Accuracy of direct magnetic resonance imaging-guided placement of drug infusion cannulae.
Abstract
An intraoperative MRI (iMRI)-compatible system has been developed for direct placement of convection-enhanced delivery (CED) cannulae using real-time imaging. To establish the precision and feasibility of this technology, the authors analyzed findings in patients who underwent direct iMRI CED cannula placement. Three consecutive patients underwent iMRI-guided placement of CED infusion cannulae (6 cannulae) for treatment of diffuse intrinsic brainstem glioma (2 patients) or Parkinson's disease (1 patient). Convective infusion cannulae were guided to the target using the ClearPoint iMRI-based naviga...
Source: Journal of Neurosurgery - January 16, 2015 Category: Neurosurgery Authors: Chittiboina P, Heiss JD, Lonser RR Tags: J Neurosurg Source Type: research
Inhibition of Histone Demethylation May Be Effective in Pediatric Glioma [Glioma]
The H3K27 demethylase inhibitor GSKJ4 suppresses H3.3 K27M–mutant pediatric brainstem glioma growth. (Source: Cancer Discovery)
Source: Cancer Discovery - January 11, 2015 Category: Cancer & Oncology Tags: Glioma Source Type: research
A phase 1 and pharmacokinetic study of enzastaurin in pediatric patients with refractory primary central nervous system tumors: a pediatric brain tumor consortium study
Conclusion
Enzastaurin was well tolerated in children with recurrent CNS malignancies, with chromaturia, fatigue, anemia, thrombocytopenia, and nausea being the most common toxicities. The recommended phase 2 dose is 440 mg/m2/day administered once daily. (Source: Neuro-Oncology)
Source: Neuro-Oncology - January 9, 2015 Category: Cancer & Oncology Authors: Kilburn, L. B., Kocak, M., Decker, R. L., Wetmore, C., Chintagumpala, M., Su, J., Goldman, S., Banerjee, A., Gilbertson, R., Fouladi, M., Kun, L., Boyett, J. M., Blaney, S. M. Tags: Pediatric Neuro-Oncology Source Type: research
Dural Arteriovenous Fistula Mimicking a Brainstem Glioma
CONCLUSIONA careful radiological study looking for dilated vessels around the brainstem is necessary in the workup of an infiltrating brainstem lesion, in order to rule out intracranial dural arteriovenous fistula. (Source: Journal of Neuroimaging)
Source: Journal of Neuroimaging - January 1, 2015 Category: Radiology Authors: Loïc Guennec, Delphine Leclercq, Zoltan Szatmary, Ahmed Idbaih, German Reyes‐Botero, Jean‐Yves Delattre, Dimitri Psimaras Tags: Case Report Source Type: research
Glioma: Targeting a histone mutant
Nature Reviews Cancer 15, 2 (2015).
doi:10.1038/nrc3885
Author: Sarah Seton-Rogers
Oncogenic mutation of histone H3.3 occurs frequently in paediatric brainstem gliomas. Funato et al. created a model of the aggressive brainstem glioma diffuse intrinsic pontine glioma (DIPG) using human embryonic stem cells (ESCs). Early neural progenitor cells (NPCs) were derived from ESCs and then (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - December 23, 2014 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Gliomas in the Sellar Turcica Region: A Retrospective Study Including Adult Cases and Comparison with Craniopharyngioma
Conclusions: Sellar gliomas affect both pediatric and adult patients with pathological changes extending beyond pilocytic astrocytomas. They have diverse clinical manifestations and imaging presentations. Differences exist regarding several aspects between sellar gliomas and craniopharyngiomas, which may facilitate a differential diagnosis.Eur Neurol 2015;73:135-143 (Source: European Neurology)
Source: European Neurology - December 19, 2014 Category: Neurology Source Type: research
[Cancer Epigenetics] Modeling brain cancer from stem to stern
Diffuse intrinsic pontine gliomas (DIPGs) are aggressive brain tumors primarily affecting children. Because the tumors arise in the brainstem, which controls many vital functions, they – [Read More] (Source: This Week in Science)
Source: This Week in Science - December 19, 2014 Category: Science Authors: Paula A. Kiberstis Tags: Cancer Epigenetics Source Type: research
A phase 1 and pharmacokinetic study of enzastaurin in pediatric patients with refractory primary central nervous system tumors: a pediatric brain tumor consortium study.
CONCLUSION: Enzastaurin was well tolerated in children with recurrent CNS malignancies, with chromaturia, fatigue, anemia, thrombocytopenia, and nausea being the most common toxicities. The recommended phase 2 dose is 440 mg/m(2)/day administered once daily.
PMID: 25431212 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - November 27, 2014 Category: Cancer & Oncology Authors: Kilburn LB, Kocak M, Decker RL, Wetmore C, Chintagumpala M, Su J, Goldman S, Banerjee A, Gilbertson R, Fouladi M, Kun L, Boyett JM, Blaney SM Tags: Neuro Oncol Source Type: research
Can Multiparametric MRI and FDG-PET Predict Outcome in Diffuse Brainstem Glioma? A Report from a Prospective Phase-II Study
Conclusions: Cumulative RPI was able to classify tumours into different grades and predicted clinical outcome. At baseline, MR hyperperfusion indicated a shorter survival for DIPG patients. Sensitivity and specificity of imaging modalities to detect low-grade gliomas were poor.Pediatr Neurosurg 2013;49:274-281 (Source: Pediatric Neurosurgery)
Source: Pediatric Neurosurgery - November 20, 2014 Category: Neurosurgery Source Type: research
Temozolomide after radiotherapy in recurrent “low grade” diffuse brainstem glioma in adults
Abstract
Diffuse brainstem glioma is a rare disease in adults. Radiotherapy (RT) is usually considered to be the standard treatment. However, the role of chemotherapy in treating relapses after RT is unclear, and this study aimed to assess the use of temozolomide (TMZ) in this situation. We conducted a retrospective analysis of patients from our database with “low grade” adult diffuse infiltrating brainstem glioma who received TMZ at relapse after failing RT. The patients were diagnosed by histology or MRI criteria compatible with a low-grade glioma. The tumors were localized in the pons, medulla ob...
Source: Journal of Neuro-Oncology - November 19, 2014 Category: Cancer & Oncology Source Type: research
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma
Nature Medicine 20, 1394 (2014).
doi:10.1038/nm.3716
Authors: Rintaro Hashizume, Noemi Andor, Yuichiro Ihara, Robin Lerner, Haiyun Gan, Xiaoyue Chen, Dong Fang, Xi Huang, Maxwell W Tom, Vy Ngo, David Solomon, Sabine Mueller, Pamela L Paris, Zhiguo Zhang, Claudia Petritsch, Nalin Gupta, Todd A Waldman & C David James
Pediatric brainstem gliomas often harbor oncogenic K27M mutation of histone H3.3. Here we show that GSKJ4 pharmacologic inhibition of K27 demethylase JMJD3 increases cellular H3K27 methylation in K27M tumor cells and demonstrate potent antitumor activity both in vitro against K27M cells and i...
Source: Nature Medicine - November 17, 2014 Category: Journals (General) Authors: Rintaro HashizumeNoemi AndorYuichiro IharaRobin LernerHaiyun GanXiaoyue ChenDong FangXi HuangMaxwell W TomVy NgoDavid SolomonSabine MuellerPamela L ParisZhiguo ZhangClaudia PetritschNalin GuptaTodd A WaldmanC David James Tags: Brief Communication Source Type: research
A phase I trial of veliparib (ABT-888) and temozolomide in children with recurrent CNS tumors: a Pediatric Brain Tumor Consortium report
Conclusions
Veliparib and TMZ at the RP2D were well tolerated in children with recurrent brain tumors. A phase I/II trial to evaluate the tolerability and efficacy of veliparib, TMZ, and radiation in children with newly diagnosed brainstem gliomas is in progress. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 14, 2014 Category: Cancer & Oncology Authors: Su, J. M., Thompson, P., Adesina, A., Li, X.-N., Kilburn, L., Onar-Thomas, A., Kocak, M., Chyla, B., McKeegan, E., Warren, K. E., Goldman, S., Pollack, I. F., Fouladi, M., Chen, A., Giranda, V., Boyett, J., Kun, L., Blaney, S. M. Tags: Pediatric Neuro-Oncology Source Type: research
Can Multiparametric MRI and FDG-PET Predict Outcome in Diffuse Brainstem Glioma A Report from a Prospective Phase-II Study
Conclusions: Cumulative RPI was able to classify tumours into different grades and predicted clinical outcome. At baseline, MR hyperperfusion indicated a shorter survival for DIPG patients. Sensitivity and specificity of imaging modalities to detect low-grade gliomas were poor.Pediatr Neurosurg (Source: Pediatric Neurosurgery)
Source: Pediatric Neurosurgery - November 6, 2014 Category: Neurosurgery Source Type: research
Ed-32 * outcomes of pediatric brainstem low grade gliomas: a single institution series
DISCUSSION: This single institution retrospective study demonstrates excellent survival rates for children with brainstem LGG, with initial surgery +/- CT or RT, and effective salvage with CT. The efficacy of the well-tolerated chemotherapy in this series supports its role in the treatment of unresectable brainstem LGG, or in those which progress after initial surgical management. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Upadhyaya, S., Muraszko, K., Garton, H., Maher, C., Robertson, P. Tags: EPIDEMIOLOGY, CLINICAL Source Type: research
Ed-06 * brainstem gliomas in adults: do adult diffuse intrinsic pontine gliomas exist?
CONCLUSIONS: Although adults with brainstem tumors involving the pons have similar presentation as children with DIPG, imaging findings and clinical outcome differ significantly. Investigation into the biology of the adult lesions, including H3.3 mutations, may help define these as more distinct entities. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Garren, N., Harris, S., Baker, E., Kreisl, T., Warren, K. Tags: EPIDEMIOLOGY, CLINICAL Source Type: research
