Type 1 diabetes: Tannic acid encapsulation protects transplanted islets from rejection
(University of Alabama at Birmingham) One therapy for Type 1 diabetes is promising -- transplanting pancreatic islets from cadavers -- but a need for immunosuppression and a reactivated autoimmunity lead to low graft viability and function after five years. Now researchers show that a protective coating of alternating layers of two biopolymers delays allograft and autoimmune-mediated rejection in mouse models of T1D. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 22, 2020 Category: Biology Source Type: news
A Bioactive Skin Allograft for Deep Full-Thickness Wounds A Bioactive Skin Allograft for Deep Full-Thickness Wounds
Is a bioactive human skin allograft an effective treatment option for difficult-to-treat deep wounds?Wounds (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 21, 2020 Category: Consumer Health News Tags: General Surgery Journal Article Source Type: news
Cerapedics Announces FDA approval of an IDE supplement
IDE Supplement allows for a reduction in the total number of patients required to be enrolled in the ASPIRE IDE Study on P15-L bone graft in the lumbar spine
WESTMINSTER, Colo., July 22, 2020 -- (Healthcare Sales & Marketing Network) -- Cerapedics, a p... Devices, Orthopaedic, Neurosurgery, FDA Cerapedics, Bone Graft, transforaminal, lumbar interbody fusion (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - July 22, 2020 Category: Pharmaceuticals Source Type: news
Additive Manufacturing and Bone Graft Enhancers in Spinal Fusion: An HSS Journal ® Webinar
HSS Journal® presents this webinar focused on innovative technologies in spinal fusion available today, including 3D printing and bone graft enhancers. (Source: Orthogate - Latest News)
Source: Orthogate - Latest News - July 20, 2020 Category: Orthopaedics Tags: Featured CME Courses Events Source Type: news
New Medical Findings From 10-year Study of 3D Printed Regenerative Implant Osteoplug
SINGAPORE, July 20, 2020 -- (Healthcare Sales & Marketing Network) -- Osteopore International Pte Ltd, a global leader in regenerative implants, today revealed new data that demonstrates the long-term safety and efficacy of Osteoplug, a 3D printed bioreso... Devices, Regenerative Medicine Osteopore International, Osteoplug, 3D printed, bone graft implant (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - July 20, 2020 Category: Pharmaceuticals Source Type: news
Primitive stem cells point to new bone grafts for stubborn-to-heal fractures
(Texas A&M University) Although most broken bones can be mended with a firm cast and a generous measure of tender loving care, more complicated fractures require treatments like bone grafting. Researchers at Texas A&M University have now created superior bone grafts using primitive stem cells. They found that these cells help create very fertile scaffolds needed for bone to regenerate at the site of repair. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 16, 2020 Category: Biology Source Type: news
LaunchPad Lands Coveted Grant for Dental Bone Graft
In more than 30% of dental implant cases, existing bone graft materials fail to achieve the desired clinical results, and another bone graft procedure must be conducted, increasing the overall time and cost of the treatment. That's where LaunchPad Medical could potentially change the game with its new dental bone graft solution based on the company's Tetranite technology.
The Lowell, MA-based company won a $1.8 million grant from the Michigan-Pittsburgh-Wyss Regenerative Medicine Resource Center to initiate a pivotal animal study of its technology. The grant was funded by the National Institutes of Health's Nat...
Source: MDDI - June 4, 2020 Category: Medical Devices Authors: Amanda Pedersen Tags: R & D Implants Source Type: news
PIRs mediate innate myeloid cell memory to nonself MHC molecules
Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. However, it is unknown whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously on subsequent encounters. In this work, we show that murine monocytes and macrophages acquire memory specific to major histocompatibility complex I (MHC-I) antigens, and we identify A-type paired immunoglobulin-like receptors (PIR-As) as the MHC-I receptors necessary for the memory response. We demonstrate that deleting PIR-A in the recipient or blocking PIR-A binding to donor MHC-...
Source: ScienceNOW - June 3, 2020 Category: Science Authors: Dai, H., Lan, P., Zhao, D., Abou-Daya, K., Liu, W., Chen, W., Friday, A. J., Williams, A. L., Sun, T., Chen, J., Chen, W., Mortin-Toth, S., Danska, J. S., Wiebe, C., Nickerson, P., Li, T., Mathews, L. R., Turnquist, H. R., Nicotra, M. L., Gingras, S., Tak Tags: Immunology reports Source Type: news
New bone-graft biomaterial gives patients a nicer smile and less pain
(Tohoku University) A new recipe for a bone-graft biomaterial that is supercooled before application should make it easier to meet dental patients' expectation of a good-looking smile while eliminating the pain associated with harvesting bone from elsewhere in their body. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 15, 2020 Category: International Medicine & Public Health Source Type: news
UCLA scientists invent nanoparticle that could improve treatment for bone defects
In test with mice, the sterosome activated bone regeneration was activated without needing additional drugsBrianna Aldrich |April 22, 2020A team of biomaterials scientists and dentists at theUCLA School of Dentistry has developed a nanoparticle that, based on initial experiments in animals, could improve treatment for bone defects.A paper describing the advance is published today in the journal Science Advances. Bone defects, which can be caused by traumatic injury, infection, osteoporosis or the removal of tumors, are difficult for orthopedic surgeons to treat. And the need for bone grafts are becoming more common thanks ...
Source: Dental Technology Blog - April 30, 2020 Category: Dentistry Source Type: news
UCLA scientists invent nanoparticle that could improve treatment for bone defects
A team of biomaterials scientists and dentists at theUCLA School of Dentistry has developed a nanoparticle that, based on initial experiments in animals, could improve treatment for bone defects.A paper describing the advance is published today in the journal Science Advances.Bone defects, which can be caused by traumatic injury, infection, osteoporosis or the removal of tumors, are difficult for orthopedic surgeons to treat. And the need for bone grafts are becoming more common thanks in part to our aging population: Bone injuries are particularly prevalent among the elderly.Today, the standard treatment for bone defects ...
Source: UCLA Newsroom: Health Sciences - April 22, 2020 Category: Universities & Medical Training Source Type: news
Hydrogel could be step forward in therapies to generate bones in head and neck
A team of UCLA School of Dentistry researchers has developed the first adhesive hydrogel specifically to regenerate bone and tissue defects following head and neck surgeries. Their invention was inspired in part by the way that marine mussels can stick to wet surfaces.Their research is published online in the journal Science Translational Medicine.Over the past few years, surgeons and clinicians have begun using hydrogels to administer therapeutic drugs and stem cells to help regenerate lost tissues and bone defects. This approach has advantages over the previous standard treatment, bone grafts, which can lead to inflamma...
Source: UCLA Newsroom: Health Sciences - March 17, 2020 Category: Universities & Medical Training Source Type: news
Amniotic Suspension Allograft for Full-Thickness Wounds Amniotic Suspension Allograft for Full-Thickness Wounds
Treatment with a human amniotic suspension allograft combined with a fetal-derived bovine acellular dermal matrix may help promote healing of complex wounds.Wounds (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 11, 2020 Category: Consumer Health News Tags: General Surgery Journal Article Source Type: news
Minimum 5-year clinical outcomes, survivorship, and return to sports after hamstring tendon autograft reconstruction for sternoclavicular joint instability - Lacheta L, Dekker TJ, Goldenberg BT, Horan MP, Rosenberg SI, Pogorzelski J, Millett PJ.
BACKGROUND: Instability of the sternoclavicular (SC) joint is a rare but potentially devastating pathologic condition, particularly when it occurs in young or active patients, where it can lead to persistent pain and impairment of shoulder function. SC joi... (Source: SafetyLit)
Source: SafetyLit - February 13, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
