Fight Aging! Newsletter, October 24th 2022
This study shows the uncoupling of lifespan and healthspan parameters (aerobic fitness and spontaneous activity) and provides new insights into SIRT3 function in CR adaptation, fuel utilization, and aging.
HDL Level, Age, and Smoking are the Largest Determinants of Mortality Risk in Old People
https://www.fightaging.org/archives/2022/10/hdl-level-age-and-smoking-are-the-largest-determinants-of-mortality-risk-in-old-people/
An interesting epidemiological study here stratifies the contributions of various metrics to mortality in later life, age 70 and older. The authors find that the largest effects arise...
Source: Fight Aging! - October 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Notes from the Rejuvenation Startup Summit, Held in Berlin in October 2022
We presented recent results showing reversal of liver inflammation and fibrosis in NASH model mice, and noted that we're raising funds to start our clinical development program leading to human trials. Therapies to reverse atherosclerosis progression will follow shortly on the heels of this work on NASH.
Robin Mansukhani of Deciduous Therapeutics discussed their approach to immune system modulation via small molecules, training invariant natural killer cells to attack senescent cells. The point was made that engaging the immune system may be a way to work around many of the present unknowns regarding senescent cell ...
Source: Fight Aging! - October 19, 2022 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Delivering real choice: the future of breast reconstruction in England
Breast Cancer Now - For those who choose it, breast reconstruction is a vital part of recovery from breast cancer or risk reducing surgery. However, this report reveals that too often, access and choice is being denied - making it harder for people to rebuild their lives. Breast Cancer Now is calling on NHS England to work in partnership with them, the Association of Breast Surgery (ABS) and the British Association of Plastic Reconstructive and Aesthetic Surgeons (BAPRAS) to develop a practical plan for breast reconstruction services that addresses the backlog, removes barriers and ensures timely and fair access to r...
Source: Health Management Specialist Library - October 19, 2022 Category: UK Health Authors: The King ' s Fund Library Tags: Patient involvement, experience and feedback Source Type: blogs
An Update on Senolytics Company Cleara Biotech
Senescent cells accumulate with age, and that accumulation is responsible for a meaningful fraction of degenerative aging. Many groups are working on ways to remove these cells and thereby reverse aspects of aging. Among their number, Cleara Biotech was founded four years ago on to advance initially promising work on the FOXO4-p53 interaction in cellular senescence, a possible targeted way to destroy senescent cells. This approach will join the numerous other mechanisms already being exploited as the basis for potential rejuvenation therapies.
A couple of companies have been looking into FOXO4 biochemistry in the co...
Source: Fight Aging! - October 17, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 17th 2022
This study investigated whether multimorbidity is associated with incident dementia and whether associations vary by different clusters of disease and genetic risk for dementia. The study used data from the UK Biobank cohort, with baseline data collected between 2006 and 2010 and with up to 15 years of follow-up. Participants included women and men without dementia and aged at least 60 years at baseline. The presence of at least 2 long-term conditions from a preselected list of 42 conditions was used to define multimorbidity.
A total of 206,960 participants (mean age 64.1 years) were included in the final sample, of...
Source: Fight Aging! - October 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cancers Force T Cells into Senescence
We report that both mouse malignant tumor cells and regulatory T cells (Tregs) can induce responder T cell senescence, similar as shown in human Treg and tumor cells. Accumulated senescent T cells also exist in the TME in tumor models of lung cancer, breast cancer, and melanoma. Induction of ataxia-telangiectasia mutated protein (ATM)-associated DNA damage is the cause for T cell senescence induced by both mouse tumor cells and Treg cells, which is also regulated by mitogen-activated protein kinase (MAPK) signaling.
Furthermore, blockages of ATM-associated DNA damage and/or MAPK signaling pathways in T cells can pre...
Source: Fight Aging! - October 13, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
TLC Todd-versations: Todd Linsky in Conversation with Dr. Alan Greene
Todd Linsky, a food and organic industry veteran, hosts the podcast Todd-versations. He interviews guests from around the globe — influencers, leaders, and innovators in their respective fields. In this episode, Todd and Dr. Greene discuss the pediatric roots of longevity, the importance of nutrition in health, Dr. Greene’s reasons for creating DrGreene.com, his next projects, and a whole host of side topics.
Transcript of Todd-versation Podcast with Todd Linsky and Dr. Greene
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this conversation is brought to you in part by Calavo Growers the family of fresh!
0:19
hey there everybody good ...
Source: Conversations with Dr Greene - October 6, 2022 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog Source Type: blogs
Weekly Australian Health IT Links – 03 October, 2022.
Here are a few I have come across the last week or so. Note: Each link is followed by a title and a few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.General Comment-----Sorry, I had to include this! I am really amazed at the International reach we see from the ADHA – true international citizens!Otherwise too much Optus and not enough good news!-----https://www.financialexpress.com/healthcare/tamil-nadu-keen-on-australian-model-for-beefing-up-digital-healthcare-platform-looks-for-partnerships/26...
Source: Australian Health Information Technology - October 3, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
4AM Night
It’s 4 AM. The hospital—once a lively and bustling place with residents responding to codes, nurses checking vitals, physical therapists helping patients walk—is now deadly silent. I stare out of the window into the darkness. Its eerily quiet. I think to myself, only 3 more hours until I am done with my night shift and get to crawl into bed. I am counting the hours.
My phone beeps and I look down. It’s a message from my resident. “New admit in the ED with SOB. Interview the patient and present to me.”
I chart and read about her history. She has breast cancer with extensive chemo and radiotherapy. I think ...
Source: Academic Medicine Blog - September 21, 2022 Category: Universities & Medical Training Authors: Laura Siegel Source Type: blogs
Weekly Overseas Health IT Links –3rd September, 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment-----https://healthitanalytics.com/news/machine-learning-tools-predict-post-op-complications-surgery-durationMachine-Learning Tools Predict Post-Op Complications, Surgery DurationResearchers from Washington University in St. Louis have developed machine-learning tools that can predict post-operative complications and surgery duration using perioperative data.ByShania K...
Source: Australian Health Information Technology - September 3, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Hippocrates is crying
My sister didn’t want to die from breast cancer. In the six years since her diagnosis of stage 4 breast cancer, she fought valiantly to stay healthy and to continue to live. A superb oncologist put her cancer into complete remission, which lasted for some time before it reappeared in distant lymph nodes but not
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Hippocrates is crying originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 30, 2022 Category: General Medicine Authors: Sydney Lou Bonnick, MD Tags: Physician Critical Care Source Type: blogs
Intelerad Acquires PenRad Technologies, Inc., Expanding Breast Imaging and Lung Screening Capabilities
The new deal will secure expanded access to essential solutions that will help ensure radiologists, technologists and other healthcare professionals can drive greater productivity and meet higher oncology screening demand, while improving patient care
Intelerad Medical Systems™, a leading global provider of enterprise medical imaging solutions, today announced its acquisition of PenRad Technologies, Inc. (PenRad), a software provider for enhancing productivity for breast imaging and lung screening. The acquisition will expand Intelerad’s product offerings for mammography and lung analytics, optimizing workflows for rad...
Source: EMR and HIPAA - August 26, 2022 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Cancer Screenings Greg Gustafson Health IT Acquisitions Healthcare M&A Intelerad Lung Screening Mammograms Medical Imaging Mike Lipps PenRad Source Type: blogs
Hackers, Breaches And The Value Of Health Data: 2022 E-Book Update
As solutions like remote care are becoming the norm, 3D printing disrupts the normal supply chain and the number of life science studies on tools like artificial intelligence (A.I.) skyrocket, it’s become clear that we are not anticipating the digital health era; we are in the digital health era. This was to come sooner or later, but the pandemic accelerated the process by years.
However, along with the enhanced healthcare landscape that digital health brings along, there is the pressing issue of privacy. To put it bluntly, there is no digital health without sacrificing a part of our privacy. The advanced techno...
Source: The Medical Futurist - August 11, 2022 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: Covid-19 Digital Health Research E-Patients Future of Medicine Future of Pharma Genomics Health Sensors & Trackers Healthcare Design Healthcare Policy Personalized Medicine Security & Privacy Telemedicine & Smartphones amazon dev Source Type: blogs
Closing the Gender Health Gap: How Digital Technology Can Support Better Women ’s Health
The following is a guest article by Juliet Bauer, Chief Growth and Marketing Officer at Livi
I’m often asked where I believe digital technology can make the biggest impact in healthcare. My answer? Women’s health. Today, women spend around a quarter of their lives in poor health or disability, compared with one fifth for men. In a health system that has historically been geared towards men, a gender health gap persists where you are more likely to receive poorer medical advice and diagnosis if you are a woman.
When I look at that gap, I see a key space for digital healthcare in helping us overcome many of the obstacles...
Source: EMR and HIPAA - August 8, 2022 Category: Information Technology Authors: Guest Author Tags: Ambulatory Communication and Patient Experience Healthcare IT Hospital - Health System Digital Technology FemTech Healthcare Discrimination Juliet Bauer Livi UK Health IT Women's Health Source Type: blogs
A breast cancer story from an Asian perspective [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! “I was first diagnosed with stage 1 breast cancer, DCIS (ductal carcinoma in situ), on May 15, 2015, at 41 years old. I had my annual exam with my gynecologist and told him I felt a small, pea-sized lump under my right armpit close
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A breast cancer story from an Asian perspective [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 3, 2022 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Oncology/Hematology Source Type: blogs