Evaluation of multiplex ARMS-PCR for detection of Helicobacter pylori mutations conferring resistance to clarithromycin and levofloxacin
ConclusionsOur assay demonstrated high diagnostic sensitivity and specificity for detection of clarithromycin and levofloxacin resistantH. pylori. Based on proven accuracy, together with high efficiency, scalability and low cost, our assay has useful clinical utility for rapid diagnosis of clarithromycin and levofloxacin resistantH. pylori infections. Our assay results will provide patients with a clear diagnosis, enabling the treating clinician to administer the most effective antibiotic regimen to help the clear the infection. (Source: Gut Pathogens)
Source: Gut Pathogens - July 10, 2020 Category: Microbiology Source Type: research

Phenotype and Molecular Detection of Clarithromycin and Levofloxacin Resistance in Helicobacter pylori Clinical Isolates in Beijing
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - July 6, 2020 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Modelled plasma concentrations of pemafibrate with co-administered typical cytochrome P450 inhibitors clopidogrel, fluconazole, or clarithromycin predicted by physiologically based pharmacokinetic modelling in virtual populations.
Abstract Oral antidyslipidaemic drug pemafibrate is cleared from human plasma via hepatic uptake by organic anion transporting polypeptide (OATP) 1B1 and oxidation by cytochromes P450 (P450) 2C8, 2C9, and 3A4. The pharmacokinetic profiles of pemafibrate with virtual administrations of P450 inhibitors and/or disease interactions were generated using a physiologically based pharmacokinetic (PBPK) model previously established for co-administration of pemafibrate with OATP1B1 inhibitors.This PBPK model was validated in the current study using reported maximum pemafibrate plasma concentrations and areas under the curve...
Source: Xenobiotica - July 6, 2020 Category: Research Authors: Ogawa SI, Shimizu M, Yamazaki H Tags: Xenobiotica Source Type: research

Pharmaceuticals' removal by constructed wetlands: a critical evaluation and meta-analysis on performance, risk reduction, and role of physicochemical properties on removal mechanisms.
Authors: Ilyas H, Masih I, van Hullebusch ED Abstract This paper presents a comprehensive and critical analysis of the removal of pharmaceuticals (PhCs), the governing physicochemical properties, and removal mechanisms in constructed wetlands (CWs). The average removal efficiency of the most widely studied 34 PhCs ranges from 21% to 93%, with the exception of one PhC that exhibited negative removal. Moreover, CWs are effective in significantly reducing the environmental risk caused by many PhCs. Based on risk assessment, 12 PhCs were classified under high risk category (oxytetracycline> ofloxacin> sulfamethox...
Source: Journal of Water and Health - June 27, 2020 Category: Environmental Health Tags: J Water Health Source Type: research

Optimizing the MIC breakpoints of amoxicillin and tetracycline for antibiotic selection in the rescue therapy of H. pylori with bismuth quadruple regimen
AbstractPurposeH. pylori with triple-drug resistance (TR) to clarithromycin, metronidazole, and levofloxacin limits the success of rescue therapy. We aimed to identify the optimal breakpoints of antibiotic minimal inhibitory concentration (MIC) to predict the success of rescue therapy for TRH. pylori infection.MethodsWe consecutively enrolled 430 patients with at least one course of failedH. pylori eradications to receive anH. pylori culture for antibiotic MIC test. Seventy-three (17%) had TRH. pylori infection (MIC of clarithromycin>  0.5, levofloxacin>  1, and metronidazole>  8 mg/L, re...
Source: European Journal of Clinical Pharmacology - June 27, 2020 Category: Drugs & Pharmacology Source Type: research

Prolonged survival following Lung Transplantation in the absence of conventional immunosuppression
In 2015, a 14-year old male with end stage cystic fibrosis (DF508 homozygous) on 24-hourly supplemental oxygen and nocturnal non-invasive ventilation underwent bilateral sequential lung transplant (LTx). He was known to have been colonized with pulmonary Pseudomonas aeruginosa and Mycobacterium abscessus (M.abscessus) from 2006. Pre-LTx M abscessus eradication was attempted with 4-months of intravenous (IV) cefazolin, amikacin and tigecycline; as well as oral (PO) clarithromycin, in addition to monthly intravenous-gammaglobulin(IVIG) (serum IgG level 3g/L). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - June 26, 2020 Category: Transplant Surgery Authors: Jaideep Vazirani, Gregory I Snell, Glen P Westall Tags: Case Anecdotes, Comments and Opinions Source Type: research

High rates of clarithromycin and levofloxacin resistance of Helicobacter pylori in patients with chronic gastritis in the South East area of Vietnam
Publication date: Available online 24 June 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Ngoc Quy Hue Dang, Thi Minh Thi Ha, Si-Tuan Nguyen, Nguyen Dang Khoa Le, Thi Minh Thi Nguyen, Thanh Hai Nguyen, Thi Thu Hang Pham, Van Huy Tran (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 25, 2020 Category: Infectious Diseases Source Type: research

Risk factors associated with antibiotic treatment failure of Buruli ulcer.
Abstract Background:Combination antibiotic therapy is highly effective in curing Buruli ulcer (BU), caused by Mycobacterium ulcerans Treatment failures have been uncommonly reported with the recommended 56 days of antibiotics, and little is known about risk factors for treatment failure.Methods:We analysed treatment failures among BU patients treated for ≥56 days of antibiotics from a prospective observational cohort at Barwon Health, Victoria, from 1/1/1998-31/12/2018. Treatment failure was defined as culture positive recurrence within 12 months of commencing antibiotics that occurred: a) following failure to ...
Source: Antimicrobial Agents and Chemotherapy - June 22, 2020 Category: Microbiology Authors: O'Brien DP, Friedman ND, Walton A, Hughes A, Athan E Tags: Antimicrob Agents Chemother Source Type: research

Asymptomatic sinusitis as an origin of infection-related glomerulonephritis manifesting steroid-resistant nephrotic syndrome: A case report
Rationale: Infection is a major trigger or pathogenic origin in a substantial proportion of glomerulonephritis (GN) patients, typically manifesting infection-related GN (IRGN). Various microorganisms, infection sites, and clinical and histopathological features are involved in IRGN. Once an infectious origin is identified and successfully eradicated, nephrotic syndrome or kidney dysfunction is spontaneously resolved. However, if patients are asymptomatic and the origin is undetermined, the diagnosis and treatment of GN is challenging. This case presentation reported on an IRGN case manifesting steroid-resistant nephrotic...
Source: Medicine - June 19, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Comparative Study of the Effect of Macrolide Antibiotics Erythromycin, Clarithromycin, and Azithromycin on the ERG1 Gene Expression in H9c2 Cardiomyoblast Cells
Drug Res (Stuttg) DOI: 10.1055/a-1185-8762Macrolides are clinically well-established class of antibiotics. Macrolides induce cardiotoxicity by blocking ether-a-go-go–related gene (ERG) potassium channels in cardiac myocytes. The aim of this study was to compare the effects of erythromycin, clarithromycin and azithromycin on cell viability and expression of ERG1 gene in H9c2 cells. Cell viability and ERG1 gene expression of H9c2 cells in 3 different concentrations, 1, 10 and 25 µg/ml, after 48 and 72 h were determined by MTT test and Real time-PCR method respectiv...
Source: Drug Research - June 19, 2020 Category: Drugs & Pharmacology Authors: Hajimirzaei, Nima Khalili, Nazila Pour Boroumand, Behshad Safari, Fatemeh Pourhosseini, Armin Judi-Chelan, Reza Tavakoli, Fatemeh Tags: Original Article Source Type: research

A Case of Non-tuberculosis Mycobacterium Tenosynovitis with Rice Bodies in a Patient with Systemic Lupus Erythematosus.
Authors: Fujieda Y, Ninagawa K, Matsui Y, Kono M, Kamishima T, Iwasaki N, Atsumi T Abstract Infectious disease with various presentations in systemic lupus erythematosus (SLE) often resembles lupus flare. A 37-year-old woman presented with a swollen left index finger that had not resolved, despite 7 years of immunosuppressive treatment. MRI showed rice-body formation in the flexor tendon sheath and tenosynovectomy demonstrated chronic synovitis with epithelioid granuloma. A mycobacterial culture confirmed invasive mycobacterial tenosynovitis due to Mycobacterium chelonae. The patient was treated with moxifloxacin a...
Source: Internal Medicine - June 18, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Helicobacter pylori : A Review of Current Diagnostic and Management Strategies
AbstractAs one of the most prevalent infections globally,Helicobacter pylori (H. pylori) continues to present diagnostic and therapeutic challenges for clinicians worldwide. Diagnostically, the “test-and-treat” strategy is the recommended approach for healthcare practitioners when managing this potentially curable disease. The choice of testing method should be based on several factors including patient age, presenting symptoms, and medication use, as well as test reliability, availabi lity, and cost. With rising antibiotic resistance, particularly of macrolides, care must be taken to ensure that therapy is sel...
Source: Digestive Diseases and Sciences - June 16, 2020 Category: Gastroenterology Source Type: research

Physicians ’ adherence to management guidelines for H. pylori infection and gastroesophageal reflux disease: a cross-sectional study
ConclusionsWe identified gaps between the practices of PCPs and the guidelines onH. pylori infection management, while guidelines on GERD management are well adopted. Simplification of the guidelines and exploring barriers towards their implementation by PCPs is warranted. (Source: Israel Journal of Health Policy Research)
Source: Israel Journal of Health Policy Research - June 11, 2020 Category: International Medicine & Public Health Source Type: research

Bacillary angiomatosis triggered by severe trauma in a healthy Caucasian patient: A case report.
Authors: Balaban M, Ioana Nedelcu R, Balmes G, Adela Todorovic T, Brinzea A, Nichita L, Gabriela Popp C, Theodor Andrei R, Andrada Zurac S, Adriana Ion D, Turcu G Abstract Bacillary angiomatosis represents a cutaneous and systemic infection caused by Bartonella species, typically described in the past in HIV-positive patients or associated with immunodeficiencies. More recent case reports had brought into attention the probability that this entity may manifest in otherwise healthy individuals, triggered by trauma and skin burns. The physiopathology of this neoproliferative process is based on the production of angi...
Source: Experimental and Therapeutic Medicine - June 9, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Recent findings on cardiovascular safety with the use of chloroquine and hydroxychloroquine for COVID-19.
In a recent review article, Aggarwal, et al1 discussed the implications for cardiovascular safety of the potential therapies for the treatment of patients with COVID-19. The authors highlight the potential toxicities and cardiovascular side effects of the controversial use of chloroquine (CQ) and hydroxychloroquine (HCQ) that should be taken into consideration before its use. At this time, other implications for cardiovascular safety, along with the prolongation of QT interval reported in small size studies2-7, have recently been addressed in regard to the use of CQ and HCQ, alone or in combination with a second-generation...
Source: The American Journal of Cardiology - June 9, 2020 Category: Cardiology Authors: Yuli Guzman-Prado Tags: Reader's comments Source Type: research

Clarithromycin vs Azithromycin and Risk of Hemorrhage in Older Adults Taking Direct Oral Anticoagulants
This population-based cohort study assesses the 30-day risk of hospital admission with hemorrhage after coprescription of clarithromycin compared with azithromycin among older adults taking a direct oral anticoagulant. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - June 8, 2020 Category: Internal Medicine Source Type: research

IJERPH, Vol. 17, Pages 4067: Detection of Pharmaceutical Residues in Surface Waters of the Eastern Cape Province
This study investigated the presence of antibiotics, anti-epilepsy and anti-inflammatory drugs in river water of selected rivers in the Eastern Cape Province in South Africa. Enzyme-linked immunosorbent assay was used for screening of sulfamethoxazole and fluoroquinolones antibiotics. The samples were collected in upper-stream, middle-stream and lower-stream regions of the rivers and effluent of selected wastewater treatment plants. Pre-concentration of the samples was conducted using lyophilisation and extraction was conducted using solid phase extraction (SPE) on Waters Oasis hydrophilic-lipophilic-balanced cartridge. Th...
Source: International Journal of Environmental Research and Public Health - June 7, 2020 Category: Environmental Health Authors: Sesethu Vumazonke Sandile Maswazi Khamanga Nosiphiwe Patience Ngqwala Tags: Article Source Type: research

10-Day Versus 14-Day Quadruple Concomitant Nonbismuth Therapy for the Treatment of Helicobacter pylori Infection: Results From a Randomized Prospective Study in a High Clarithromycin Resistance Country
Conclusion: In Greece, the 10-day concomitant nonbismuth quadruple regimen for first-line treatment remains the most efficient strategy for H. pylori eradication. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 6, 2020 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Treatment of pulmonary disease caused by Mycobacterium kansasii.
Abstract As a cause of lung disease (LD), Mycobacterium kansasii is regarded as a highly virulent species among nontuberculous mycobacteria (NTM). Both the frequency of M. kansasii isolates and global prevalence of M. kansasii-LD have increased gradually over recent decades. Treatment of M. kansasii-LD is recommended because of the disease's poor prognosis and fatal outcome. The decision on the optimal time point for treatment initiation should be based on both the benefits and risks posed by multiple antimicrobial agents. For treatment-naïve patients with M. kansasii-LD, rifampin-containing multiple antimicr...
Source: J Formos Med Assoc - June 3, 2020 Category: General Medicine Authors: Huang HL, Lu PL, Lee CH, Chong IW Tags: J Formos Med Assoc Source Type: research

Combination of thrombolytic and immunosuppressive therapy for coronavirus disease 2019: A case report
A 68-year-old man presented to the emergency department of our hospital complaining of high-grade fever for the last 10 days. He was receiving a broad-spectrum antibiotic (Clarithromycin) and an antiviral drug (Oseltamivir) for 3 days prior to admission with no improvement. His medical history included hypertension and well-controlled Type 2 diabetes mellitus, under treatment with oral anti-diabetic agents. Arterial blood gases revealed acute hypoxemic (Type I) respiratory failure. Multiple diffuse infiltrates on both lungs were apparent in his chest X-ray. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - June 1, 2020 Category: Infectious Diseases Authors: Panagiotis Papamichalis, Antonios Papadogoulas, Periklis Katsiafylloudis, Apostolia-Lemonia Skoura, Michail Papamichalis, Evangelia Neou, Dimitrios Papadopoulos, Spyridon Karagiannis, Tilemachos Zafeiridis, Dimitris Babalis, Apostolos Komnos Tags: Case Report Source Type: research

AR-12 Exhibits Direct and Host-targeted Antibacterial Activity toward Mycobacterium abscessus.
In conclusion, AR-12 is active against M. abscessus in vitro and in vivo, and does not antagonize the most frequently used anti-M. abscessus drugs. As such, AR-12 is a potential candidate to include in novel strategies to treat M. abscessus infections. PMID: 32482678 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - June 1, 2020 Category: Microbiology Authors: Zhang S, Zou Y, Guo Q, Chen J, Xu L, Wan X, Zhang Z, Li B, Chu H Tags: Antimicrob Agents Chemother Source Type: research

Evaluation of cold-weather wastewater nitrification technology for removal of polar chemicals of emerging concern from rural Manitoba wastewaters.
In this study, we evaluated removal of polar chemicals of emerging concern (CECs), including pharmaceuticals, personal care products, and pesticides, at SAGR installations in two Manitoba First Nations communities (MCN and LPFN) under cold winter conditions. Both showed some removal of diclofenac, naproxen, clarithromycin, metoprolol, and trimethoprim, likely by biotransformation. Average naproxen removal was 21% (2.53 × 103 ng L-1) in MCN and 64% (1.58 × 103 ng L-1) in LPFN. Atenolol was well-removed by SAGR, by 80% on average (range of 64%-94%). Clarithromycin, metoprol...
Source: Chemosphere - May 30, 2020 Category: Chemistry Authors: Anderson JC, Jabari P, Parajas A, Loeb E, Luong KH, Vahedi A, Wong CS Tags: Chemosphere Source Type: research

Prevalence and Antibiotic Resistance Patterns of Helicobacter pylori Infection in Koh Kong, Cambodia.
CONCLUSIONS: H. pylori infection remains common infection in Cambodia. High prevalence of clarithromycin, metronidazole, levofloxacin and multidrug-resistant H. pylori is still major problems in Cambodia. Treatment regimens without clarithromycin and quinolone such as 14-day bismuth-based quadruple therapy might be an appropriate choice for H. pylori eradication in this particular area. PMID: 32458649 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - May 28, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Protective effects of Helicobacter pylori membrane vesicles against stress and antimicrobial agents.
Abstract Outer-membrane vesicles (OMVs) produced by Helicobacter pylori deliver bacterial components to host cells, provide a mechanism for stabilization of secreted components and may allow the bacteria to exert 'long-range' effects in the gastric niche, promoting persistence. In addition to their well-characterized host cell interactions, membrane vesicles improve stress survival in other bacterial species, and are constitutively produced by both pathogenic and non-pathogenic bacteria. We aimed to determine whether OMVs could improve H. pylori survival of a range of stressors. The effects of purified OMVs on the...
Source: Microbiology - May 28, 2020 Category: Microbiology Authors: Murray BO, Dawson RA, Alsharaf LM, Anne Winter J Tags: Microbiology Source Type: research

Synthesis and antibacterial activity of new N-alkylammonium and carbonate-triazole derivatives within desosamine of 14- and 15-membered lactone macrolides.
Abstract Desosamine of azithromycin ( AZM ) and clarithromycin ( CLA ) was modified via S N 2 and CuAAC dipolar cycloaddition. The biological studies revealed higher antibacterial potency of quaternary N -alkylammonium bromides of CLA as compared to AZM . SAR studies of CLA salts, including biological, conformation and molecular docking analysis, enriched by physico-chemical parameters, showed the importance of less bulky and unsaturated substituent for efficient docking mode at the ribosomal tunnel and good antibacterial potency against clinical and standard Streptococcus pneumoniae and Streptococcus pyogenes str...
Source: ChemMedChem - May 27, 2020 Category: Chemistry Authors: Janas A, Pecyna P, Gajecka M, Bartl F, Przybylski P Tags: ChemMedChem Source Type: research

Novel mutations in the resistome of a new sequence type (ST262) of clarithromycin resistant Mycobacterium abscessus subsp. massiliense
Publication date: June 2020Source: Journal of Global Antimicrobial Resistance, Volume 21Author(s): Maiara dos Santos Carneiro, Daiana de Lima-Morales, Marina Niada Crispim, Luciana de Souza Nunes, Afonso Luis Barth (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - May 16, 2020 Category: Infectious Diseases Source Type: research

Optimized diagnosis of Helicobacter pylori and tailored eradication therapy for preventing gastric cancer: a proposal for SHAKE strategy.
Authors: Cho JH, Jin SY Abstract Introduction: To decrease gastric cancer-related mortality, the Korean National Cancer Screening Program provides biennial screening gastroscopy to all individuals aged> 40 years. However, a test-and-treat strategy of Helicobacter pylori for preventing gastric cancer has not been established.Areas covered: In this review, we present up-to-date results of endoscopic findings of H. pylori gastritis, optimal sites for H. pylori detection, gastric cancer risk assessment using serum pepsinogen, tailored eradication based on the antimicrobial resistance against H. pylori, and post-erad...
Source: Expert Review of Gastroenterology and Hepatology - May 16, 2020 Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research

Association of antibiotics therapy during pregnancy with spontaneous miscarriage: a systematic review and meta-analysis
ConclusionFindings support a significant positive association between use of macrolides (especially clarithromycin), quinolones, and tetracyclines during pregnancy and spontaneous miscarriage, although it should be interpreted with caution in the context of limitations of the available data.Review registrationInternational register for systematic reviews; PROSPEROCRD42018093465. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - May 14, 2020 Category: OBGYN Source Type: research

Macrolide resistant Mycobacterium avium complex pulmonary disease following clarithromycin and ethambutol combination therapy
Whether two-drug therapy (clarithromycin and ethambutol) for Mycobacterium avium complex (MAC) pulmonary disease contributes to the development of macrolide-resistant MAC is unclear. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 14, 2020 Category: Respiratory Medicine Authors: Yasuhiro Ito, Seiichi Miwa, Masahiro Shirai, Miho Kanai, Kaoru Fujita, Hisano Ohba, Eriko Iwaizumi, Tomoko Oshima, Suguru Kojima, Takafumi Suda, Hiroshi Hayakawa Source Type: research

Retrospective analysis of the global antibiotic residues that exceed the predicted no effect concentration for antimicrobial resistance in various environmental matrices.
CONCLUSION: While most environmental monitoring studies have focused on municipal wastewater treatment plants, the limited number of studies on hospital wastewater and industrial wastewater revealed that a large number of antibiotic residues coming from these sources exceeded their PNEC values. Our study highlights the importance of implementing on-site treatment systems that aim to destroy antibiotics prior to discharging wastewater to surface waters. Attention needs to be focused on the role that environmental matrices, particularly our wastewater sites, play in promoting antibiotic resistance. Novel treatment technologi...
Source: Environment International - May 14, 2020 Category: Environmental Health Authors: Booth A, Aga DS, Wester AL Tags: Environ Int Source Type: research

Novel mutations in the resistome of a new sequence type, ST262, of clarithromycin resistant Mycobacterium abscessus subsp. massiliense
Publication date: Available online 6 May 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Maiara dos Santos Carneiro, Daiana de Lima-Morales, Marina Niada Crispim, Luciana de Souza Nunes, Afonso Luis Barth (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - May 7, 2020 Category: Infectious Diseases Source Type: research

Mycobacterium abscessus mimicking tubercular spondylodiscitis following ozone therapy: A case report and review of literature.
Conclusion: Early diagnosis and appropriate therapy is required to treat NTM which is more prevalent in epidemic/endemic regions. PMID: 32363058 [PubMed] (Source: Surgical Neurology International)
Source: Surgical Neurology International - May 5, 2020 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Rifabutin-Based Triple Therapy (RHB-105) for Helicobacter pylori Eradication: A Double-Blind, Randomized, Controlled Trial.
Abstract Background: Although consensus supports eradication of Helicobacter pylori infections, antimicrobial resistance has substantially reduced eradication rates with most current therapies. Objective: To assess the effectiveness of a novel rifabutin-based therapy (RHB-105) for H pylori eradication. Design: Phase 3, double-blind trial (ERADICATE Hp2). (ClinicalTrials.gov: NCT03198507). Setting: 55 clinical research sites in the United States. Participants: 455 treatment-naive adults with epigastric discomfort and confirmed H pylori infection. Intervention: RHB-105 (amoxicillin, 3 g; ome...
Source: Annals of Internal Medicine - May 5, 2020 Category: Internal Medicine Authors: Graham DY, Canaan Y, Maher J, Wiener G, Hulten KG, Kalfus IN Tags: Ann Intern Med Source Type: research

Surgical Site Infection Caused by Mycobacterium Septicum Following Blepharoplasty
Conclusion: There are a few reports of M septicum catheter-related infection and pulmonary disease, but surgical site infection has not been reported. When a localized mass on a surgical site is found, surgeons should consider M septicum infection and find out the pathogen with its antibiotics susceptibility. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - May 1, 2020 Category: Surgery Tags: Brief Clinical Studies Source Type: research

The Clinico-Epidemiological Profile of Patients with Gonorrhoea and Challenges in the Management of Neisseria gonorrhoeae Infection in an STI clinic, Ternopil, Ukraine (2013-2018).
Authors: Boiko I, Akimova V, Mazur L, Savchenko I, Kohut I, Krynytska I Abstract Gonorrhea is the second most common sexually transmitted infection spreading worldwide and a serious public health problem. However, further data are required to improve the management of gonorrhea. Our aim was to review the features of gonococcal infection and characterize the challenges of its management. A retrospective descriptive study of the medical records of 136 adult patients with gonorrhea that visited Ternopil Regional Sexually Transmitted Infections Clinic (Ukraine) in 2013-2018 was performed. The male-to-female ratio was 6...
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Talicia - A 3-Drug Combination for Helicobacter pylori Infection
Date: June 1, 2020 Issue #:  1599Summary:  The FDA has approved a fixed-dose combination of omeprazole, amoxicillin, and rifabutin (Talicia– RedHill) for treatment ofHelicobacter pylori infection in adults.Talicia is the first rifabutin-based product to be approved for this indication. (Source: The Medical Letter)
Source: The Medical Letter - April 29, 2020 Category: Drugs & Pharmacology Authors: admin Tags: Amoxicillin Antibacterials Bismuth subsalicylate Clarithromycin Helicobacter pylori infection Levofloxacin metronidazole Omeprazole Proton pump inhibitors Rifabutin Talicia Tetracycline Tinidazole Source Type: research

Efficacy of Omeprazole, Tetracycline, and 4 Times Daily Dosing of Amoxicillin in Helicobacter pylori Eradication in Limited Resource Area in Bhutan: A Prospective Randomized Trial (BHUTAN Study).
CONCLUSIONS: Fourteen-day regimen might be an acceptable regimen for H. pylori eradication in limited resource area such as Bhutan. Female and age ≥40 years should receive longer duration of treatment. This 14-day regimen could at least reduce the risk of developing H. pylori-associated diseases especially peptic ulcer with complications and gastric cancer which lead to many deaths in Bhutan.. PMID: 32334478 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Antibiotic residues in final effluents of European wastewater treatment plants and their impact on the aquatic environment.
M, Virta M, Do TT, Walsh F, Manaia CM Abstract A comprehensive monitoring of a broad set of antibiotics in the final effluent of wastewater treatment plants (WWTPs) of 7 European countries (Portugal, Spain, Ireland, Cyprus, Germany, Finland, and Norway) was carried out in two consecutive years (2015 and 2016). This is the first study of this kind performed at an international level. Within the 53 antibiotics monitored 17 were detected at least once in the final effluent of the WWTPs, i.e.: ciprofloxacin, ofloxacin, enrofloxacin, orbifloxacin, azithromycin, clarithromycin, sulfapyridine, sulfamethoxazole, trimethop...
Source: Environment International - April 27, 2020 Category: Environmental Health Authors: Rodriguez-Mozaz S, Vaz-Moreira I, Varela Della Giustina S, Llorca M, Barceló D, Schubert S, Berendonk TU, Michael-Kordatou I, Fatta-Kassinos D, Martinez JL, Elpers C, Henriques I, Jaeger T, Schwartz T, Paulshus E, O'Sullivan K, Pärnänen KMM, Virta M, D Tags: Environ Int Source Type: research

Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin
COVID-19 pandemics is a challenge for public health and infectious diseases clinicians, especially for the therapeutical approach that is not yet adequately defined. Amid this situation, investigational agents... (Source: Annals of Clinical Microbiology and Antimicrobials)
Source: Annals of Clinical Microbiology and Antimicrobials - April 24, 2020 Category: Microbiology Authors: Jos é Millán-Oñate, William Millan, Luis Alfonso Mendoza, Carlos Guillermo Sánchez, Hugo Fernandez-Suarez, D. Katterine Bonilla-Aldana and Alfonso J. Rodríguez-Morales Tags: Case report Source Type: research

Cutaneous Mycobacterium haemophilum infection: A rare cutaneous manifestation in a patient with Crohn's disease
A 66-year-old woman with Crohn's disease received adalimumab therapy for 3 years. She developed some erythematous induration throughout her lower legs (Fig. 1). The nodules became tender and spread to the hands and elbows within 3 months (Fig. 2). Skin biopsy revealed chronic dermatitis with marked necrotizing panniculitis (Fig. 3). Acid-fast staining was positive (Fig. 4). External consultation suggested Mycobacterium haemophilum infection; thus, adalimumab therapy was ceased and combination therapy with clarithromycin, ciprofloxacin, and ethambutol was commenced. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 24, 2020 Category: Gastroenterology Authors: Chih-Jung Chen, Hsu-Heng Yen Tags: Image of the Month Source Type: research

Anti-Helicobacter pylori, Anti-Inflammatory, Cytotoxic, and Antioxidant Activities of Mace Extracts from Myristica fragrans.
In conclusion, the ethanolic mace extract had anti-H. pylori, anti-inflammatory, antioxidant, and anticancer activities. These data support further preclinical and clinical investigation to see if the mace extract could have a role in treating patients with dyspepsia, peptic ulcers, and possibly gastric cancer. PMID: 32308716 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 22, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Molecular Assessment of Resistance to Clarithromycin in Helicobacter pylori Strains Isolated from Patients with Dyspepsia by Fluorescent In Situ Hybridization in the Center of Iran.
Conclusion: As presented in the study, the high prevalence of clarithromycin-resistant H. pylori due to point mutations of the 23S rRNA gene indicates the necessity of revising the standard treatment regimen based on antibiotic susceptibility pattern of each region. PMID: 32309428 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - April 22, 2020 Category: Research Authors: Vazirzadeh J, Falahi J, Moghim S, Narimani T, Rafiei R, Karbasizadeh V Tags: Biomed Res Int Source Type: research

Efficacy of a bismuth-based quadruple therapy regimen for Helicobacter pylori eradication in Saudi Arabia
Conclusions: Treatment with a bismuth-based quadruple therapy was effective in eradicating H. pylori infection in 78.3% of Saudi patients with an ITT analysis and in 87.8% as per-protocol analysis. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - April 21, 2020 Category: Gastroenterology Authors: Fahad Alsohaibani Mohammed Alquaiz Khalid Alkahtani Hamad Alashgar Musthafa Peedikayil Abdulrahman AlFadda Majid Almadi Source Type: research

Granulomatosis with polyangiitis with acute tubulointerstitial nephritis in absence of glomerulonephritis
We report a 77 year old female with well-controlled hypertension who presented with lethargy. She had received antimicrobial treatment with ceftriaxone, levofloxacin and clarithromycin for acute sinusitis and pneumonia 2 weeks prior to presentation. Serum creatinine was 51 µmol/L then. At presentation, she had acute kidney injury with peak serum creatinine of 482 µmol/L and required dialysis. Urine analysis noted few iso-morphic red blood cells and white blood cells and proteinuria of 2.03 g/24 hours. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 20, 2020 Category: General Medicine Authors: Weiwen Guo, Keng Thye Woo, Jason CJ Choo, Puay Hoon Tan, Cynthia Ciwei Lim Tags: Clinical Communication to the Editor Source Type: research

Pharmacologic management of Mycobacterium ulcerans infection.
Abstract Introduction: Pharmacological treatment of Buruli ulcer (Mycobacterium ulcerans infection; BU) is highly effective, as shown in two randomized trials in Africa.Areas covered: We review BU drug treatment - in vitro, in vivo and clinical trials (PubMed: '(Buruli OR (Mycobacterium AND ulcerans)) AND (treatment OR therapy).' We also highlight the pathogenesis of M. ulcerans infection that is dominated by mycolactone, a secreted exotoxin, that causes skin and soft tissue necrosis, and impaired immune response and tissue repair. Healing is slow, due to the delayed wash-out of mycolactone. An array of repurpo...
Source: Pharmacological Reviews - April 20, 2020 Category: Drugs & Pharmacology Authors: Van Der Werf TS, Barogui YT, Converse PJ, Phillips RO, Stienstra Y Tags: Expert Rev Clin Pharmacol Source Type: research

Granulomatosis with Polyangiitis and Acute Tubulointerstitial Nephritis in the Absence of Glomerulonephritis
We report a 77-year-old woman with well-controlled hypertension who presented with lethargy. She had received antimicrobial treatment with ceftriaxone, levofloxacin, and clarithromycin for acute sinusitis and pneumonia 2 weeks prior to presentation. Serum creatinine was 51 µmol/L at that time. At presentation, she had acute kidney injury with peak serum creatinine of 482 µmol/L and required dialysis. Urine analysis noted few isomorphic red blood cells and white blood cells and proteinuria of 2.03 g/24 h. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 20, 2020 Category: General Medicine Authors: Weiwen Guo, Keng Thye Woo, Jason CJ Choo, Puay Hoon Tan, Cynthia Ciwei Lim Tags: Clinical Communication to the Editor Source Type: research

Helicobacter pylori antibiotic resistance and correlation with cagA motifs and homB gene.
Conclusion: The Resistance rate to selected antibiotics in Shiraz is higher than years ago. The presence of cagA-homB+ is associated with antibiotic resistance and also homB can be used as a marker to antibiotic resistance status prediction in H. pylori isolated in this area. PMID: 32281451 [PubMed - as supplied by publisher] (Source: Postgraduate Medicine)
Source: Postgraduate Medicine - April 15, 2020 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Evidence of Clinically Meaningful Drug –Drug Interaction With Concomitant Use of Colchicine and Clarithromycin
ConclusionClinical manifestations of colchicine –clarithromycin interaction may resemble other systemic diseases and may be life threatening. Understanding this clinically meaningful interaction can help clinicians avoid unsafe medication combinations. (Source: Drug Safety)
Source: Drug Safety - April 9, 2020 Category: Drugs & Pharmacology Source Type: research

A persuasive approach to antimicrobial stewardship in Christchurch hospitals produced a sustained decrease in intravenous clarithromycin dosing and expenditure via a switch to azithromycin orally.
CONCLUSIONS: A persuasive multimodel approach to support adoption of CAP guidelines produced a sustained decrease in IV clarithromycin use, which may have clinical benefits such as reduced occurrence of catheter-related complications. PMID: 32242175 [PubMed - in process] (Source: New Zealand Medical Journal)
Source: New Zealand Medical Journal - April 5, 2020 Category: General Medicine Tags: N Z Med J Source Type: research

Clarithromycin effectively enhances doxorubicin-induced cytotoxicity and apoptosis in MCF7 cells through dysregulation of autophagy
Publication date: September 2020Source: Advances in Medical Sciences, Volume 65, Issue 2Author(s): Nahid Amani, Mohammad Shokrzadeh, Fatemeh Shaki (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - April 4, 2020 Category: Biomedical Science Source Type: research