Protective effects of sodium butyrate on fluorosis in rats by regulating bone homeostasis and serum metabolism
In this study, a rat model of fluorosis induced by 100 mg/L sodium fluoride was used to investigate the impact of NaB on bone homeostasis and serum metabolomics. It was found that NaB significantly reduced the levels of bone resorption markers CTX-Ⅰ and TRACP-5B in fluorosis rats. Moreover, NaB increased calcium and magnesium levels in bone, while decreasing phosphorus levels. In addition, NaB improved various bone microstructure parameters, including bone mineral density (BMD), trabecular thickness (Tb. Th), trabecular bone separation (Tb. SP), and structural model index (SMI) in the femur. Notably, NaB intervention als...
Source: Ecotoxicology and Environmental Safety - April 6, 2024 Category: Environmental Health Authors: Ying Li Fengmei Yang Jie Liu Mengqi Jiang Ye Yu Qingyi Zhou Lu Sun Zhuo Zhang Lin Zhou Source Type: research
Extracellular glucose and dysfunctional insulin receptor signaling independently upregulate arterial smooth muscle TMEM16A expression
Am J Physiol Cell Physiol. 2024 Apr 1;326(4):C1237-C1247. doi: 10.1152/ajpcell.00555.2023. Epub 2024 Mar 4.ABSTRACTDiabetes alters the function of ion channels responsible for regulating arterial smooth muscle membrane potential, resulting in vasoconstriction. Our prior research demonstrated an elevation of TMEM16A in diabetic arteries. Here, we explored the mechanisms involved in Transmembrane protein 16A (TMEM16A) gene expression. Our data indicate that a Snail-mediated repressor complex regulates arterial TMEM16A gene transcription. Snail expression was reduced in diabetic arteries while TMEM16A expression was upregulat...
Source: American Journal of Physiology. Cell Physiology - April 6, 2024 Category: Cytology Authors: Somasundaram Raghavan Masuma Akter Brishti Angelica Bernardelli Alejandro Mata-Daboin Jonathan H Jaggar M Dennis Leo Source Type: research
Extracellular glucose and dysfunctional insulin receptor signaling independently upregulate arterial smooth muscle TMEM16A expression
Am J Physiol Cell Physiol. 2024 Apr 1;326(4):C1237-C1247. doi: 10.1152/ajpcell.00555.2023. Epub 2024 Mar 4.ABSTRACTDiabetes alters the function of ion channels responsible for regulating arterial smooth muscle membrane potential, resulting in vasoconstriction. Our prior research demonstrated an elevation of TMEM16A in diabetic arteries. Here, we explored the mechanisms involved in Transmembrane protein 16A (TMEM16A) gene expression. Our data indicate that a Snail-mediated repressor complex regulates arterial TMEM16A gene transcription. Snail expression was reduced in diabetic arteries while TMEM16A expression was upregulat...
Source: Am J Physiol Cell Ph... - April 6, 2024 Category: Cytology Authors: Somasundaram Raghavan Masuma Akter Brishti Angelica Bernardelli Alejandro Mata-Daboin Jonathan H Jaggar M Dennis Leo Source Type: research
Spinal bestrophin-1 and anoctamin-1 channels have a pronociceptive role in the tactile allodynia induced by REM sleep deprivation in rats
This study aimed to determine if anoctamin-1 and bestrophin-1 are involved in the pain hypersensitivity induced by REMSD. We used the multiple-platform method to induce REMSD. REM sleep deprivation for 48 h induced tactile allodynia and a transient increase in corticosterone concentration at the beginning of the protocol (12 h) in female and male rats. REMSD enhanced c-Fos and α2δ-1 protein expression but did not change activating transcription factor 3 (ATF3) and KCC2 expression in dorsal root ganglia and dorsal spinal cord. Intrathecal injection of CaCCinh-A01, a non-selective bestrophin-1 blocker, and T16Ainh-A01, a s...
Source: Brain Research - April 6, 2024 Category: Neurology Authors: Carlos J Mart ínez-Magaña Paulina A Mu ñoz-Castillo Janet Murbarti án Source Type: research
Kinetic resolution of 1,1 ’-binaphthyl-2,2’-diamine derivatives by chiral calcium phosphate-catalyzed acylation
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00355A, PaperTatsuhiro Uchikura, Yuki Kanno, Yukino Fukuda, Mikoto Sato, Takahiko Akiyama 1,1 ’-Binaphthyl-2,2’-diamine (BINAM) is a useful axially chiral compound. The kinetic resolution of BINAM is one of the most crucial methods for synthesizing chiral BINAM. We have developed a chiral calcium... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 6, 2024 Category: Molecular Biology Authors: Tatsuhiro Uchikura Source Type: research
