New Data on US Opioid Overdose Deaths New Data on US Opioid Overdose Deaths
Overdose deaths involving prescription opioids and heroin declined from 2017 to 2018, while deaths involving synthetic opioids increased, according to the latest federal data.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - March 19, 2020 Category: Neurology Tags: Psychiatry News Source Type: news

Drug Trials Snapshots: LUTATHERA
For the treatment of somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs) (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - March 19, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Brain-boosting berberine: Study shows it reduces likelihood of Alzheimer's disease
(Natural News) Berberine is a naturally occurring compound found in the plants that belong to the genus Berberis. Today, it is used as a supplement and is known to provide a wide variety of health benefits, including weight loss, reduced blood sugar and improved heart health. But recently, researchers from Hong Kong and Macau found... (Source: NaturalNews.com)
Source: NaturalNews.com - March 19, 2020 Category: Consumer Health News Source Type: news

"Hero" Proteins May Shield Other Proteins from Harm
Flexible proteins appear to protect molecules from becoming denatured in extreme conditions such as heat and from clumping up, as happens in some neurodegenerative diseases. (Source: The Scientist)
Source: The Scientist - March 19, 2020 Category: Science Tags: News & Opinion Source Type: news

Researchers find key to keep working memory working
Yale researchers ’ discovery of a key molecule in the brain could lead to potential treatments for neurocognitive disorders like schizophrenia and Alzheimer’s. (Source: Yale Science and Health News)
Source: Yale Science and Health News - March 19, 2020 Category: Universities & Medical Training Source Type: news

Sports Concussion Recovery May Be Slower Than Thought
THURSDAY, March 19, 2020 -- Less than half of patients with sports-related mild traumatic brain injury (SR-mTBI) achieve clinical recovery within two weeks after injury, according to a study published in the March issue of the Clinical Journal of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 19, 2020 Category: Pharmaceuticals Source Type: news

Plasma exosome-derived microRNAs as novel biomarkers of traumatic brain injury in rats - Wang P, Ma H, Zhang Y, Zeng R, Yu J, Liu R, Jin X, Zhao Y.
Traumatic brain injury (TBI) is a widespread central nervous system (CNS) condition and a leading cause of death, disability, and long-term disability including seizures and emotional and behavioral issues. To date, applicable diagnostic biomarkers have no... (Source: SafetyLit)
Source: SafetyLit - March 19, 2020 Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news

Substance use on admission toxicology screen is associated with peri-injury factors and six-month outcome after traumatic brain injury: a TRACK-TBI pilot study - Yue JK, Phelps RRL, Winkler EA, Deng H, Upadhyayula PS, Vassar MJ, Madhok DY, Schnyer DM, Puccio AM, Lingsma HF, Yuh EL, Mukherjee P, Valadka AB, Okonkwo DO, Manley GT.
Substance use is commonly associated with traumatic brain injury (TBI). We investigate associations between active substance use, peri-injury factors, and outcome after TBI across three U.S. Level I trauma centers. TBI subjects from the prospective Transfo... (Source: SafetyLit)
Source: SafetyLit - March 19, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

PTSD, but not history of mTBI, is associated with altered myelin in combat-exposed Iraq and Afghanistan Veterans - Jak AJ, Jurick S, Hoffman S, Evangelista ND, DeFord N, Keller A, Merritt VC, Sanderson-Cimino M, Sorg S, Delano-Wood L, Bangen KJ.
Objective: To investigate the biological, cognitive, and psychological presentations of combat-exposed Veterans with a history of mild traumatic brain injury (mTBI) and/or posttraumatic stress disorder (PTSD) using a novel white matter imaging techn... (Source: SafetyLit)
Source: SafetyLit - March 19, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

New ischemic lesions on brain MRI in patients with blunt traumatic cerebrovascular injury - Harrigan MR, Griffin RL, Deveikis JP, Prattipati V, Chimowitz MI, Jansen JO.
BACKGROUND: Patients with blunt cerebrovascular injuries (BCVI) are at risk of thromboembolic stroke. Although primary prevention with antithrombotic therapy is widely used in this setting, its effectiveness is not well defined, and requires further invest... (Source: SafetyLit)
Source: SafetyLit - March 19, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Estimating the epidemiology of mild traumatic brain injury in France from case mix of emergency departments - Manitchoko L, Bourdin V, Azouvi P, Hellmann R, Josseran L.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - March 19, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Comparison of care system and treatment approaches for patients with Traumatic Brain Injury in China versus Europe: a CENTER-TBI survey study - Feng JF, van Veen E, Yang C, Huijben JA, Lingsma HF, Gao GY, Jiang J, Maas A.
TBI poses a huge public health and societal problem worldwide. Uncertainty exists on how care system and treatment approaches for TBI worked in China may differ from those in Europe. Better knowledge on this is important to facilitate interpretation of fin... (Source: SafetyLit)
Source: SafetyLit - March 19, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

The Canadian High-Resolution Traumatic Brain Injury (CAHR-TBI) Research Collaborative - Bernard F, Gallagher C, Griesdale D, Kramer A, Sekhon M, Zeiler FA.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - March 19, 2020 Category: International Medicine & Public Health Tags: Commentary Source Type: news

A multicenter look at multidisciplinary youth concussion/mild traumatic brain injury programs: the Four Corners Youth Consortium (4CYC) - Choe MC, Rosenbaum P, Rivara FP, Gioia GA, Giza CC.
Over 3.8 million sport-related concussions (SRCs)/mild traumatic brain injuries (mTBIs) occur annually, and approximately half a million children are seen in the emergency department setting each year.1 Recreational activities, particularly contact spo... (Source: SafetyLit)
Source: SafetyLit - March 19, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Craniofacial and neck burns in the pediatric population - Othman S, Sethi HK, Cohn JE, Shokri T, Davis WJ.
INTRODUCTION: Burn injuries can present with catastrophic physical and psychiatric harm with extensive, long-term sequelae. The pediatric population may especially be at-risk given this population's early neurocognitive and behavioral state of development.... (Source: SafetyLit)
Source: SafetyLit - March 19, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

10 Years Later, Obamacare ’s Complicated Legacy Still Shapes the Nation
Maurine Stuart credits the Affordable Care Act (ACA) for saving her family. In 2014, Stuart was diagnosed with HELLP syndrome, a rare disease that causes heart, liver and lymphatic problems. As a result, she was unable to continue working full time—which meant losing her employer-sponsored health insurance. But thankfully, she says, that same year, her home state of West Virginia opted in to the 2010 Affordable Care Act’s Medicaid-coverage expansion, and she qualified. Over the next few years, as bad news kept rolling in, ACA protections continued to keep Stuart’s family afloat. When Stuart was diagnosed ...
Source: TIME: Health - March 19, 2020 Category: Consumer Health News Authors: Abigail Abrams Tags: Uncategorized Source Type: news

Early Self-Directed Home Exercise Program After ACDF Early Self-Directed Home Exercise Program After ACDF
How might an early self-directed home exercise program impact outcomes after ACDF surgery?Spine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 19, 2020 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

7T MRI sheds new light on risks associated with stroke
Using 7-tesla MRI, Dutch researchers have identified the three most influential...Read more on AuntMinnie.comRelated Reading: 7T MRI finds promising MS biomarker 7T MRI opens door to detailed brain images 7T MRI warrants its own set of safety guidelines 7T MRI shows path to MS progression 7T finds epilepsy abnormalities missed at lower field strengths (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 19, 2020 Category: Radiology Source Type: news

ORION: Inclisiran Phase 3 Trials Published ORION: Inclisiran Phase 3 Trials Published
Three phase 3 trials of the novel RNA agent have been published, all showing an approximate halving of LDL cholesterol levels with the drug, which is given just twice a year by subcutaneous injection.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - March 19, 2020 Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news

New contrast agent for early diagnosis of brain metastases
(Forschungsverbund Berlin) A group of researchers led by Leif Schroeder from the Leibniz-Forschungsinstitut fuer Molekulare Pharmakologie (FMP) have found a way to detect metastases in certain types of cancer in the brain at an early stage, using only minimal amounts of contrast agent. To this end, the team uses a synthetic molecule that helps to detect the formation of new blood vessels, producing much more sophisticated imaging than is possible with conventional methods of diagnosis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 19, 2020 Category: Cancer & Oncology Source Type: news

High-speed microscope captures fleeting brain signals
(University of California - Berkeley) UC Berkeley neuroscientists can now capture millisecond electrical changes in neurons in the cortex of an alert mouse, allowing tracing of neural signals, including subthreshold events, in the brain. The new technique combines all-optical scanning with two-photon fluorescence imaging to produce a 2D rasterized picture every 1,000-3,000 milliseconds. That and another technique that allows 3D imaging of large areas of the mouse cortex to a depth of 650 microns will aid study of neural circuits. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 19, 2020 Category: International Medicine & Public Health Source Type: news

Researchers find brain cell that triggers tremor and how to control it
(Baylor College of Medicine) Researchers have improved our understanding of how tremor -- the most common movement disorder -- happens, opening the possibility of novel therapies for this condition. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 19, 2020 Category: International Medicine & Public Health Source Type: news

Ritalin and similar medications cause brain to focus on benefits of work, not costs
(Brown University) New research from cognitive neuroscientists at Brown and Radboud universities has pinpointed how stimulants such as Ritalin and Adderall can change people's motivation to complete difficult tasks. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - March 19, 2020 Category: International Medicine & Public Health Source Type: news

Special issue of 'Neurochemical Research' honors Vittorio Gallo, Ph.D.
(Children's National Hospital) Investigators from around the world penned manuscripts that were assembled in a special issue of 'Neurochemical Research' that honors Vittorio Gallo, Ph.D., for his leadership in the field of neural development and regeneration. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 19, 2020 Category: International Medicine & Public Health Source Type: news

Neuroscience conference avoids cancellation by taking place online
(Aalto University) The OHBMX conference takes place online, giving it a low carbon footprint and making it perfect for allowing collaboration while following social distancing rules. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 19, 2020 Category: International Medicine & Public Health Source Type: news

New brain disorder discovery
(Murdoch Childrens Research Institute) A study has uncovered a new neurodegenerative disorder in which children experience developmental regression and severe epilepsy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 19, 2020 Category: International Medicine & Public Health Source Type: news

Action needed to cut stillbirth, baby death and brain injury
Report highlights complex clinical and non-clinical factors for maternity teams to address Related items fromOnMedica C-section death rates highest in low-income countries Maternal stress affects baby ’s brain development Antiseptic prevents deaths in newborns Midwives demand ‘equivalence’ in prison perinatal care Has austerity reversed decline in infant mortality? (Source: OnMedica Latest News)
Source: OnMedica Latest News - March 19, 2020 Category: UK Health Source Type: news

Sex differentiation in the human social brain
(Source: ScienceNOW)
Source: ScienceNOW - March 19, 2020 Category: Science Authors: LaBar, K. S. Tags: twis Source Type: news

Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals
The structural and functional complexity of multicellular biological systems, such as the brain, are beyond the reach of human design or assembly capabilities. Cells in living organisms may be recruited to construct synthetic materials or structures if treated as anatomically defined compartments for specific chemistry, harnessing biology for the assembly of complex functional structures. By integrating engineered-enzyme targeting and polymer chemistry, we genetically instructed specific living neurons to guide chemical synthesis of electrically functional (conductive or insulating) polymers at the plasma membrane. Electro...
Source: ScienceNOW - March 19, 2020 Category: Science Authors: Liu, J., Kim, Y. S., Richardson, C. E., Tom, A., Ramakrishnan, C., Birey, F., Katsumata, T., Chen, S., Wang, C., Wang, X., Joubert, L.-M., Jiang, Y., Wang, H., Fenno, L. E., Tok, J. B.- H., Pasca, S. P., Shen, K., Bao, Z., Deisseroth, K. Tags: Engineering reports Source Type: news

The genetic architecture of the human cerebral cortex
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal...
Source: ScienceNOW - March 19, 2020 Category: Science Authors: Grasby, K. L., Jahanshad, N., Painter, J. N., Colodro-Conde, L., Bralten, J., Hibar, D. P., Lind, P. A., Pizzagalli, F., Ching, C. R. K., McMahon, M. A. B., Shatokhina, N., Zsembik, L. C. P., Thomopoulos, S. I., Zhu, A. H., Strike, L. T., Agartz, I., Alhu Tags: Genetics, Online Only r-articles Source Type: news

Neuron-targeted electrical modulation
(Source: ScienceNOW)
Source: ScienceNOW - March 19, 2020 Category: Science Authors: Otto, K. J., Schmidt, C. E. Tags: perspective Source Type: news

Is it worth the effort?
(Source: ScienceNOW)
Source: ScienceNOW - March 19, 2020 Category: Science Authors: Janes, A. C. Tags: Neuroscience perspective Source Type: news

Responsible use of psychostimulants
(Source: ScienceNOW)
Source: ScienceNOW - March 19, 2020 Category: Science Authors: Stern, P. Tags: Neuroscience, Psychology twis Source Type: news

Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work
Stimulants such as methylphenidate are increasingly used for cognitive enhancement but precise mechanisms are unknown. We found that methylphenidate boosts willingness to expend cognitive effort by altering the benefit-to-cost ratio of cognitive work. Willingness to expend effort was greater for participants with higher striatal dopamine synthesis capacity, whereas methylphenidate and sulpiride, a selective D2 receptor antagonist, increased cognitive motivation more for participants with lower synthesis capacity. A sequential sampling model informed by momentary gaze revealed that decisions to expend effort are related to ...
Source: ScienceNOW - March 19, 2020 Category: Science Authors: Westbrook, A., van den Bosch, R., Määttä, J. I., Hofmans, L., Papadopetraki, D., Cools, R., Frank, M. J. Tags: Neuroscience, Psychology reports Source Type: news

Top neuroscientist leaving Mexican university
(Source: ScienceNOW)
Source: ScienceNOW - March 19, 2020 Category: Science Authors: Gutierrez, I., Service, R. Tags: Latin American News, Scientific Community In Depth Source Type: news

Surgery Cuts Chronic Sciatica Pain vs Conservative Treatment Surgery Cuts Chronic Sciatica Pain vs Conservative Treatment
Surgery is superior to conservative treatment for chronic sciatica caused by lumbar disc herniation.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - March 18, 2020 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Forensic nursing examination to screen for traumatic brain injury following intimate partner violence - Ralston B, Rable J, Larson T, Handmaker H, Lifshitz J.
Intimate partner violence (IPV) causes harm to an estimated 42 million victims each year. Routine forensic examination excludes specific evaluation of traumatic brain injury (TBI), thereby missing an opportunity to diagnose and offer treatment. This qualit... (Source: SafetyLit)
Source: SafetyLit - March 18, 2020 Category: International Medicine & Public Health Tags: Risk Factor Prevalence, Injury Occurrence Source Type: news

Rethinking traumatic brain injury from intimate partner violence: a theoretical model of the cycle of transmission - Ivany AS, Schminkey D.
Despite growing evidence of the repeated nature of traumatic brain injury (TBI) in women experiencing intimate partner violence (IPV), there is no theoretical model depicting TBIs as a cyclical process throughout a lifetime. Situational analysis methodolog... (Source: SafetyLit)
Source: SafetyLit - March 18, 2020 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Traumatic brain injury in victims of domestic violence - Lifshitz J, Crabtree-Nelson S, Kozlowski DA.
The article serves as the introduction to a special issue of the journal focused on traumatic brain injury in the context of domestic and intimate partner violence. The scope of the problem is enormous, where upwards of 90% of all individuals with a histor... (Source: SafetyLit)
Source: SafetyLit - March 18, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Traumatic brain injury within domestic relationships: complications, consequences and contributing factors - Baxter K, Hellewell SC.
Traumatic brain injury (TBI) resulting from episodes of domestic violence (DV) is a serious yet greatly underreported issue. Head injuries arising in these circumstances are often concussive or sub-concussive in nature, and are unlikely to be isolated inci... (Source: SafetyLit)
Source: SafetyLit - March 18, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

The effect of intimate partner violence and probable traumatic brain injury on mental health outcomes for Black women - Cimino AN, Yi G, Patch M, Alter Y, Campbell JC, Gundersen KK, Tang JT, Tsuyuki K, Stockman JK.
Severe intimate partner violence (IPV) including loss of consciousness from head injuries and/or strangulation can result in traumatic brain injury (TBI), a brain pathology characterized by altered brain function, cognitive impairment, and mental health di... (Source: SafetyLit)
Source: SafetyLit - March 18, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Restoring more than smiles in broken homes: dental and oral biomarkers of brain injury in domestic violence - Ellis TW, Brownstein S, Beitchman K, Lifshitz J.
While much of the focus on brain injury has centered on athletes and military veterans, victims of domestic violence (DV) comprise an under-represented cohort. Epidemiological studies show that a majority of domestic violence cases have a history of trauma... (Source: SafetyLit)
Source: SafetyLit - March 18, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Provider perceptions and domestic violence (DV) survivor experiences of traumatic and anoxic-hypoxic brain injury: implications for DV advocacy service provision - Nemeth JM, Mengo C, Kulow E, Brown A, Ramirez R.
This study characterized: 1) provider perception of the impact of BI on DV survivors' experiences with advocacy se... (Source: SafetyLit)
Source: SafetyLit - March 18, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Intimate partner violence (IPV) and neurological outcomes: a review for practitioners - Monahan K.
Thirty-eight million women will experience intimate partner violence (IPV) during the course of their lifetime. Many of these women will experience brain injuries as a result of IPV and may not seek medical attention. Several types of practitioners who wor... (Source: SafetyLit)
Source: SafetyLit - March 18, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Exploring the use of neurofeedback therapy in mitigating symptoms of traumatic brain injury in survivors of intimate partner violence - Brown J, Clark D, Pooley AE.
Traumatic Brain Injury (TBI) is an injury to the brain caused by an acute injury to the head, neck, or face, such as a blunt force trauma. Survivors of Intimate Partner Violence (IPV) are at high risk for TBI, given how frequently they are repeatedly struc... (Source: SafetyLit)
Source: SafetyLit - March 18, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Exploring correlates of probable traumatic brain injury among intimate partner violence survivors - Hunnicutt G, Murray C, Lundgren K, Crowe A, Olson L.
Although intimate partner violence (IPV) related (TBI) is increasingly recognized as an important area of concern, there is no existing research that seeks to identify correlates of IPV related TBI. Given the profound consequences of TBI, it is important t... (Source: SafetyLit)
Source: SafetyLit - March 18, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Correlates of brain injuries in women subjected to intimate partner violence: identifying the dangers and raising awareness - Valera EM, Campbell J, Gill J, Iverson KM.
Awareness of the highly detrimental and long-term sequelae of brain injuries, and in particular repetitive mild traumatic brain injuries (mTBIs/concussions), has been rapidly growing. Specifically, there has been significant focus on repetitive mTBIs in ma... (Source: SafetyLit)
Source: SafetyLit - March 18, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Risk and protective factors for childhood suicidality: a US population-based study - Janiri D, Doucet GE, Pompili M, Sani G, Luna B, Brent DA, Frangou S.
We examined correlates of suicidality in a US population-based sample of children participating in the Adolescent Brain and Cognitive Development (ABCD) study. The ABCD study aim... (Source: SafetyLit)
Source: SafetyLit - March 18, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Coronavirus: Craig Ruston 'youngest UK death'
Craig Ruston, who had motor neurone disease, died on Monday morning in Kettering. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - March 18, 2020 Category: Consumer Health News Source Type: news

Neuromodulation: More Than a Placebo Effect? Neuromodulation: More Than a Placebo Effect?
Despite promising studies on the efficacy of neuromodulation for chronic pain, securing high-quality evidence faces many challenges. Where do we currently stand, and where do we need to go from here?Pain (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 18, 2020 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news