Emerging drugs in phase II and III clinical development for the treatment of alcohol use disorder
Expert Opin Emerg Drugs. 2024 Apr 12. doi: 10.1080/14728214.2024.2342951. Online ahead of print.ABSTRACTINTRODUCTION: Alcohol Use Disorder (AUD) poses an ongoing significant global health burden. AUD is highly prevalent and affects not only the individuals with AUD, but also their communities and society at large. Even though pharmacotherapy is an integral part of AUD treatment, the few available substances show limited efficacy and limited clinical impact. Thus, there is a need for new innovative pharmacotherapeutic approaches.AREAS COVERED: This paper provides a comprehensive review of drugs approved for the treatment of...
Source: Expert Opinion on Emerging Drugs - April 12, 2024 Category: Drugs & Pharmacology Authors: Sophie K öhne Thomas Hillemacher Alexander Glahn Patrick Bach Source Type: research
Utilizing combination intrathecal baclofen and analgesic medication to manage spasticity and pain in patients with pediatric-onset disability: Case series
CONCLUSION: Use of pumps with antispasmodic and analgesic medication for combination intrathecal medication delivery should be considered in the management of patients with childhood-onset disabilities who have both severe spasticity and pain.PMID:38552121 | DOI:10.3233/PRM-220100 (Source: Journal of Pediatric Rehabilitation Medicine)
Source: Journal of Pediatric Rehabilitation Medicine - March 29, 2024 Category: Rehabilitation Authors: Denesh Ratnasingam Tess Woehrlen Samantha Koerber Emma Drenth Neena Marupudi Melisa Concepcion Erika Erlandson Source Type: research
Utilizing combination intrathecal baclofen and analgesic medication to manage spasticity and pain in patients with pediatric-onset disability: Case series
CONCLUSION: Use of pumps with antispasmodic and analgesic medication for combination intrathecal medication delivery should be considered in the management of patients with childhood-onset disabilities who have both severe spasticity and pain.PMID:38552121 | PMC:PMC10977390 | DOI:10.3233/PRM-220100 (Source: Journal of Pediatric Rehabilitation Medicine)
Source: Journal of Pediatric Rehabilitation Medicine - March 29, 2024 Category: Rehabilitation Authors: Denesh Ratnasingam Tess Woehrlen Samantha Koerber Emma Drenth Neena Marupudi Melisa Concepcion Erika Erlandson Source Type: research
Synthesis of R-GABA Derivatives via Pd(II) Catalyzed Enantioselective C(sp3)-H Arylation and Virtual Validation with GABAB1 Receptor for Potential leads
Chem Asian J. 2024 Mar 18:e202400064. doi: 10.1002/asia.202400064. Online ahead of print.ABSTRACTGABA (γ-amino butyric acid) analogues like baclofen, tolibut, phenibut, etc., are well-known GABAB1 inhibitors and pharmaceutically important drugs. However, there is a huge demand for more chiral GABA aryl analogues with promising pharmacological actions. Here, we demonstrate the chiral ligand acetyl-protected amino quinoline (APAQ) mediated enantioselective synthesis of GABAB1 inhibitor drug scaffolds from easily accessible GABA via Pd-catalyzed C(sp3)-H activation. The synthetic methodology shows moderate to good yields, up...
Source: Chemistry, an Asian Journal - March 18, 2024 Category: Chemistry Authors: Smitha Mohanlal Diprupa Saha Shubhant Pandey Rudresh Acharya Nagendra K Sharma Source Type: research
Effects of Baclofen on Central Paroxysmal Positional Downbeat Nystagmus
This study aims to elucidate the mechanism of central positional nystagmus (CPN) by determining the effects of baclofen on the intensity of paroxysmal positional downbeat nystagmus due to central lesions. Fifteen patients with paroxysmal downbeat CPN were subjected to manual straight head-hanging before administration of baclofen, while taking baclofen 30 mg per day for at least one week, and two weeks after discontinuation of baclofen. The maximum slow phase velocity (SPV) and time constant (TC) of the induced paroxysmal downbeat CPN were analyzed. The positional vertigo was evaluated using an 11-point numerical rating sc...
Source: Cerebellum - March 18, 2024 Category: Neuroscience Authors: So-Yeon Yun Jong-Hee Lee Hyo-Jung Kim Jeong-Yoon Choi Ji-Soo Kim Source Type: research
Effects of Baclofen on Central Paroxysmal Positional Downbeat Nystagmus
This study aims to elucidate the mechanism of central positional nystagmus (CPN) by determining the effects of baclofen on the intensity of paroxysmal positional downbeat nystagmus due to central lesions. Fifteen patients with paroxysmal downbeat CPN were subjected to manual straight head-hanging before administration of baclofen, while taking baclofen 30 mg per day for at least one week, and two weeks after discontinuation of baclofen. The maximum slow phase velocity (SPV) and time constant (TC) of the induced paroxysmal downbeat CPN were analyzed. The positional vertigo was evaluated using an 11-point numerical rating ...
Source: The Cerebellum - March 18, 2024 Category: Neurology Source Type: research
Comparative Risk of Injury with Concurrent Use of Opioids and Skeletal Muscle Relaxants
In conclusion, the relative injury rate associated with different SMRs used concurrently with the three most dispensed opioids appears to vary depending on the specific opioid and the order of combination initiation. If confirmed by future studies, clinicians should consider the varying injury rates when prescribing SMRs to individuals using hydrocodone, oxycodone, and tramadol.PMID:38482733 | DOI:10.1002/cpt.3248 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - March 14, 2024 Category: Drugs & Pharmacology Authors: Cheng Chen Sean Hennessy Colleen M Brensinger Todd A Miano Warren B Bilker Sascha Dublin Sophie P Chung John R Horn Anika Tiwari Charles E Leonard Source Type: research
Comparative Risk of Injury with Concurrent Use of Opioids and Skeletal Muscle Relaxants
In conclusion, the relative injury rate associated with different SMRs used concurrently with the three most dispensed opioids appears to vary depending on the specific opioid and the order of combination initiation. If confirmed by future studies, clinicians should consider the varying injury rates when prescribing SMRs to individuals using hydrocodone, oxycodone, and tramadol.PMID:38482733 | DOI:10.1002/cpt.3248 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - March 14, 2024 Category: Drugs & Pharmacology Authors: Cheng Chen Sean Hennessy Colleen M Brensinger Todd A Miano Warren B Bilker Sascha Dublin Sophie P Chung John R Horn Anika Tiwari Charles E Leonard Source Type: research
Pharmacological and Non-pharmacological Approaches for the Management of Neuropathic Pain in Multiple Sclerosis
The objective of this ar ticle is to provide an overview of literature on pharmacological and non-pharmacological strategies employed in the management of neuropathic pain in multiple sclerosis. Pharmacological options include cannabinoids, muscle relaxants (tizanidine, baclofen, dantrolene), anticonvulsants (benzodiazepine s, gabapentin, phenytoin, carbamazepine, lamotrigine), antidepressants (duloxetine, venlafaxine, tricyclic antidepressants), opioids (naltrexone), and botulinum toxin variants, which have evidence from various clinical trials. Non-pharmacological approaches for trigeminal neuralgia may include neuro sur...
Source: CNS Drugs - February 29, 2024 Category: Neurology Source Type: research
Physician Approaches to the Pharmacologic Treatment of Dystonia in Cerebral Palsy
CONCLUSIONS: This study summarizes current indications and dosing for the six most commonly used medications to treat dystonia in CP as per treating physicians in the US and Canada and also demonstrates physician support for a randomized trial comparing the effectiveness of these treatments.ARTICLE SUMMARY: Dystonia is common and debilitating in people with CP, with little data on pharmacologic treatments. We describe physicians' current approaches to using these treatments.WHAT’S KNOWN ON THIS SUBJECT: Comparing the effectiveness of existing pharmacologic treatments for dystonia in CP is a research priority shared by cl...
Source: Pain Physician - February 14, 2024 Category: Anesthesiology Authors: Emma Lott Darcy Fehlings Rose Gelineau-Morel Michael Kruer Jonathan W Mink Sruthi P Thomas Steve Wisniewski Bhooma Aravamuthan Source Type: research
