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Impact of temperature-controlled endobiliary radiofrequency ablation for inoperable hilar cholangiocarcinoma: A propensity score –matched analysis
Conclusions Temperature-controlled endobiliary RFA resulted in favorable stent patency without increasing the rate of AEs but it did not significantly increase OS in patients with inoperable hilar CCA (Clinical trial registration number: KCT0008576). [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - April 15, 2024 Category: Gastroenterology Authors: Shin, Il Sang Moon, Jong Ho Lee, Yun Nah Myeong, Jun Ho Lee, Tae Hoon Yang, Jae Kook Cho, Young Deok Park, Sang-Heum Tags: Original article Source Type: research

Identification of Novel Cuproptosis-Related Genes Mediating the Prognosis and Immune Microenvironment in Cholangiocarcinoma
CONCLUSIONS: Collectively, we established and verified an effective prognostic model that could separate cholangiocarcinoma patients into 2 heterogeneous cuproptosis subtypes based on the molecular or protein characteristics of 10 cuproptosis-related genes. These findings may provide potential benefits for unveiling molecular characteristics and defining subgroups could improve the early diagnosis and individualized treatment of cholangiocarcinoma patients.PMID:38613350 | DOI:10.1177/15330338241239139 (Source: Cell Research)
Source: Cell Research - April 13, 2024 Category: Cytology Authors: Qiang Liu Jianpeng Zhu Zhicheng Huang Xiaofeng Zhang Jianfeng Yang Source Type: research

Identification of Novel Cuproptosis-Related Genes Mediating the Prognosis and Immune Microenvironment in Cholangiocarcinoma
CONCLUSIONS: Collectively, we established and verified an effective prognostic model that could separate cholangiocarcinoma patients into 2 heterogeneous cuproptosis subtypes based on the molecular or protein characteristics of 10 cuproptosis-related genes. These findings may provide potential benefits for unveiling molecular characteristics and defining subgroups could improve the early diagnosis and individualized treatment of cholangiocarcinoma patients.PMID:38613350 | DOI:10.1177/15330338241239139 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 13, 2024 Category: Cancer & Oncology Authors: Qiang Liu Jianpeng Zhu Zhicheng Huang Xiaofeng Zhang Jianfeng Yang Source Type: research

Identification of Novel Cuproptosis-Related Genes Mediating the Prognosis and Immune Microenvironment in Cholangiocarcinoma
CONCLUSIONS: Collectively, we established and verified an effective prognostic model that could separate cholangiocarcinoma patients into 2 heterogeneous cuproptosis subtypes based on the molecular or protein characteristics of 10 cuproptosis-related genes. These findings may provide potential benefits for unveiling molecular characteristics and defining subgroups could improve the early diagnosis and individualized treatment of cholangiocarcinoma patients.PMID:38613350 | PMC:PMC11015765 | DOI:10.1177/15330338241239139 (Source: Cell Research)
Source: Cell Research - April 13, 2024 Category: Cytology Authors: Qiang Liu Jianpeng Zhu Zhicheng Huang Xiaofeng Zhang Jianfeng Yang Source Type: research

Identification of Novel Cuproptosis-Related Genes Mediating the Prognosis and Immune Microenvironment in Cholangiocarcinoma
CONCLUSIONS: Collectively, we established and verified an effective prognostic model that could separate cholangiocarcinoma patients into 2 heterogeneous cuproptosis subtypes based on the molecular or protein characteristics of 10 cuproptosis-related genes. These findings may provide potential benefits for unveiling molecular characteristics and defining subgroups could improve the early diagnosis and individualized treatment of cholangiocarcinoma patients.PMID:38613350 | PMC:PMC11015765 | DOI:10.1177/15330338241239139 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 13, 2024 Category: Cancer & Oncology Authors: Qiang Liu Jianpeng Zhu Zhicheng Huang Xiaofeng Zhang Jianfeng Yang Source Type: research

Identification of clinically relevant subsets CD39 + PD-1 + CD8 + T cells and CD39 + regulatory T cells in intrahepatic cholangiocarcinoma using single-cell CyTOF
This study utilized mass cytometry by time of flight (CyTOF) to comprehensively analyze immune cell populations in fresh iCCA tumor samples and adjacent peritumor liver tissues. Notably, NK cell percentages significantly decreased in iCCA lesions compared to peritumor liver tissues. Conversely, an enrichment of immunosuppressive CD39+Foxp3+CD4+ regulatory T cells (CD39+T-regs) and exhausted-like CD8+T cells (with pronounced CD39 and PD-1 expression) within TIME was identified and confirmed by multiplex immunofluorescence staining in an independent patient cohort (n = 140). Crucially, tumor-infiltrating CD39+T-regs and CD39...
Source: Translational Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Qi-Wei Zhang Meng-Xuan Zhu Wen-Feng Liu Wei-Wei Rui Yong Chen Xiao-Yi Ding Yong-Sheng Jiang Zhi-Yuan Wu Bin-Bin Liu Source Type: research

False-negative factors of percutaneous transluminal clamp biopsy for suspected malignant biliary stricture: 194 cases analyzed from a single center
ConclusionPTCB is an effective minimally invasive interventional technique for BS diagnosis. Non-cholangiocarcinoma BS is an independent risk factor for FNV.Critical relevance statementIdentifying factors that are predictive of false-negative results by percutaneous transluminal clamp biopsy in the setting of biliary stricture may have a guiding effect on clinical practice.Key points• Factors predictive of false negatives in the diagnosis of biliary stricture etiology by PTCB may aid in the interpretation of results.• Non-cholangiocarcinoma BS is an independent risk factor for FNV on PTCB.• PTCB is an effective minim...
Source: Insights into Imaging - April 12, 2024 Category: Radiology Source Type: research

ASO Author Reflections: ICC PRS Score: Clinically Useful Tool to Predict Post-recurrence Survival and Guide Management of Recurrent Intrahepatic Cholangiocarcinoma
Ann Surg Oncol. 2024 Apr 11. doi: 10.1245/s10434-024-15269-x. Online ahead of print.NO ABSTRACTPMID:38602579 | DOI:10.1245/s10434-024-15269-x (Source: Ann Oncol)
Source: Ann Oncol - April 11, 2024 Category: Cancer & Oncology Authors: Diamantis I Tsilimigras Timothy M Pawlik Source Type: research

Differences in Lymph Node Metastases Patterns Among Non-pancreatic Periampullary Cancers and Histologic Subtypes: An International Multicenter Retrospective Cohort Study and Systematic Review
CONCLUSION: This study is the first to comprehensively demonstrate the differences and similarities in lymph node metastases spread among NPPCs, to identify the existing research gaps, and to underscore the importance of standardized lymphadenectomy and pathologic assessment for AAC, dCCA, and DAC.PMID:38602578 | DOI:10.1245/s10434-024-15213-z (Source: Ann Oncol)
Source: Ann Oncol - April 11, 2024 Category: Cancer & Oncology Authors: Bas A Uijterwijk Dani ël H Lemmers Giuseppe Kito Fusai Alessandro Zerbi Roberto Salvia Ernesto Sparrelid Steven White Bergthor Bj örnsson Vasileios K Mavroeidis Keith J Roberts Michele Mazzola Santiago S ánchez Cabús Zahir Soonawalla Dimitris Korkolis Source Type: research

Predicting prognosis in intrahepatic cholangiocarcinoma by the histopathological features
CONCLUSION: High tumor budding and glandular structure are two important histopathological features that serve as prognostic factors for ICC patients undergoing hepatectomy.PMID:38604849 | DOI:10.1016/j.asjsur.2024.03.085 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 11, 2024 Category: Surgery Authors: Hu Liu Tian Lan Yun-Shi Cai Ying-Hao Lyu Jiang Zhu Si-Nan Xie Feng-Juan Hu Chang Liu Hong Wu Source Type: research

Novel definition of textbook outcome in biliary system cancers and its influence on patients' survival and quality of life
ConclusionsThe novel definition of textbook outcome was able to address the specific nature of recovery after resection of biliary system cancers. Expanding the scope of textbook outcome and addressing the influence on survival and quality of life provides a comprehensive concept able to reflect physical, psychological and functioning enhancements in patients recovery. (Source: Cancer Medicine)
Source: Cancer Medicine - April 11, 2024 Category: Cancer & Oncology Authors: Manar Mikhail Atyah, Li Xu, Zhiying Yang Tags: RESEARCH ARTICLE Source Type: research

Impact of surgery-induced myeloid-derived suppressor cells and the NOX2/ROS axis on post-operative survival in human pancreatic cancer
This study included 17 patients with periampullary cancer (pancreatic ductal adenocarcinoma (PDAC) n=14, ampullary carcinoma n=2, cholangiocarcinoma n=1) undergoing major pancreatic cancer surgery with curative intent. We analyzed the potential impact of pre- and postoperative immune phenotypes and function on postoperative survival with >30 months follow-up. The surgery entailed prompt expansion of monocytic myeloid-derived suppressor cells (M-MDSC) that generated NOX2-derived reactive oxygen species (ROS). Strong induction of immunosuppressive M-MDSC after surgery predicted poor post-operative survival and coincided w...
Source: Cell Research - April 10, 2024 Category: Cytology Authors: Hanna Grauers Wiktorin Ebru Aydin Roberta Kiffin Caroline Vilhav Johan Bourghardt Fagman Mustafa Kaya Sanchari Paul Beatrice Westman Svein Olav Bratlie Peter Naredi Kristoffer Hellstrand Anna Martner Source Type: research