Avian ‘Bird’ Flu – undue media panic or genuine concern for pandemic potential requiring global preparedness action?
epidemics, avian influenza, H5N1, highly pathogenic avian influenza, HPAI (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 15, 2024 Category: Infectious Diseases Authors: Eskild Petersen, Ziad A Memish, David S Hui, Alessandra Scagliarini, Lone Simonsen, Edgar Simulundu, Jennifer Bloodgood, Lucille Blumberg, Shui- Shan Lee, Alimuddin Zumla Tags: Editorial Source Type: research
Optical controlled and nuclear targeted CECR2 competitor to downregulate CSF-1 for metastatic breast cancer immunotherapy
This study provides a promising therapeutic target and reliable strategy for metastatic breast cancer treatment by interrupting immunosuppressive crosstalk between tumor cells and macrophages.PMID:38615488 | DOI:10.1016/j.biomaterials.2024.122568 (Source: Biomaterials)
Source: Biomaterials - April 14, 2024 Category: Materials Science Authors: Yi Cen Ying Chen Xinxuan Li Xiayun Chen Baixue Yu Mengyi Yan Ni Yan Hong Cheng Shiying Li Source Type: research
Future proofing of chondroitin sulphate production: Importance of sustainability and quality for the end-applications
Int J Biol Macromol. 2024 Apr 12:131577. doi: 10.1016/j.ijbiomac.2024.131577. Online ahead of print.ABSTRACTChondroitin sulphates (CSs) are the most well-known glycosaminoglycans (GAGs) found in any living organism, from microorganisms to invertebrates and vertebrates (including humans), and provide several health benefits. The applications of CSs are numerous including tissue engineering, osteoarthritis treatment, antiviral, cosmetics, and skincare applications. The current commercial production of CSs mostly uses animal, bovine, porcine, and avian tissues as well as marine organisms, marine mammals, sharks, and other fis...
Source: International Journal of Biological Macromolecules - April 14, 2024 Category: Biochemistry Authors: Sushanta Kumar Saha Yin Zhu Patrick Murray Lena Madden Source Type: research
Viruses, Vol. 16, Pages 605: Host Immune Response Modulation in Avian Coronavirus Infection: Tracheal Transcriptome Profiling In Vitro and In Vivo
l Abdul-Careem
Infectious bronchitis virus (IBV) is a highly contagious Gammacoronavirus causing moderate to severe respiratory infection in chickens. Understanding the initial antiviral response in the respiratory mucosa is crucial for controlling viral spread. We aimed to characterize the impact of IBV Delmarva (DMV)/1639 and IBV Massachusetts (Mass) 41 at the primary site of infection, namely, in chicken tracheal epithelial cells (cTECs) in vitro and the trachea in vivo. We hypothesized that some elements of the induced antiviral responses are distinct in both infection models. We inoculated cTECs and infected young...
Source: Viruses - April 14, 2024 Category: Virology Authors: Kelsey O ’Dowd Ishara M. Isham Safieh Vatandour Martine Boulianne Charles M. Dozois Carl A. Gagnon Neda Barjesteh Mohamed Faizal Abdul-Careem Tags: Article Source Type: research
Discovery andsynthesis of novel benzoylhydrazone neuraminidase inhibitors
Bioorg Med Chem Lett. 2024 Apr 10:129743. doi: 10.1016/j.bmcl.2024.129743. Online ahead of print.ABSTRACTNeuraminidase (NA) serves as a promising target for the exploration and development of anti-influenza drugs. In this work, lead compound 5 was discovered through pharmacophore-based virtual screening and molecular dynamics simulation, and 14 new compounds were obtained by modifying the lead compound 5 based on pharmacophore features. The biological activity test shows that 5n (IC50 = 0.13 μM) has a better inhibitory effect on wild-type NA (H5N1), while 5i (IC50 = 0.44 μM) has a prominent inhibitory effect on mutant NA...
Source: Bioorganic and Medicinal Chemistry Letters - April 12, 2024 Category: Chemistry Authors: Shi Kai Fu Li Ping Cheng Source Type: research
Viruses, Vol. 16, Pages 593: Antiviral Chemotherapy in Avian Medicine & mdash;A Review
Viruses, Vol. 16, Pages 593: Antiviral Chemotherapy in Avian Medicine—A Review
Viruses doi: 10.3390/v16040593
Authors:
Ines Szotowska
Aleksandra Ledwoń
This review article describes the current knowledge about the use of antiviral chemotherapeutics in avian species, such as farm poultry and companion birds. Specific therapeutics are described in alphabetical order including classic antiviral drugs, such as acyclovir, abacavir, adefovir, amantadine, didanosine, entecavir, ganciclovir, interferon, lamivudine, penciclovir, famciclovir, oseltamivir, ribavirin, and zidovudine, repurposed drugs, such as iver...
Source: Viruses - April 12, 2024 Category: Virology Authors: Ines Szotowska Aleksandra Ledwo ń Tags: Review Source Type: research
Viruses, Vol. 16, Pages 598: Avian Influenza Virus and Avian Paramyxoviruses in Wild Waterfowl of the Western Coast of the Caspian Sea (2017 & ndash;2020)
Viruses, Vol. 16, Pages 598: Avian Influenza Virus and Avian Paramyxoviruses in Wild Waterfowl of the Western Coast of the Caspian Sea (2017–2020)
Viruses doi: 10.3390/v16040598
Authors:
Murashkina
Sharshov
Gadzhiev
Petherbridge
Derko
Sobolev
Dubovitskiy
Loginova
Kurskaya
Kasianov
Kabilov
Mine
Uchida
Tsunekuni
Saito
Alekseev
Shestopalov
The flyways of many different wild waterfowl pass through the Caspian Sea region. The western coast of the middle Caspian Sea is an area with many wetlands, where wintering grounds with large concentrations of birds are loca...
Source: Viruses - April 12, 2024 Category: Virology Authors: Murashkina Sharshov Gadzhiev Petherbridge Derko Sobolev Dubovitskiy Loginova Kurskaya Kasianov Kabilov Mine Uchida Tsunekuni Saito Alekseev Shestopalov Tags: Article Source Type: research
Opportunistic sampling of yellow canary (Crithagra flaviventris) has revealed a high genetic diversity of detected parvoviral sequences
Virology. 2024 Apr 4;595:110081. doi: 10.1016/j.virol.2024.110081. Online ahead of print.ABSTRACTParvoviruses are known to be significant viral pathogens that infect a wide range of species globally. However, little is known about the parvoviruses circulating in Australian birds, including yellow canaries. Here, we present four parvoviral sequences including three novel parvoviruses detected from 10 yellow canaries (Crithagra flaviventris), named canary chaphamaparvovirus 1 and -2 (CaChPV1 and CaChPV2), canary dependoparvovirus 1 and -2 (CaDePV1 and CaDePV2). The whole genome sequences of CaChPV1, CaChPV2, CaDePV1, and CaD...
Source: Virology - April 10, 2024 Category: Virology Authors: Yuhao Zhang Saranika Talukder Md Safiul Alam Bhuiyan Lei He Subir Sarker Source Type: research
Opportunistic sampling of yellow canary (Crithagra flaviventris) has revealed a high genetic diversity of detected parvoviral sequences
Virology. 2024 Apr 4;595:110081. doi: 10.1016/j.virol.2024.110081. Online ahead of print.ABSTRACTParvoviruses are known to be significant viral pathogens that infect a wide range of species globally. However, little is known about the parvoviruses circulating in Australian birds, including yellow canaries. Here, we present four parvoviral sequences including three novel parvoviruses detected from 10 yellow canaries (Crithagra flaviventris), named canary chaphamaparvovirus 1 and -2 (CaChPV1 and CaChPV2), canary dependoparvovirus 1 and -2 (CaDePV1 and CaDePV2). The whole genome sequences of CaChPV1, CaChPV2, CaDePV1, and CaD...
Source: Virology - April 10, 2024 Category: Virology Authors: Yuhao Zhang Saranika Talukder Md Safiul Alam Bhuiyan Lei He Subir Sarker Source Type: research
Opportunistic sampling of yellow canary (Crithagra flaviventris) has revealed a high genetic diversity of detected parvoviral sequences
Virology. 2024 Apr 4;595:110081. doi: 10.1016/j.virol.2024.110081. Online ahead of print.ABSTRACTParvoviruses are known to be significant viral pathogens that infect a wide range of species globally. However, little is known about the parvoviruses circulating in Australian birds, including yellow canaries. Here, we present four parvoviral sequences including three novel parvoviruses detected from 10 yellow canaries (Crithagra flaviventris), named canary chaphamaparvovirus 1 and -2 (CaChPV1 and CaChPV2), canary dependoparvovirus 1 and -2 (CaDePV1 and CaDePV2). The whole genome sequences of CaChPV1, CaChPV2, CaDePV1, and CaD...
Source: Virology - April 10, 2024 Category: Virology Authors: Yuhao Zhang Saranika Talukder Md Safiul Alam Bhuiyan Lei He Subir Sarker Source Type: research
Opportunistic sampling of yellow canary (Crithagra flaviventris) has revealed a high genetic diversity of detected parvoviral sequences
Virology. 2024 Apr 4;595:110081. doi: 10.1016/j.virol.2024.110081. Online ahead of print.ABSTRACTParvoviruses are known to be significant viral pathogens that infect a wide range of species globally. However, little is known about the parvoviruses circulating in Australian birds, including yellow canaries. Here, we present four parvoviral sequences including three novel parvoviruses detected from 10 yellow canaries (Crithagra flaviventris), named canary chaphamaparvovirus 1 and -2 (CaChPV1 and CaChPV2), canary dependoparvovirus 1 and -2 (CaDePV1 and CaDePV2). The whole genome sequences of CaChPV1, CaChPV2, CaDePV1, and CaD...
Source: Virology - April 10, 2024 Category: Virology Authors: Yuhao Zhang Saranika Talukder Md Safiul Alam Bhuiyan Lei He Subir Sarker Source Type: research
Isolation and genetic characteristics of Novel H4N1 Avian Influenza viruses in ChongQing, China
Avian influenza viruses (AIVs) constitute significant zoonotic pathogens encompassing a broad spectrum of subtypes. Notably, the H4 subtype of AIVs has a pronounced ability to shift hosts. The escalating preva... (Source: Virology Journal)
Source: Virology Journal - April 10, 2024 Category: Virology Authors: Jinyue He, Jing Deng, Xianxian Wen, Mengyuan Yan, Yang Liu, Yunqiu Zhou, XuBin Du, Han Yang and Xiaobin Peng Tags: Research Source Type: research
Immunopathological investigation and genetic evolution of Avian leukosis virus Subgroup-J associated with myelocytomatosis in broiler flocks in Egypt
Avian leukosis virus Subgroup-J (ALV-J) is a rapidly oncogenic evolving retrovirus infecting a variety of avian species; causing severe economic losses to the local poultry industry. (Source: Virology Journal)
Source: Virology Journal - April 10, 2024 Category: Virology Authors: Ahmed Fotouh, Eman Abd El-Menamm Shosha, Ali Mahmood Zanaty and Marwa Mostafa Darwesh Tags: Research Source Type: research
Generation and characterization of a nanobody against the avian influenza virus H7 subtype
This study screened a strain of Nb with high hemagglutination inhibition activity and enhanced its antiviral activity through oligomerization, which may have great potential for developing effective agents for the prevention, diagnosis, and treatment of AIV H7 subtype infection.PMID:38593899 | DOI:10.1016/j.ijbiomac.2024.131458 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 9, 2024 Category: Biochemistry Authors: Xiuqin Huang Weiye Li Xuewei Cao Qi Zhang Yizhen Lin Siqi Xu Xinying Dong Peiqi Liu Yutong Liu Ge He Kaijian Luo Saixiang Feng Source Type: research
The virus is out of the barn: the emergence of HPAI as a pathogen of avian and mammalian wildlife around the globe
Am J Vet Res. 2024 Apr 13:1-7. doi: 10.2460/ajvr.24.01.0018. Online ahead of print.ABSTRACTHighly pathogenic avian influenza (HPAI) has persisted as a One Health threat whose current circulation and impact are addressed in the companion Currents in One Health by Puryear and Runstadler, JAVMA, March 2024. Highly pathogenic avian influenza emerged as a by-product of agricultural practices and adapted to endemic circulation in wild bird species. Over more than 20 years, continued evolution in a complex ecology involving multiple hosts has produced a lineage that expanded globally over the last 2 years. Understanding the conti...
Source: American Journal of Veterinary Research - April 9, 2024 Category: Veterinary Research Authors: Jonathan A Runstadler Wendy B Puryear Source Type: research
