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Treatment of BK Polyomavirus-Associated Nephropathy in Paediatric Kidney Transplant Recipients: Leflunomide Versus Cidofovir
CONCLUSIONS: Leflunomide and cidofovir showed similar efficacy for treatment of BK polyomavirus-associated nephropathy.PMID:38149668 | DOI:10.6002/ect.2023.0091 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - December 27, 2023 Category: Transplant Surgery Authors: G ülşah Kaya Aksoy Mine Erkan Mustafa Koyun Elif Çomak Havva Serap Toru Derya Mutlu Bahar Akkaya Sema Akman Source Type: research

Assessment of the cytolytic potential of a multivirus-targeted T cell therapy using a vital dye-based, flow cytometric assay
Reliable and sensitive characterization assays are important determinants of the successful clinical translation of immunotherapies. For the assessment of cytolytic potential, the chromium 51 (51Cr) release assay has long been considered the gold standard for testing effector cells. However, attaining the approvals to access and use radioactive isotopes is becoming increasingly complex, while technical aspects [i.e. sensitivity, short (4-6 hours) assay duration] may lead to suboptimal performance. This has been the case with our ex vivo expanded, polyclonal (CD4+ and CD8+) multivirus-specific T cell (multiVST) lines, which...
Source: Frontiers in Immunology - December 22, 2023 Category: Allergy & Immunology Source Type: research

The molecular footprints of BK virus in the product of conception over the second and third gestational trimesters
Prior studies have shown controversial results on the vertical transmission of BK virus (BKV). The present study aimed to assess the possibility of BKV vertical transmission from mother to fetus in the product... (Source: BMC Research Notes)
Source: BMC Research Notes - December 11, 2023 Category: Research Authors: Mona Shokoofeh, Somayeh Shatizadeh Malekshahi and Haleh Soltanghoraee Tags: Research Note Source Type: research

Effect of Leflunomide on Treatment of Pediatric Renal Transplant Recipients With BK Virus Infection
CONCLUSIONS: Treatment with leflunomide resulted in rapid BK virus clearance and preservation of renal function with no adverse effects.PMID:37965958 | DOI:10.6002/ect.2023.0258 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2023 Category: Transplant Surgery Authors: Evangelia Gole Andromachi Mitsioni Maria Darema Georgia Malakasioti Varvara Askiti Source Type: research

Comparative Study of Intravenous Immunoglobulin and Leflunomide Combination Therapy With Intravenous Immunoglobulin Single Therapy in Kidney Transplant Patients With BK Virus Infection: Single-Center Clinical Trial
CONCLUSIONS: Although BK viral load decreased significantly in both groups, there was a significant difference between patients who received intravenous immunoglobulin versus those who received the combination of intravenous immunoglobulin + leflunomide after 3 months. The addition of leflunomide to the intravenous immunoglobulin treatment seems to have a better effect in reducing BK viral load. However, further studies with a larger sample and longer duration are needed.PMID:37965956 | DOI:10.6002/ect.2023.0071 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2023 Category: Transplant Surgery Authors: Nakisa Rasaei Leila Malekmakan Ghazal Gholamabbas Pedram Abdizadeh Source Type: research