Effect of Antenatal Oral Vitamin D Supplementation on Serum 25(OH)D Concentration in Exclusively Breastfed Infants at 6 Months of age - A Randomized Double-Blind Placebo-Controlled Trial
CONCLUSIONS: Oral supplementation of vitamin D3 to pregnant women in the third trimester prevents severe hypovitaminosis D in the EBF infants at 6-months of age.PMID:38584410 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 8, 2024 Category: Pediatrics Authors: Prashant Prabhakar M M A Faridi Anju Aggarwal Rachna Aggarwal S V Madhu Rajeev Malhotra Source Type: research
Neural tissue tolerance to synthetic dural mater graft implantation in a rabbit durotomy model
This study evaluated the safety of ArtiFascia, a synthetic dura mater graft composed of poly(l-lactic-co-caprolactone acid) and poly(d-lactic-co-caprolactone acid), in a rabbit durotomy model. Previously, ArtiFascia demonstrated positive local tolerance and biodegradability in a 12-month preclinical trial. Here, specialized stains were used to evaluate potential brain damage associated with ArtiFascia use. Histochemical and immunohistochemical assessments included Luxol Fast Blue, cresyl Violet, Masson's Trichrome, neuronal nuclei,, Glial Fibrillary Acidic Protein, and ionized calcium-binding adaptor molecule 1 stains. The...
Source: Journal of Toxicologic Pathology - April 8, 2024 Category: Toxicology Authors: Yuval Ramot Noam Kronfeld Michal Steiner Nora Nseir Manassa Amir Bahar Abraham Nyska Source Type: research
Anisotropic composite aerogel with thermal insulation and flame retardancy from cellulose nanofibers, calcium alginate and boric acid
Int J Biol Macromol. 2024 Apr 6:131450. doi: 10.1016/j.ijbiomac.2024.131450. Online ahead of print.ABSTRACTWith the increasing severity of energy shortages and environmental pollution, there is an urgent need for advanced thermal insulation materials with excellent comprehensive performance, including low thermal conductivity, high flame resistance, and strong compressive strength. Herein, an anisotropic composite aerogel based on cellulose nanofibers (CNF), calcium alginate (CA), and boric acid (BA) is fabricated using a directional freeze-drying strategy. The CA and BA, as double cross-linking agents, associated with ori...
Source: International Journal of Biological Macromolecules - April 8, 2024 Category: Biochemistry Authors: Jintao Zhu Yangyang Wang Xiaoyi Zhao Nan Li Xiaoyun Guo Liang Zhao Yuanyuan Yin Source Type: research
Determination of calcium, iron, and selenium in human serum by isotope dilution analysis using nitrogen microwave inductively coupled atmospheric pressure plasma mass spectrometry (MICAP-MS)
In this study, we demonstrate the applicability of nitrogen microwave inductively coupled atmospheric pressure mass spectrometry (MICAP-MS) for Ca, Fe, and Se quantification in human serum using isotope dilution (ID) analysis. The matrix tolerance of MICAP-MS in Na matrix was investigated, revealing that high Na levels can suppress the signal intensity. This suppression is likely due to the plasma loading and the space charge effect. Moreover, 40Ca and 44Ca isotopic fractionation was noted at elevated Na concentration. Nine certified serum samples were analyzed using both external calibration and ID analysis. Overestimatio...
Source: Analytical and Bioanalytical Chemistry - April 8, 2024 Category: Chemistry Authors: Zengchao You Alexander Winckelmann Jochen Vogl Sebastian Recknagel Carlos Abad Source Type: research
Combined Effects of Cadmium and Lead on Growth Performance and Kidney Function in Broiler Chicken
Biol Trace Elem Res. 2024 Apr 8. doi: 10.1007/s12011-024-04173-w. Online ahead of print.ABSTRACTCadmium (Cd) and lead (Pb) are heavy metals prevalent in the environment and feed, and they reduce production performance of domestic animals, as well as they result in residue in animal tissues. The kidney is the target tissue for Cd and Pb. And the kidney is crucial for the reabsorption of calcium (Ca), which consequently influences bone strength. However, there are relatively few studies related to the effects of Cd and Pb exposure on performance, bone strength and kidney damage in livestock. The purpose of this experiment wa...
Source: Biological Trace Element Research - April 8, 2024 Category: Biology Authors: Man Zhao Longqiang Xie Wenbin Huang Meiling Li Xin Gu Wei Zhang Jintao Wei Niya Zhang Source Type: research
Effects of plant extracts and derivatives on cardiac K < sup > + < /sup > , Nav, and Ca < sub > v < /sub > channels: a review
Nat Prod Res. 2024 Apr 8:1-28. doi: 10.1080/14786419.2024.2337112. Online ahead of print.ABSTRACTNatural products (NPs) are endless sources of compounds for fighting against several pathologies. Many dysfunctions, including cardiovascular disorders, such as cardiac arrhythmias have their modes of action regulation of the concentration of electrolytes inside and outside the cell targeting ion channels. Here, we highlight plant extracts and secondary metabolites' effects on the treatment of related cardiac pathologies on hERG, Nav, and Cav of cardiomyocytes. The natural product's pharmacology of expressed receptors like alph...
Source: Natural Product Research - April 8, 2024 Category: Biochemistry Authors: Insa Seck Samba Fama Ndoye Michelle Vanessa Kamga Kapchoup Filomain Nguemo Ismaila Ciss Lalla Aicha Ba Abda Ba Seynabou Sokhna Matar Seck Source Type: research
Advances in TRPV6 inhibitors for tumors by targeted therapies: Macromolecular proteins, synthetic small molecule compounds, and natural compounds
Eur J Med Chem. 2024 Apr 1;270:116379. doi: 10.1016/j.ejmech.2024.116379. Online ahead of print.ABSTRACTTRPV6, a Ca2+-selective member of the transient receptor potential vanilloid (TRPV) family, plays a key role in extracellular calcium transport, calcium ion reuptake, and maintenance of a local low calcium environment. An increasing number of studies have shown that TRPV6 is involved in the regulation of various diseases. Notably, overexpression of TRPV6 is closely related to the occurrence of various cancers. Research confirmed that knocking down TRPV6 could effectively reduce the proliferation and invasiveness of tumor...
Source: European Journal of Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Weikang Liu Wenwen Deng Liqing Hu Hui Zou Source Type: research
Effect of Antenatal Oral Vitamin D Supplementation on Serum 25(OH)D Concentration in Exclusively Breastfed Infants at 6 Months of age - A Randomized Double-Blind Placebo-Controlled Trial
CONCLUSIONS: Oral supplementation of vitamin D3 to pregnant women in the third trimester prevents severe hypovitaminosis D in the EBF infants at 6-months of age.PMID:38584410 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 8, 2024 Category: Pediatrics Authors: Prashant Prabhakar M M A Faridi Anju Aggarwal Rachna Aggarwal S V Madhu Rajeev Malhotra Source Type: research
Assessing groundwater quality dynamics in madhya pradesh: chemical contaminants and their temporal patterns
This study primarily aims to investigate the spatio-temporal variations in groundwater quality and evaluate its suitability for potable purposes in the region of Madhya Pradesh. The study combines the Mann-Kendall (MK) test and Sen's Slope (SS) to analyze the changes in groundwater quality of all 51 districts of Madhya Pradesh, India, utilizing 12 water quality indices using MATLAB. Data was sourced from the Central Ground Water Board (CGWB) in India from the year 2001 to 2021. The data was then tested for homogeneity at all 1154 sampling stations using the software XLSTAT. Piper plot clustering characterized the state's g...
Source: Environmental Research - April 8, 2024 Category: Environmental Health Authors: Satyam Mishra Mrityunjay Singh Chauhan Suresh Sundaramurthy Source Type: research
Neural tissue tolerance to synthetic dural mater graft implantation in a rabbit durotomy model
This study evaluated the safety of ArtiFascia, a synthetic dura mater graft composed of poly(l-lactic-co-caprolactone acid) and poly(d-lactic-co-caprolactone acid), in a rabbit durotomy model. Previously, ArtiFascia demonstrated positive local tolerance and biodegradability in a 12-month preclinical trial. Here, specialized stains were used to evaluate potential brain damage associated with ArtiFascia use. Histochemical and immunohistochemical assessments included Luxol Fast Blue, cresyl Violet, Masson's Trichrome, neuronal nuclei,, Glial Fibrillary Acidic Protein, and ionized calcium-binding adaptor molecule 1 stains. The...
Source: Journal of Toxicologic Pathology - April 8, 2024 Category: Toxicology Authors: Yuval Ramot Noam Kronfeld Michal Steiner Nora Nseir Manassa Amir Bahar Abraham Nyska Source Type: research
Effects of plant extracts and derivatives on cardiac K < sup > + < /sup > , Nav, and Ca < sub > v < /sub > channels: a review
Nat Prod Res. 2024 Apr 8:1-28. doi: 10.1080/14786419.2024.2337112. Online ahead of print.ABSTRACTNatural products (NPs) are endless sources of compounds for fighting against several pathologies. Many dysfunctions, including cardiovascular disorders, such as cardiac arrhythmias have their modes of action regulation of the concentration of electrolytes inside and outside the cell targeting ion channels. Here, we highlight plant extracts and secondary metabolites' effects on the treatment of related cardiac pathologies on hERG, Nav, and Cav of cardiomyocytes. The natural product's pharmacology of expressed receptors like alph...
Source: Natural Product Research - April 8, 2024 Category: Biochemistry Authors: Insa Seck Samba Fama Ndoye Michelle Vanessa Kamga Kapchoup Filomain Nguemo Ismaila Ciss Lalla Aicha Ba Abda Ba Seynabou Sokhna Matar Seck Source Type: research
