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Investigate the Therapeutic Effect of Ibandronate Sodium on Knee Osteoarthritis Based on TLRs/MyD88/NF- κB Signaling Pathway in Vitro and in Vivo 
CONCLUSIONS: Ibandronate sodium demonstrates a protective effect on articular chondrocytes and exhibits the potential to decelerate the pathological progression of knee osteoarthritis (KOA) in rats. This mechanism is likely achieved through the inhibition of the TLRs/MyD88/NF-κB signaling pathway.PMID:38273750 | DOI:10.24976/Discov.Med.202436180.9 (Source: Discovery Medicine)
Source: Discovery Medicine - January 26, 2024 Category: Research Authors: Mingxing Luo Qingze Wang Junguo Bao Source Type: research

Radiolabeling, Quality Control, and Cell Binding Studies of New 99m Tc-Labeled Bisphosphonates: 99m Tc-Ibandronate Sodium
CONCLUSION: The newly produced radiopharmaceutical is very promising according to the results of in vitro cell culture, HA binding, and quality studies, and will be a step forward for further studies in nuclear medicine for bone cancer diagnostics.PMID:37161446 | DOI:10.4274/tjps.galenos.2022.01346 (Source: Cancer Control)
Source: Cancer Control - May 10, 2023 Category: Cancer & Oncology Authors: Meliha Ekinci Derya İlem Özdemir Emre Özgenç Evren G ündoğdu Makbule A şıkoğlu Source Type: research

Ibandronate sodium and zoledronate sodium in the treatment of senile osteoporosis: efficacy, impact on quality of life and cost-effectiveness analysis
CONCLUSION: In the treatment of senile osteoporosis, the efficacy and adverse reactions of ibandronate sodium and zoledronate sodium are similar, both of them can effectively improve the quality of life. However, the cost-effectiveness of ibandronate sodium is better than that of zoledronate sodium.PMID:33841700 | PMC:PMC8014411 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Shuang Liang Shaozhen Hu Hong Guo Leilei Dong Guoqiang Liu Yang Liu Source Type: research