pH regulating mechanisms of astrocytes: A critical component in physiology and disease of the brain
Cell Calcium. 2024 Apr 8;120:102882. doi: 10.1016/j.ceca.2024.102882. Online ahead of print.ABSTRACTStrict homeostatic control of pH in both intra- and extracellular compartments of the brain is fundamentally important, primarily due to the profound impact of free protons ([H+]) on neuronal activity and overall brain function. Astrocytes, crucial players in the homeostasis of various ions in the brain, actively regulate their intracellular [H+] (pHi) through multiple membrane transporters and carbonic anhydrases. The activation of astroglial pHi regulating mechanisms also leads to corresponding alterations in the acid-base...
Source: Cell Calcium - April 17, 2024 Category: Cytology Authors: Shefeeq M Theparambil Gulnaz Begum Christine R Rose Source Type: research
Hypouricemia with hypercalciuria: Longitudinal study and review of the topic
CONCLUSION: Our patients with hypercalciuria and hypouricemia would be affected by a variant of idiopathic hypercalciuria in which, due to an unknown cause, the proximal tubular reabsorption of urate is modestly reduced and improves over time. Hypouricemia with hypercalciuria and decreased bone density may not be a specific entity.PMID:38631961 | DOI:10.1016/j.nefroe.2024.03.023 (Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - April 17, 2024 Category: Urology & Nephrology Authors: Teresa Moraleda Mesa Cristina de la Torre Sandoval Sara Duque Gonz ález Ana Karina Rolo Álvarez Mar ía Isabel Luis Yanes V íctor M García Nieto Source Type: research
High phosphate and calcium induce osteoblastic phenotype switching and calcification of corneal epithelial cells in a Runx2-dependent and synergistic manner; a possible mechanism of chronic kidney disease-associated corneal calcification
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167171. doi: 10.1016/j.bbadis.2024.167171. Online ahead of print.ABSTRACTPatients with advanced chronic kidney disease (CKD) have elevated circulating calcium × phosphate product levels and exhibit soft tissue calcification. Besides the cardiovascular system, calcification is commonly observed in the cornea in CKD patients on hemodialysis. Cardiovascular calcification is a cell-mediated, highly regulated process, and we hypothesized that a similar regulatory mechanism is implicated in corneal calcification with the involvement of corneal epithelial cells (CECs). We establish...
Source: Molecular Medicine - April 17, 2024 Category: Molecular Biology Authors: Haneen Ababneh Andrea T óth Gr éta Lente Enik ő Balogh D ávid Máté Csiki B éla Nagy Árpád Szöőr Vikt ória Jeney Source Type: research
On the performance of Sargassum-derived calcium alginate ion exchange resins for Pb < sup > 2+ < /sup > adsorption: batch and packed bed applications
Environ Sci Pollut Res Int. 2024 Apr 17. doi: 10.1007/s11356-024-33314-w. Online ahead of print.ABSTRACTDriven by climate change and human activity, Sargassum blooming rates have intensified, producing copious amount of the invasive, pelagic seaweed across the Caribbean and Latin America. Battery recycling and lead-smelter wastes have heavily polluted the environment and resulted in acute lead poisoning in children through widespread heavy metal contamination particular in East Trinidad. Our study details a comprehensive investigation into the use of Sargassum (S. natans), as a potential resource-circular feedstock for the...
Source: Environmental Science and Pollution Research International - April 17, 2024 Category: Environmental Health Authors: Akeem Mohammed Chantal Mohammed Andreas Mautner Matika Kistow Pooran Chaitram Alexander Bismarck Keeran Ward Source Type: research
Acute cervical epidural abscess with concurrent calcium pyrophosphate deposition after cervical spinal surgery: A case report
CONCLUSION: An acute onset of SEA complicated with CPPD after cervical surgery has rarely been reported. The suppurative inflammation fostered by the crystal-induced inflammation may account for the acute symptomatology.PMID:38628534 | PMC:PMC11021091 | DOI:10.25259/SNI_740_2023 (Source: Hand Surgery)
Source: Hand Surgery - April 17, 2024 Category: Surgery Authors: Koki Mitani Manabu Minami Toshiyuki Takahashi Mariko Toyoda Ryo Kanematsu Junya Hanakita Source Type: research
Cisd2 deficiency impairs neutrophil function by regulating calcium homeostasis via Calnexin and SERCA
BMB Rep. 2024 Apr 17:6179. Online ahead of print.ABSTRACTIn the context of aging, the susceptibility to infectious diseases increases, leading to heightened morbidity and mortality. This phenomenon, termed immunosenescence, is characterized by dysregulation in the aging immune system, including abnormal alterations in lymphocyte composition, elevated basal inflammation, and the accumulation of senescent T cells. Such changes contribute to increased autoimmune diseases, enhanced infection severity, and reduced responsiveness to vaccines. Utilizing aging animal models becomes imperative for a comprehensive understanding of i...
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Un Yung Choi Youn Jung Choi Shin-Ae Lee Ji-Seung Yoo Source Type: research
Deep lymph node enlargement and renal failure caused by hypercalcemia ‑associated sarcoidosis: A case report
Exp Ther Med. 2024 Mar 27;27(5):235. doi: 10.3892/etm.2024.12524. eCollection 2024 May.ABSTRACTSarcoidosis is a rare disease that severely affects the lungs and superficial lymph nodes. In addition, this disease can also affect the skin, eyes and kidneys to varying degrees. The present report described a 32-year-old male patient who was admitted to Renmin Hospital of Wuhan University (Wuhan, China) due to joint pain in the extremities. He was diagnosed with uncorrectable hypercalcemia. A lymph node biopsy revealed the hypercalcemia to be associated with sarcoidosis, with the patient also demonstrating renal failure and lym...
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Zezhou Liu Zhigang Tang Jingping Yuan Ke Su Yonghong Jian Hongyan Liu Source Type: research
Synthesis and characterization of novel guar gum based waste material derived nanocomposite for effective removal of hexabromocyclododecane and lindane
Int J Biol Macromol. 2024 Apr 15:131535. doi: 10.1016/j.ijbiomac.2024.131535. Online ahead of print.ABSTRACTHerein, efficient degradation of hexabromocyclododecane (HBCD) and Lindane, a persistent organic pollutant using guar gum based calcium oxide doped silicon dioxide (GG-CaO@SiO2) has been reported. The nanocomposite was prepared by waste egg shell (CaO) and rice husk (SiO2) was well characterized. The maximum degradation of HBCD and Lindane were observed at 8 mg catalyst loading, basic pH, and 2 mg L-1 of pollutant amount. The photocatalytic performance of GG-CaO@SiO2 for HBCD and Lindane photodegradation was evaluate...
Source: International Journal of Biological Macromolecules - April 17, 2024 Category: Biochemistry Authors: None Keshu Manviri Rani Uma Shanker Source Type: research
Learning enhances representations of taste-guided decisions in the mouse gustatory insular cortex
Curr Biol. 2024 Apr 12:S0960-9822(24)00374-9. doi: 10.1016/j.cub.2024.03.034. Online ahead of print.ABSTRACTLearning to discriminate overlapping gustatory stimuli that predict distinct outcomes-a feat known as discrimination learning-can mean the difference between ingesting a poison or a nutritive meal. Despite the obvious importance of this process, very little is known about the neural basis of taste discrimination learning. In other sensory modalities, this form of learning can be mediated by either the sharpening of sensory representations or the enhanced ability of "decision-making" circuits to interpret sensory info...
Source: Current Biology - April 17, 2024 Category: Biology Authors: Joshua F Kogan Alfredo Fontanini Source Type: research
Inorganic polyphosphate and ion transport across biological membranes
Biochem Soc Trans. 2024 Apr 17:BST20230522. doi: 10.1042/BST20230522. Online ahead of print.ABSTRACTInorganic polyphosphate (polyP) is widely recognized for playing important roles and processes involved in energy and phosphate storage, regulation of gene expression, and calcium signaling. The less well-known role of polyP is as a direct mediator of ion transport across biological membranes. Here, we will briefly summarize current knowledge of the molecular mechanisms of how polyP can be involved in membrane ion transport. We discuss three types of mechanisms that might involve polyP: (1) formation of non-protein channel c...
Source: Biochemical Society Transactions - April 17, 2024 Category: Biochemistry Authors: Yaw Akosah Jingyi Yang Evgeny Pavlov Source Type: research
Myosin XI, a model of its conserved role in plant cell tip growth
Biochem Soc Trans. 2024 Apr 17:BST20220783. doi: 10.1042/BST20220783. Online ahead of print.ABSTRACTIn eukaryotic cells, organelle and vesicle transport, positioning, and interactions play crucial roles in cytoplasmic organization and function. These processes are governed by intracellular trafficking mechanisms. At the core of that trafficking, the cytoskeleton and directional transport by motor proteins stand out as its key regulators. Plant cell tip growth is a well-studied example of cytoplasm organization by polarization. This polarization, essential for the cell's function, is driven by the cytoskeleton and its assoc...
Source: Biochemical Society Transactions - April 17, 2024 Category: Biochemistry Authors: Edward J Chocano-Coralla Luis Vidali Source Type: research
High phosphate and calcium induce osteoblastic phenotype switching and calcification of corneal epithelial cells in a Runx2-dependent and synergistic manner; a possible mechanism of chronic kidney disease-associated corneal calcification
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167171. doi: 10.1016/j.bbadis.2024.167171. Online ahead of print.ABSTRACTPatients with advanced chronic kidney disease (CKD) have elevated circulating calcium × phosphate product levels and exhibit soft tissue calcification. Besides the cardiovascular system, calcification is commonly observed in the cornea in CKD patients on hemodialysis. Cardiovascular calcification is a cell-mediated, highly regulated process, and we hypothesized that a similar regulatory mechanism is implicated in corneal calcification with the involvement of corneal epithelial cells (CECs). We establish...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Haneen Ababneh Andrea T óth Gr éta Lente Enik ő Balogh D ávid Máté Csiki B éla Nagy Árpád Szöőr Vikt ória Jeney Source Type: research
Mitochondrial calcium signaling in non-neuronal cells: Implications for Alzheimer's disease pathogenesis
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167169. doi: 10.1016/j.bbadis.2024.167169. Online ahead of print.ABSTRACTMitochondrial dysregulation is pivotal in Alzheimer's disease (AD) pathogenesis. Calcium governs vital mitochondrial processes impacting energy conversion, oxidative stress, and cell death signaling. Disruptions in mitochondrial calcium (mCa2+) handling induce calcium overload and trigger the opening of mitochondrial permeability transition pore, ensuing energy deprivation and resulting in AD-related neuronal cell death. However, the role of mCa2+ in non-neuronal cells (microglia, astrocytes, oligodendro...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Darpan Raghav Shatakshi Shukla Pooja Jadiya Source Type: research
Materials analysis in three paintings of Thomas Gainsborough (1727-1788) by portable X-ray fluorescence
Appl Radiat Isot. 2024 Apr 16;209:111324. doi: 10.1016/j.apradiso.2024.111324. Online ahead of print.ABSTRACTThree paintings of Thomas Gainsborough (1727-1788), one of the most influential English portrait painters of the late 18th century, from the collection of the Museu de Arte de São Paulo (MASP) - "Francis Rawdon" (1783-1784), "Portrait of Mrs. John Bolton" (1770), and "Drinkstone Park" (1747) - were investigated using portable X-ray fluorescence (pXRF), employing a W tube anode and an XR-100CR detector. These artworks represent the only paintings by Thomas Gainsborough located in the southern hemisphere. Through an ...
Source: Applied Radiation and Isotopes - April 17, 2024 Category: Radiology Authors: Let ícia Martins Birelo Carlos Roberto Appoloni Source Type: research
Acute cervical epidural abscess with concurrent calcium pyrophosphate deposition after cervical spinal surgery: A case report
CONCLUSION: An acute onset of SEA complicated with CPPD after cervical surgery has rarely been reported. The suppurative inflammation fostered by the crystal-induced inflammation may account for the acute symptomatology.PMID:38628534 | PMC:PMC11021091 | DOI:10.25259/SNI_740_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Koki Mitani Manabu Minami Toshiyuki Takahashi Mariko Toyoda Ryo Kanematsu Junya Hanakita Source Type: research
