Phase I/II Study to Reduce Post-transplantation Cyclophosphamide Dosing for Older or Unfit Patients Undergoing Bone Marrow Transplantation for Hematologic Malignancies
Condition:   Hematologic Neoplasms Interventions:   Drug: Mycophenolate Mofetil;   Procedure: Allogeneic HSCT;   Drug: Fludarabine;   Drug: Sirolimus;   Drug: Filgrastim;   Drug: Cyclophosphamide;   Drug: Mesna;   Procedure: Total Body Irradiation (TBI) Sponsor:   National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 13, 2021 Category: Research Source Type: clinical trials

Reconvalescent plasma/camostat mesylate in early SARS-CoV-2 Q-PCR positive high-risk individuals (RES-Q-HR): a structured summary of a study protocol for a randomized controlled trial
This study is a 4-arm (parallel group), multicenter, randomized (2:2:1:1 ratio), partly double-blind, controlled trial to evaluate the safety and efficacy of convalescent plasma (CP) or camostat mesylate with control or placebo in adult patients diagnosed with SARS-CoV-2 infection and high risk for progression to moderate/severe COVID-19. Superiority of the intervention arms will be tested.ParticipantsThe trial is conducted at 10 –15 tertiary care centers in Germany. Individuals aged 18 years or above with ability to provide written informed consent with SARS-CoV-2 infection, confirmed by PCR within 3 days or less be...
Source: Trials - May 17, 2021 Category: Research Source Type: clinical trials

A Modified Dose of Rabbit Anti-thymocyte Globulin (rATG) in Children and Adults Receiving Treatment to Help Prepare Their Bodies for a Bone Marrow Transplant
Conditions:   Acute Myeloid Leukemia (AML);   Acute Lymphoid Leukemia (ALL);   Myelodysplastic Syndromes (MDS) Interventions:   Other: Personalized rATG (P-rATG);   Radiation: Hyper fractionated total body irradiation;   Drug: Thiotepa;   Drug: Cyclophosphamide;   Drug: GCSF;   Drug: Busulfan;   Drug: Melphalan;   Drug: Fludarabine Sponsor:   Memorial Sloan Kettering Cancer Center Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - May 4, 2021 Category: Research Source Type: clinical trials