Fight Aging! Newsletter, January 23rd 2023
This study explored the association between tap drinking water and longevity in Cilento, Italy, to understand whether trace elements in local drinking water may have an influence on old, nonagenarian, and centenarian people and promote their health and longevity. Data on population and water sources were collected through the National Demographic Statistics, the Cilento Municipal Archives, and the Cilento Integrated Water Service. Ordinary least squares (OLS) regression and a geographically weight regression (GWR) model were used to study the spatial relationship between the explanatory and outcome variables of long...
Source: Fight Aging! - January 22, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Tau Aggregation Drives Neuroinflammation via Transposable Element Activation
Evidence suggests that there is a bidirectional relationship between tau aggregation and inflammation in the aging brain. Both occur in all brains, and when present to a greater degree contribute to the neurodegenerative conditions termed tauopathies. The most well known of these is Alzheimer's disease, in which tau aggregates and their surrounding toxic biochemistry cause the widespread cell death and severe symptoms that characterize the final stages of the condition. Various studies individually support each of the two directions of the relationship between tau and inflammation. Removing senescent cells from the ...
Source: Fight Aging! - January 20, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Towards Ways to Encourage Cells to Degrade Greater Amounts of Tau Protein
Researchers here report on an investigation of mechanisms regulating the turnover of tau protein in brain cells. The hope is to find approaches that will more aggressively clear the tau aggregates found in neurodegenerative conditions via the usual cell maintenance processes responsible for breaking down excess proteins, such as autophagy and proteasomal degradation. It is far too early to say how promising this approach might turn out to be at the end of the day, but the initial exploration is interesting. A novel screening approach led researchers to 11 new in vivo validated tau regulators. Of these, three tar...
Source: Fight Aging! - January 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Some Short-Chain Fatty Acids Made by Gut Microbes Increase Neuroinflammation in the Aging Brain
Researchers are attempting to determine exactly how the gut microbiome contributes to age-related chronic inflammation, particularly inflammation in the brain. This may be largely due to a few compounds produced by specific microbial species, some of which become more populous with age at the expense of beneficial microbes. The results noted here are an example of the output of this sort of research. Ultimately, this will lead to more deterministic ways of adjusting the gut microbiome in older individuals. At present the most effective approach is to transplant a fecal sample from a young individual, sidestepping our compa...
Source: Fight Aging! - January 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

A Method of Inducing Epigenetic Aging via Damage to DNA
You may recall the work linking DNA double strand break repair to epigenetic changes characteristic of aging. Repeated cycles of this repair cause some form of depletion of necessary factors or other disarray in the mechanisms controlling gene expression. This is a compelling way to link random DNA damage, largely occurring in parts of the genome that are inactive in any given cell, largely occurring in cells that will not go on to divide many times, and occurring in completely different locations from cell to cell, to a consistent, characteristic aspect of aging. Beyond the question of cancer risk, the only other compelli...
Source: Fight Aging! - January 19, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Exploring Correlations Between Trace Elements in Drinking Water and Longevity
This study explored the association between tap drinking water and longevity in Cilento, Italy, to understand whether trace elements in local drinking water may have an influence on old, nonagenarian, and centenarian people and promote their health and longevity. Data on population and water sources were collected through the National Demographic Statistics, the Cilento Municipal Archives, and the Cilento Integrated Water Service. Ordinary least squares (OLS) regression and a geographically weight regression (GWR) model were used to study the spatial relationship between the explanatory and outcome variables of long...
Source: Fight Aging! - January 19, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Quantifying the Ability of Fasting and Exercise to Increase BDNF Expression
Upregulation of BDNF is a useful goal, as it produces greater neurogenesis in the brain. Neurogenesis, the production of new neurons from neural stem cells, and their integration into neural circuits, is important in memory, learning, and the resilience of the brain to damage and aging. Increased levels of BDNF may also improve metabolism and reduce inflammation in brain tissue. BDNF levels decline with age, but evidence suggests that BDNF expression can be boosted via calorie restriction and exercise. Researchers here compare these approaches for effectiveness, finding that short bursts of high intensity exercise produce ...
Source: Fight Aging! - January 19, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The Gut Microbiome is Distinct in Parkinson's Disease
Parkinson's disease is characterized by aggregation of α-synuclein, one of a number of harmful protein aggregates that form and spread in the aging brain. At present, it is thought that in many patients this process of aggregation starts in the intestines rather than in the brain. So it is perhaps not that surprising to find that alterations in the balance of microbial populations in the gut microbiome are characteristic of Parkinson's disease. Researchers have been looking into correlations between the microbiome and various age-related diseases with increasing energy for some years now. Exactly how the gut microb...
Source: Fight Aging! - January 18, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Age-Related Loss of Sense of Smell Correlates with Degree of Frailty
The many aspects of degenerative aging arise from a smaller set of common underlying processes of damage, giving rise to a web of interacting consequences. It can be hard to pin down the chains of cause and effect, and the degree to which any one contributing cause is responsible for the end result, but nonetheless many aspects of aging correlate with one another for the simple reason that the root causes are much the same. This can be the case even when degeneration occurs in very different bodily systems. For example, as shown here, loss of sense of smell and general physical frailty show a correlation. To exami...
Source: Fight Aging! - January 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

More on the Work of the Longevity Escape Velocity Foundation
The Longevity Escape Velocity Foundation (LEVF) is initially working to assess combinations of approaches to the treatment of aging, to assess the degree to which mouse life span is affected. Aging consists of many distinct mechanisms, and comprehensive rejuvenation will require a diverse package of therapies. Yet the research and development community undertakes little work on combined treatments. Here, the Lifespan.io team talks to Aubrey de Grey about some of the details of the work presently under way. We are obviously very excited about LEVF's robust mouse rejuvenation (RMR) project. Could you walk our reader...
Source: Fight Aging! - January 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Extracellular Matrix Stiffening Contributes to Cartilage Aging and Osteoarthritis
Age-related changes in the structure of the extracellular matrix that surrounds and supports cells are not as well studied as changes in cell behavior. Nonetheless, there is plenty of evidence for changes in the extracellular matrix to negatively affect tissue function. Cells create and maintain the matrix, but the state of the matrix in turn influences cells, and over time is affected by more than just cell behavior. Metabolic processes can alter and fragment elastin, cross-link collagen molecules, and so forth. Cross-linking of matrix molecules occurs with age as a byproduct of the normal operation of metabolism, ...
Source: Fight Aging! - January 17, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

The Impact of Aging on Skin Healing
Skin heals poorly in old people, the consequence of mechanisms of aging such as the growing number of senescent cells present in aged tissues. Senescent cells are normally generated for a short period of time during wound healing and their pro-growth, pro-inflammatory signals help to coordinate the intricate dance of cell populations involved in regrowth following injury. The constant presence of senescent cells and their signals is disruptive to the healing process, however. As noted in this review paper, a number of other mechanisms are also relevant to the declining capacity for regeneration of skin in older people. ...
Source: Fight Aging! - January 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

A Role for Transposable Elements in Cellular Senescence
In this study, using cross-species models and multiple techniques, we revealed an uncharacterized role of endogenous retrovirus resurrection as a biomarker and driver for aging. Specifically, we identified endogenous retrovirus expression associated with cellular and tissue aging and that the accumulation of HERVK retrovirus-like particles (RVLPs) mediates the aging-promoting effects in recipient cells. These HERVK RVLPs constitute a transmissible message to elicit senescence phenotypes in young cells, which can be blocked by neutralizing antibodies. We can thus inhibit endogenous retrovirus-mediated pro-senescence effec...
Source: Fight Aging! - January 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Periodic Reprogramming via Gene Therapy Doubles Remaining Life Span in Old Mice
Perhaps the most important early measure of the quality of a given approach to the treatment of aging is its effect on remaining life span in old mice. Prevention is a good approach, but it has the disadvantage of only working to its greatest effect in those who are not yet old. The best approaches to the treatment of aging will produce rejuvenation, and thus be applicable to both (a) prevention of degenerative aging in people who are entering later life and (b) reversal of degenerative aging in those already suffering its effects. Reversal of the cell and tissue damage that causes aging, when periodically applied prior to...
Source: Fight Aging! - January 16, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

ADAR1 in Immunity and Aging
This short overview skims recent work on the role of ADAR1 expression in aging. Levels of ADAR1 are reduced with age in many tissues, and this may affect a number of processes relevant to aging, such as cellular senescence. ADAR1 edits RNA, affecting the behavior of gene expression at a very low level. It is a good example of a protein that is thus involved in many, many processes in the cell, and which has indirect effects on any number of cell behaviors. It is exceptionally challenging to pin down specific important roles for such proteins. There is such a large space of possibilities to cover that decades of work may or...
Source: Fight Aging! - January 16, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs