Study to Test the Efficacy and Safety of Vafidemstat in Adult Borderline Personality Disorder Population
Condition:   Borderline Personality Disorder Interventions:   Drug: vafidemstat;   Drug: Placebo Sponsor:   Oryzon Genomics S.A. Recruiting (Source:
Source: - June 21, 2021 Category: Research Source Type: clinical trials

Assessing the efficacy of a stepped-care group treatment programme for borderline personality disorder: study protocol for a pragmatic trial
AbstractBackgroundBorderline personality disorder (BPD) is a high prevalence and serious mental health disorder that has historically challenged the finite resources of health services. Despite empirical evidence supporting structured psychological therapy as the first line of treatment, there remains significant barriers in providing timely access to evidence-based treatment for this population. The primary aim of this study is to evaluate the effectiveness of providing a stepped-care structured psychological group treatment to individuals with BPD within local mental health services. The secondary aims of the study are t...
Source: Trials - June 7, 2021 Category: Research Source Type: clinical trials

Treatment of Acute Mood Depressive Episode in Borderline Personality Disorder With rTMS
Conditions:   Depressive Disorder, Major;   Borderline Personality Disorder Interventions:   Device: Left Dorsolateral Prefrontal Cortex (L-DLPFC);   Device: Dorsomedial Prefrontal Cortex (DMPFC);   Device: Sham Stimulation Sponsor:   Stanford University Not yet recruiting (Source:
Source: - May 3, 2021 Category: Research Source Type: clinical trials

Neuroimaging of adolescent borderline personality disorder with and without post-traumatic stress disorder
Condition:   Borderline Personality Disorder Intervention:   Other: Brain MRI Sponsors:   University Hospital, Caen;   CHU de Rouen - Accueil;   Centre Hospitalier Universitaire de Caen;   Université de Caen Normandie;   Centre Hospitalier du Rouvray;   Institut National de la Santé Et de la Recherche Médicale, France;   Groupe Hospitalier du Havre Not yet recruiting (Source:
Source: - April 21, 2021 Category: Research Source Type: clinical trials

Effectiveness of a Short and Telematic Version of Cognitive-behavioral Treatment for Borderline Personality Disorder
Condition:   Borderline Personality Disorder Interventions:   Behavioral: Dialectical Behavior Therapy -3-months;   Behavioral: Dialectical Behavior Therapy -6-months Sponsors:   Pontificia Universidad Catolica de Chile;   University Diego Portales Not yet recruiting (Source:
Source: - April 2, 2021 Category: Research Source Type: clinical trials

ORYZON Enrolls First Patient in PORTICO, a Phase IIb Clinical Trial with Vafidemstat in Borderline Personality Disorder
MADRID, SPAIN and CAMBRIDGE, MA, UNITED STATES, March 29th, 2021 - Oryzon Genomics, S.A. (ISIN Code: ES0167733015, ORY), a clinical-stage biopharmaceutical company leveraging epigenetics to develop therapies in diseases with strong unmet... (Source: - Clinical Trials)
Source: - Clinical Trials - March 29, 2021 Category: Pharmaceuticals Source Type: clinical trials

Trial of a Brief Psychological Intervention for Suicidal Patients With Borderline Personality Disorder in the Emergency Department
Conditions:   Borderline Personality Disorder;   Suicide and Self-harm Interventions:   Behavioral: Brief 4-session intervention for borderline personality disorder;   Behavioral: Treatment as usual Sponsor:   Centre for Addiction and Mental Health Not yet recruiting (Source:
Source: - March 3, 2021 Category: Research Source Type: clinical trials

Narrative enhancement and cognitive therapy (NECT) to improve social functioning in people with serious mental illness: study protocol for a stepped-wedge cluster randomized controlled trial
DiscussionNECT is a promising intervention for reducing self-stigma and improving recovery-related outcomes in SMI. If shown to be effective in this trial, it is likely that NECT will be implemented in psychiatric rehabilitation services with subsequent implications for routine clinical practice.Trial registrationClinicalTrials.govNCT03972735.  Trial registration date 31 May 2019. (Source: Trials)
Source: Trials - February 8, 2021 Category: Research Source Type: clinical trials

Effect of Repeated Transcranial Magnetic Stimulation on Aggressive Impulsive Behavior in Patients With Borderline Personality Disorder in a Social Exclusion Paradigm.
Condition:   Borderline Personality Disorder Intervention:   Device: repeated transcranial magnetic stimulation Sponsor:   Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente Recruiting (Source:
Source: - January 25, 2021 Category: Research Source Type: clinical trials