Multiscale topology in interactomic network: from transcriptome to antiaddiction drug repurposing
This study embarked on an innovative and rigorous strategy to unearth potential drug repurposing candidates for opioid and cocaine addiction treatment, bridging the gap between transcriptomic data analysis and drug discovery. We initiated our approach by conducting differential gene expression analysis on addiction-related transcriptomic data to identify key genes. We propose a novel topological differentiation to identify key genes from a protein-protein interaction network derived from DEGs. This method utilizes persistent Laplacians to accurately single out pivotal nodes within the network, conducting this analysis in a...
Source: Briefings in Bioinformatics - March 18, 2024 Category: Bioinformatics Authors: Hongyan Du Guo-Wei Wei Tingjun Hou Source Type: research

Molecular docking analysis of flavonoids with AChE and BACE-1
Bioinformation. 2024 Feb 29;20(2):103-109. doi: 10.6026/973206300200103. eCollection 2024.ABSTRACTFlavonoids are promising therapeutics for the treatment of Alzheimer's disease (AD). Therefore, it is of interest to study the anti-AD potential of 35 flavonoids towards the inhibition of AchE and BACE-1. Hence, the physicochemical, pharmacokinetic parameters, toxicity risk and drug-likeliness of the selected 35 flavonoids were computed. Further, the molecular docking analysis of flavonoids with AChE and BACE-1 were completed. A binding energy of -10.42 kcal/mol Epicatechin gallate, -10.16 kcal/mol sterubin and -10.11 kcal/mol...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Sittarthan Viswanathan Thennavan Arumugam Kavimani Subramanian Rengaraj Sivaraj Vimalavathini Ramesh A Hannah Rachel Vasanthi Source Type: research

Amino acid pattern reveals multi-functionality of ORF3 protein from HEV
Bioinformation. 2024 Feb 29;20(2):121-135. doi: 10.6026/973206300200121. eCollection 2024.ABSTRACTThe smallest open reading frame (ORF) encoded protein ORF3 of hepatitis E virus (HEV), recently, has been demonstrated to perform multiple functions besides accessory roles. ORF3 could act as a target for vaccine against HEV infections. The IDR (intrinsically disordered region); IDP (ID protein)/IDPR (ID protein region), plays critical role in various regulatory functions of viruses. The dark proteome of HEV-ORF3 protein including its structure and function was systematically examined by computer predictors to explicate its ro...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Zoya Shafat Asimul Islam Shama Parveen Source Type: research

Knowledge, attitudes and demographic effect on menopausal experiences among Indian rural women
This study underscored the need for tailored interventions in rural settings, considering the influence of cultural, regional, and demographic factors on menopausal experiences. The findings contributed to bridging the research gap and emphasized the importance of individualized approaches for promoting the well-being of menopausal women in rural communities.PMID:38497080 | PMC:PMC10941773 | DOI:10.6026/973206300200175 (Source: Bioinformation)
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: N Sivasubramanian Chaudhari Pinalben Madhabhai Amita Shilpa Gottlieb B Mahalakshmi Payal Vaghela Sandeep Garg Source Type: research

Impact of oil massage on newborn behavioural responses in rural India
This study, conducted in a rural setting, aims to bridge traditional practices with evidence-based care, exploring the impact of oil massage on newborn behavioural responses. A quasi-experimental design involving 60 newborns (30 in each group) assessed behavioural responses through a pre and post-test approach. Results indicate a significant improvement in selected behavioural responses among newborns receiving oil massage, emphasizing its potential integration into routine care. The control group showed a pre-test mean of 14.83 (SD = 2.41) and a post-test mean of 16.23, while the experimental group exhibited a pre-test me...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: B Mahalakshmi Patel Urvi Sureshbhai Amita Shilpa Gottlieb N Sivasubramanian Gnanadesigan Ekambaram Ravi Kant Source Type: research

Bio-ceramics application in Dentistry
Bioinformation. 2024 Feb 29;20(2):136-139. doi: 10.6026/973206300200136. eCollection 2024.ABSTRACTBioceramics have gained significant attention in dentistry due to their unique properties, including biocompatibility, osseointegration, and tissue regeneration. Therefore, it is of interest to report the various applications of bioceramics in dentistry, their advantages, limitations, and future considerations. Bio-ceramics such as zirconia and hydroxyapatite offer high biocompatibility and durability for dental application. They support bone integration for implants, resist wear, and mimic natural tooth aesthetics. Used in cr...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Pratik Surana Kanika Singh Dhull Ashtha Arya Sara Samreen Milind Rajan Anuj Singh Parihar Source Type: research

A 2023 nationwide study on adjustment disorder among first year MBBS students in India
Bioinformation. 2024 Feb 29;20(2):190-195. doi: 10.6026/973206300200190. eCollection 2024.ABSTRACTAmidst the complex transition to medical college, encompassing a myriad of academic, social, and personal adjustments, MBBS students in India confront multifaceted challenges that can precipitate adjustment disorder, a phenomenon understudied within the Indian context. Therefore, it is of interest to assess adjustment disorder among first-year MBBS students within six months of enrolment. We used a Google form encompassing adjustment disorder new-module 20 for data collection and found that 67% of the 401 responses from first-...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Mayank Agarwal Priyanka Sharma Ayan Goswami Roopali Mittal Source Type: research

Deciphering aging-associated molecular mechanisms in bone marrow derived hematopoietic stem cells in the elderly using NGS data
Bioinformation. 2024 Feb 29;20(2):180-189. doi: 10.6026/973206300200180. eCollection 2024.ABSTRACTAging is a complex process that is not yet fully understood. Despite advancements in research, a deeper understanding of the underlying biological mechanisms is necessary to develop interventions that promote healthy longevity. The aim of this study was to elucidate the complex mechanisms associated with healthy aging and longevity in healthy elderly individuals. The RNA sequencing (RNA-seq) data used in this study was obtained from the Gene Expression Omnibus (GEO) database (accession number GSE104406), which was collected fr...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Hind A Alkhatabi Source Type: research

Adiponectin and HbA1c levels among Indian patients with diabetes mellitus
Bioinformation. 2024 Feb 29;20(2):202-207. doi: 10.6026/973206300200202. eCollection 2024.ABSTRACTAdiponectin is closely related to glucose metabolism and newly diagnosed type 2 diabetes mellitus (T2DM), and other kinds of diabetes linked to the risk of T2DM. Therefore, it is of interest to report the correlation between adiponectin levels and glycosylated hemoglobin (HbA1c) as a diagnostic marker of T2DM and healthy control. Total 210 participants were included of IPD & OPD healthy controls with glycosylated hemoglobin levels under 6% were included. Blood samples, collected using sterile clot activator or plain vials,...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Mohammad Arif Shreya Nigoskar Manish Kumar Verma Source Type: research

Mathematical model for assessing glycemic control in type 2 diabetes mellitus
Bioinformation. 2024 Feb 29;20(2):116-120. doi: 10.6026/973206300200116. eCollection 2024.ABSTRACTGlycated hemoglobin (HbA1c) and glycated albumin (GA) are vital markers for assessing glucose control in diabetes. This cross-sectional study involving 901 diagnosed type 2 diabetics aimed to compare calculated HbA1c, using the formula HbA1c = 2.6 + 0.03 x FBS (mg/dL), with directly measured HbA1c. Simultaneously, the study assessed the agreement between the two methods through regression analysis and explored correlations with various measures of glycemic control. The non-parametric Kolmogorov-Smirnov test indicated a non-nor...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Anitha Misquith Harish Rangareddy Venkateshappa Chikkanarayanappa Ayesha Sultana Srinivasaiah Ashakiran Source Type: research

Insights into amyloid precursor protein target through PPI network analysis
Bioinformation. 2024 Feb 29;20(2):140-145. doi: 10.6026/973206300200140. eCollection 2024.ABSTRACTAlzheimer's disease (AD) is the leading cause of dementia worldwide with therapeutic lacunae till date. The beta-amyloid (Aβ) accumulation triggers AD pathogenesis, though clinical trials lowering Aβ have not altered disease outcomes suggesting other interacting factors to be identified for drug design of AD. Therefore, it is of interest to identify potential hub proteins interlinked with disease-driving pathways using a network-based approach for AD therapeutic designing. Literature mining was done to identify proteins impl...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Annu Grewal Deepak Sheokand Raveena Chauhan Vandana Saini Ajit Kumar Source Type: research

Exploring eating behaviors, knowledge and attitudes of adolescent Indian girls
Bioinformation. 2024 Feb 29;20(2):165-169. doi: 10.6026/973206300200165. eCollection 2024.ABSTRACTData on the eating behaviors, knowledge, and attitudes of adolescent girls in Visnagar, India, focusing on the prevalence of non-communicable diseases [NCDs] and their association with dietary practices is of interest. Adolescence, a crucial developmental phase, sets the foundation for lifelong health habits, necessitating an understanding of the determinants influencing eating behaviors. The research aims to identify gaps in knowledge, attitudes, and practices [KAP], providing insights for culturally sensitive public health s...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: N Sivasubramanian Desai Nehaben Jashubhai B Mahalakshmi Gnanadesigan Ekambaram Ravi Kant Source Type: research

Molecular docking analysis of marine phytochemicals with BACE-1
Bioinformation. 2024 Feb 29;20(2):151-155. doi: 10.6026/973206300200151. eCollection 2024.ABSTRACTAlzheimer's disease (AD), a debilitating neurodegenerative condition, is characterized by progressive cognitive decline brought about by the deposition of amyloid beta (Aβ) plaques in the brain initiates downstream neuronal dysfunction and death in AD pathogenesis. The β-secretase (BACE-1) enzyme plays a crucial role in generating Aβ from amyloid precursor protein (APP). Hence, we report the virtual screening of marine phytochemicals as BACE-1 inhibitors. 2583 compounds, retrieved from Comprehensive Marine Natural Product D...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Deepak Sheokand Annu Grewal Pawan Kumar Raveena Chauhan Vandana Saini Ajit Kumar Source Type: research

Effect of aerobic exercise on anthropometric parameters among Indian primary school children
This study addresses the rising rates of obesity among school-age children (10-12 years) and investigates the effectiveness of aerobic exercise interventions in improving anthropometric parameters, specifically focusing on BMI and mid-arm circumference (MAC). The study emphasizes the role of schools in shaping children's behaviors and aims to contribute empirical evidence to inform health promotion strategies for this demographic. The research employs a quasi-experimental design, involving 60 school-age children in Visnagar, Gujarat, India. The 12-week aerobic exercise intervention, conducted three times a week, comprises ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: B Mahalakshmi Anjana Jagashibhai Chaudhary Amita Shilpa Gottlieb N Sivasubramanian Padmavathi Parthasarathy G Ramalakshmi P Jamunarani Source Type: research

Disability from cardiovascular diseases at Osh city, Kyrgyz Republic
We report the prevalence of disability in both urban and rural areas, highlighting the impact of regional disparities in medical and social services. Data shows that adult cardiovascular disease impairment in Kyrgyzstan suggests challenges in accessing medical and social support, particularly in rural regions. Thus, the rural-urban divide in critical disability metrics impedes equitable research. Comprehensive assessments and interventions are imperative to mitigate cardiovascular diseases and associated disabilities in both rural and urban populations at Kyrgyz Republic.PMID:38497069 | PMC:PMC10941784 | DOI:10.6026/973206...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Tazhidinovich Gulamov Isabek Kalmatovich Kalmatov Romanbek Sagynbaevich Sydykov Akylbek Temirzhanovich Abylov Kuttubek Nurlan Raiimbekuulu Akbalaevna Akbalaeva Begimai Siddiqui Mohd Faizan Source Type: research