Role of Ivabradine on Heart Rate and Quality of Life in Patients With Mitral Stenosis in Sinus Rhythm
Conditions: Mitral Stenosis Interventions: Drug: Ivabradine; Drug: Beta blocker Sponsors: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 17, 2024 Category: Research Source Type: clinical trials
Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of oesophageal varices: study protocol for a randomised controlled trial
DiscussionThe BOPPP trial aims to investigate the clinical and cost-effectiveness of carvedilol in patients with cirrhosis and small oesophageal varices to determine whether this non-selective beta-blocker can prevent or reduce hepatic decompensation. There is clinical equipoise on whether intervening in cirrhosis, at an earlier stage of portal hypertension, with NSBB therapy is beneficial. Should the trial yield a positive result, we anticipate that the administration and use of carvedilol will become widespread with pathways developed to standardise the administration of the medication in primary care.Ethics and dissemin...
Source: Trials - April 16, 2024 Category: Research Source Type: clinical trials
Prospective Multicenter Randomized and Controlled Study Evaluating the Benefit of Early Pulmonary Vein Isolation Compared to Usual Treatment in Patients Aged Over 75 Years and Presenting With Atrial Fibrillation
Conditions: Atrial Fibrillation Interventions: Procedure: Rhythm control by Pulmonary Vein Isolation (PVI) procedure; Drug: Conventional care by antiarrhythmic drugs (flecainide, sotalol, amiodarone) or bradycardic drugs (all betablocker or calcium channel blocker therapy, digoxin) Sponsors: Nantes University Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 20, 2024 Category: Research Source Type: clinical trials
Colchicine Versus Beta-blockers, Angiotensin-converting Enzyme Inhibitors, and Statins for Prevention of Chemotherapy-Induced Cardiomyopathy
Conditions: Chemotherapy Induced Systolic Dysfunction Interventions: Drug: Carvedilol; Drug: Ramipril; Drug: Rosuvastatin; Drug: Colchicine; Drug: Placebo Sponsors: Arab Contractors Medical Centre Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 11, 2024 Category: Research Source Type: clinical trials
Beta-Blocker Influences on Inflammatory and Neural Responses to Stress
Conditions: Cardiovascular Disease Interventions: Drug: Propranolol; Drug: Placebo Sponsors: University of North Carolina, Chapel Hill; National Heart, Lung, and Blood Institute (NHLBI); University of California, Los Angeles; Dartmouth College Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 16, 2024 Category: Research Source Type: clinical trials
Association Between Pre-op Non-Selective Beta-Blockers and Hepatocellular Carcinoma Recurrence Post-Liver Transplant
Conditions: Hepatocellular Carcinoma Recurrent; Hepatocellular Carcinoma Interventions: Drug: Non-Selective Beta-Adrenoreceptor Agonists for Systemic Use Sponsors: Asan Medical Center; Korea Health Industry Development Institute Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 31, 2024 Category: Research Source Type: clinical trials
N-of-1 in ATS and MEPPC
Conditions: Andersen Tawil Syndrome; Multifocal Ectopic Purkinje-related Premature Contractions Interventions: Drug: Flecainide; Drug: Flecainide + beta-blocker Sponsors: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 15, 2024 Category: Research Source Type: clinical trials
A treatment strategy with nifedipine versus labetalol for women with pregnancy hypertension: study protocol for a randomised controlled trial (Giant PANDA)
DiscussionThis trial aims to address the uncertainty of which antihypertensive treatment is associated with optimal maternal and neonatal outcomes. The trial results are intended to provide definitive evidence to inform guidelines and linked, shared decision-making tools, thus influencing clinical practice.Trial registrationEudraCT number: 2020 –003410-12, ISRCTN: 12,792,616 registered on 18 November 2020. (Source: Trials)
Source: Trials - September 12, 2023 Category: Research Source Type: clinical trials
CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes
Conditions: End-Stage Kidney Disease; End-Stage Renal Disease Interventions: Drug: Metoprolol Succinate; Drug: Carvedilol Sponsor: VA Office of Research and Development Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 5, 2023 Category: Research Source Type: clinical trials
