Case report: The first case of concurrent breast myeloid sarcoma and borderline phyllodes tumor with malignant features
ConclusionThis case highlights the importance of considering the possibility of concurrent malignancies in the differential diagnosis of complex breast masses and underscores the challenges involved in diagnosing and managing such cases. Additionally, we also emphasize the value of neoadjuvant radiotherapy and chemotherapy in MS. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 19, 2024 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 16, Pages 419: Dkk1 as a Prognostic Marker for Neoadjuvant Chemotherapy Response in Breast Cancer Patients
Conclusions: In this study, we demonstrated for the first time that Dkk1 could be identified as an independent predictor of NACT response in BC patients, particularly those with TNBC. Further research with a multicentric expanded (pre-/post-therapy) sample set and better-defined populations in terms of molecular subtypes, therapy modality, and long-term follow-up is recommended to obtain more solid evidence. (Source: Cancers)
Source: Cancers - January 18, 2024 Category: Cancer & Oncology Authors: Kasoha Steinbach Bohle Linxweiler Haj Hamoud Doerk Nigdelis Stotz Zimmermann Solomayer Kaya Radosa Tags: Article Source Type: research

Kinase inhibitor pulldown assay (KiP) for clinical proteomics
AbstractProtein kinases are frequently dysregulated and/or mutated in cancer and represent essential targets for therapy. Accurate quantification is essential. For breast cancer treatment, the identification and quantification of the protein kinase ERBB2 is critical for therapeutic decisions. While immunohistochemistry (IHC) is the current clinical diagnostic approach, it is only semiquantitative. Mass spectrometry-based proteomics offers quantitative assays that, unlike IHC, can be used to accurately evaluate hundreds of kinases simultaneously. The enrichment of less abundant kinase targets for quantification, along with ...
Source: Clinical Proteomics - January 16, 2024 Category: Biochemistry Source Type: research

Cancers, Vol. 16, Pages 317: Reducing the Risk of Needle Tract Seeding or Tumor Cell Dissemination during Needle Biopsy Procedures
Conclusions: Technical modifications of needle biopsy procedures can reduce the risk of breast needle-biopsy-induced cancer cell displacement and potentially reduce the risk of local recurrence, especially in patients for whom whole breast radiation is to be omitted. (Source: Cancers)
Source: Cancers - January 11, 2024 Category: Cancer & Oncology Authors: Dennis R. Holmes Tags: Review Source Type: research

Quantitative ultrasound parameters from scattering and propagation may reduce the biopsy rate for breast tumor
Ultrasonics. 2023 Dec 30;138:107233. doi: 10.1016/j.ultras.2023.107233. Online ahead of print.ABSTRACTBreast cancer has become the most common cancer worldwide, and early screening improves the patient's survival rate significantly. Although pathology with needle-based biopsy is the gold standard for breast cancer diagnosis, it is invasive, painful, and expensive. Meanwhile it makes patients suffer from misplacement of the needle, resulting in misdiagnosis and further assessment. Ultrasound imaging is non-invasive and real-time, however, benign and malignant tumors are hard to differentiate in grayscale B-mode images. We h...
Source: Ultrasonics - January 3, 2024 Category: Physics Authors: Jiaqi Han Pengfei Sun Qizhen Sun Zhun Xie Lijun Xu Xiangdong Hu Jianguo Ma Source Type: research

Morphological and Metabolic Criteria of COVID-19 Vaccine Associated Axillary Nodes on 18-Fluorodeouxyglucose PET/CT Imaging in Breast Cancer Patients
CONCLUSION: In COVID-19 vaccinated patients with BC, 18FDG avid nodes in VSA may pose diagnostic challenge. However, morphological (size < 10 mm short axis, intact fatty hila without fat stranding) and metabolic criteria (SUVmax <2.4 with negative correlation with time of inoculation) have higher diagnostic accuracy in resolving the dilemma. Nodes in VSA having SUVmax > 2 SD of hepatic SUVmax should be considered for FNA to rule out possible metastasis.PMID:38156837 | DOI:10.31557/APJCP.2023.24.12.4053 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 29, 2023 Category: Cancer & Oncology Authors: Nosheen Fatima Unaiza Zaman Areeba Zaman Sidra Zaman Rabia Tahseen Maseeh Uz Zaman Source Type: research

Expression and promoter methylation of mitogen-activated protein kinase 1 in tumor and marginal cells of breast cancer
CONCLUSION: Our findings suggest that while MAPK1 expression, might be a promising biomarker for evaluating oncogenic activity in patients suspected of BCa. We were not able to detect a prognostic/diagnostic role for MAPK1 promoter methylation.PMID:38143331 | DOI:10.3233/BD-230001 (Source: Breast Disease)
Source: Breast Disease - December 25, 2023 Category: Cancer & Oncology Authors: Solmaz Goldoost Habib Zarredar Milad Asadi Milad Shirvaliloo Mortaza Raeisi Source Type: research