Daily radiation-chemo helps save bladder in cancer patients
A regimen of gemcitabine chemotherapy with daily radiation therapy led to good...Read more on AuntMinnie.comRelated Reading: PET with Axumin boosts prostate cancer outcomes Single-session SBRT speeds treatment of lung metastases Photon IMRT falls short in glioblastoma study Stereotactic body radiation eases spinal cancer pain (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - October 28, 2020 Category: Radiology Source Type: news

Effectiveness of gemcitabine & daily RT for bladder preservation in muscle-invasive bladder cancer
(NRG Oncology) Bladder preservation with trimodality therapy can be a safe and effective alternative to cystectomy for selected patients with muscle-invasive bladder cancer. The phase II NRG Oncology NRG-RTOG 0712 trial evaluated two regimens. One was the prior RTOG standard using 5-flourouracil and cisplatin with twice daily radiation (FCT), and the other a regimen of gemcitabine and daily radiation (GD) which had demonstrated efficacy in single institution clinical trials. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 26, 2020 Category: International Medicine & Public Health Source Type: news

Dual checkpoint blockade promising as pre-surgical approach for certain patients with localized bladder cancer
(University of Texas M. D. Anderson Cancer Center) Phase I trial finds neoadjuvant combination checkpoint inhibitors (anti-CTLA-4 plus anti-PD-1) was well tolerated and showed early signs of activity in certain patients with bladder cancer. These patients cannot be treated with chemotherapy and have no standard treatment options available. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 12, 2020 Category: Cancer & Oncology Source Type: news

Urine-based liquid biopsy test outperforms urine cytology in detecting bladder cancer
(American Association for Cancer Research) Analysis of DNA copy number variants (CNVs) in the cells exfoliated in urine showed better sensitivity and similar specificity in detecting urothelial carcinoma compared with urine cytology (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 9, 2020 Category: Cancer & Oncology Source Type: news

Smoking Tied to Worse Bladder Cancer Outcomes After Surgery
Poor outcomes include lower response rate to chemotherapy, higher mortality, recurrence (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - October 7, 2020 Category: Cancer & Oncology Tags: Oncology, Surgery, Urology, Journal, Source Type: news

Smoking Tied to Worse Bladder Cancer Outcomes After Surgery
WEDNESDAY, Oct. 7, 2020 -- Smoking is tied to worse bladder cancer outcomes following radical cystectomy, according to a review published online Oct. 1 in The Journal of Urology. Giovanni E. Cacciamani, M.D., from the University of Southern... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 7, 2020 Category: Pharmaceuticals Source Type: news

Robotic surgery in the COVID-19 era: Urologists take on the challenges
(Wolters Kluwer Health) Robotic surgery plays a major role in modern management of prostate cancer, bladder cancer, and other conditions treated by urologists. But it also poses some special challenges as hospitals resume elective surgery amid the COVID-19 pandemic. Problems and solutions facing urologic robotic surgery in the era of COVID-19 are reviewed inUrology Practice ®, an Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 6, 2020 Category: International Medicine & Public Health Source Type: news

Why aren't doctors warning women with bladder cancer that surgery cure can also end their love life?
Thousands of women across the UK with bladder cancer are having life-changing surgery without realising it will end their sex lives, the Mail on Sunday has learned. (Source: the Mail online | Health)
Source: the Mail online | Health - October 3, 2020 Category: Consumer Health News Source Type: news

Bladder Cancer: Developing Drugs and Biologics for Adjuvant Treatment
Draft guidance for industry: Bladder Cancer: Developing Drugs and Biologics for Adjuvant Treatment (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - October 1, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

DNA changes in healthy bladder provide clues on how cancer arises
(Wellcome Trust Sanger Institute) The first comprehensive study of DNA changes in healthy and diseased human bladder tissue has revealed that 'cancer-driving' mutations are common in healthy bladder tissue. The study, conducted by scientists at the Wellcome Sanger Institute, the University of Cambridge and their collaborators, provides an unprecedented view of the first steps towards bladder cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 1, 2020 Category: Cancer & Oncology Source Type: news

Extensive heterogeneity in somatic mutation and selection in the human bladder
This study reveals a rich landscape of mutational processes and selection in normal urothelium with large heterogeneity across clones and individuals. (Source: ScienceNOW)
Source: ScienceNOW - September 30, 2020 Category: Science Authors: Lawson, A. R. J., Abascal, F., Coorens, T. H. H., Hooks, Y., ONeill, L., Latimer, C., Raine, K., Sanders, M. A., Warren, A. Y., Mahbubani, K. T. A., Bareham, B., Butler, T. M., Harvey, L. M. R., Cagan, A., Menzies, A., Moore, L., Colquhoun, A. J., Turner, Tags: Genetics, Medicine, Diseases r-articles Source Type: news

Macroscopic somatic clonal expansion in morphologically normal human urothelium
In this study, we investigated somatic clonal events in morphologically normal human urothelium (MNU; epithelium lining the bladder and ureter) and identified macroscopic clonal expansions. Aristolochic acid (AA), a natural herb-derived compound, was a major mutagenic driving factor in MNU. AA drastically accelerates mutation accumulation and enhances clonal expansion. Mutations in MNU were widely observed in chromatin remodeling genes such as KMT2D and KDM6A but rarely in TP53, PIK3CA, and FGFR3. KMT2D mutations were found to be common in urothelial cells, regardless of whether the cells experience exogenous mutagen expos...
Source: ScienceNOW - September 30, 2020 Category: Science Authors: Li, R., Du, Y., Chen, Z., Xu, D., Lin, T., Jin, S., Wang, G., Liu, Z., Lu, M., Chen, X., Xu, T., Bai, F. Tags: Genetics, Medicine, Diseases r-articles Source Type: news

SIMPONI ARIA ® (golimumab) Approved by the U.S. Food and Drug Administration for Active Polyarticular Juvenile Idiopathic Arthritis and Extension of Its Active Psoriatic Arthritis Indication in Patients 2 Years of Age and Older
HORSHAM, PA, September 30, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) has approved SIMPONI ARIA® (golimumab) for patients 2 years of age and older for the treatment of active pJIA and has extended the PsA indication for this same patient population. “This latest FDA approval of SIMPONI ARIA for pediatric use in active pJIA and active PsA not only brings a new option to young patients living with these diseases but also adds to the growing body of evidence for this treatment,” said Mathai Mammen, M.D., Ph.D., Global Head, Jans...
Source: Johnson and Johnson - September 30, 2020 Category: Pharmaceuticals Source Type: news

A Manly Response to Disease
A conventional model of masculinity inhibits some men from expressing their emotional responses to assaults on the body. (Source: NYT Health)
Source: NYT Health - September 24, 2020 Category: Consumer Health News Authors: Susan Gubar Tags: Bladder Cancer Men and Boys Lehman, David Source Type: news

Smoking Reduces Survival Odds After Bladder Cancer Surgery
Title: Smoking Reduces Survival Odds After Bladder Cancer SurgeryCategory: Health NewsCreated: 9/23/2020 12:00:00 AMLast Editorial Review: 9/24/2020 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - September 24, 2020 Category: Cancer & Oncology Source Type: news