Mitochondrial calcium signaling in non-neuronal cells: Implications for Alzheimer's disease pathogenesis
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167169. doi: 10.1016/j.bbadis.2024.167169. Online ahead of print.ABSTRACTMitochondrial dysregulation is pivotal in Alzheimer's disease (AD) pathogenesis. Calcium governs vital mitochondrial processes impacting energy conversion, oxidative stress, and cell death signaling. Disruptions in mitochondrial calcium (mCa2+) handling induce calcium overload and trigger the opening of mitochondrial permeability transition pore, ensuing energy deprivation and resulting in AD-related neuronal cell death. However, the role of mCa2+ in non-neuronal cells (microglia, astrocytes, oligodendro...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Darpan Raghav Shatakshi Shukla Pooja Jadiya Source Type: research
Materials analysis in three paintings of Thomas Gainsborough (1727-1788) by portable X-ray fluorescence
Appl Radiat Isot. 2024 Apr 16;209:111324. doi: 10.1016/j.apradiso.2024.111324. Online ahead of print.ABSTRACTThree paintings of Thomas Gainsborough (1727-1788), one of the most influential English portrait painters of the late 18th century, from the collection of the Museu de Arte de São Paulo (MASP) - "Francis Rawdon" (1783-1784), "Portrait of Mrs. John Bolton" (1770), and "Drinkstone Park" (1747) - were investigated using portable X-ray fluorescence (pXRF), employing a W tube anode and an XR-100CR detector. These artworks represent the only paintings by Thomas Gainsborough located in the southern hemisphere. Through an ...
Source: Applied Radiation and Isotopes - April 17, 2024 Category: Radiology Authors: Let ícia Martins Birelo Carlos Roberto Appoloni Source Type: research
Acute cervical epidural abscess with concurrent calcium pyrophosphate deposition after cervical spinal surgery: A case report
CONCLUSION: An acute onset of SEA complicated with CPPD after cervical surgery has rarely been reported. The suppurative inflammation fostered by the crystal-induced inflammation may account for the acute symptomatology.PMID:38628534 | PMC:PMC11021091 | DOI:10.25259/SNI_740_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Koki Mitani Manabu Minami Toshiyuki Takahashi Mariko Toyoda Ryo Kanematsu Junya Hanakita Source Type: research
Impact of Age on Prescribing Patterns of Cardiovascular Medications in Older Japanese Patients with Non-Dialysis-Dependent Chronic Kidney Disease: A Cross-Sectional Study
CONCLUSIONS: This study suggests that age is a potential barrier to the treatment of patients with CKD and highlights the need to establish individualized treatment strategies for cardiovascular protection in this population.PMID:38631869 | DOI:10.5551/jat.64798 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 17, 2024 Category: Cardiology Authors: Shigeru Tanaka Hiromasa Kitamura Kazuhiko Tsuruya Takanari Kitazono Toshiaki Nakano FKR Study Collaboration Group Source Type: research
Single-cell transcriptomics reveal metastatic CLDN4+ cancer cells underlying the recurrence of malignant pleural effusion in patients with advanced non-small-cell lung cancer
CONCLUSIONS: CLDN4 could be considered as a predictive marker of recurrent MPE among patients with advanced NSCLC. Further validation for its clinical value in cohorts with larger sample size and in-depth mechanism studies on its biological function are warranted.TRIAL REGISTRATION: Not applicable.PMID:38629624 | DOI:10.1002/ctm2.1649 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Xiaoshen Zhang Xuanhe Wang Yaokai Wen Shen Chen Caicun Zhou Fengying Wu Source Type: research
Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation
CONCLUSIONS: Taken together, our findings reveal that NR4A3-mediated histone lactylation is a novel metabolome-epigenome signaling cascade mechanism that participates in the pathogenesis of medial arterial calcification.PMID:38629274 | DOI:10.1161/CIRCRESAHA.123.323699 (Source: Circulation Research)
Source: Circulation Research - April 17, 2024 Category: Cardiology Authors: Wenqi Ma Kangni Jia Haomai Cheng Hong Xu Zhigang Li Hang Zhang Hongyang Xie Lingfang Zhuang Ziyang Wang Yuke Cui Hang Sun Lei Yi Zhiyong Chen Shengzhong Duan Motoaki Sano Keiichi Fukuda Lin Lu Fei Gao Ruiyan Zhang Xiaoxiang Yan Source Type: research
Assessment of atherosclerotic plaque burden: comparison of AI-QCT versus SIS, CAC, visual and CAD-RADS stenosis categories
This study assesses the agreement of Artificial Intelligence-Quantitative Computed Tomography (AI-QCT) with qualitative approaches to atherosclerotic disease burden codified in the multisociety 2022 CAD-RADS 2.0 Expert Consensus. 105 patients who underwent cardiac computed tomography angiography (CCTA) for chest pain were evaluated by a blinded core laboratory through FDA-cleared software (Cleerly, Denver, CO) that performs AI-QCT through artificial intelligence, analyzing factors such as % stenosis, plaque volume, and plaque composition. AI-QCT plaque volume was then staged by recently validated prognostic thresholds, and...
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Hufsa Khan Kopal Bansal William F Griffin Catherine Cantlay Alfateh Sidahmed Nick S Nurmohamed Robert K Zeman Richard J Katz Ron Blankstein James P Earls Andrew D Choi Source Type: research
Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation
CONCLUSIONS: Taken together, our findings reveal that NR4A3-mediated histone lactylation is a novel metabolome-epigenome signaling cascade mechanism that participates in the pathogenesis of medial arterial calcification.PMID:38629274 | DOI:10.1161/CIRCRESAHA.123.323699 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Wenqi Ma Kangni Jia Haomai Cheng Hong Xu Zhigang Li Hang Zhang Hongyang Xie Lingfang Zhuang Ziyang Wang Yuke Cui Hang Sun Lei Yi Zhiyong Chen Shengzhong Duan Motoaki Sano Keiichi Fukuda Lin Lu Fei Gao Ruiyan Zhang Xiaoxiang Yan Source Type: research
Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation
CONCLUSIONS: Taken together, our findings reveal that NR4A3-mediated histone lactylation is a novel metabolome-epigenome signaling cascade mechanism that participates in the pathogenesis of medial arterial calcification.PMID:38629274 | DOI:10.1161/CIRCRESAHA.123.323699 (Source: Cell Research)
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Wenqi Ma Kangni Jia Haomai Cheng Hong Xu Zhigang Li Hang Zhang Hongyang Xie Lingfang Zhuang Ziyang Wang Yuke Cui Hang Sun Lei Yi Zhiyong Chen Shengzhong Duan Motoaki Sano Keiichi Fukuda Lin Lu Fei Gao Ruiyan Zhang Xiaoxiang Yan Source Type: research
Deep lymph node enlargement and renal failure caused by hypercalcemia ‑associated sarcoidosis: A case report
Exp Ther Med. 2024 Mar 27;27(5):235. doi: 10.3892/etm.2024.12524. eCollection 2024 May.ABSTRACTSarcoidosis is a rare disease that severely affects the lungs and superficial lymph nodes. In addition, this disease can also affect the skin, eyes and kidneys to varying degrees. The present report described a 32-year-old male patient who was admitted to Renmin Hospital of Wuhan University (Wuhan, China) due to joint pain in the extremities. He was diagnosed with uncorrectable hypercalcemia. A lymph node biopsy revealed the hypercalcemia to be associated with sarcoidosis, with the patient also demonstrating renal failure and lym...
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Zezhou Liu Zhigang Tang Jingping Yuan Ke Su Yonghong Jian Hongyan Liu Source Type: research
Cisd2 deficiency impairs neutrophil function by regulating calcium homeostasis via Calnexin and SERCA
BMB Rep. 2024 Apr 17:6179. Online ahead of print.ABSTRACTIn the context of aging, the susceptibility to infectious diseases increases, leading to heightened morbidity and mortality. This phenomenon, termed immunosenescence, is characterized by dysregulation in the aging immune system, including abnormal alterations in lymphocyte composition, elevated basal inflammation, and the accumulation of senescent T cells. Such changes contribute to increased autoimmune diseases, enhanced infection severity, and reduced responsiveness to vaccines. Utilizing aging animal models becomes imperative for a comprehensive understanding of i...
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Un Yung Choi Youn Jung Choi Shin-Ae Lee Ji-Seung Yoo Source Type: research
Meat consumption and the risk of hip fracture in women and men: two prospective Swedish cohort studies
ConclusionA modest linear association was found between a higher meat intake and the risk of hip fractures. Our results from the sub-cohorts further suggest that possible mechanisms linking meat intake and hip fracture risk may be related to the regulation of bone turnover, subclinical inflammation, and oxidative stress. Although estimates are modest, limiting red and processed meat intake in a healthy diet is advisable to prevent hip fractures. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - April 17, 2024 Category: Nutrition Source Type: research
Assessment of atherosclerotic plaque burden: comparison of AI-QCT versus SIS, CAC, visual and CAD-RADS stenosis categories
This study assesses the agreement of Artificial Intelligence-Quantitative Computed Tomography (AI-QCT) with qualitative approaches to atherosclerotic disease burden codified in the multisociety 2022 CAD-RADS 2.0 Expert Consensus. 105 patients who underwent cardiac computed tomography angiography (CCTA) for chest pain were evaluated by a blinded core laboratory through FDA-cleared software (Cleerly, Denver, CO) that performs AI-QCT through artificial intelligence, analyzing factors such as % stenosis, plaque volume, and plaque composition. AI-QCT plaque volume was then staged by recently validated prognostic thresholds, and...
Source: The International Journal of Cardiovascular Imaging - April 17, 2024 Category: Radiology Source Type: research
Genome-wide identification and stress response analysis of BcaCPK gene family in amphidiploid Brassica carinata
This study aimed to identify an... (Source: BMC Plant Biology)
Source: BMC Plant Biology - April 17, 2024 Category: Biology Authors: Dan Zuo, Shaolin Lei, Fang Qian, Lei Gu, Hongcheng Wang, Xuye Du, Tuo Zeng and Bin Zhu Tags: Research Source Type: research
Functional expression, purification, biochemical and biophysical characterizations, and molecular dynamics simulation of a histidine acid phosphatase from Saccharomyces cerevisiae
AbstractA histidine acid phosphatase (HAP) (PhySc) with 99.50% protein sequence similarity with PHO5 fromSaccharomyces cerevisiae was expressed functionally with the molecular mass of ∼110 kDa through co-expression along with the set of molecular chaperones dnaK, dnaJ, GroESL. The purified HAP illustrated the optimum activity of 28.75 ± 0.39 U/mg at pH 5.5 and 40 ˚C. The Km and Kcat values towards calcium phytate were 0.608 ± 0.09 mM and 650.89 ± 3.6 s− 1. The half-lives (T1/2) at 55 and 60 ˚C were 2.75 min and 55 s, respectively. The circular dichroism (CD) demonstrated that PhySc includes 30.5...
Source: World Journal of Microbiology and Biotechnology - April 17, 2024 Category: Microbiology Source Type: research
