Case report: The first case of concurrent breast myeloid sarcoma and borderline phyllodes tumor with malignant features
ConclusionThis case highlights the importance of considering the possibility of concurrent malignancies in the differential diagnosis of complex breast masses and underscores the challenges involved in diagnosing and managing such cases. Additionally, we also emphasize the value of neoadjuvant radiotherapy and chemotherapy in MS. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 19, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 419: Dkk1 as a Prognostic Marker for Neoadjuvant Chemotherapy Response in Breast Cancer Patients
Conclusions: In this study, we demonstrated for the first time that Dkk1 could be identified as an independent predictor of NACT response in BC patients, particularly those with TNBC. Further research with a multicentric expanded (pre-/post-therapy) sample set and better-defined populations in terms of molecular subtypes, therapy modality, and long-term follow-up is recommended to obtain more solid evidence. (Source: Cancers)
Source: Cancers - January 18, 2024 Category: Cancer & Oncology Authors: Kasoha Steinbach Bohle Linxweiler Haj Hamoud Doerk Nigdelis Stotz Zimmermann Solomayer Kaya Radosa Tags: Article Source Type: research
Kinase inhibitor pulldown assay (KiP) for clinical proteomics
AbstractProtein kinases are frequently dysregulated and/or mutated in cancer and represent essential targets for therapy. Accurate quantification is essential. For breast cancer treatment, the identification and quantification of the protein kinase ERBB2 is critical for therapeutic decisions. While immunohistochemistry (IHC) is the current clinical diagnostic approach, it is only semiquantitative. Mass spectrometry-based proteomics offers quantitative assays that, unlike IHC, can be used to accurately evaluate hundreds of kinases simultaneously. The enrichment of less abundant kinase targets for quantification, along with ...
Source: Clinical Proteomics - January 16, 2024 Category: Biochemistry Source Type: research
