Notes from the Field: Wound Botulism Outbreak Among a Group of Persons Who Inject Drugs - Dallas, Texas, 2020
This report describes a 2020 outbreak of wound botulism among a group of people who inject drugs in Texas. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - April 14, 2022 Category: American Health Tags: Botulism Diseases & Conditions Injection Safety MMWR Morbidity Mortality Weekly Report Outbreaks Public Health Source Type: news

What Are Some Initial Evaluations for Suspected Congenital Muscle Diseases?
Discussion Usually congenital myopathies (CM, e.g. nemaline, core, centronuclear myopathies, etc.) and congenital muscular dystrophy (CMD, e.g. LAMA2-related, collage VI-related, alpha-dystroglycan-related muscular dystrophy, etc.) have been diagnosed based on physical examination and histopathology. Traditionally CMs are due to problems with the muscle contractile apparatus and structures that assist excitation-contraction coupling. CMD are due to problems with the extracellular matrix, muscle membrane and sarcolemmal membrane. Differentiating between CM and CMD have become more blurred as genetic testing and additional r...
Source: PediatricEducation.org - January 17, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Beneath a Covid Vaccine Debacle, 30 Years of Government Culpability
Washington has rejected plans to revamp vaccine preparedness for decades and repeatedly paid a price. The Biden administration is at a similar crossroads. (Source: NYT Health)
Source: NYT Health - December 23, 2021 Category: Consumer Health News Authors: Chris Hamby and Sheryl Gay Stolberg Tags: Emergent BioSolutions Inc Politics and Government Government Contracts and Procurement Public-Private Sector Cooperation Coronavirus (2019-nCoV) Vaccination and Immunization Smallpox Drugs (Pharmaceuticals) Anthrax Botulism Biological Source Type: news

CDC: New Botulism Guidelines Focus on Mass-Casualty Events CDC: New Botulism Guidelines Focus on Mass-Casualty Events
Botulinum toxin is said to be the most lethal substance known. Inhaling just 1-3 nanograms of toxin per kilogram of body mass constitutes a lethal dose.Medscape Medical News (Source: Medscape Emergency Medicine Headlines)
Source: Medscape Emergency Medicine Headlines - June 2, 2021 Category: Emergency Medicine Tags: Infectious Diseases News Source Type: news

New Botulism Guidelines Focus on Mass-Casualty Events New Botulism Guidelines Focus on Mass-Casualty Events
Botulinum toxin is said to be the most lethal substance known. Inhaling just 1-3 nanograms of toxin per kilogram of body mass constitutes a lethal dose.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - June 1, 2021 Category: Neurology Tags: Infectious Diseases News Source Type: news

Guidelines Developed for Diagnosing, Treating Botulism
WEDNESDAY, May 19, 2021 -- In new evidence-based clinical guidelines published in the May 7 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report, recommendations are presented for diagnosing, monitoring,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 19, 2021 Category: Pharmaceuticals Source Type: news

What Are Toxin-Mediated Diseases?
Discussion A poison is a generic term for “a substance with an inherent property that tends to destroy life or impair health.” A toxin is more specific and is “any poison produced by an organism, characterized by antigenicity in certain animals and high molecular weight, and including the bacterial toxins that are the causative agents of tetanus, diphtheria, etc., and such plant and animal toxins as ricin and snake venom.” A toxin does not include those substances that are made synthetically produced. Venom is also a toxin that is used by animals and insects for predation or defense which can cause ...
Source: PediatricEducation.org - April 12, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Botulism breakthrough? Taming botulinum toxin to deliver therapeutics
(Boston Children's Hospital) Currently there's no treatment for botulism once the toxin gets into neurons. This novel treatment neutralized the toxin with a second, modified botulinum toxin that delivered a mini antibody into the cells - reversing paralysis in mice. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 8, 2021 Category: International Medicine & Public Health Source Type: news

Decoy toxin harnessed to fight botulism
(Source: ScienceNOW)
Source: ScienceNOW - January 7, 2021 Category: Science Authors: Servick, K. Tags: Cell Biology, Medicine, Diseases In Depth Source Type: news

CytoDel announces successful intra-neuronal antibody delivery without a viral vector
(CytoDel Inc) Preclinical data published inScience Translational Medicine showed that post-symptomatic administration of Cyto-111 produced antidotal rescue in three animal species following a lethal botulism challenge. Study authors concluded, " atoxic BoNT derivatives can be harnessed to deliver therapeutic protein moieties to the neuronal cytoplasm where they bind and neutralize intracellular targets in experimental models. The generalizability of this platform might enable delivery of antibodies and other protein-based therapeutics to previously inaccessible intraneuronal targets. " (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 6, 2021 Category: International Medicine & Public Health Source Type: news

Toxin chimeras slip therapeutics into neurons to treat botulism in animals
(American Association for the Advancement of Science) Taking advantage of the chemical properties of botulism toxins, two teams of researchers have fashioned non-toxic versions of these compounds that can deliver therapeutic antibodies to treat botulism, a potentially fatal disease with few approved treatments. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 6, 2021 Category: International Medicine & Public Health Source Type: news

New strategy to fight botulinum toxin - expert available
(Wake Forest Baptist Medical Center) Published research shows a new " Trojan horse " approach that produces strong antidotal efficacy in treating lethal botulism. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 6, 2021 Category: International Medicine & Public Health Source Type: news

Notes from the Field: Botulism Type B After Intravenous Methamphetamine Use - New Jersey, 2020
This report describes the risk for wound botulism among all persons who inject drugs. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - October 1, 2020 Category: American Health Tags: Botulism MMWR Morbidity & Mortality Weekly Report Source Type: news

Children ’ s Robitussin And Dimetapp Cough Medicines Recalled For Potential Overdose Risks
(CNN) — Parents take note: GlaxoSmithKline Consumer Healthcare has voluntarily recalled three lots of its children’s cough syrups — Children’s Robitussin Honey Cough and Chest Congestion DM and Children’s Dimetapp Cold and Cough — due to the products having incorrect dosing cups in their packaging. That means parents might accidentally overdose a child by putting too much syrup in the cup. Symptoms of overdose of either product may include impaired coordination, elevated blood pressure, dizziness, seizure, nausea, vomiting, constipation, diarrhea, abdominal pain, hallucinations, among other conc...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - June 19, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Consumer Health News CNN Cough Syrup Recall Source Type: news