3D Bioprinted Breast Tumors for Immunotherapy Testing
A team of scientists at Penn State has bioprinted breast tumor mimics with significant complexity, including a form of vascularization and the ability to precisely place cells in certain locations within the construct. The scientists used a technique called aspiration-assisted bioprinting to achieve this. With many anti-cancer therapies failing at the clinical trial stage and the ethical considerations of animal studies, there is a need for better in vitro cancer models that allow for advanced therapeutic testing. The models have allowed the researchers to test advanced therapies, including CAR-T immune cell therapies....
Source: Medgadget - October 27, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Oncology Source Type: blogs

What is pericardial effusion – Cardiology Basics
What is pericardial effusion – Cardiology Basics Pericardial effusion is collection of fluid between the visceral and parietal layers of the pericardium. If the amount of pericardial fluid is large or there is a rapid increase in the amount of pericardial fluid, compression of the heart prevents its proper filling. This reduces cardiac output and causes hypotension and is known as cardiac tamponade. Cardiac tamponade needs urgent pericardial aspiration or surgical drainage if the fluid is very thick. Very thick fluid can be there in purulent bacterial pericarditis. Sometimes it can be a hemopericardium due to bleedin...
Source: Cardiophile MD - October 24, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Weekly Overseas Health IT Links – 22nd October, 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment-----https://mhealthintelligence.com/news/partnership-to-add-virtual-primary-care-feature-to-smart-tvsPartnership to Add Virtual Primary Care Feature to Smart TVsTelehealth provider HealthTap has partnered with Samsung to add a virtual healthcare feature to the tech giant ' s Smart TVs to expand access to primary care.ByMark MelchionnaOctober 14, 2022 - Aiming to ...
Source: Australian Health Information Technology - October 22, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

AI and Multispectral Photoacoustic Imaging to Diagnose Thyroid Cancer
This study is significant in that it is the first to acquire photoacoustic images of thyroid nodules and classify malignant nodules using machine learning,” said Chulhong Kim, a researcher involved in the study, in a Pohang press release. “In addition to minimizing unnecessary biopsies in thyroid cancer patients, this technique can also be applied to a variety of other cancers, including breast cancer.” “The ultrasonic device based on photoacoustic imaging will be helpful in effectively diagnosing thyroid cancer commonly found during health checkups and in reducing the number of biopsies,” ...
Source: Medgadget - July 13, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Oncology Radiology Source Type: blogs

Off Our Chests: No Secrets Left Behind
By CHADI NABHAN She was a successful corporate lawyer turned professional volunteer and a housewife. He was a charismatic, successful, and world-renowned researcher in gastrointestinal oncology. He was jealous of all breast cancer research funding and had declared that disease his nemesis. They were married; life was becoming a routine, and borderline predictable. Both appeared to have lost some appreciation of each other and their sacrifices. Then, she saw a lump, and was diagnosed with breast cancer. Not any breast cancer, but triple negative breast cancer. The kind that is aggressive and potentially lethal. ...
Source: The Health Care Blog - May 27, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Patients Physicians Book Review Breast cancer Chadi Nabhan illness narratives John Marshall Liza Marshall Off Our Chests triple negative breast cancer Source Type: blogs

Terrified of needles? That can affect your health
No one likes getting stuck by a needle. Whether for a blood test, vaccination, or blood donation, needle sticks are something most people would prefer to avoid. Yet, judging only by schedules for routine vaccinations and tests, the average healthy person can expect at least 165 needle sticks over a lifetime. Get hospitalized? That might add dozens or even hundreds more. And the number of needle sticks experienced by people with diabetes, HIV, and some other illnesses hovers in the “don’t ask” range. For many, this may be more of an annoyance than a real problem. But if you have a strong fear of needles or aversion to...
Source: Harvard Health Blog - April 27, 2021 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Anxiety and Depression Behavioral Health Coronavirus and COVID-19 Source Type: blogs

Do hair dyes increase cancer risk?
This study also had several limitations. First, participants were female nurses of mostly European descent, meaning the findings are not necessarily generalizable to men or to other racial or ethnic groups. Next, the study could not account for every single cancer risk factor (for example, exposure to pesticides and other environmental chemicals). Data were not collected on other hair grooming products beyond hair dyes, and subjects may have mistakenly reported use of permanent hair dyes when they were in fact using semi-permanent or natural dyes. Without data on actual color of hair dyes used, the authors assumed that hai...
Source: Harvard Health Blog - January 20, 2021 Category: Consumer Health News Authors: Shinjita Das, MD Tags: Cancer Skin and Hair Care Source Type: blogs

Hologic Releases SuperSonic MACH 40 Breast Ultrasound in U.S.
Hologic is launching in the U.S. its first cart-based breast ultrasound system, the SuperSonic MACH 40. The company touts the device as a premium ultrasound that produces high fidelity images and features a number of capabilities that improve clinical efficiency and diagnostic accuracy. Some of these features include ShearWave PLUS elastography, which produces a real-time color map of tissue stiffness as the transducer is moved across the breast, and Angio PLUS imaging, an ultrasensitive Doppler mode for tracking blood flow within microvessels. TriVu imaging is an interesting imaging mode that provides a look at mor...
Source: Medgadget - July 10, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Ob/Gyn Oncology Radiology Source Type: blogs

The Itchy, Bumpy Blues: How to Treat and Prevent Mosquito Bites and Related Conditions
Mosquito bites may be a nuisance, but fortunately, in the U.S., they tend to amount to nothing more than that. Upon being bitten, most Americans experience a bit of swelling and itchiness, and nothing more. However, there are exceptions to this, including stronger allergic reactions to bites and cases of mosquito-borne illness.  Insect and arachnid bites, including ticks, account for approximately 2,000 cases of malaria and 30,000 cases of Lyme disease in the U.S. annually. In addition, millions of people worldwide die of malaria each year. It is helpful to protect yourself against insect bites, not only to avoid pesk...
Source: Conversations with Dr Greene - June 7, 2020 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog Environmental Health Insect Bites & Stings Insects & Animals Outdoor Safety Source Type: blogs

Hope as a Source of Healing
Hope is a concept that has come up often in my therapy practice. Some have been on the verge of graduating high school and entering college and like many have received several thumbs up and are still waiting for that cherished letter of acceptance from a few more. Their hope is that they get into the “right” school that has all of the educational and social components desired. In the meantime, anxiety visits daily with the mantra “what if?” chanting repetitiously. Others have been long-married in admittedly dysfunctional relationships. They express frustration and a sense of helplessness with their situations. As ...
Source: World of Psychology - March 1, 2020 Category: Psychiatry & Psychology Authors: Edie Weinstein, MSW, LSW Tags: Grief and Loss Motivation and Inspiration Perfectionism Personal anxiety change Failure grieving hope Worry Source Type: blogs

Insights on Feeding and Swallowing Differences for Infants with Cleft Palate/Cleft Lip and Palate
Infants with cleft palate or cleft lip and palate (CP/CLP) have specific feeding needs based upon unique anatomy and swallow physiology. Poor or absent inner oral pressure and compensatory muscle movements affect all phases—oral, pharyngeal, and esophageal—of swallowing, and in some cases, increase risk of aspiration. These babies expend a significant amount of energy in the act of feeding. They demonstrate an average rate of 109.26 sucks per minute compared to infants without clefts who averaged 75.07 sucks per minute. Increased energy expenditure might lead to fatigue. Under these conditions, infants experience chall...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - December 23, 2019 Category: Speech-Language Pathology Authors: Allyson Goodwyn-Craine Tags: Health Care Private Practice Slider Speech-Language Pathology Dysphagia Early Intervention Feeding Disorders Swallowing Disorders Source Type: blogs

RSNA 2019 AI Round-Up
Shah Islam Hugh Harvey By HUGH HARVEY, MBBS and SHAH ISLAM, MBBS AI in medical imaging entered the consciousness of radiologists just a few years ago, notably peaking in 2016 when Geoffrey Hinton declared radiologists’ time was up, swiftly followed by the first AI startups booking exhibiting booths at RSNA. Three years on, the sheer number and scale of AI-focussed offerings has gathered significant pace, so much so that this year a decision was made by the RSNA organising committee to move the ever-growing AI showcase to a new space located in the lower level of the North Hall. In some ways it made sense to offe...
Source: The Health Care Blog - December 10, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Artificial Intelligence Health Tech Start-Ups AI Hugh Harvey Radiology RSNA RSNA 2019 RSNA19 Shah Islam Source Type: blogs

Fight Aging! Newsletter, August 19th 2019
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - August 18, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, April 15th 2019
In this study, we found that senescent chondrocytes isolated from OA patients secrete more EVs compared with nonsenescent chondrocytes. These EVs inhibit cartilage ECM deposition by healthy chondrocytes and can induce a senescent state in nearby cells. We profiled the miR and protein content of EVs isolated from the synovial fluid of OA joints from mice with SnCs. After treatment with a molecule to remove SnCs, termed a senolytic, the composition of EV-associated miR and protein was markedly altered. The senolytic reduced OA development and enhanced chondrogenesis, and these were attributable to several specific differenti...
Source: Fight Aging! - April 14, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs