Alkannin inhibits CCL3 and CCL5 production in human periodontal ligament cells.
Abstract Alkannin, which is found in Alkanna tinctoria, a member of the borage family, is used as a food coloring. Alkannin has recently been reported to have certain biological functions, such as anti-microbial and anti-oxidant effects. It is known that CC chemokine receptor (CCR) 5-positive leukocytes contribute to alveolar bone resorption in periodontal lesions. The aim of this study was to examine whether alkannin inhibits the production of CC chemokine ligand (CCL) 3 and CCL5, which are CCR5 ligands, in human periodontal ligament cells (HPDLC). Interleukin (IL)-1β induced CCL3 and CCL5 production in ...
Source: Cell Biology International - October 14, 2016 Category: Cytology Authors: Hosokawa Y, Hosokawa I, Shindo S, Ohta Y, Ozaki K, Matsuo T Tags: Cell Biol Int Source Type: research

Purification of polyphenol oxidase from borage (Trachystemon orientalis L.) by using three-phase partitioning and investigation of kinetic properties.
In this study a Polyphenol oxidase from borage plant was purified with 3.59-fold enrichment in the specific activity and 68.75% recovery of the total activity by using three-phase partitioning purification technique for the first time. Its molecular weight was found around 80kDa with sodium dodecyl sulfate polyacrylamide gel electrophoresis. The optimum pH and temperature values of the enzyme for the used four substrates ranged between the pH 5.0-7.5 and 5-30°C. The kcat/Km values showed that the enzyme has the greatest reactivity toward caffeic acid among the substrates used. Ascorbic acid, L-cysteine and sodium metabisu...
Source: International Journal of Biological Macromolecules - September 20, 2016 Category: Biochemistry Authors: Alıcı EH, Arabacıa G Tags: Int J Biol Macromol Source Type: research

Green and rapid synthesis of silver nanoparticles using Borago officinalis leaf extract: anticancer and antibacterial activities.
This study highlights the facile, reliable, cost effective, and ecofriendly synthesis of silver nanoparticles (AgNPs) using Borago officinalis leaves extract efficiently. The biosynthesis of AgNPs was verified by UV-Vis spectrum which showed the surface plasmon resonance (SPR) band at 422 nm. Transmission electron microscope (TEM) analysis revealed that the particles were spherical, hexagonal, and irregular in shape and had size ranging from 30 to 80 nm. The energy dispersive X-ray spectroscopy (EDX) and elemental mapping have displayed the purity and maximum distribution of silver in the AgNPs. The crystalline nature ...
Source: Artificial Cells, Nanomedicine and Biotechnology - September 7, 2016 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Green and rapid synthesis of silver nanoparticles using Borago officinalis leaf extract: anticancer and antibacterial activities
. (Source: Artificial Cells, Blood Substitutes, and Biotechnology)
Source: Artificial Cells, Blood Substitutes, and Biotechnology - September 5, 2016 Category: Biotechnology Authors: Hina Singh Juan Du Tae-Hoo Yi Source Type: research

Evaluation of the Effect of Different Herbal Tea on Discoloration of Different Kinds of Composite
Conclusion: All tested restorative materials showed a color shift after immersion in herbal teas, which Tetric N ceram displayed the highest color change in Hibiscus tea and Borago tea induced lowest discoloration on Grandio after 24 h immersion. Thyme tea induced the highest level of discoloration on Gradia Direct and least discoloration was found in Borago tea on Grandio after 48 hours immersion. (Source: Journal of Dental Materials and Techniques)
Source: Journal of Dental Materials and Techniques - August 31, 2016 Category: Dentistry Source Type: research

Using a lipidomics approach for nutritional phenotyping in response to a test meal containing gamma-linolenic acid
Conclusion Using polyunsaturated fatty acid metabolism as an example, this study demonstrates inter-individual differences in enzymatic capacities to inform exact nutritional and metabolic phenotyping that could be used for precision medicine. Graphical Abstract (Source: Metabolomics)
Source: Metabolomics - July 11, 2016 Category: Biology Source Type: research

Review of Anti-Inflammatory Herbal Medicines.
Authors: Ghasemian M, Owlia S, Owlia MB Abstract Medicinal plants and their secondary metabolites are progressively used in the treatment of diseases as a complementary medicine. Inflammation is a pathologic condition that includes a wide range of diseases such as rheumatic and immune-mediated conditions, diabetes, cardiovascular accident, and etcetera. We introduce some herbs which their anti-inflammatory effects have been evaluated in clinical and experimental studies. Curcuma longa, Zingiber officinale, Rosmarinus officinalis, Borago officinalis, evening primrose, and Devil's claw are some of the introd...
Source: Advances in Pharmacological Sciences - June 3, 2016 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

Effect of scCO2 sorption capacity on the total amount of borage oil loaded by scCO2 impregnation/deposition into a polyurethane-based wound dressing
Publication date: September 2016 Source:The Journal of Supercritical Fluids, Volume 115 Author(s): C.V. da Silva, V.J. Pereira, P.T.V. Rosa, E.C.M. Cabral-Albuquerque, S.A.B. Vieira de Melo, G.M.N. Costa, A.M.A. Dias, H.C. de Sousa, M.E.M. Braga In this work, experimental equilibrium solubility data of scCO2 in polyurethane (PUR) foam (scCO2 sorption capacity) was measured by a gravimetric method for different isotherms (308, 318 and 328K), scCO2 densities (650, 750 and 850kgm−3) and scCO2 exposure times (0.5, 2, 4, 8 and 16h). Sorption data and CO2 desorption coefficients were estimated from desorp...
Source: The Journal of Supercritical Fluids - April 24, 2016 Category: Chemistry Source Type: research

Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction.
CONCLUSION: Borage oil attenuates progression of cardiac remodeling after myocardial infarction and congestive heart failure. PMID: 27050790 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - February 29, 2016 Category: Surgery Authors: Maldonado-Menetti Jdos S, Vitor T, Edelmuth RC, Ferrante FA, Souza PR, Koike MK Tags: Acta Cir Bras Source Type: research

Content of micronutrients, mineral and trace elements in some Mediterranean spontaneous edible herbs
Conclusion: The examined species are a good source of mineral elements and micronutrients, making them particularly adapt to integrate a well-balanced diet. The accumulation of heavy metals showed that contaminants in plants may reflect the environmental state in which they develop. Results showed high concentrations of heavy metals in samples taken in locations characterized by high human activity and in some samples from the local market, of which no one knows the collection area. (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - October 14, 2015 Category: Chemistry Authors: Maria VolpeMelissa NazzaroMichele Di StasioFrancesco SianoRaffaele CoppolaAnna De Marco Source Type: research

Officinalioside, a new lignan glucoside from Borago officinalis L.
Abstract A new lignan glucoside, officinalioside (1), was isolated from n-BuOH fraction of the aerial parts of Borago officinalis L., together with four known compounds: actinidioionoside (2), roseoside (3), crotalionoside C (4) and kaempferol 3-O-β-D-galactopyranoside (5). The structure of the new compound was established by means of spectroscopic and chemical analyses. Compounds 1 and 2 showed a moderate DPPH radical scavenging activity (IC50: 52.6 ± 1.70 and 41.3 ± 0.25 μM, respectively) comparable with that of the standard trolox (16.6 ± 2.2 μM) without any significant cytotoxicity toward...
Source: Natural Product Research - September 18, 2015 Category: Biochemistry Authors: Samy MN, Hamed AN, Sugimoto S, Otsuka H, Kamel MS, Matsunami K Tags: Nat Prod Res Source Type: research

Photoimmunological properties of borage in bovine neutrophil in vitro model
Publication date: Available online 19 August 2015 Source:Journal of Photochemistry and Photobiology B: Biology Author(s): Firouzeh Asadollahi, Jalil Mehrzad, Mohammad Javad Chaichi, Alireza Taghavi Razavizadeh Borage (Echium amoenum fisch) is one of the most commonly used medicinal plants, and has long been used as a traditional herbal medicine for many (non)infectious diseases in Iran. Study on photoredox and photoimmunology of borage is little. Natural immunomodulatory plants with minimal adverse/toxic effects could help boost animal health and, ultimately, public health. To determine the effect of borage on ...
Source: Journal of Photochemistry and Photobiology B: Biology - August 19, 2015 Category: Speech Therapy Source Type: research

Mass Spectrometric Confirmation of γ -Linolenic Acid Ester-Linked Ceramide 1 in the Epidermis of Borage Oil Fed Guinea Pigs
Abstract Ceramide 1 (Cer1), a Cer species with eicosasphingenine (d20:1) amide-linked to two different ω-hydroxy fatty acids (C30wh:0:C32wh:1), which are, in turn, ester-linked to linoleic acid (LNA; 18:2n-6), plays a critical role in maintaining the structural integrity of the epidermal barrier. Prompted by the recovery of a disrupted epidermal barrier with dietary borage oil [BO: 36.5 % LNA and 23.5 % γ-linolenic acid (GLA; 18:3n-6)], in essential fatty acid (EFA)-deficient guinea pigs, we further investigated the effects of BO on the substitution of ester-linked GLA for LNA in these two epidermal C...
Source: Lipids - August 2, 2015 Category: Lipidology Source Type: research

Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver [Research Articles]
The objective of this study was to determine whether botanical oils enriched in the FADS2 products 18:3 n-6 versus 18:4 n-3 are equally atheroprotective. LDL receptor KO mice were fed one of four atherogenic diets containing 0.2% cholesterol and 10% calories as palm oil (PO) plus 10% calories as: 1) PO; 2) borage oil (BO; 18:3 n-6 enriched); 3) EO (18:4 n-3 enriched); or 4) FO for 16 weeks. Mice fed BO, EO, and FO versus PO had significantly lower plasma total and VLDL cholesterol concentrations; hepatic neutral lipid content and inflammation, aortic CE content, aortic root intimal area and macrophage content; and peritone...
Source: The Journal of Lipid Research - May 29, 2015 Category: Lipidology Authors: Shewale, S. V., Boudyguina, E., Zhu, X., Shen, L., Hutchins, P. M., Barkley, R. M., Murphy, R. C., Parks, J. S. Tags: Research Articles Source Type: research