What Are Toxin-Mediated Diseases?
Discussion A poison is a generic term for “a substance with an inherent property that tends to destroy life or impair health.” A toxin is more specific and is “any poison produced by an organism, characterized by antigenicity in certain animals and high molecular weight, and including the bacterial toxins that are the causative agents of tetanus, diphtheria, etc., and such plant and animal toxins as ricin and snake venom.” A toxin does not include those substances that are made synthetically produced. Venom is also a toxin that is used by animals and insects for predation or defense which can cause ...
Source: PediatricEducation.org - April 12, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Botulism breakthrough? Taming botulinum toxin to deliver therapeutics
(Boston Children's Hospital) Currently there's no treatment for botulism once the toxin gets into neurons. This novel treatment neutralized the toxin with a second, modified botulinum toxin that delivered a mini antibody into the cells - reversing paralysis in mice. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 8, 2021 Category: International Medicine & Public Health Source Type: news

Decoy toxin harnessed to fight botulism
(Source: ScienceNOW)
Source: ScienceNOW - January 7, 2021 Category: Science Authors: Servick, K. Tags: Cell Biology, Medicine, Diseases In Depth Source Type: news

New strategy to fight botulinum toxin - expert available
(Wake Forest Baptist Medical Center) Published research shows a new " Trojan horse " approach that produces strong antidotal efficacy in treating lethal botulism. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 6, 2021 Category: International Medicine & Public Health Source Type: news

CytoDel announces successful intra-neuronal antibody delivery without a viral vector
(CytoDel Inc) Preclinical data published inScience Translational Medicine showed that post-symptomatic administration of Cyto-111 produced antidotal rescue in three animal species following a lethal botulism challenge. Study authors concluded, " atoxic BoNT derivatives can be harnessed to deliver therapeutic protein moieties to the neuronal cytoplasm where they bind and neutralize intracellular targets in experimental models. The generalizability of this platform might enable delivery of antibodies and other protein-based therapeutics to previously inaccessible intraneuronal targets. " (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 6, 2021 Category: International Medicine & Public Health Source Type: news

Toxin chimeras slip therapeutics into neurons to treat botulism in animals
(American Association for the Advancement of Science) Taking advantage of the chemical properties of botulism toxins, two teams of researchers have fashioned non-toxic versions of these compounds that can deliver therapeutic antibodies to treat botulism, a potentially fatal disease with few approved treatments. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 6, 2021 Category: International Medicine & Public Health Source Type: news

Notes from the Field: Botulism Type B After Intravenous Methamphetamine Use - New Jersey, 2020
This report describes the risk for wound botulism among all persons who inject drugs. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - October 1, 2020 Category: American Health Tags: Botulism MMWR Morbidity & Mortality Weekly Report Source Type: news

Children ’ s Robitussin And Dimetapp Cough Medicines Recalled For Potential Overdose Risks
(CNN) — Parents take note: GlaxoSmithKline Consumer Healthcare has voluntarily recalled three lots of its children’s cough syrups — Children’s Robitussin Honey Cough and Chest Congestion DM and Children’s Dimetapp Cold and Cough — due to the products having incorrect dosing cups in their packaging. That means parents might accidentally overdose a child by putting too much syrup in the cup. Symptoms of overdose of either product may include impaired coordination, elevated blood pressure, dizziness, seizure, nausea, vomiting, constipation, diarrhea, abdominal pain, hallucinations, among ot...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - June 19, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Consumer Health News CNN Cough Syrup Recall Source Type: news

Ultraviolet Light Treats Influenza?
The healing power of ultraviolet light (UV) has flown under the radar for decades. Yet, it’s one of the most powerful detoxifying agents known to man. It kills bacteria and viruses and can be used in a clinical setting. The therapeutic benefits of light have been known for millennia. Hippocrates, the father of modern medicine, believed light was essential to balance the body and emotions. And there is good reason why, during the Spanish flu pandemic of 1918, medics discovered that severely ill patients had hugely better recovery rates when they were nursed outside and had regular exposure to sunlight.1 You see, UV r...
Source: Al Sears, MD Natural Remedies - May 21, 2020 Category: Complementary Medicine Authors: Dr.A.Sears Tags: Health Source Type: news

Vaccines, Antibodies and Drug Libraries. The Possible COVID-19 Treatments Researchers Are Excited About
In early April, about four months after a new, highly infectious coronavirus was first identified in China, an international group of scientists reported encouraging results from a study of an experimental drug for treating the viral disease known as COVID-19. It was a small study, reported in the New England Journal of Medicine, but showed that remdesivir, an unapproved drug that was originally developed to fight Ebola, helped 68% of patients with severe breathing problems due to COVID-19 to improve; 60% of those who relied on a ventilator to breathe and took the drug were able to wean themselves off the machines after 18...
Source: TIME: Health - April 14, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

Blood Plasma Treatment for Coronavirus Set to Get Its First Trial Run in New York
The New York Blood Center (NYBC) is the first blood-gathering organization in the U.S. to collect plasma from COVID-19 patients to use as a possible treatment for the disease. Before antibiotics rendered the practice moot, it was common to treat infectious bacterial diseases by infusing the blood of recovered patients into those struggling with infection. That approach has also been tried against viral infections like H1N1 influenza, SARS and MERS, with inconsistent success. Some patients benefited, but other did not and doctors don’t have a clear understanding of why. But during an evolving pandemic like COVID-19, p...
Source: TIME: Health - March 26, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

Botulinum toxin as biological warfare agent: poisoning, diagnosis and countermeasures - Pohanka M.
Botulinum toxin is a neurotoxin produced by Clostridium botulinum and some other relative species. It causes lethal disease called botulism. It can enter body via infections by Clostridium (e.g. wound and children botulism) or by a direct contact with the ... (Source: SafetyLit)
Source: SafetyLit - March 2, 2020 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

Smoked Salmon Recalled for Botulism Risk
The recalled products were sold in Arizona, Colorado, Connecticut, Florida, Georgia, Illinois, Iowa, Maine, Massachusetts, Michigan, Montana, New Jersey, New York, Ohio, Pennsylvania, Rhode Island, Tennessee, Texas, Utah, Vermont, Virginia, Washington, and Wisconsin. (Source: WebMD Health)
Source: WebMD Health - November 8, 2019 Category: Consumer Health News Source Type: news

Notes from the Field: Botulism Type E After Consumption of Salt-Cured Fish - New Jersey, 2018
An emergency department in New Jersey treated two patients for suspected foodborne botulism associated with eating uneviscerated salt-cured fish. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - November 7, 2019 Category: American Health Tags: Botulism Foodborne Disease MMWR Morbidity & Mortality Weekly Report Source Type: news

Salmon caviar recalled due to botulism fears
Product sold in four states is possibly tainted with toxin that can cause life-threatening illness or death (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - August 16, 2019 Category: Consumer Health News Source Type: news

Medical News Today: Everything you need to know about infant botulism
Infant botulism is an illness that can occur when a baby ingests the bacterium Clostridium botulinum. It causes a range of symptoms and can be fatal without treatment. Learn more here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 2, 2019 Category: Consumer Health News Tags: Pediatrics / Children's Health Source Type: news

Neuroterrorism preparedness for the neurohospitalist - Ralston MSA, Murray MBP, Vela-Duarte D, Orjuela KD, Pastula DM.
In this review article, we highlight several potential biologic and chemical agents of "neuroterrorism" of which neurohospitalists should be aware: anthrax, botulism toxin, brucella, plague, smallpox, organophosphates and nerve agents, cyanide, and carfent... (Source: SafetyLit)
Source: SafetyLit - June 29, 2019 Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news

Botulism Outbreak Associated With Home-Canned Peas Botulism Outbreak Associated With Home-Canned Peas
This outbreak underscores the importance of educating home canners on safe home-canning practices to prevent botulism.Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 5, 2019 Category: Consumer Health News Tags: Public Health & Prevention Journal Article Source Type: news

Notes from the Field: Botulism Outbreak Associated with Home-Canned Peas --- New York City, 2018
On June 6, 2018, at 1:30 p.m., the New York City Department of Health and Mental Hygiene was notified of three related women who had arrived at a hospital 4 hours earlier for evaluation for acute nausea, dizziness, blurred vision, slurred speech, ptosis, thick-feeling tongue, and shortness of breath. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - March 14, 2019 Category: American Health Tags: Botulism MMWR Morbidity & Mortality Weekly Report Public Health Source Type: news

Botulism
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - February 27, 2019 Category: General Medicine Source Type: news

Nine Cases of Wound Botulism ID ’ d in Injection Drug Users
All patients used injection drugs; seven reported using black tar heroin and six practiced skin popping (Source: The Doctors Lounge - Psychiatry)
Source: The Doctors Lounge - Psychiatry - January 9, 2019 Category: Psychiatry Tags: Infections, Internal Medicine, Critical Care, Emergency Medicine, Pharmacy, Psychiatry, Journal, Source Type: news

Nine Cases of Wound Botulism ID'd in Injection Drug Users
WEDNESDAY, Jan. 9, 2019 -- Among persons who inject drugs, nine cases of wound botulism were identified in Southern California from September 2017 to April 2018, according to research published in the Jan. 4 issue of the U.S. Centers for Disease... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 9, 2019 Category: Pharmaceuticals Source Type: news

Wound Botulism Outbreak Among Persons Who Use Black Tar Heroin --- San Diego County, California, 2017--2018
During September 2017-April 2018, nine cases of wound botulism were reported in San Diego County, California; all patients reported injecting heroin and seven used black tar heroin, including subcutaneous injection in six patients. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - January 3, 2019 Category: American Health Tags: Botulism Injection Safety MMWR Morbidity & Mortality Weekly Report Outbreaks Source Type: news

Everything you need to know about botulism
(Natural News) Botulism is one of the scariest infections that you’ll ever hear of in your life. This condition is caused by toxins from the bacteria Clostridium botulinum, which attack the nervous system. It’s usually very rare for healthy adults to contract botulism. However, improper food prepping practices increase the risk of getting this infection since stored food... (Source: NaturalNews.com)
Source: NaturalNews.com - December 19, 2018 Category: Consumer Health News Source Type: news

Del Monte recalls canned corn because of botulism risk
Del Monte Foods Inc. issued a recall of some of its canned corn this week. (Source: CNN.com - Health)
Source: CNN.com - Health - December 13, 2018 Category: Consumer Health News Source Type: news

Del Monte recalls canned corn for botulism risk
Walmart and Target among retailers that sold incompletely sterilized food that could cause life-threatening illness (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - December 13, 2018 Category: Consumer Health News Source Type: news

Health officials fear a contaminated batch of heroin is being sold on England's streets
A memo leaked to MailOnline shows Public Health England has issued a warning to A&E units across the country, urging them to be aware of potential botulism cases among heroin addicts. (Source: the Mail online | Health)
Source: the Mail online | Health - December 11, 2018 Category: Consumer Health News Source Type: news

Honey-filled pacifiers linked to cases of botulism
Four infants in Texas were treated for botulism after being given a honey-containing pacifiers purchased in Mexico (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - November 19, 2018 Category: Consumer Health News Source Type: news

Don't Give Infants Honey-Filled Pacifiers: FDA
The agency issued the warning after receiving reports of four infants in Texas who were hospitalized with botulism after using pacifiers containing honey. (Source: WebMD Health)
Source: WebMD Health - November 19, 2018 Category: Consumer Health News Source Type: news

4 Texas Infants Got Botulism, Why You Should Never Give Infants Honey Pacifiers
The FDA is reminding everyone to not feed honey to anyone less than one years old. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - November 19, 2018 Category: Pharmaceuticals Authors: Bruce Y. Lee, Contributor Source Type: news

Researchers identify possible botulism antidote
Researchers have identified a possible antidote to botulism, which is considered the most poisonous compound known to mankind. (Source: Health News - UPI.com)
Source: Health News - UPI.com - November 5, 2018 Category: Consumer Health News Source Type: news

Notes from the Field: Intestinal Colonization and Possible Iatrogenic Botulism in Mouse Bioassay-Negative Serum Specimens --- Los Angeles County, California, November 2017
Mouse bioassay is the standard test for botulinum neurotoxin detection. However, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry testing can be 10-100 times more sensitive than MBA but is not yet widely available. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - November 1, 2018 Category: American Health Tags: Hepatitis Hepatitis A MMWR Morbidity & Mortality Weekly Report Travelers' Health Vaccines Source Type: news

Kraft Heinz issues recall of Taco Bell cheese dip over botulism risk
In a statement on Tuesday, Kraft Heinz announced that it was issuing a voluntarily recall of its Taco Bell Salsa Con Queso Mild Cheese Dip over fears that consuming it could lead to botulism. (Source: the Mail online | Health)
Source: the Mail online | Health - July 25, 2018 Category: Consumer Health News Source Type: news

Kraft Heinz recalls Taco Bell cheese dip for botulism risk
An estimated 7,000 cases of Taco Bell Salsa Con Queso Mild Cheese Dip are being recalled because there are signs of product separation that could lead to botulism, the US Food and Drug Administration said Tuesday. There have been no reported illnesses or consumer complaints, Kraft Heinz Foods Company said in a statement. (Source: CNN.com - Health)
Source: CNN.com - Health - July 25, 2018 Category: Consumer Health News Source Type: news

Taco Bell cheese dip recalled due to botulism risk
Food manufacturer Kraft Heinz says 7,000 cases of the Taco Bell product have been distributed to U.S. retailers (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - July 25, 2018 Category: Consumer Health News Source Type: news

Kraft recalls Taco Bell cheese dip due to botulism risk
Food manufacturer says about 7,000 cases of the product have been distributed to U.S. retailers (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - July 25, 2018 Category: Consumer Health News Source Type: news

Kraft Heinz recalling cheese dip on botulism risk
Kraft Heinz Co said on Tuesday it was voluntarily recalling about 7,000 cases of its Taco Bell Cheese Dip as the product showed signs that it could allow for the growth of the bacteria that causes botulism. (Source: Reuters: Health)
Source: Reuters: Health - July 25, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Health Tip: When Canning Food at Home
-- Canning food is a long-standing tradition in many households and a perfect way to enjoy the freshness of summer foods year round. But improper canning can lead to nasty consequences, such as botulism, a potentially deadly illness produced by a... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 25, 2018 Category: General Medicine Source Type: news

Improperly home-canned green beans sent couple to the hospital with botulism; after 5 months in intensive care, they recovered completely
(Natural News) A married couple from Germany were left paralyzed and fighting for their lives in intensive care for about five months after eating some home-canned green beans. The anonymous husband and wife were diagnosed with botulism, an extremely rare but life-threatening bacterial illness. Botulism is caused by the Clostridium botulinum bacteria which grow on food and produce lethal... (Source: NaturalNews.com)
Source: NaturalNews.com - June 13, 2018 Category: Consumer Health News Source Type: news

Products Approved for Other Bioterrorism Emergencies
U.S. Food and Drug Administration. 09/08/2017 This Web page lists products approved for seven bioterrorism emergencies: Botulism due to Clostridium botulinum toxin; Ebola Virus Disease (EVD); Glanders and Melioidosis due to Burkholderia mallei and B. pseudomallei, respectively; Plague due to Yersinia pestis; Smallpox due to Variola major and Variola minor; Tularemia due to Francisella tularensis; and Zika Virus Disease. (Text) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - May 9, 2018 Category: International Medicine & Public Health Authors: The U.S. National Library of Medicine Source Type: news

BabyBIG (Botulism Immune Globulin Intravenous (Human) (BIG-IV) for Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 7, 2018 Category: Drugs & Pharmacology Source Type: news

Annual Epidemiological Report for 2015: Botulism
European Union, European Centre for Disease Prevention and Control. 04/30/2018 This five-page report is based on data for 2015 retrieved from the European Surveillance System (TESSy). It found that in 2015, 18 European Union/European Economic Area countries reported 201 cases of botulism, 146 of which (72.6 percent) were confirmed. Twelve countries notified zero cases. The report discusses methods, epidemiology, age and gender distribution, seasonable distribution and trend, threats description for 2015, and public health implications. (PDF) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - May 2, 2018 Category: International Medicine & Public Health Authors: The U.S. National Library of Medicine Source Type: news

BabyBIG (Botulism Immune Globulin Intravenous (Human) (BIG-IV) for Injection) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 2, 2018 Category: Drugs & Pharmacology Source Type: news

Foodborne Botulism Due to Ingestion of Home-canned Beans Foodborne Botulism Due to Ingestion of Home-canned Beans
These cases indicate that full recovery from foodborne botulism is possible even in patients with long-lasting intensive care, but raises questions about the timing of antitoxin administration.Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 6, 2018 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

Shot by a gun … missed by a provider - Garcia E, Zaid AH, Calello DP, McHugh L, Arzumanov G, Asrar N, Sapin A, Fless KG.
BACKGROUND: Botulism is a paralytic disease caused by the neurotoxin produced by Clostridium botulinum. The majority of cases are due to ingestion or injection drug use. Wound botulism from traumatic injury is exceedingly rare, with only one to two cases r... (Source: SafetyLit)
Source: SafetyLit - February 19, 2018 Category: International Medicine & Public Health Tags: Commentary Source Type: news

Scientists have discovered a new type of Botox
(University of Waterloo) A new source of the botulinum neurotoxin was discovered by Canadian and American scientists in a strain of animal gut bacteria known as Enterococcus faecium. The neurotoxic protein is known for its paradoxical ability to remove wrinkles yet cause botulism, a potentially fatal illness associated with food poisoning. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 26, 2018 Category: International Medicine & Public Health Source Type: news

Botulinum-type toxins jump to a new kind of bacteria
(Boston Children's Hospital) A toxin much like the one that causes botulism has unexpectedly turned up in a completely different type of bacteria - Enterococcus. Where it came from is unclear, but the finding is concerning because enterococci have lately become a leading cause of multi-drug-resistant infections, especially in health care settings. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 26, 2018 Category: International Medicine & Public Health Source Type: news

Botulism can kill you are you sure your preserved foods are safe? 8 signs they aren’t
(Natural News) Knowing how to preserve food is an important skill for a prepper, but you also need to read up on food safety if you’re interested in learning about food preservation. If you make a mistake during the canning and preserving process, anyone who eats the food you preserved can get sick and they... (Source: NaturalNews.com)
Source: NaturalNews.com - January 22, 2018 Category: Consumer Health News Source Type: news

The Proven & Unproven Health Benefits Of Honey
By Sandee LaMotte, CNN (CNN) — Move over, prehistoric bears. Humans have loved honey since the Stone Age. Rock art pictures of honey harvesting, which at first glance look like drawings from A.A. Milne’s Winnie-the-Pooh, date to about 8000 B.C. Beeswax has been found on pottery dating as far back as 7000 B.C., most likely used for waterproofing. The ancient Egyptians offered honey to the gods and then joined the Greeks, Romans and Chinese in using it as a salve for wounds and a treatment for fevers and stomach ailments. Today, proponents of honey tout its miraculous healing properties, claiming that it can prev...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 20, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Honey Source Type: news

We May Never Know Whether North Korea Tortured Otto Warmbier, Coroner Says
(CINCINNATI) — A coroner said Wednesday her office could not determine what led to the fatal brain damage of a young Ohio man detained in North Korea for more than a year. While the parents of 22-year-old Otto Warmbier and President Donald Trump have accused the North Korean government of torturing him, Dr. Lakshmi Sammarco said evidence has led to no “scientific facts” to solve Warmbier’s mysterious death. “We don’t know what happened to him, and this is the bottom line,” she said. The cause of the death may never be known, she added. A coroner’s report dated Sept. 11 shows ...
Source: TIME.com: Top Science and Health Stories - September 28, 2017 Category: Consumer Health News Authors: Dan Sewell / AP Tags: Uncategorized North Korea onetime Otto Warmbier Source Type: news