Adjuvant melatonin for uveal melanoma (AMUM): protocol for a randomized open-label phase III study
DiscussionMelatonin has been found to positively impact our immune system, inhibit angiogenesis, stimulate apoptosis in malignant cells, and act as a potent antioxidant. Previous clinical trials have used similar doses of melatonin with positive results, particularly in advanced stages of cancer. Previous animal and human studies have found the toxicity of the hormone to be low. Considering the potential benefits and limited risks of melatonin, as well as its global availability, it may be a suitable candidate for an adjuvant treatment in patients with uveal melanoma.Trial registrationOur trial protocol has been approved a...
Source: Trials - March 26, 2023 Category: Research Source Type: clinical trials
Organ Preservation in Rectal Cancer: Contact X-ray Brachytherapy vs Extending the Waiting Interval and Local Excision
Conditions: Organ Preservation; Rectal Cancer; Quality of Life; Locally Advanced Rectal Carcinoma Interventions: Radiation: Contact x-ray brachytherapy; Procedure: Local excision Sponsors: The Netherlands Cancer Institute; Catharina Ziekenhuis Eindhoven; ZonMw: The Netherlands Organisation for Health Research and Development Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 17, 2023 Category: Research Source Type: clinical trials
Anlotinib Combined With Concurrent Chemoradiotherapy in the Treatment of Locally Advanced Cervical Cancer
Condition: To Evaluate the Efficacy and Safety of Anlotinib Combined With Concurrent Chemoradiotherapy in the Treatment of Locally Advanced Cervical Cancer Interventions: Drug: Hydrochloride anlotinib; Drug: cis Platinum/carboplatin; Radiation: External beam radiotherapy and brachytherapy Sponsor: The First Affiliated Hospital with Nanjing Medical University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 16, 2023 Category: Research Source Type: clinical trials
