Galectin-8-like isoform X1 mediates antibacterial, antiviral, and antioxidant responses in red-lip mullet (Planiliza haematocheilus) through positive modulation of pro-inflammatory cytokine, chemokine, and enzymatic antioxidant activity
This study identified Galectin-8-like isoform X1 (PhGal8X1) from red-lip mullet (Planiliza haematocheilus) and investigated its role in regulating fish immunity. The open reading frame of PhGal8X1 was 918bp, encoding a soluble protein of 305 amino acids. The protein had a theoretical isoelectric (pI) point of 7.7 and an estimated molecular weight of 34.078 kDa. PhGal8X1 was expressed in various tissues of the fish, with prominent levels in the brain, stomach, and intestine. PhGal8X1 expression was significantly (p<0.05) induced in the blood and spleen upon challenge with different immune stimuli, including polyinosinic:...
Source: Developmental and Comparative Immunology - April 18, 2024 Category: Allergy & Immunology Authors: W A D L R Warnakula H M V Udayantha D S Liyanage E M T Tharanga W K M Omeka M A H Dilshan H A C R Hanchapola J D H E Jayasinghe Taehyug Jeong Qiang Wan Jehee Lee Source Type: research
Cell-specific extracellular vesicle-encapsulated exogenous GABA controls seizures in epilepsy
CONCLUSION: For the first time, the study demonstrated that exogenous GABA could be delivered to the brain through brain cell-derived EVs, which could regulate seizures in temporal lobe epilepsy. It is identified that the cellular origin of EVs plays a vital role in seizure control with exogenous GABA.PMID:38637847 | DOI:10.1186/s13287-024-03721-4 (Source: Cell Research)
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Abhijna Ballal R Shivakumar Reddy K Divya Chandran Sumukha Hegde Raghavendra Upadhya Praveen Kumar Se Smita Shenoy Vasudha Devi Dinesh Upadhya Source Type: research
Effect of 2-aminoethoxydiphenyl borate on the functions of mouse skeletal muscle mitochondria
Biochem Biophys Res Commun. 2024 Apr 16;712-713:149944. doi: 10.1016/j.bbrc.2024.149944. Online ahead of print.ABSTRACTThis work examined the effect of 2-aminoethoxydiphenyl borate (2-APB) on the functioning of isolated mouse skeletal muscle mitochondria and modeled its putative interaction with mitochondrial proteins. We have shown that 2-APB is able to dose-dependently suppress mitochondrial respiration in state 3 and 3UDNP driven by substrates of complex I and II. This effect of 2-APB was accompanied by a slight dose-dependent decrease in mitochondrial membrane potential and appears to be due to inhibition of complex I ...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Mikhail V Dubinin Alexander V Chulkov Anastasia D Igoshkina Alena A Cherepanova Natalia V Mikina Source Type: research
Mining and exploration of rehabilitation nursing targets for colorectal cancer
CONCLUSIONS: High MYC and NCAPG2 expression has been observed in colorectal cancer, and increased MYC and NCAPG2 expression correlates with worse prognosis.PMID:38637125 | DOI:10.18632/aging.205739 (Source: Aging)
Source: Aging - April 18, 2024 Category: Biomedical Science Authors: Ruipu Li Jie He Zhijie Ni Jie Zhang Xiaoqian Chi Chunbo Kang Zhongbo Li Xubin Li Source Type: research
Intramyocardial calcification in apical hypertrophic cardiomyopathy assessed using multimodality imaging: a case series
We report five cases of ApHCM, with evidence of intramyocardial calcification on echocardiogram. On cardiac magnetic imaging (MRI), a hypointense component at early gadolinium enhancement (EGE) sequences, compatible with calcium, and a deep layer, with hyperintensity at late gadolinium enhancement (LGE) sequences, referable to fibrosis, suggest an endomyocardial fibrosis (EMF) diagnosis. EMF pathologic hallmark is endocardium and myocardium scarring, evolving to dystrophic calcification. It is found only in few ApHCM patients. Our series is the largest one described until now. Analysing patients' history, coexistent inflam...
Source: ESC Heart Failure - April 18, 2024 Category: Cardiology Authors: Ilaria Radano,
Barbara Mabritto,
Stefania Luceri,
Sergio Bongioanni,
Francesco Maiellaro,
Luca Zappia,
Chiara Lario,
Annalisa Macera,
Stefano Cirillo,
Alfredo Pizzuti,
Rodolfo Citro,
Gennaro Galasso,
Giuseppe Musumeci Tags: Case Report Source Type: research
A prospective cross-sectional study on hypocalcemia after total thyroidectomy in patients with Graves ’ disease: insights on secondary hyperparathyroidism
ConclusionsHyperfunctioning parathyroid glands in the SHPT state were more susceptible to postoperative PTH reduction, which, combined with low preoperative Ca levels, increased the risk of postoperative hypocalcemia in patients with Graves ’ disease. (Source: Surgery Today)
Source: Surgery Today - April 18, 2024 Category: Surgery Source Type: research
Enhanced cytotoxic activity of natural killer cells from increased calcium influx induced by electrical stimulation
This study suggests a promising immunotherapeutic approach without genetic modifications and elucidates the correlation between cytolytic effector function and intracellular Ca2+ levels in electrically stimulated NK cells. (Source: PLoS One)
Source: PLoS One - April 18, 2024 Category: Biomedical Science Authors: Minseon Lee Source Type: research
A prospective cross-sectional study on hypocalcemia after total thyroidectomy in patients with Graves ’ disease: insights on secondary hyperparathyroidism
ConclusionsHyperfunctioning parathyroid glands in the SHPT state were more susceptible to postoperative PTH reduction, which, combined with low preoperative Ca levels, increased the risk of postoperative hypocalcemia in patients with Graves ’ disease. (Source: Surgery Today)
Source: Surgery Today - April 18, 2024 Category: Surgery Source Type: research
Genes, Vol. 15, Pages 507: Assessment of the Effect of Leonurine Hydrochloride in a Mouse Model of PCOS by Gene Expression Profiling
ia Shang
Xinli Gu
Polycystic ovary syndrome (PCOS) is an endocrine disease commonly associated with metabolic disorders in females. Leonurine hydrochloride (Leo) plays an important role in regulating immunity, tumours, uterine smooth muscle, and ovarian function. However, the effect of Leo on PCOS has not been reported. Here, we used dehydroepiandrosterone to establish a mouse model of PCOS, and some mice were then treated with Leo by gavage. We found that Leo could improve the irregular oestros cycle of PCOS mice, reverse the significantly greater serum testosterone (T) and luteinising hormone (LH) levels, significa...
Source: Genes - April 18, 2024 Category: Genetics & Stem Cells Authors: Mengmeng Wang Li Yang Guojie Sun Yongbin Shao Yuran Liu Huiying Yang Yan Wang Mengyuan Zhang Yunxia Shang Xinli Gu Tags: Article Source Type: research
Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation
CONCLUSIONS: Taken together, our findings reveal that NR4A3-mediated histone lactylation is a novel metabolome-epigenome signaling cascade mechanism that participates in the pathogenesis of medial arterial calcification.PMID:38629274 | DOI:10.1161/CIRCRESAHA.123.323699 (Source: Circulation Research)
Source: Circulation Research - April 17, 2024 Category: Cardiology Authors: Wenqi Ma Kangni Jia Haomai Cheng Hong Xu Zhigang Li Hang Zhang Hongyang Xie Lingfang Zhuang Ziyang Wang Yuke Cui Hang Sun Lei Yi Zhiyong Chen Shengzhong Duan Motoaki Sano Keiichi Fukuda Lin Lu Fei Gao Ruiyan Zhang Xiaoxiang Yan Source Type: research
Acute cervical epidural abscess with concurrent calcium pyrophosphate deposition after cervical spinal surgery: A case report
CONCLUSION: An acute onset of SEA complicated with CPPD after cervical surgery has rarely been reported. The suppurative inflammation fostered by the crystal-induced inflammation may account for the acute symptomatology.PMID:38628534 | PMC:PMC11021091 | DOI:10.25259/SNI_740_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Koki Mitani Manabu Minami Toshiyuki Takahashi Mariko Toyoda Ryo Kanematsu Junya Hanakita Source Type: research
Impact of Age on Prescribing Patterns of Cardiovascular Medications in Older Japanese Patients with Non-Dialysis-Dependent Chronic Kidney Disease: A Cross-Sectional Study
CONCLUSIONS: This study suggests that age is a potential barrier to the treatment of patients with CKD and highlights the need to establish individualized treatment strategies for cardiovascular protection in this population.PMID:38631869 | DOI:10.5551/jat.64798 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 17, 2024 Category: Cardiology Authors: Shigeru Tanaka Hiromasa Kitamura Kazuhiko Tsuruya Takanari Kitazono Toshiaki Nakano FKR Study Collaboration Group Source Type: research
Single-cell transcriptomics reveal metastatic CLDN4+ cancer cells underlying the recurrence of malignant pleural effusion in patients with advanced non-small-cell lung cancer
CONCLUSIONS: CLDN4 could be considered as a predictive marker of recurrent MPE among patients with advanced NSCLC. Further validation for its clinical value in cohorts with larger sample size and in-depth mechanism studies on its biological function are warranted.TRIAL REGISTRATION: Not applicable.PMID:38629624 | PMC:PMC11022306 | DOI:10.1002/ctm2.1649 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Xiaoshen Zhang Xuanhe Wang Yaokai Wen Shen Chen Caicun Zhou Fengying Wu Source Type: research
Measurement and Application of Incidentally Detected Coronary Calcium: JACC Review Topic of the Week
J Am Coll Cardiol. 2024 Apr 23;83(16):1557-1567. doi: 10.1016/j.jacc.2024.01.039.ABSTRACTCoronary artery calcium (CAC) scoring is a powerful tool for atherosclerotic cardiovascular disease risk stratification. The nongated, noncontrast chest computed tomography scan (NCCT) has emerged as a source of CAC characterization with tremendous potential due to the high volume of NCCT scans. Application of incidental CAC characterization from NCCT has raised questions around score accuracy, standardization of methodology including the possibility of deep learning to automate the process, and the risk stratification potential of an ...
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Shyon Parsa Adam Saleh Viraj Raygor Natalie Hoeting Anjali Rao Ann Marie Navar Anand Rohatgi Fernando Kay Suhny Abbara Amit Khera Parag H Joshi Source Type: research
Assessment of atherosclerotic plaque burden: comparison of AI-QCT versus SIS, CAC, visual and CAD-RADS stenosis categories
This study assesses the agreement of Artificial Intelligence-Quantitative Computed Tomography (AI-QCT) with qualitative approaches to atherosclerotic disease burden codified in the multisociety 2022 CAD-RADS 2.0 Expert Consensus. 105 patients who underwent cardiac computed tomography angiography (CCTA) for chest pain were evaluated by a blinded core laboratory through FDA-cleared software (Cleerly, Denver, CO) that performs AI-QCT through artificial intelligence, analyzing factors such as % stenosis, plaque volume, and plaque composition. AI-QCT plaque volume was then staged by recently validated prognostic thresholds, and...
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Hufsa Khan Kopal Bansal William F Griffin Catherine Cantlay Alfateh Sidahmed Nick S Nurmohamed Robert K Zeman Richard J Katz Ron Blankstein James P Earls Andrew D Choi Source Type: research
