Autophagy-dependent lysosomal calcium overload and the ATP5B-regulated lysosomes-mitochondria calcium transmission induce liver insulin resistance under perfluorooctane sulfonate exposure
In this study, we found that PFOS exposure noticeably raised lysosomal calcium in L-02 hepatocytes from 0.5 h. In the PFOS-cultured L-02 cells, inhibiting autophagy alleviated lysosomal calcium overload. Inhibition of mitochondrial calcium uptake aggravated the accumulation of lysosomal calcium, while inhibition of lysosomal calcium outflowing reversed PFOS-induced mitochondrial calcium overload and IR. Transient receptor potential mucolipin 1 (TRPML1), the calcium output channel of lysosomes, interacted with voltage-dependent anion channel 1 (VDAC1), the calcium intake channel of mitochondria, in the PFOS-cultured cells. ...
Source: Ecotoxicology and Environmental Safety - April 16, 2024 Category: Environmental Health Authors: Jixun Li Yu Ma Tianming Qiu Jianyu Wang Jingyuan Zhang Xiance Sun Liping Jiang Qiujuan Li Xiaofeng Yao Source Type: research
2023 Australian guideline for assessing and managing cardiovascular disease risk
Med J Aust. 2024 Apr 16. doi: 10.5694/mja2.52280. Online ahead of print.ABSTRACTINTRODUCTION: The 2023 Australian guideline for assessing and managing cardiovascular disease risk provides updated evidence-based recommendations for the clinical assessment and management of cardiovascular disease (CVD) risk for primary prevention. It includes the new Australian CVD risk calculator (Aus CVD Risk Calculator), based on an equation developed from a large New Zealand cohort study, customised and recalibrated for the Australian population. The new guideline replaces the 2012 guideline that recommended CVD risk assessment using the...
Source: Med J Aust - April 16, 2024 Category: General Medicine Authors: Mark R Nelson Emily Banks Alex Brown Clara K Chow David P Peiris Nigel P Stocks Rebecca Davies Ao Natalie Raffoul Lisa Kalman Emily Bradburn Garry Jennings Source Type: research
Comparative Analysis of Transoral Endoscopic Parathyroidectomy Vestibular Approach and Focused Open Surgery for Primary Hyperparathyroidism Treatment: A Single Center Experience
CONCLUSIONS TOEPVA is a safe method in patients who underwent parthyroid surgery to avoid cervical scarring.PMID:38622842 | DOI:10.12659/MSM.944128 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 16, 2024 Category: Research Authors: Mehmet Zafer Sabuncuoglu Isa Sozen İsmail Zihni Girayhan Celik Nesime Inci Ery ılmaz Fatma Nur Dal Demet Gunduz Ozer Makay Source Type: research
Drug-Induced Liver Injury in Pregnancy: The U.S. Drug-Induced Liver Injury Network Experience
Obstet Gynecol. 2024 Apr 16. doi: 10.1097/AOG.0000000000005585. Online ahead of print.ABSTRACTThere are limited data on the causative agents and characteristics of drug-induced liver injury in pregnant individuals. Data from patients with drug-induced liver injury enrolled in the ongoing multicenter Drug-Induced Liver Injury Network between 2004 and 2022 and occurring during pregnancy or 6 months postpartum were reviewed and compared with cases of drug-induced liver injury in nonpregnant women of childbearing age. Among 325 individuals of childbearing age in the Drug-Induced Liver Injury Network, 16 cases of drug-induced l...
Source: Obstetrics and Gynecology - April 16, 2024 Category: OBGYN Authors: Umair Masood Nicholas Venturini Paola Nicoletti Andrew Dellinger David Kleiner Herbert L Bonkovsky Huiman Barnhart Raj Vuppalanchi Simona Rossi Joseph A Odin Tatyana Kushner Source Type: research
2023 Australian guideline for assessing and managing cardiovascular disease risk
Med J Aust. 2024 Apr 16. doi: 10.5694/mja2.52280. Online ahead of print.ABSTRACTINTRODUCTION: The 2023 Australian guideline for assessing and managing cardiovascular disease risk provides updated evidence-based recommendations for the clinical assessment and management of cardiovascular disease (CVD) risk for primary prevention. It includes the new Australian CVD risk calculator (Aus CVD Risk Calculator), based on an equation developed from a large New Zealand cohort study, customised and recalibrated for the Australian population. The new guideline replaces the 2012 guideline that recommended CVD risk assessment using the...
Source: Medical Journal of Australia - April 16, 2024 Category: General Medicine Authors: Mark R Nelson Emily Banks Alex Brown Clara K Chow David P Peiris Nigel P Stocks Rebecca Davies Ao Natalie Raffoul Lisa Kalman Emily Bradburn Garry Jennings Source Type: research
Photothermal conversion enabled temperature modulation for the growth of complex polymorphic architectures of calcium carbonate
J. Mater. Chem. A, 2024, Accepted Manuscript DOI: 10.1039/D4TA00802B, PaperBoning Shi, Lifu Zhang, Zeda Yang, Jiangnan Deng, Shun An, Benwei Fu, Chengyi Song, Peng Tao, Tao Deng, Wen Shang As a highly efficient and eco-friendly heat generation approach, photothermal conversion process has been applied to many important areas such as desalination and medical treatments. We explored in this work... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)
Source: RSC - J. Mater. Chem. latest articles - April 16, 2024 Category: Chemistry Authors: Boning Shi Source Type: research
In-band pumped Kerr-lens mode-locked Tm,Ho-codoped calcium aluminate laser
We report on a Kerr-lens mode-locked Tm,Ho-codoped calcium aluminate laser with in-band pumping of the Tm ions by a spatially single-mode ... (Source: Optics Express)
Source: Optics Express - April 16, 2024 Category: Physics Authors: Huang-Jun Zeng Wen-Ze Xue Robert T. Murray Chen Cui Li Wang Zhongben Pan Pavel Loiko Xavier Mateos FeiFei Yuan Ge Zhang Uwe Griebner Valentin Petrov Weidong Chen Source Type: research
GSE244171 Ciliogenesis defects after neurulation impact brain development and neuronal activity in larval zebrafish
Contributors : N Jurisch-Yaksi ; P P D'GamaSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioCilia are slender, hair-like structures extending from cell surfaces and playing essential roles in diverse physiological processes. Within the nervous system, primary cilia contribute to signaling and sensory perception, while motile cilia facilitate cerebrospinal fluid flow. Here, we investigated the impact of ciliary loss on neural circuit development using a zebrafish line displaying ciliogenesis defects. We found that cilia defects after neurulation affects neurogenesis and brain morphology...
Source: GEO: Gene Expression Omnibus - April 16, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Danio rerio Source Type: research
Cadherin-17 as a target for the immunoPET of adenocarcinoma
ConclusionTaken together, these data underscore that [89Zr]Zr-DFO-D2101 is a highly promising probe for the non-invasive visualization of CDH17 expression in PDAC. We contend that this radioimmunoconjugate could have a significant impact on the clinical management of patients with both PDAC and gastrointestinal adenocarcinoma, most likely as a theranostic imaging tool in support of CDH17-targeted therapies. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 16, 2024 Category: Nuclear Medicine Source Type: research
Blood Calcium, Genetic Risk, and Risk of Incident Kidney Stone: A Population-Based Cohort Study
To investigate the association between blood calcium concentration and incident kidney stone as well as to assess the role played by genetic susceptibility. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 16, 2024 Category: Internal Medicine Authors: Xi Cao, Si Li, Yunlong Guan, Zhonghe Shao, Minghui Jiang, Miao Wang, Xingjie Hao Tags: Original Article Source Type: research
Assessment of a novel electrochemically deposited smart bioactive trabecular coating (SBTC ®): a randomized controlled clinical trial
A randomized controlled clinical trial of dental implants was conducted to compare the clinical properties of a novel electrochemically deposited calcium phosphate coating to those of a common marketed surface... (Source: Head and Face Medicine)
Source: Head and Face Medicine - April 16, 2024 Category: ENT & OMF Authors: Mark Adam Antal, Ram óna Kiscsatári, Gábor Braunitzer, József Piffkó, Endre Varga and Noam Eliaz Tags: Research Source Type: research
Cadherin-17 as a target for the immunoPET of adenocarcinoma
ConclusionTaken together, these data underscore that [89Zr]Zr-DFO-D2101 is a highly promising probe for the non-invasive visualization of CDH17 expression in PDAC. We contend that this radioimmunoconjugate could have a significant impact on the clinical management of patients with both PDAC and gastrointestinal adenocarcinoma, most likely as a theranostic imaging tool in support of CDH17-targeted therapies. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 16, 2024 Category: Nuclear Medicine Source Type: research
GlycA Levels Independently Predict Coronary Artery Calcium Incidence and Progression in the ELSA-Brasil Cohort (Brazilian Longitudinal Study of Adult Health)
Atherosclerosis is an inflammatory disease. Coronary artery calcium (CAC) is a marker of atherosclerotic disease events and mortality risk. Elevated GlycA, an emerging marker of inflammation, is associated with a higher risk for coronary artery disease (CAD). However, there is conflicting evidence on whether GlycA predicts subclinical CAD progression. We hypothesized that GlycA can predict subclinical CAC incidence/progression in healthy individuals. We included 2,690 ELSA-Brasil cohort participants without cardiovascular/chronic inflammatory disease not receiving statin therapy who had GlycA levels measured and two interv...
Source: The American Journal of Cardiology - April 16, 2024 Category: Cardiology Authors: Ronaldo C. Fabiano Filho, Giuliano Generoso, Rhanderson Cardoso, Steven R. Jones, Raul D. Santos, Peter P. Toth, Isabela M Bensenor, Paulo A Lotufo, Marcio S. Bittencourt Source Type: research
Protective Effect of Fermented Sea Tangle Extract on Skin Cell Damage Caused by Particulate Matter
Int J Med Sci. 2024 Mar 31;21(5):937-948. doi: 10.7150/ijms.93034. eCollection 2024.ABSTRACTThe skin is directly exposed to atmospheric pollutants, especially particulate matter 2.5 (PM2.5) in the air, which poses significant harm to skin health. However, limited research has been performed to identify molecules that can confer resistance to such substances. Herein, we analyzed the effect of fermented sea tangle (FST) extract on PM2.5-induced human HaCaT keratinocyte damage. Results showed that FST extract, at concentrations less than 800 μg/mL, exhibited non-significant toxicity to cells and concentration-dependent inhib...
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Mei Jing Piao Kyoung Ah Kang Pincha Devage Sameera Madushan Fernando Herath Mudiyanselage Udari Lakmini Herath Young Sang Koh Hee Kyoung Kang Yung Hyun Choi Jin Won Hyun Source Type: research
