A lesion in two: Buruli ulcer and squamous cell carcinoma coexistence
This report presents an intriguing case of concurrent diagnoses, with clues alluding to more than one skin condition being present. The case involves a 73-year-old man with BU diagnosed on the scalp, an atypical location, which led to the consideration of malignancy, ultimately revealing concurrent SCC. This case highlights the importance of considering both conditions in patients with epidemiological risk factors, necessitating multiple lines of investigation for accurate diagnosis. Medical practitioners must remain vigilant and incorporate this possibility into their diagnostic algorithms for suspicious skin lesions to o...
Source: PLoS Neglected Tropical Diseases - February 8, 2024 Category: Tropical Medicine Authors: Jessica C. O ’Keeffe Source Type: research
Pseudogenomic insights into the evolution of Mycobacterium ulcerans
Buruli ulcer (BU) disease, caused by Mycobacterium ulcerans (MU), and characterized by necrotic ulcers is still a health problem in Africa and Australia. The genome of the bacterium has several pseudogenes due to... (Source: BMC Genomics)
Source: BMC Genomics - January 22, 2024 Category: Genetics & Stem Cells Authors: Edwin Sakyi Kyei-Baffour, Kwabena Owusu-Boateng, Abiola Isawumi and Lydia Mosi Tags: Research Source Type: research
The current status of neglected tropical diseases in Japan: A scoping review
by Yuriko Harada, Hanako Iwashita, Taeko Moriyasu, Sachiyo Nagi, Nobuo Saito, Mariko Sugawara-Mikami, Kota Yoshioka, Rie Yotsu, on behalf of Japan NTD Study Group
Little attention has been paid to neglected tropical diseases (NTDs) in high-income countries and no literature provides an overview of NTDs in Japan. This scoping review aims to synthesize the latest evidence and information to understand epidemiology of and public health response to NTDs in Japan. Using three academic databases, we retrieved articles that mentioned NTDs in Japan, written in English or Japanese, and published between 2010 and 2020. Websites of ...
Source: PLoS Neglected Tropical Diseases - January 2, 2024 Category: Tropical Medicine Authors: Yuriko Harada Source Type: research
How our molecular understanding of the pathogenesis of < em > Mycobacterium ulcerans < /em > infection can improve diagnosis of Buruli ulcer
Expert Rev Mol Diagn. 2023 Dec 11:1-4. doi: 10.1080/14737159.2023.2294333. Online ahead of print.NO ABSTRACTPMID:38073533 | DOI:10.1080/14737159.2023.2294333 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - December 11, 2023 Category: Laboratory Medicine Authors: Gerd Pluschke Louisa Warryn Source Type: research
How our molecular understanding of the pathogenesis of < em > mycobacterium ulcerans < /em > infection can improve diagnosis of Buruli ulcer
Expert Rev Mol Diagn. 2023 Dec 11. doi: 10.1080/14737159.2023.2294333. Online ahead of print.NO ABSTRACTPMID:38073533 | DOI:10.1080/14737159.2023.2294333 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - December 11, 2023 Category: Laboratory Medicine Authors: Gerd Pluschke Louisa Warryn Source Type: research
How our molecular understanding of the pathogenesis of < em > Mycobacterium ulcerans < /em > infection can improve diagnosis of Buruli ulcer
Expert Rev Mol Diagn. 2023 Dec 11:1-4. doi: 10.1080/14737159.2023.2294333. Online ahead of print.NO ABSTRACTPMID:38073533 | DOI:10.1080/14737159.2023.2294333 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - December 11, 2023 Category: Laboratory Medicine Authors: Gerd Pluschke Louisa Warryn Source Type: research
< i > Mycobacterium ulcerans < /i > - < i > Bordetella trematum < /i > chronic tropical cutaneous ulcer: A four-case series, C ôte d’Ivoire
Conclusions/significanceIn four cases of Buruli ulcer in C ôte d’Ivoire,B.trematum was a co-pathogen which was resistant to rifampicin and clarithromycin, unmatchingM.ulcerans antibiotic susceptibility profile and counteracting the current treatment of Buruli ulcer in West Africa and Australia. Thus, we report here chronic mixedM.ulcerans-B.trematum chronic tropical ulcer as a specific form of Buruli ulcer in West Africa. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - December 7, 2023 Category: Tropical Medicine Authors: Bi Gor é Oscar Tchan Source Type: research
< i > Mycobacterium ulcerans < /i > not detected by PCR on human skin in Buruli ulcer endemic areas of south eastern Australia
ConclusionsM.ulcerans was not detected on the skin of humans from highly Buruli endemic areas. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - October 12, 2023 Category: Tropical Medicine Authors: Anita Velink Source Type: research
Repurposing of statins for Buruli Ulcer treatment: antimicrobial activity against Mycobacterium ulcerans
In conclusion, statins hold promise as potential treatment options for Buruli Ulcer. Further studies are necessary to validate their effectiveness and understand the mechanism of action of statins against M. ulcerans. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - September 29, 2023 Category: Microbiology Source Type: research
Endemic infectious cutaneous ulcers syndrome in the Oti Region of Ghana: Study of cutaneous leishmaniasis, yaws and < i > Haemophilus ducreyi < /i > cutaneous ulcers
Conclusions/SignificanceThis study detected single and mixed occurrence of the causative organisms of CL, yaws, andH.ducreyi cutaneous ulcers in CL endemic communities of the Oti Region in Ghana. These findings emphasize the importance of integrating multiple skin diseases on a common research platform and calls for the development of a comprehensive guideline for diagnosing and treating tropical ulcers in the study areas. (Source: PLoS One)
Source: PLoS One - September 27, 2023 Category: Biomedical Science Authors: Richard Adjei Akuffo Source Type: research
Comprehensive Case-Control Study of Protective and Risk Factors for Buruli Ulcer, Southeastern Australia
Emerg Infect Dis. 2023 Oct;29(10):2032-2043. doi: 10.3201/eid2910.230011.ABSTRACTTo examine protective and risk factors for Buruli ulcer (BU), we conducted a case-control study of 245 adult BU cases and 481 postcode-matched controls across BU-endemic areas of Victoria, Australia. We calculated age- and sex-adjusted odds ratios for socio-environmental, host, and behavioral factors associated with BU by using conditional logistic regression. Odds of BU were >2-fold for persons with diabetes mellitus and persons working outdoors who had soil contact in BU-endemic areas (compared with indoor work) but were lower among perso...
Source: Emerging Infectious Diseases - September 22, 2023 Category: Infectious Diseases Authors: Bridgette J McNamara Kim R Blasdell Arvind Yerramilli Ina L Smith Simone L Clayton Michael Dunn Ee Laine Tay Katherine B Gibney Nilakshi T Waidyatillake Mohammad A Hussain Michael Muleme Daniel P O'Brien Eugene Athan Source Type: research
