mechanical threshold by the von Frey test. Also, adverse effects were assessed using a score scale, the rotarod, and open field tests. Results indicate that the administration of r-Phα1β provoked antinociception in animals ...
Source: Toxicon - April 13, 2024 Category: Toxicology Authors: Mariana de Melo Cardoso Rahisa Scussel Jessica da Silva Abel Fernando Oriques Pereira Lidiane Anast ácio Cruz Franciane da Costa Constante Ellen De Pieri Helena Mendes Abelaira Juliano Ferreira Marcus Vin ícius Gomez Fl ávia K Rigo Ricardo Andrez Macha Source Type: research
Carboxymethylated Rhizoma alismatis polysaccharides reduces the risk of calcium oxalate stone formation by reducing cellular inflammation and oxidative stress
This study aims to elucidate the mechanism and potential ofRhizoma alismatis polysaccharides (RAPs) in preventing oxidative damage to human renal proximal tubule epithelial cells. The experimental approach involved incubating HK-2 cells with 100 nm calcium oxalate monohydrate for 24 h to establish a cellular injury model. Protection was provided by RAPs with varying carboxyl group contents: 3.57%, 7.79%, 10.84%, and 15.33%. The safeguarding effect of RAPs was evaluated by analyzing relevant cellular biochemical indicators. Findings demo nstrate that RAPs exhibit notable antioxidative properties. They effectively dimini...
Source: Urolithiasis - April 13, 2024 Category: Urology & Nephrology Source Type: research
