Pharmacotherapy of Chronic Rhinosinusitis with a Focus on Clarithromycin: An Expert Opinion.
Authors: Bhargava SK, Peethambaran K Abstract Chronic Rhinosinusitis (CRS) is frequently distinguished as persistent symptomatic inflammation of the nasal and sinus mucosa and is recognized as one of the most common chronic diseases, with high incidence rate. It has a major impact on overall quality of life. Although, the etiology and pathogenesis of CRS are not clearly understood, there are several hypotheses on CRS etiology and pathogenesis. The presence of biofilms and bacterial infection, as well as fungal infection, allergy, environmental pollutants, and smoking are considered as a possible environmental facto...
Source: Journal of the Association of Physicians of India - July 20, 2019 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Post-surgical atypical mycobacteriosis in 125 patients in Rio de Janeiro
CONCLUSIONS: Despite the need for multidrug therapy and long treatment duration, most included patients adhered to treatment and experienced cure without relapse. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - July 18, 2019 Category: Tropical Medicine Source Type: research

Providing insight into the incubation period of Mycobacterium ulcerans disease: two case reports
ConclusionsBuruli ulcer should be included in the differential diagnosis of neonates who present with characteristic lesions. The incubation period of Buruli ulcer in neonates is probably shorter than is reported for adults. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - July 18, 2019 Category: General Medicine Source Type: research

Prevalence of clarithromycin-resistant Helicobacter pylori in children living in South of Sweden: a 12-year follow-up.
Conclusions: More than one in every ten (12%) children investigated with upper endoscopy in the southernmost parts of Sweden were gastric HP-DNA positive of which 21% were crHP regardless of indication for investigation. Clarithromycin is therefore not recommended as first line empirical treatment for eradicating an HP infection in children. PMID: 31305189 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - July 16, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

IJERPH, Vol. 16, Pages 2471: A Cheek Nodule in a Child: Be Aware of Idiopathic Facial Aseptic Granuloma and Its Differential Diagnosis
Conclusion: This case shows how to differentiate IFAG from other dermatologic diseases associated with a negative evolution. Treatment with oral clarithromycin was effective in our patient. However, more scientific evidence is needed to evaluate the most suitable antibiotic therapy. Further studies are also needed to establish whether antibiotics actually impact IFAG prognosis. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - July 11, 2019 Category: Environmental Health Authors: Francesco Miconi Nicola Principi Lorenzo Cassiani Federica Celi Roberta Crispoldi Ada Russo Susanna Esposito Manuela Papini Tags: Case Report Source Type: research

A rare case of pulmonary mycobacteriosis caused by rifabutin resistant Mycobacterium celatum and review of the literature
Publication date: Available online 8 July 2019Source: Respiratory Medicine Case ReportsAuthor(s): Marcela Doktorova Demmin, Adrian GillissenAbstractThe present case demonstrates an atypical pulmonary mycobacteriosis that mimicked classical symptoms and radiology findings for tuberculosis. While T-SPOT Test and PCR analyses proved negative for tuberculosis, microscopic sputum evaluation showed acid-fast bacilli and Mycobacterium celatum was found in culture. Uniquely, in our case M. celatum was resistant to rifabutin. Therefore, after not responding to combination treatment including rifabutin, our patient was treated with ...
Source: Respiratory Medicine Case Reports - July 9, 2019 Category: Respiratory Medicine Source Type: research

Antimicrobial susceptibility patterns and MICs among non-photochromogenic rapidly growing Mycobacteroides and Mycolicibacterium species.
CONCLUSION: NPRGM clade-specific susceptibility patterns suggest an urgent need to establish distinct breakpoints for Myco and Mycolici species. PMID: 31282855 [PubMed - as supplied by publisher] (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - July 8, 2019 Category: Microbiology Authors: Yoshida S, Tsuyuguchi K, Chikamatsu K, Aono A, Takaki A, Mitarai S, Kobayashi T, Inoue Y, Suzuki K Tags: J Med Microbiol Source Type: research

Interaction of swine organic anion transporting polypeptide 1a2 with tetracycline, macrolide and β-lactam antibiotics.
Interaction of swine organic anion transporting polypeptide 1a2 with tetracycline, macrolide and β-lactam antibiotics. Toxicol Appl Pharmacol. 2019 Jul 06;:114649 Authors: Lin X, Xiang Z, Wang B, Chen H, Zhou T, Hong M Abstract Organic anion-transporting polypeptides (human OATPs; animals Oatps; gene symbol SLCO/Slco) are integral membrane proteins that mediate the sodium-independent transport of a wide range of endogenous compounds as well as many xenobiotics. Antibiotics, antidiabetic drugs, anti-inflammatory drugs, antifungals, antivirals, antihistamines, antihypertensives, fibrates, statins, ...
Source: Toxicology and Applied Pharmacology - July 6, 2019 Category: Toxicology Authors: Lin X, Xiang Z, Wang B, Chen H, Zhou T, Hong M Tags: Toxicol Appl Pharmacol Source Type: research

The differential effect of clarithromycin and azithromycin on induction of macrolide resistance in Mycobacterium Abscessus
Future Microbiology, Ahead of Print. (Source: Future Microbiology)
Source: Future Microbiology - July 4, 2019 Category: Microbiology Authors: Jodie A Schildkraut Lian J Pennings Mike M Ruth Arjan PM de Brouwer Heiman FL Wertheim Wouter Hoefsloot Arjan de Jong Jakko van Ingen Source Type: research

Efficacy of a tailored PCR-guided triple therapy in the treatment of Helicobacter pylori infection.
CONCLUSION: In a country with a high level of clarithromycin resistance, tailored PCR-guided therapy was superior to empirical triple therapy for H. pylori eradication (https://www.ClinicalTrials.gov: NCT01168063). PMID: 31257067 [PubMed - as supplied by publisher] (Source: Medecine et Maladies Infectieuses)
Source: Medecine et Maladies Infectieuses - July 3, 2019 Category: Infectious Diseases Tags: Med Mal Infect Source Type: research

Novel designed TFC membrane based on host-guest interaction for organic solvent nanofiltration (OSN)
Publication date: Available online 2 July 2019Source: Journal of Membrane ScienceAuthor(s): Sun-Jie Xu, Qian Shen, Zhen-Liang Xu, Zhe-Qin DongAbstractActive layers with outstanding organic solvent nanofiltration (OSN) performances were designed novelly by adopting host-guest (HG) interaction to realize adamantane structure immobilization. During the fabrication process, β-cyclodextrin (β-CD) served as the “host” while adamantylamine/adamantanemethylamine (AMA/AMmA) worked as the “guest”. Stechiometrical experiment results demonstrated that one half molar ratio of the “guest” to...
Source: Journal of Membrane Science - July 2, 2019 Category: Materials Science Source Type: research

Visual Hallucinations Induced by Clarithromycin in a Child: A Case Report and Literature Review
Conclusion This report highlights neuropsychological adverse effects due to therapeutic doses of clarithromycin therapy as a possible adverse effect in children. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Antimicrobial Susceptibility of Clinical and Environmental Mycobacterium chimaera isolates.
In conclusion, our results show that clarithromycin, amikacin, rifabutin and streptomycin had best activity against M. chimaera isolates, while susceptibility rates were lower for rifampicin and ethambutol. In contrast, there was a high prevalence of isolates not susceptible to moxifloxacin or linezolid. While factors additional to antibiotic susceptibility may determine the outcome of treatment of M. chimaera infections, our results should inform on the selection of antimicrobials as part of the overall therapeutic strategy. PMID: 31262760 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - July 1, 2019 Category: Microbiology Authors: Mok S, Hannan MM, Nölke L, Stapleton P, O'Sullivan N, Murphy P, McLaughlin AM, McNamara E, Fitzgibbon M, Rogers TR Tags: Antimicrob Agents Chemother Source Type: research

Efficacy of Vonoprazan for Helicobacter pylori Eradication.
Authors: Kiyotoki S, Nishikawa J, Sakaida I Abstract Helicobacter pylori can infect the gastric mucosa and cause chronic inflammation, resulting in various diseases, including gastric cancer. Eradication of H. pylori in all infected subjects is recommended; however, the number of H. pylori strains with antibiotic resistance has increased, and the eradication rate has decreased. Vonoprazan, a potassium-competitive acid blocker, produces a stronger acid-inhibitory effect than proton pump inhibitors (PPIs). The H. pylori eradication rate with vonoprazan was found to be higher than that with PPIs. The H. pylori eradica...
Source: Internal Medicine - June 29, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Helicobacter pylori Mutations Detected by Next-Generation Sequencing in Formalin-Fixed, Paraffin-Embedded Gastric Biopsy Specimens Are Associated with Treatment Failure [Bacteriology]
In this study, formalin-fixed, paraffin-embedded (FFPE) gastric biopsy specimens from a cohort of individuals from northern Ohio in the United States were examined using a next-generation sequencing (NGS) assay to detect H. pylori mutations that are known to confer resistance to clarithromycin, levofloxacin, and tetracycline. From January 2016 to January 2017, 133 H. pylori-infected gastric biopsy specimens were identified histologically and subsequently analyzed by NGS to detect mutations in gyrA, 23S rRNA, and 16S rRNA genes. The method successfully detected H. pylori in 126 of 133 cases (95% sensitivity). Mutations conf...
Source: Journal of Clinical Microbiology - June 25, 2019 Category: Microbiology Authors: Nezami, B. G., Jani, M., Alouani, D., Rhoads, D. D., Sadri, N. Tags: Bacteriology Source Type: research

Genotypic determination of resistance and heteroresistance to clarithromycin in Helicobacter pylori isolates from antrum and corpus of Colombian symptomatic patients
The effectiveness of Helicobacter pylori first-line treatment has decreased drastically with the rise of strains resistant to clarithromycin. Therapy failure has also been described in patients with infections by... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - June 21, 2019 Category: Infectious Diseases Authors: Betsy Ver ónica Arévalo-Jaimes, Diana F. Rojas-Rengifo, Carlos Alberto Jaramillo, Belén Mendoza de Molano, José Fernando Vera-Chamorro and María del Pilar Delgado Tags: Research article Source Type: research

IJERPH, Vol. 16, Pages 2205: Characterization and Phylogenetic Analysis of Campylobacter Species Isolated from Paediatric Stool and Water Samples in the Northwest Province, South Africa
This study suggests the possible circulation of potentially pathogenic antibiotic-resistant Campylobacter in the Northwest Province, South Africa with drinking water being a possible vector for disease transmission in this area. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - June 21, 2019 Category: Environmental Health Authors: Chukwu Luther King Abia Ubomba-Jaswa Obi Dewar Tags: Article Source Type: research

A Case of Pulmonary Mycobacterium abscessus Subspecies abscessus Disease That Showed a Discrepancy Between the Genotype and Phenotype of Clarithromycin Resistance.
Authors: Yamaba Y, Takakuwa O, Saito M, Kawae D, Yoshihara M, Mori Y, Kunii E, Ito Y, Yoshida S, Akita K Abstract Mycobacterium abscessus subspecies abscessus is major subspecies in the M. abscessus complex and is usually refractory to standard antibiotherapy. Genetic tracing of erm (41) T28 is a mechanism for monitoring macrolide resistance. We treated a patient with a pulmonary infection caused by M. abscessus subsp. abscessus with the erm (41) T28 polymorphism, which was susceptible to clarithromycin, and his clinical treatment course was good. The identification of the M. abscessus complex genotype is important...
Source: Internal Medicine - June 12, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Retrospective Analysis Confirms Tetracycline Quadruple as Best Helicobacter pylori Regimen in the USA
ConclusionQuadruple therapy is superior to triple therapy within the Rhode Island population. Fourteen-day therapy achieves superior eradication compared to 10-day therapy, and doxycycline is inferior to tetracycline for quadruple therapy. Our findings support adherence to ACG and international guidelines advising 14-day quadruple therapy. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - June 11, 2019 Category: Gastroenterology Source Type: research

Prevalence of Helicobacter pylori infection and antibiotic resistance profile in Armenia
ConclusionsHelicobacter pylori infection is estimated to be about 42% among adults in Armenia and the low clarithromycin resistance allows the use of the standard triple therapy as a first line therapy. (Source: Gut Pathogens)
Source: Gut Pathogens - June 8, 2019 Category: Microbiology Source Type: research

Distribution and ecological risk of pharmaceuticals in surface water of the Yeongsan river, Republic of Korea.
This study examined the distribution of pharmaceuticals in Yeongsan River and at point sources (PSs) in the associated water system, and performed a risk assessment based on our findings. The samples included effluents collected from three sewage treatment plants (PS1, PS2, and PS3) and two industrial complexes (PS4 and PS5) as well as surface water collected from seven mainstreams and 11 tributaries of the river. The target pharmaceuticals were acetylsalicylic acid, carbamazepine, clarithromycin, naproxen, sulfamethazine, sulfamethoxazole, sulfathiazole, and trimethoprim, which were detected by liquid chromatography-tande...
Source: Ecotoxicology and Environmental Safety - June 8, 2019 Category: Environmental Health Authors: Na TW, Kang TW, Lee KH, Hwang SH, Jung HJ, Kim K Tags: Ecotoxicol Environ Saf Source Type: research

The modulation of drug-loading stability within lipid membranes via medium chain triglycerides incorporation
Publication date: Available online 3 June 2019Source: International Journal of PharmaceuticsAuthor(s): Lifeng Luo, Qiuyue Chen, Nana Wei, Yi Liu, Haibing He, Yu Zhang, Tian Yin, Jingxin Gou, Xing TangAbstractThe current research aimed to explore medium chain triglycerides (MCT) incorporation in liposomes to overcome stability challenges when drugs with high molecular weight and payload are loaded within lipid membranes. A model drug clarithromycin was loaded in lipid dispersions with various MCT/phospholipids ratios (RM/P = 0, 0.5, 1.75 and 7.5 w/w). TEM images demonstrated a liposome-to-emulsion structural transformation ...
Source: International Journal of Pharmaceutics - June 4, 2019 Category: Drugs & Pharmacology Source Type: research

Improved performance predicting clarithromycin resistance in Mycobacterium abscessus on an independent dataset.
Abstract In our recent study of 203 sequential isolates evaluating the ability of whole genome sequencing (WGS) to predict clarithromycin resistance in Mycobacterium abscessus (M. abscessus) (1), we demonstrated high sensitivity but poor specificity of mutations identified in a literature search. …. PMID: 31160290 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - June 3, 2019 Category: Microbiology Authors: Lipworth S, Hough N, Buchanan R, Smith EG, Robinson E, Alexander E, Peto T, Crook D, Walker T Tags: Antimicrob Agents Chemother Source Type: research

Mo1340 A 7 DAY TRIPLE THERAPY EFFICACY IS SIMILAR WITH 14-DAY THERAPY FOR THE ERADICATION OF HELICOBACTER PYLORI WITH NO POINT MUTATION IN 23S RRNA
Eradication rates decline due to high rates of resistance to antibiotics, especially clarithromycin. Therefore, several guidelines recommend the 14 days eradication for Helicobacter pylori to overcome this problem. Real-time PCR test has been used to detect the 23S rRNA point mutation associated with clarithromycin resistance. The aim of this study is to compare the efficacy of 7 day and 14 day triple therapy for the eradication of Helicobacter pylori with no mutation of 23S rRNA. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - June 1, 2019 Category: Gastroenterology Authors: Su Jin Kim, Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Hyeong Seok Nam, Dae Gon Ryu, Jung Wook Lee, Kwang Uk Bae Tags: Monday abstract Source Type: research

Effect of clarithromycin on the production of volatile fatty acids from waste activated sludge anaerobic fermentation.
This study investigated the effect of Clarithromycin (CLA) on volatile fatty acids (VFAs) production during waste activated sludge (WAS) anaerobic fermentation for the first time. Experimental results showed that when CLA concentration in WAS increased from 0 to 1000 mg/kg TSS, the maximum yield of VFAs increased from 27.7 to 35.7 mg COD/g VSS (without pH pretreatment) and from 59.3 to 65.6 mg COD/g VSS (initial pH 9 pretreatment), respectively. Mechanism exploration revealed that CLA facilitated the disruption of extracellular polymeric substances, thus promoting WAS solubilization. CLA inhibited all the other anaer...
Source: Bioresource Technology - June 1, 2019 Category: Biotechnology Authors: Huang X, Xu Q, Wu Y, Wang D, Yang Q, Chen F, Wu Y, Pi Z, Chen Z, Li X, Zhong Q Tags: Bioresour Technol Source Type: research

Endoscopic and Histological Findings among Israeli Populations Infected with Helicobacter pylori: Does Ethnicity Matter?
Authors: Mahamid M, Mari A, Khoury T, Bragazzi NL, Ghantous M, Abu-Elhija O, Watad A Abstract BACKGROUND: The prevalence of Helicobacter pylori varies geographically by age, race, and socioeconomic status (SES). However, the impact of ethnicity on endoscopic outcomes in infected individuals is not well known. OBJECTIVES: To assess the impact of ethnicity among Israelis with biopsy-proven H. pylori infection. METHODS: A retrospective study, including patients who underwent gastroscopy and were diagnosed histologically with H. pylori infection, was conducted. Information on demographics, SES, medications, and...
Source: The Israel Medical Association Journal - May 31, 2019 Category: General Medicine Tags: Isr Med Assoc J Source Type: research

Structure-activity relationships of potentiators of the antibiotic activity of clarithromycin against Escherichia coli.
Abstract Several studies that have identified agents that potentiate the antimicrobial activity of antibiotics, but there are limited insights into their structure-activity relationships (SAR). The SAR associated with select N-alkylaryl amide derivatives of ornithine was performed to establish those structural features that were associated with potentiation of the antimicrobial activity of clarithromycin against E. coli ATCC 25922. The data indicate that the N-propyl derivative was slightly more active in reducing the effective MIC of clarithromycin against E. coli ATCC 25922. In addition, the S-enantiomer of comp...
Source: European Journal of Medicinal Chemistry - May 29, 2019 Category: Chemistry Authors: Blankson G, Parhi AK, Kaul M, Pilch DS, LaVoie EJ Tags: Eur J Med Chem Source Type: research

Influence of levofloxacin and clarithromycin on the structure of DPPC monolayers
Publication date: Available online 28 May 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Stephanie Ortiz-Collazos, Paulo H.S. Picciani, Osvaldo N. Oliveira, Andre S. Pimentel, Karen J. EdlerAbstractResearch on lipid/drug interactions at the nanoscale underpins the emergence of synergistic mechanisms for topical drug administration. The structural understanding of bio-mimetic systems employing 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) as a lung surfactant model mixed with antibiotics, as well as their biophysical properties, is of critical importance to modulate the effectiveness of therap...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - May 28, 2019 Category: Biochemistry Source Type: research

Population-level macrolide consumption is associated with clarithromycin resistance in Helicobacter pylori: an ecological analysis
(Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - May 28, 2019 Category: Infectious Diseases Authors: Chris Kenyon Tags: Short Communication Source Type: research

Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 ( SLCO1B1 ) Drug –Drug–Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole
ConclusionsWhole-body PBPK models of gemfibrozil, repaglinide, and pioglitazone have been built and qualified for DDI and DGI prediction. PBPK modeling is applicable to investigate complex interactions between multiple drugs and genetic polymorphisms. (Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - May 25, 2019 Category: Drugs & Pharmacology Source Type: research

A filtration optimized on-line SPE–HPLC–MS/MS method for determination of three macrolide antibiotics dissolved and bound to suspended solids in surface water
Publication date: July 2019Source: Microchemical Journal, Volume 148Author(s): Viktória Licul-Kucera, Márta Ladányi, Géza Hizsnyik, Gyula Záray, Victor G. MihuczAbstractIn this work, a simple, automated multiresidue method consisting of on-line solid phase extraction coupled to liquid chromatography tandem mass spectrometry has been developed for the determination of three macrolide antibiotic residues – erythromycin, clarithromycin and azithromycin – included in the current Watch List (Decision 2018/840) of Water Framework Directive of the European Union in surface water. Due...
Source: Microchemical Journal - May 21, 2019 Category: Chemistry Source Type: research

Refractory Helicobacter Pylori gastritis: The hidden predictors of resistance
ConclusionDiabetes, HCV and NAFLD predispose to refractory H. Pylori which need culture and sensitivity testing. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - May 19, 2019 Category: Infectious Diseases Source Type: research

A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Model of Dabigatran Etexilate, Dabigatran and Dabigatran Glucuronide in Healthy Adults and Renally Impaired Patients
ConclusionThis is the first implementation of a PBPK model for dabigatran to distinguish between the prodrug, active moiety, and main active metabolite. Following adjustment of the UGT2B15 metabolism and P-gp transport rates, the PBPK model accurately predicts the pharmacokinetics in renally impaired patients. (Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - May 18, 2019 Category: Drugs & Pharmacology Source Type: research

Distribution of genes encoding resistance to macrolides, lincosamides, and streptogramins among methicillin-resistant Staphylococcus aureus strains isolated from burn patients.
This study aimed to investigate the prevalence of ermA, ermB, ermC, and msrA in MRSA strains isolated from burn patients in Ahvaz, southwest of Iran. A total of 76 isolates of S. aureus were collected from January to May 2017 from Taleghani Burn Hospital in Ahvaz. Among 76 S. aureus strains collected, 60 (78.9%) isolates were MRSA. The antimicrobial susceptibility testing for MRSA showed extreme high resistance rate to clarithromycin (100%) and azithromycin (100%), followed by erythromycin (98.3%). The PCR assay revealed that the frequency rates of msrA, ermA, and ermC genes were 23 (38.3%), 28 (46.7%), and 22 (36.7%), res...
Source: Acta Microbiologica et Immunologica Hungarica - May 17, 2019 Category: Microbiology Authors: Khoshnood S, Shahi F, Jomehzadeh N, Montazeri EA, Saki M, Mortazavi SM, Maghsoumi-Norouzabad L Tags: Acta Microbiol Immunol Hung Source Type: research

Drug susceptibility profile of Mycobacterium kansasii clinical isolates from Brazil
ConclusionsWe have observed worrying results regarding susceptibility to some drugs used as first-line agents in the treatment of diseases caused byM. kansasii. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - May 15, 2019 Category: Infectious Diseases Source Type: research

Occurrence of selected pharmaceuticals in wastewater treatment plants of Tuscany: An effect-based approach to evaluate the potential environmental impact.
Abstract Municipal wastewaters may pose a risk to the aquatic environment and ultimately to human kind. Their treatment is a fundament step but the actual WWTPs performances cannot be taken for granted, claiming instead for continuous evaluation campaigns. Our waters are indeed threatened by the continuous input of various persistent micropollutants that are part of human daily routine life; the potential effects of their presence in the receiving waters have to be quantified. The present paper reports data of a monitoring campaign focused on nine pharmaceuticals belonging to different therapeutic groups in three ...
Source: International Journal of Hygiene and Environmental health - May 14, 2019 Category: Environmental Health Authors: Palli L, Spina F, Varese GC, Vincenzi M, Aragno M, Arcangeli G, Mucci N, Santianni D, Caffaz S, Gori R Tags: Int J Hyg Environ Health Source Type: research

High primary resistance to metronidazole and levofloxacin, and a moderate resistance to clarithromycin in Helicobacter pylori isolated from Karnataka patients
ConclusionHigh primary resistance to metronidazole and levofloxacin, and a modest occurrence of clarithromycin resistance were revealed inH. pylori strains isolated from Karnataka patients. Therefore metronidazole-, levofloxacin- and clarithromycin-based triple therapies are not suitable as first-line treatment in Karnataka. Both amoxicillin and tetracycline can still be used to eradicateH. pylori infection in this region. We also revealed novel mutations in GyrA protein that possibly contribute toH. pylori resistance in levofloxacin, which merit further investigations. (Source: Gut Pathogens)
Source: Gut Pathogens - May 13, 2019 Category: Microbiology Source Type: research

A new anti-Helicobacter pylori juglone from Reynoutria japonica.
Abstract A 70% ethanol extract from the root portion of Reynoutria japonica afforded one new and three known juglone derivatives, namely, 2-methoxy-6-acetyl-7-methyljuglone (1), 2-ethoxy-6-acetyl-7-methyljuglone (2), 2-methoxy-7-acetonyljuglone (3), and 3-acetyl-7-methoxy-2-methyljuglone (4) together with two phenolics (5 and 6), an anthraquinone (7), a stilbene (8) and a phthalide (9). Their structures were elucidated on the basis of comprehensive spectroscopic studies including IR, MS, and 1H, 13C, 2D NMR spectra. Compound 3 is a new compound in nature, and compounds 4-6 have been isolated for the first time fro...
Source: Archives of Pharmacal Research - May 9, 2019 Category: Drugs & Pharmacology Authors: Khalil AAK, Park WS, Lee J, Kim HJ, Akter KM, Goo YM, Bae JY, Chun MS, Kim JH, Ahn MJ Tags: Arch Pharm Res Source Type: research

The Diagnosis and Therapy of < b > < i > Helicobacter pylori < /i > < /b > Infection in Hungary: Comparison of Strategies Applied by Family Physicians and Internists
Conclusion: The adherence to the recent recommendations of current guidelines is moderate. There is a need to increase adherence to current recommendations by family physicians and internists.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - May 8, 2019 Category: Gastroenterology Source Type: research

Pre-clinical pharmacokinetic and pharmacodynamic data to support cefoxitin nebulization for the treatment of Mycobacterium abscessus.
ck JM Abstract Mycobacterium abscessus is responsible for difficult-to-treat chronic pulmonary infections in humans. Current regimens including parenteral administrations of cefoxitin (FOX) in combination with amikacin and clarithromycin raise compliance problems and are frequently associated with high failure and development of resistance. Aerosol delivery of FOX could be an interesting alternative. FOX was administered to healthy rats by intravenous bolus or intra-tracheal nebulization and concentrations were determined in plasma and epithelial lining fluid (ELF) by liquid chromatography-tandem mass spectrometry...
Source: Antimicrobial Agents and Chemotherapy - May 6, 2019 Category: Microbiology Authors: Mehta S, Aranzana-Climent V, Rammaert B, Grégoire N, Marchand S, Couet W, Buyck JM Tags: Antimicrob Agents Chemother Source Type: research

Single-run ultra-high performance liquid chromatography for quantitative determination of ultra-traces of ten popular active pharmaceutical ingredients by quadrupole time-of-flight mass spectrometry after offline preconcentration by solid phase extraction from drinking and river waters as well as treated wastewater
Publication date: July 2019Source: Microchemical Journal, Volume 148Author(s): Dániel Krakkó, Viktória Licul-Kucera, Gyula Záray, Victor G. MihuczAbstractA fit-to-purpose ultra-high performance liquid chromatographic high resolution mass spectrometric method was developed for the ultra-trace analysis of 10 active pharmaceutical ingredients in one chromatographic run as follows: atorvastatin, carbamazepine (CARB), ciprofloxacin (CIPR), clarithromycin (CLAR), diclofenac (DICL), metoprolol (METO), naproxen (NAPR), sitagliptin (SITA), sulfamethoxazole (SULF) and tetracycline. By applying Oasis HLB s...
Source: Microchemical Journal - May 4, 2019 Category: Chemistry Source Type: research

Preventing Postoperative Atypical Mycobacterial Infection
Conclusions: Atypical mycobacterium infection, although rare, should be considered as a possible diagnosis in a blepharoplasty patient with delayed development of nodular lesions. Long-term clarithromycin therapy and debridement have shown good outcomes for these patients; however, the best treatment for any infection is prevention. This study provides the first evidence based approach within the ophthalmic literature for reducing the mycobacterium infection rate in blepharoplasty patients. (Source: Ophthalmic Plastic and Reconstructive Surgery)
Source: Ophthalmic Plastic and Reconstructive Surgery - May 1, 2019 Category: Opthalmology Tags: Original Investigations Source Type: research

CYP2C19 Genotype, CagA Genotype and Antibiotic Resistant Strain of Helicobacter pylori Infection
Conclusions: PDS, CYP2C19 RM genotype and CagA 2a gene of H. pylori infection were the predominant type of FD in Thailand. Metronidazole remain the most common antibiotic resistant strain of H. pylori infection in FD patients. PDS (host factor) was significantly related to CagA2a genotype (bacterial factors) only in patients with intermediate metabolizer. Appropriate dose of proton pump inhibitor (PPI) and correct regimens for H. pylori eradication in FD patients should be consider to improve clinical outcomes. PMID: 31030500 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - May 1, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Factitial Panniculitis Associated With Cosmetic Filler
A 47-year-old woman presented with a 5-year history of multiple hospitalizations for recurrent cutaneous ulcers and nodules of the abdomen, buttocks, and arms starting 1 year after liposuction and fat grafting of her abdomen and hips. She had had extensive evaluation, including biopsies of multiple affected areas for histopathological examination and tissue cultures for bacteria, fungi, and mycobacteria. No specific diagnosis was rendered, and results of tissue cultures were negative. However, because concern for nontuberculous mycobacterial infection (NTM) was high, the patient was treated empirically with imipenem, linez...
Source: Mayo Clinic Proceedings - May 1, 2019 Category: Internal Medicine Authors: Zerelda Esquer Garrigos, Audrey N. Schuetz, Margot S. Peters Tags: Letter to the Editor Source Type: research

Standard triple therapy in Helicobacter pylori eradication in Turkey: Systematic evaluation and meta-analysis of 10-year studies.
CONCLUSION: A systematic meta-analysis of studies conducted during the period 2004-2013 in Turkey revealed that the rate of first-line Hp eradication using STT was unacceptably low, and the duration of treatment and PPI used made no difference. PMID: 31060997 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - May 1, 2019 Category: Gastroenterology Authors: Sezgin O, Aydın MK, Özdemir AA, Kanık AE Tags: Turk J Gastroenterol Source Type: research

Clarithromycin and endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps: study protocol for the MACRO randomised controlled trial
Chronic rhinosinusitis (CRS) is a common source of ill health; 11% of UK adults reported CRS symptoms in a worldwide population study. Guidelines are conflicting regarding whether antibiotics should be include... (Source: Trials)
Source: Trials - April 29, 2019 Category: General Medicine Authors: Carl Philpott, Steffi le Conte, David Beard, Jonathan Cook, William Sones, Steve Morris, Caroline S. Clarke, Mike Thomas, Paul Little, Jane Vennik, Valerie Lund, Helen Blackshaw, Anne Schilder, Stephen Durham, Spiros Denaxas, James Carpenter & hellip; Tags: Study protocol Source Type: research

Effect of Helicobacter pylori biofilm formation on susceptibility to amoxicillin, metronidazole and clarithromycin
Publication date: Available online 26 April 2019Source: Microbial PathogenesisAuthor(s): Hideo Yonezawa, Takako Osaki, Fuhito Hojo, Shigeru KamiyaAbstractThe human gastric pathogen Helicobacter pylori forms biofilms in vitro and in vivo. We previously demonstrated that H. pylori biofilm formation in vitro decreased its susceptibility to clarithromycin (CAM). The aim of this study was to evaluate the effects of biofilm formation on amoxicillin (AMPC) and metronidazole (MNZ) susceptibility. In addition, we assessed the influence of biofilms of CAM resistant H. pylori on CAM susceptibility. It was shown that high levels of ef...
Source: Microbial Pathogenesis - April 28, 2019 Category: Infectious Diseases Source Type: research

Development of Helicobacter pylori treatment: How do we manage antimicrobial resistance?
Abstract Helicobacter pylori (H. pylori) antimicrobial resistance is an urgent, global issue. In 2017, the World Health Organization designated clarithromycin-resistant H. pylori as a high priority bacterium for antibiotic research and development. In addition to clarithromycin, resistance to metronidazole and fluoroquinolones has also increased worldwide. Recent international guidelines for management of H. pylori infection recommend bismuth or non-bismuth quadruple therapy for 14 d as a first-line treatment for H. pylori in areas of high clarithromycin and/or metronidazole resistance. Although these treatment re...
Source: World Journal of Gastroenterology : WJG - April 28, 2019 Category: Gastroenterology Authors: Suzuki S, Esaki M, Kusano C, Ikehara H, Gotoda T Tags: World J Gastroenterol Source Type: research

The Effects of Clarithromycin on the Pharmacokinetics of Apixaban in Healthy Volunteers: A Single-Sequence Crossover Study
ConclusionsApixabanCmax and AUC(INF) increased 30% and 60%, respectively, when multiple doses of clarithromycin were coadministered with apixaban versus administration of apixaban alone. The increase in apixabanCmax and AUC(INF) with concomitant clarithromycin was less than that which has been observed when apixaban was given with ketoconazole. Administration of apixaban alone and in combination with clarithromycin bid was safe and generally well-tolerated by the healthy adult subjects in this study.Clinical Trial RegistrationClinicalTrials.gov identifier number NCT02912234. (Source: American Journal of Cardiovascular Drugs)
Source: American Journal of Cardiovascular Drugs - April 27, 2019 Category: Cardiology Source Type: research

Infantile Acute Conjunctivitis Induced by β-Lactamase–Positive Amoxicillin–Clavulanate–Resistant Strain of Haemophilus influenzae: A Report of Three Cases
This study is a retrospectively recruited case series. We report three infants with acute conjunctivitis induced by β-lactamase–positive, ampicillin/clavulanic acid-resistant strains of Haemophilus influenzae (BLPACR). Patients with BLPACR-positive cultures were recruited from among 5,107 patients with inflammatory diseases of the ocular surface who underwent examinations, including bacterial culturing of conjunctival sac or corneal scrapings, between 2000 and 2015. Three BLPACR-positive patients were recruited, including a 10-month-old boy, a 4-month-old girl, and a 7-month-old girl. All three demonstrated BLPA...
Source: Eye and Contact Lens: Science and Clinical Practice - April 26, 2019 Category: Opthalmology Tags: Case Report Source Type: research