Notice of NICHD Withdrawal from Participation in PAR-24-043 "Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development of Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional)
Notice NOT-HD-24-005 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 22, 2024 Category: Research Source Type: funding
BRAIN Initiative: Scaled reagent resources for brain cell type-specific access across vertebrate species (U01 Clinical Trial Not Allowed)
Funding Opportunity RFA-MH-25-100 from the NIH Guide for Grants and Contracts. This BRAIN Initiative Notice of Funding Opportunity (NOFO) is to scale up efforts for viral, non-viral, transgenic, and gene regulatory element screening technologies and create reagent resources to access brain cell types. This NOFO is part of the BRAIN Initiative Armamentarium for Brain Cell Access transformative project. Reagent development efforts will apply gene transfer, gene regulation, genome engineering, activity sensor/effector, and atlasing technologies for use in both genetically tractable and less tractable systems, including pri...
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 20, 2024 Category: Research Source Type: funding
BRAIN Initiative: Production and distribution facilities for brain cell type-specific access reagents (U24 Clinical Trial Not Allowed)
Funding Opportunity RFA-MH-25-105 from the NIH Guide for Grants and Contracts. This BRAIN Initiative Notice of Funding Opportunity (NOFO) is to support scaled reagent production and distribution facilities involving technologies to access brain cell types. Facilities for production and distribution of these reagents by a broad and diverse set of neuroscientists will be encouraged. This NOFO is part of the BRAIN Initiative Armamentarium for Brain Cell Access transformative project. Efforts will be supported to produce and distribute gene transfer, gene regulation, and genome engineering reagents for use in both genetical...
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 20, 2024 Category: Research Source Type: funding
Development and Validation of Human Cellular Models for Alzheimer's Disease-Related Dementias (ADRD) (R01 - Clinical Trial Not Allowed)
Funding Opportunity RFA-NS-24-032 from the NIH Guide for Grants and Contracts. This NOFO would support development and validation of novel clinically- and/or pathophysiologically-relevant human cellular models of ADRD. The cellular model systems would be expected to capture the multi-faceted pathologies and multiple cell types observed in ADRDs. Validation includes internal, face, construct, and predictive (to the extent possible) validation. These models can be developed/validated with the goal of supporting therapy development or better understanding of human disease mechanisms and mechanisms that uncover predispositi...
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 16, 2024 Category: Research Source Type: funding
BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R21 Clinical Trial Optional)
Funding Opportunity RFA-MH-25-171 from the NIH Guide for Grants and Contracts. Guided by the goals established in BRAIN 2025: A Scientific Vision and reinforced by the Advisory Council to the Director Working Group on BRAIN 2.0 Neuroethics Subgroup, this Notice of Funding Opportunity (NOFO) from the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is intended to support efforts addressing core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements supported by the BRAIN Initiative. This NOFO encourages research proj...
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 15, 2024 Category: Research Source Type: funding
BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R01 Clinical Trial Optional)
Funding Opportunity RFA-MH-25-170 from the NIH Guide for Grants and Contracts. Guided by the goals established in BRAIN 2025: A Scientific Vision and reinforced by the Advisory Council to the Director Working Group on BRAIN 2.0 Neuroethics Subgroup, this Notice of Funding Opportunity (NOFO) from the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is intended to support efforts addressing core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements supported by the BRAIN Initiative. This NOFO encourages research proj...
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 15, 2024 Category: Research Source Type: funding
NINDS Research Education Programs for Residents and Fellows in Neurological Disorders and Stroke (UE5 - Clinical Trial Not Allowed)
Funding Opportunity PAR-24-079 from the NIH Guide for Grants and Contracts. The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this National Insitute of Neurological Disorders and Stroke R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs.To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on research experiences, designed to foster the devel...
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 14, 2024 Category: Research Source Type: funding
Notice of Change: Extension of PAR-21-163 Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (UG3/UH3)
Notice NOT-NS-24-049 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 13, 2024 Category: Research Source Type: funding
Open Measurement Coordinating Network for Non-Pharmacological Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) Primary Prevention Trials (U24 Clinical Trail Not Allowed)
Funding Opportunity RFA-AG-25-005 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites U24 Cooperative Agreement applications that propose to establish a national Open Measurement Coordinating Network for Non-Pharmacological Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) Primary Prevention Trials. The Network will serve as a centralized hub for developing, validating, standardizing, and disseminating measures and measurement methods for AD/ADRD primary prevention trials. It will incorporate measures and measurement methods across neuropsychological, biomarker, and func...
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 13, 2024 Category: Research Source Type: funding
NIH Director Statement on Catalyzing the Development of Novel Alternative Methods
This report, which the ACD enthusiastically endorsed and conveyed to the agency, recommended that NIH work with the community to:
Prioritize the development and use of combinatorial NAMs
Establish resources, infrastructure, and collaborations to promote the use of interoperable, reliable, and well curated/high quality datasets produced from research using NAMs
Promote effective dissemination and interconnection of NAM technologies
Invest in comprehensive training to bolster continuous advances in development and use of NAMs
Facilitate multidisciplinary teams with expertise across technologies and the lifecy...
Source: NIH Extramural Nexus - February 9, 2024 Category: Research Authors: Mike Lauer Tags: blog Open Mike Alternatives to Animals Animal Welfare rigor Source Type: funding
Notice of Change: Extension of PAR-21-153 "NINDS Faculty Development Award to Promote Diversity in Neuroscience Research (K01 Clinical Trial Required)"
Notice NOT-NS-24-039 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 8, 2024 Category: Research Source Type: funding
Notice of Change: Extension of PAR-21-233 "Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System U44"
Notice NOT-NS-24-050 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 8, 2024 Category: Research Source Type: funding
Investigating Distinct and Overlapping Mechanisms in TDP-43 Proteinopathies, including in LATE, FTD and other ADRDs (R01 - Clinical Trial Not Allowed)
Funding Opportunity PAR-24-148 from the NIH Guide for Grants and Contracts. This FOA would support establishing deeper mechanistic insight and causal relationships between TDP-43 pathology and phenotypic outcomes, as well as mechanistic interactions between TDP-43 and other co-pathologies, such TMEM106B. Additionally, it would include comparisons (including mechanistic, molecular, structural, cellular, genetic, -omic, anatomical, neuropathological, etc.) between TDP-43 proteinopathies, including LATE, with or without AD-NC, and FTD and/or ALS. (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 6, 2024 Category: Research Source Type: funding
Mechanistic Investigations into ADRD Multiple Etiology Dementias (R01 - Clinical Trial Not Allowed)
Funding Opportunity PAR-24-147 from the NIH Guide for Grants and Contracts. This NOFO would support investigations with a minimum of two relevant co-pathologies (e.g., tau, alpha-synuclein, TDP-43, TMEM106B, vascular), with optional risk factors and co-morbidities, to identify cellular and molecular mechanisms of how/why multi-proteinopathy interactions drive worsening neurodegenerative processes and phenotypic outcomes. Studies should examine co-pathology cellular and molecular interactions across brain regions and time in proximate cell population, across various intracellular dynamics and localization, and upstream a...
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 6, 2024 Category: Research Source Type: funding
Notice of Change to Award Budget for RFA-NS-24-014 "NIH Blueprint and BRAIN Initiative Program for Enhancing Neuroscience Diversity through Undergraduate Research Education Experiences (BP BRAIN-ENDURE) (R25 Clinical Trial Not Allowed)"
Notice NOT-NS-24-055 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 6, 2024 Category: Research Source Type: funding
