Cell-specific extracellular vesicle-encapsulated exogenous GABA controls seizures in epilepsy
CONCLUSION: For the first time, the study demonstrated that exogenous GABA could be delivered to the brain through brain cell-derived EVs, which could regulate seizures in temporal lobe epilepsy. It is identified that the cellular origin of EVs plays a vital role in seizure control with exogenous GABA.PMID:38637847 | DOI:10.1186/s13287-024-03721-4 (Source: Cell Research)
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Abhijna Ballal R Shivakumar Reddy K Divya Chandran Sumukha Hegde Raghavendra Upadhya Praveen Kumar Se Smita Shenoy Vasudha Devi Dinesh Upadhya Source Type: research
Effect of 2-aminoethoxydiphenyl borate on the functions of mouse skeletal muscle mitochondria
Biochem Biophys Res Commun. 2024 Apr 16;712-713:149944. doi: 10.1016/j.bbrc.2024.149944. Online ahead of print.ABSTRACTThis work examined the effect of 2-aminoethoxydiphenyl borate (2-APB) on the functioning of isolated mouse skeletal muscle mitochondria and modeled its putative interaction with mitochondrial proteins. We have shown that 2-APB is able to dose-dependently suppress mitochondrial respiration in state 3 and 3UDNP driven by substrates of complex I and II. This effect of 2-APB was accompanied by a slight dose-dependent decrease in mitochondrial membrane potential and appears to be due to inhibition of complex I ...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Mikhail V Dubinin Alexander V Chulkov Anastasia D Igoshkina Alena A Cherepanova Natalia V Mikina Source Type: research
Mining and exploration of rehabilitation nursing targets for colorectal cancer
CONCLUSIONS: High MYC and NCAPG2 expression has been observed in colorectal cancer, and increased MYC and NCAPG2 expression correlates with worse prognosis.PMID:38637125 | DOI:10.18632/aging.205739 (Source: Aging)
Source: Aging - April 18, 2024 Category: Biomedical Science Authors: Ruipu Li Jie He Zhijie Ni Jie Zhang Xiaoqian Chi Chunbo Kang Zhongbo Li Xubin Li Source Type: research
Intramyocardial calcification in apical hypertrophic cardiomyopathy assessed using multimodality imaging: a case series
We report five cases of ApHCM, with evidence of intramyocardial calcification on echocardiogram. On cardiac magnetic imaging (MRI), a hypointense component at early gadolinium enhancement (EGE) sequences, compatible with calcium, and a deep layer, with hyperintensity at late gadolinium enhancement (LGE) sequences, referable to fibrosis, suggest an endomyocardial fibrosis (EMF) diagnosis. EMF pathologic hallmark is endocardium and myocardium scarring, evolving to dystrophic calcification. It is found only in few ApHCM patients. Our series is the largest one described until now. Analysing patients' history, coexistent inflam...
Source: ESC Heart Failure - April 18, 2024 Category: Cardiology Authors: Ilaria Radano,
Barbara Mabritto,
Stefania Luceri,
Sergio Bongioanni,
Francesco Maiellaro,
Luca Zappia,
Chiara Lario,
Annalisa Macera,
Stefano Cirillo,
Alfredo Pizzuti,
Rodolfo Citro,
Gennaro Galasso,
Giuseppe Musumeci Tags: Case Report Source Type: research
A prospective cross-sectional study on hypocalcemia after total thyroidectomy in patients with Graves ’ disease: insights on secondary hyperparathyroidism
ConclusionsHyperfunctioning parathyroid glands in the SHPT state were more susceptible to postoperative PTH reduction, which, combined with low preoperative Ca levels, increased the risk of postoperative hypocalcemia in patients with Graves ’ disease. (Source: Surgery Today)
Source: Surgery Today - April 18, 2024 Category: Surgery Source Type: research
Enhanced cytotoxic activity of natural killer cells from increased calcium influx induced by electrical stimulation
This study suggests a promising immunotherapeutic approach without genetic modifications and elucidates the correlation between cytolytic effector function and intracellular Ca2+ levels in electrically stimulated NK cells. (Source: PLoS One)
Source: PLoS One - April 18, 2024 Category: Biomedical Science Authors: Minseon Lee Source Type: research
A prospective cross-sectional study on hypocalcemia after total thyroidectomy in patients with Graves ’ disease: insights on secondary hyperparathyroidism
ConclusionsHyperfunctioning parathyroid glands in the SHPT state were more susceptible to postoperative PTH reduction, which, combined with low preoperative Ca levels, increased the risk of postoperative hypocalcemia in patients with Graves ’ disease. (Source: Surgery Today)
Source: Surgery Today - April 18, 2024 Category: Surgery Source Type: research
Genes, Vol. 15, Pages 507: Assessment of the Effect of Leonurine Hydrochloride in a Mouse Model of PCOS by Gene Expression Profiling
ia Shang
Xinli Gu
Polycystic ovary syndrome (PCOS) is an endocrine disease commonly associated with metabolic disorders in females. Leonurine hydrochloride (Leo) plays an important role in regulating immunity, tumours, uterine smooth muscle, and ovarian function. However, the effect of Leo on PCOS has not been reported. Here, we used dehydroepiandrosterone to establish a mouse model of PCOS, and some mice were then treated with Leo by gavage. We found that Leo could improve the irregular oestros cycle of PCOS mice, reverse the significantly greater serum testosterone (T) and luteinising hormone (LH) levels, significa...
Source: Genes - April 18, 2024 Category: Genetics & Stem Cells Authors: Mengmeng Wang Li Yang Guojie Sun Yongbin Shao Yuran Liu Huiying Yang Yan Wang Mengyuan Zhang Yunxia Shang Xinli Gu Tags: Article Source Type: research
Cisd2 deficiency impairs neutrophil function by regulating calcium homeostasis via Calnexin and SERCA
BMB Rep. 2024 Apr 17:6179. Online ahead of print.ABSTRACTIn the context of aging, the susceptibility to infectious diseases increases, leading to heightened morbidity and mortality. This phenomenon, termed immunosenescence, is characterized by dysregulation in the aging immune system, including abnormal alterations in lymphocyte composition, elevated basal inflammation, and the accumulation of senescent T cells. Such changes contribute to increased autoimmune diseases, enhanced infection severity, and reduced responsiveness to vaccines. Utilizing aging animal models becomes imperative for a comprehensive understanding of i...
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Un Yung Choi Youn Jung Choi Shin-Ae Lee Ji-Seung Yoo Source Type: research
Learning enhances representations of taste-guided decisions in the mouse gustatory insular cortex
Curr Biol. 2024 Apr 12:S0960-9822(24)00374-9. doi: 10.1016/j.cub.2024.03.034. Online ahead of print.ABSTRACTLearning to discriminate overlapping gustatory stimuli that predict distinct outcomes-a feat known as discrimination learning-can mean the difference between ingesting a poison or a nutritive meal. Despite the obvious importance of this process, very little is known about the neural basis of taste discrimination learning. In other sensory modalities, this form of learning can be mediated by either the sharpening of sensory representations or the enhanced ability of "decision-making" circuits to interpret sensory info...
Source: Current Biology - April 17, 2024 Category: Biology Authors: Joshua F Kogan Alfredo Fontanini Source Type: research
Myosin XI, a model of its conserved role in plant cell tip growth
Biochem Soc Trans. 2024 Apr 17:BST20220783. doi: 10.1042/BST20220783. Online ahead of print.ABSTRACTIn eukaryotic cells, organelle and vesicle transport, positioning, and interactions play crucial roles in cytoplasmic organization and function. These processes are governed by intracellular trafficking mechanisms. At the core of that trafficking, the cytoskeleton and directional transport by motor proteins stand out as its key regulators. Plant cell tip growth is a well-studied example of cytoplasm organization by polarization. This polarization, essential for the cell's function, is driven by the cytoskeleton and its assoc...
Source: Biochemical Society Transactions - April 17, 2024 Category: Biochemistry Authors: Edward J Chocano-Coralla Luis Vidali Source Type: research
Inorganic polyphosphate and ion transport across biological membranes
Biochem Soc Trans. 2024 Apr 17:BST20230522. doi: 10.1042/BST20230522. Online ahead of print.ABSTRACTInorganic polyphosphate (polyP) is widely recognized for playing important roles and processes involved in energy and phosphate storage, regulation of gene expression, and calcium signaling. The less well-known role of polyP is as a direct mediator of ion transport across biological membranes. Here, we will briefly summarize current knowledge of the molecular mechanisms of how polyP can be involved in membrane ion transport. We discuss three types of mechanisms that might involve polyP: (1) formation of non-protein channel c...
Source: Biochemical Society Transactions - April 17, 2024 Category: Biochemistry Authors: Yaw Akosah Jingyi Yang Evgeny Pavlov Source Type: research
High phosphate and calcium induce osteoblastic phenotype switching and calcification of corneal epithelial cells in a Runx2-dependent and synergistic manner; a possible mechanism of chronic kidney disease-associated corneal calcification
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167171. doi: 10.1016/j.bbadis.2024.167171. Online ahead of print.ABSTRACTPatients with advanced chronic kidney disease (CKD) have elevated circulating calcium × phosphate product levels and exhibit soft tissue calcification. Besides the cardiovascular system, calcification is commonly observed in the cornea in CKD patients on hemodialysis. Cardiovascular calcification is a cell-mediated, highly regulated process, and we hypothesized that a similar regulatory mechanism is implicated in corneal calcification with the involvement of corneal epithelial cells (CECs). We establish...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Haneen Ababneh Andrea T óth Gr éta Lente Enik ő Balogh D ávid Máté Csiki B éla Nagy Árpád Szöőr Vikt ória Jeney Source Type: research
Mitochondrial calcium signaling in non-neuronal cells: Implications for Alzheimer's disease pathogenesis
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15;1870(5):167169. doi: 10.1016/j.bbadis.2024.167169. Online ahead of print.ABSTRACTMitochondrial dysregulation is pivotal in Alzheimer's disease (AD) pathogenesis. Calcium governs vital mitochondrial processes impacting energy conversion, oxidative stress, and cell death signaling. Disruptions in mitochondrial calcium (mCa2+) handling induce calcium overload and trigger the opening of mitochondrial permeability transition pore, ensuing energy deprivation and resulting in AD-related neuronal cell death. However, the role of mCa2+ in non-neuronal cells (microglia, astrocytes, oli...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Darpan Raghav Shatakshi Shukla Pooja Jadiya Source Type: research
Materials analysis in three paintings of Thomas Gainsborough (1727-1788) by portable X-ray fluorescence
Appl Radiat Isot. 2024 Apr 16;209:111324. doi: 10.1016/j.apradiso.2024.111324. Online ahead of print.ABSTRACTThree paintings of Thomas Gainsborough (1727-1788), one of the most influential English portrait painters of the late 18th century, from the collection of the Museu de Arte de São Paulo (MASP) - "Francis Rawdon" (1783-1784), "Portrait of Mrs. John Bolton" (1770), and "Drinkstone Park" (1747) - were investigated using portable X-ray fluorescence (pXRF), employing a W tube anode and an XR-100CR detector. These artworks represent the only paintings by Thomas Gainsborough located in the southern hemisphere. Through an ...
Source: Applied Radiation and Isotopes - April 17, 2024 Category: Radiology Authors: Let ícia Martins Birelo Carlos Roberto Appoloni Source Type: research
