Black Cohosh Interactions with Prescription Medications Associated with Serotonin Toxicity and Rhabdomyolysis: A Case Report
Serotonin toxicity is a well-described phenomenon that is commonly attributed to a variety of drug-drug combinations. Some unregulated herbal supplements have been implicated in the onset of serotonin toxicity, however there is currently minimal literature available that demonstrates the potential for black cohosh to contribute to rhabdomyolysis and serotonin toxicity, despite its known serotonergic properties. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - January 9, 2024 Category: Emergency Medicine Authors: Matthew Robert Dernbach, Joseph E Carpenter, Nihar Shah, George Benjamin Carter Tags: Selected Topics: Toxicology Source Type: research
In Vitro and In Vivo Imaging-Based Evaluation of Doxorubicin Anticancer Treatment in Combination with the Herbal Medicine Black Cohosh
In this study, we evaluated the viability and survival of BC- and DOX-treated MCF-7 cells. A preclinical model of MCF-7 xenografts was used to determine the influence of BC and DOX administration on tumor growth and metabolism. The number of apoptotic cells after incubation with both DOX and BC was significantly increased (~100%) compared to the control. Treatment with DOX altered the potential of MCF-7 cells to form colonies; however, coincubation with BC did not affect this process. In vivo, PET-CT imaging showed that combined treatment of DOX and BC induced a significant reduction in both metabolic activity (29%) and an...
Source: Cancer Control - December 23, 2023 Category: Cancer & Oncology Authors: Agata P łoska Marcin Wozniak Jamila Hedhli Christian J Konopka Antonios Skondras Sarah Matatov Andrew Stawarz Sarah Schuh Andrzej Czerwinski Lawrence W Dobrucki Leszek Kalinowski Iwona T Dobrucki Source Type: research
Phytochemistry and ethnopharmacological studies of genus Cimicifuga: A systematic and comprehensive review
CONCLUSION: This article discusses the medicinal and traditional histories of various Cimicifuga species. Because quality control and safety assessments of Cimicifuga species are currently lacking, only a limited portion of the plant may be used as medication. The majority of current research focuses on triterpene glycosides. Although there are a variety of additional molecules that may have novel biological functions, systematic investigations of these compounds are lacking. The Cimicifuga plant has to go through a lot of studies before it can be completely used in clinics as a viable medicinal contender.PMID:38052334 | D...
Source: Fitoterapia - December 5, 2023 Category: Biochemistry Authors: Shireen Fatima Mahima Verma Irfan Ahmad Ansari Source Type: research
Phytochemistry and ethnopharmacological studies of genus Cimicifuga: A systematic and comprehensive review
CONCLUSION: This article discusses the medicinal and traditional histories of various Cimicifuga species. Because quality control and safety assessments of Cimicifuga species are currently lacking, only a limited portion of the plant may be used as medication. The majority of current research focuses on triterpene glycosides. Although there are a variety of additional molecules that may have novel biological functions, systematic investigations of these compounds are lacking. The Cimicifuga plant has to go through a lot of studies before it can be completely used in clinics as a viable medicinal contender.PMID:38052334 | D...
Source: Fitoterapia - December 5, 2023 Category: Biochemistry Authors: Shireen Fatima Mahima Verma Irfan Ahmad Ansari Source Type: research
Phytochemistry and ethnopharmacological studies of genus Cimicifuga: A systematic and comprehensive review
CONCLUSION: This article discusses the medicinal and traditional histories of various Cimicifuga species. Because quality control and safety assessments of Cimicifuga species are currently lacking, only a limited portion of the plant may be used as medication. The majority of current research focuses on triterpene glycosides. Although there are a variety of additional molecules that may have novel biological functions, systematic investigations of these compounds are lacking. The Cimicifuga plant has to go through a lot of studies before it can be completely used in clinics as a viable medicinal contender.PMID:38052334 | D...
Source: Cancer Control - December 5, 2023 Category: Cancer & Oncology Authors: Shireen Fatima Mahima Verma Irfan Ahmad Ansari Source Type: research
Extract of Cimicifuga racemosa (L.) Nutt protects ovarian follicle reserve of mice against in vitro deleterious effects of dexamethasone
Braz J Med Biol Res. 2023 Sep 22;56:e12811. doi: 10.1590/1414-431X2023e12811. eCollection 2023.ABSTRACTThe present study aims to investigate if Cimicifuga racemosa (L.) Nutt extract (CIMI) reduces deleterious effects of dexamethasone (DEXA) in ovaries cultured in vitro. Mouse ovaries were collected and cultured in DMEM+ only or supplemented with 5 ng/mL of CIMI, or 4 ng/mL DEXA, or both CIMI and DEXA. The ovaries were cultured at 37.5°C in 5% CO2 for 6 days. Ovarian morphology, follicular ultrastructure, and the levels of mRNA for Bax, Bcl-2, and Caspase-3 were evaluated. The results showed that DEXA reduced the percentag...
Source: Braz J Med Biol Res - October 4, 2023 Category: Research Authors: E I T de Assis V A N Azevedo M F de Lima Neto F C Costa L R F M Paulino P A A Barroso M H T Matos A P O do Monte M A M Donato C A Peixoto A N Godinho J M O Freire A L P Souza J R V Silva A W B Silva Source Type: research
Extract of Cimicifuga racemosa (L.) Nutt protects ovarian follicle reserve of mice against in vitro deleterious effects of dexamethasone
Braz J Med Biol Res. 2023 Sep 22;56:e12811. doi: 10.1590/1414-431X2023e12811. eCollection 2023.ABSTRACTThe present study aims to investigate if Cimicifuga racemosa (L.) Nutt extract (CIMI) reduces deleterious effects of dexamethasone (DEXA) in ovaries cultured in vitro. Mouse ovaries were collected and cultured in DMEM+ only or supplemented with 5 ng/mL of CIMI, or 4 ng/mL DEXA, or both CIMI and DEXA. The ovaries were cultured at 37.5°C in 5% CO2 for 6 days. Ovarian morphology, follicular ultrastructure, and the levels of mRNA for Bax, Bcl-2, and Caspase-3 were evaluated. The results showed that DEXA reduced the percentag...
Source: Brazilian Journal of Medical and Biological Research - October 4, 2023 Category: Research Authors: E I T de Assis V A N Azevedo M F de Lima Neto F C Costa L R F M Paulino P A A Barroso M H T Matos A P O do Monte M A M Donato C A Peixoto A N Godinho J M O Freire A L P Souza J R V Silva A W B Silva Source Type: research
Extract of Cimicifuga racemosa (L.) Nutt protects ovarian follicle reserve of mice against in vitro deleterious effects of dexamethasone
Braz J Med Biol Res. 2023 Sep 22;56:e12811. doi: 10.1590/1414-431X2023e12811. eCollection 2023.ABSTRACTThe present study aims to investigate if Cimicifuga racemosa (L.) Nutt extract (CIMI) reduces deleterious effects of dexamethasone (DEXA) in ovaries cultured in vitro. Mouse ovaries were collected and cultured in DMEM+ only or supplemented with 5 ng/mL of CIMI, or 4 ng/mL DEXA, or both CIMI and DEXA. The ovaries were cultured at 37.5°C in 5% CO2 for 6 days. Ovarian morphology, follicular ultrastructure, and the levels of mRNA for Bax, Bcl-2, and Caspase-3 were evaluated. The results showed that DEXA reduced the percentag...
Source: Braz J Med Biol Res - October 4, 2023 Category: Research Authors: E I T de Assis V A N Azevedo M F de Lima Neto F C Costa L R F M Paulino P A A Barroso M H T Matos A P O do Monte M A M Donato C A Peixoto A N Godinho J M O Freire A L P Souza J R V Silva A W B Silva Source Type: research
Extract of Cimicifuga racemosa (L.) Nutt protects ovarian follicle reserve of mice against in vitro deleterious effects of dexamethasone
Braz J Med Biol Res. 2023 Sep 22;56:e12811. doi: 10.1590/1414-431X2023e12811. eCollection 2023.ABSTRACTThe present study aims to investigate if Cimicifuga racemosa (L.) Nutt extract (CIMI) reduces deleterious effects of dexamethasone (DEXA) in ovaries cultured in vitro. Mouse ovaries were collected and cultured in DMEM+ only or supplemented with 5 ng/mL of CIMI, or 4 ng/mL DEXA, or both CIMI and DEXA. The ovaries were cultured at 37.5°C in 5% CO2 for 6 days. Ovarian morphology, follicular ultrastructure, and the levels of mRNA for Bax, Bcl-2, and Caspase-3 were evaluated. The results showed that DEXA reduced the percentag...
Source: Braz J Med Biol Res - October 4, 2023 Category: Research Authors: E I T de Assis V A N Azevedo M F de Lima Neto F C Costa L R F M Paulino P A A Barroso M H T Matos A P O do Monte M A M Donato C A Peixoto A N Godinho J M O Freire A L P Souza J R V Silva A W B Silva Source Type: research
Extract of Cimicifuga racemosa (L.) Nutt protects ovarian follicle reserve of mice against in vitro deleterious effects of dexamethasone
Braz J Med Biol Res. 2023 Sep 22;56:e12811. doi: 10.1590/1414-431X2023e12811. eCollection 2023.ABSTRACTThe present study aims to investigate if Cimicifuga racemosa (L.) Nutt extract (CIMI) reduces deleterious effects of dexamethasone (DEXA) in ovaries cultured in vitro. Mouse ovaries were collected and cultured in DMEM+ only or supplemented with 5 ng/mL of CIMI, or 4 ng/mL DEXA, or both CIMI and DEXA. The ovaries were cultured at 37.5°C in 5% CO2 for 6 days. Ovarian morphology, follicular ultrastructure, and the levels of mRNA for Bax, Bcl-2, and Caspase-3 were evaluated. The results showed that DEXA reduced the percentag...
Source: Brazilian Journal of Medical and Biological Research - October 4, 2023 Category: Research Authors: E I T de Assis V A N Azevedo M F de Lima Neto F C Costa L R F M Paulino P A A Barroso M H T Matos A P O do Monte M A M Donato C A Peixoto A N Godinho J M O Freire A L P Souza J R V Silva A W B Silva Source Type: research
Extract of Cimicifuga racemosa (L.) Nutt protects ovarian follicle reserve of mice against in vitro deleterious effects of dexamethasone
Braz J Med Biol Res. 2023 Sep 22;56:e12811. doi: 10.1590/1414-431X2023e12811. eCollection 2023.ABSTRACTThe present study aims to investigate if Cimicifuga racemosa (L.) Nutt extract (CIMI) reduces deleterious effects of dexamethasone (DEXA) in ovaries cultured in vitro. Mouse ovaries were collected and cultured in DMEM+ only or supplemented with 5 ng/mL of CIMI, or 4 ng/mL DEXA, or both CIMI and DEXA. The ovaries were cultured at 37.5°C in 5% CO2 for 6 days. Ovarian morphology, follicular ultrastructure, and the levels of mRNA for Bax, Bcl-2, and Caspase-3 were evaluated. The results showed that DEXA reduced the percentag...
Source: Braz J Med Biol Res - October 4, 2023 Category: Research Authors: E I T de Assis V A N Azevedo M F de Lima Neto F C Costa L R F M Paulino P A A Barroso M H T Matos A P O do Monte M A M Donato C A Peixoto A N Godinho J M O Freire A L P Souza J R V Silva A W B Silva Source Type: research
Extract of Cimicifuga racemosa (L.) Nutt protects ovarian follicle reserve of mice against in vitro deleterious effects of dexamethasone
Braz J Med Biol Res. 2023 Sep 22;56:e12811. doi: 10.1590/1414-431X2023e12811. eCollection 2023.ABSTRACTThe present study aims to investigate if Cimicifuga racemosa (L.) Nutt extract (CIMI) reduces deleterious effects of dexamethasone (DEXA) in ovaries cultured in vitro. Mouse ovaries were collected and cultured in DMEM+ only or supplemented with 5 ng/mL of CIMI, or 4 ng/mL DEXA, or both CIMI and DEXA. The ovaries were cultured at 37.5°C in 5% CO2 for 6 days. Ovarian morphology, follicular ultrastructure, and the levels of mRNA for Bax, Bcl-2, and Caspase-3 were evaluated. The results showed that DEXA reduced the percentag...
Source: Brazilian Journal of Medical and Biological Research - October 4, 2023 Category: Research Authors: E I T de Assis V A N Azevedo M F de Lima Neto F C Costa L R F M Paulino P A A Barroso M H T Matos A P O do Monte M A M Donato C A Peixoto A N Godinho J M O Freire A L P Souza J R V Silva A W B Silva Source Type: research
Extract of Cimicifuga racemosa (L.) Nutt protects ovarian follicle reserve of mice against in vitro deleterious effects of dexamethasone
Braz J Med Biol Res. 2023 Sep 22;56:e12811. doi: 10.1590/1414-431X2023e12811. eCollection 2023.ABSTRACTThe present study aims to investigate if Cimicifuga racemosa (L.) Nutt extract (CIMI) reduces deleterious effects of dexamethasone (DEXA) in ovaries cultured in vitro. Mouse ovaries were collected and cultured in DMEM+ only or supplemented with 5 ng/mL of CIMI, or 4 ng/mL DEXA, or both CIMI and DEXA. The ovaries were cultured at 37.5°C in 5% CO2 for 6 days. Ovarian morphology, follicular ultrastructure, and the levels of mRNA for Bax, Bcl-2, and Caspase-3 were evaluated. The results showed that DEXA reduced the percentag...
Source: Braz J Med Biol Res - October 4, 2023 Category: Research Authors: E I T de Assis V A N Azevedo M F de Lima Neto F C Costa L R F M Paulino P A A Barroso M H T Matos A P O do Monte M A M Donato C A Peixoto A N Godinho J M O Freire A L P Souza J R V Silva A W B Silva Source Type: research
Extract of Cimicifuga racemosa (L.) Nutt protects ovarian follicle reserve of mice against in vitro deleterious effects of dexamethasone
Braz J Med Biol Res. 2023 Sep 22;56:e12811. doi: 10.1590/1414-431X2023e12811. eCollection 2023.ABSTRACTThe present study aims to investigate if Cimicifuga racemosa (L.) Nutt extract (CIMI) reduces deleterious effects of dexamethasone (DEXA) in ovaries cultured in vitro. Mouse ovaries were collected and cultured in DMEM+ only or supplemented with 5 ng/mL of CIMI, or 4 ng/mL DEXA, or both CIMI and DEXA. The ovaries were cultured at 37.5°C in 5% CO2 for 6 days. Ovarian morphology, follicular ultrastructure, and the levels of mRNA for Bax, Bcl-2, and Caspase-3 were evaluated. The results showed that DEXA reduced the percentag...
Source: Brazilian Journal of Medical and Biological Research - October 4, 2023 Category: Research Authors: E I T de Assis V A N Azevedo M F de Lima Neto F C Costa L R F M Paulino P A A Barroso M H T Matos A P O do Monte M A M Donato C A Peixoto A N Godinho J M O Freire A L P Souza J R V Silva A W B Silva Source Type: research
Extract of Cimicifuga racemosa (L.) Nutt protects ovarian follicle reserve of mice against in vitro deleterious effects of dexamethasone
Braz J Med Biol Res. 2023 Sep 22;56:e12811. doi: 10.1590/1414-431X2023e12811. eCollection 2023.ABSTRACTThe present study aims to investigate if Cimicifuga racemosa (L.) Nutt extract (CIMI) reduces deleterious effects of dexamethasone (DEXA) in ovaries cultured in vitro. Mouse ovaries were collected and cultured in DMEM+ only or supplemented with 5 ng/mL of CIMI, or 4 ng/mL DEXA, or both CIMI and DEXA. The ovaries were cultured at 37.5°C in 5% CO2 for 6 days. Ovarian morphology, follicular ultrastructure, and the levels of mRNA for Bax, Bcl-2, and Caspase-3 were evaluated. The results showed that DEXA reduced the percentag...
Source: Braz J Med Biol Res - October 4, 2023 Category: Research Authors: E I T de Assis V A N Azevedo M F de Lima Neto F C Costa L R F M Paulino P A A Barroso M H T Matos A P O do Monte M A M Donato C A Peixoto A N Godinho J M O Freire A L P Souza J R V Silva A W B Silva Source Type: research
