Kyverna Therapeutics Granted FDA Fast Track Designation for KYV-101 in the Treatment of Patients With Refractory Progressive Multiple Sclerosis
EMERYVILLE, Calif., Jan. 19, 2024. Kyverna Therapeutics, Inc. (Kyverna), a patient-centered clinical-stage biopharmaceutical company focused on developing cell therapies for patients suffering from autoimmune diseases, today announced it received... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - January 19, 2024 Category: Pharmaceuticals Source Type: clinical trials
CAR-T for Autoimmune Hemolytic Anemia Patients Who Have Failed Three or More Lines of Therapy
Conditions: Autoimmune Hemolytic Anemia; CD19 CAR-T Cell Infusion Interventions: Biological: ThisCART19A Sponsors: Institute of Hematology& Blood Diseases Hospital, China; Suzhou Fundamenta Therapeutics Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 18, 2024 Category: Research Source Type: clinical trials
F01 in the Treatment of Autoimmune Diseases
Conditions: Autoimmune Diseases Interventions: Drug: After preconditioning with Fludarabine and Cyclophosphamide, F01 will be evaluated. Sponsors: RenJi Hospital; Shanghai Simnova Biotechnology Co.,Ltd. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 17, 2024 Category: Research Source Type: clinical trials
Tacrolimus versus mycophenolate for AutoImmune hepatitis patients with incompLete response On first-line therapy (TAILOR study): a study protocol for a phase III, open-label, multicentre, randomised controlled trial
DiscussionThis is the first randomised controlled trial comparing two second-line therapies for AIH. Currently, second-line treatment is based on retrospective cohort studies. The rarity of AIH is the main issue in clinical research for alternative treatment options. The results of this trial can be implemented in existing international clinical guidelines.Trial registrationClinicalTrials.govNCT05221411. Retrospectively registered on 3 February 2022; EudraCT number 2021 –003420-33. Prospectively registered on 16 June 2021. (Source: Trials)
Source: Trials - January 17, 2024 Category: Research Source Type: clinical trials
A SHR0302 BA Study on Healthy Subjects
Conditions: Autoimmune Diseases Interventions: Drug: SHR0302 quick release tablets; Drug: SHR0302 sustained-release tablets Sponsors: Jiangsu HengRui Medicine Co., Ltd. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 11, 2024 Category: Research Source Type: clinical trials
Gut microbiota in children with autoimmune liver disease and its effect on treatment response
Conditions: Autoimmune Diseases Interventions: Other: No intervention Sponsors: Institute of Liver and Biliary Sciences, India Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 27, 2023 Category: Research Source Type: clinical trials
Prevalence of Peripheral Vascular Diseases and Presentation in Patients With Autoimmune Diseases
Conditions: Peripheral Vascular Diseases and Presentation in Patient With Autoimmune Diseases Interventions: Other: cross sectional study Sponsors: Hossam Adly Mohamed Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 14, 2023 Category: Research Source Type: clinical trials
CARTIMMUNE: Study of Patients With Autoimmune Diseases Receiving KYV-101
Conditions: Idiopathic Inflammatory Myopathies; Diffuse Cutaneous Systemic Sclerosis; SLE Nephritis; ANCA Associated Vasculitis Interventions: Drug: KYV-101; Drug: Cyclophosphamide; Drug: Fludarabine Sponsors: David Porter; Kyverna Therapeutics Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 30, 2023 Category: Research Source Type: clinical trials
The IBD-FITT study — moderate-intensity exercise for patients with inflammatory bowel disease with moderate disease activity: an open-label randomized controlled trial
DiscussionThis will be a clinical trial investigating the effect of exercise on patients with Crohn ’s disease and ulcerative colitis. This trial will add to the evidence on the possible effect of exercise and might clarify whether exercise can benefit as a supplementary treatment addendum. Thus, the trial may provide a new patient-active disease management approach.Trial registrationClinicalTrials.gov NCT04816812. Date of first registration: March 23, 2021. (Source: Trials)
Source: Trials - November 20, 2023 Category: Research Source Type: clinical trials
Personalized therapy in rheumatoid arthritis (PETRA): a protocol for a randomized controlled trial to test the effect of a psychological intervention in rheumatoid arthritis
AbstractRheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects cartilage and bone. Psychological stress can both trigger disease exacerbation and result from disease activity. As standard pharmacological interventions alone have limited success in treating RA, a more comprehensive biopsychosocial approach to treatment has been recommended . In this prospective randomized controlled trial (RCT), a psychotherapeutically guided, group-based intervention program will be conducted with RA patients over a period of 9 months. This program combines a dynamic-interactional model with disorder-specifi...
Source: Trials - November 20, 2023 Category: Research Source Type: clinical trials
Study of Clinical Features of Patients With Autoimmune Liver Disease Complicated With Covid-19 and the Immune Mechanism Affecting Prognosis
Conditions: Autoimmune Liver Disease, COVID-19 Interventions: Other: Different types of disease Sponsors: The Second Affiliated Hospital of Chongqing Medical University Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 25, 2023 Category: Research Source Type: clinical trials
Digital Exercise for Middle-Aged Adults With Type 1 Diabetes and Other Absolute Insulin Deficiency Diabetes
Conditions: Type 1 Diabetes; Latent Autoimmune Diabetes in Adults; Pancreatitis Interventions: Behavioral: Digital Exercise Sponsors: Yale University; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Exerscrip LLC Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 24, 2023 Category: Research Source Type: clinical trials
Periodontal Status in Patients With Chronic Skin Diseases
Conditions: Periodontal Diseases; Psoriasis; Atopic Dermatitis; Autoimmune Bullous Dermatosis; Systemic Lupus Erythematosus Interventions: Diagnostic Test: oral health status Sponsors: University of Medicine and Pharmacy at Ho Chi Minh City Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 9, 2023 Category: Research Source Type: clinical trials
Implementation of Support in the Care of Adults Living With Type 1 Diabetes
Conditions: Type 1 Diabetes; Metabolic Disease; Endocrine System Diseases; Autoimmune Diseases; Immune System Diseases Interventions: Behavioral: Support platform Sponsors: McGill University; Centre hospitalier de l ' Universit é de Montréal (CHUM); Institut de Recherches Cliniques de Montreal; Centre Hospitalier de l ' Universit é Laval; Centre de médecine métabolique de Lanaudière Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 6, 2023 Category: Research Source Type: clinical trials
National Registry of Rare Kidney Diseases
Conditions: Adenine Phosphoribosyltransferase Deficiency; AH Amyloidosis; AHL Amyloidosis; AL Amyloidosis; Alport Syndrome; Atypical Hemolytic Uremic Syndrome; Autoimmune Distal Renal Tubular Acidosis; Autosomal Recessive Proximal Renal Tubular Acidosis; Autosomal Recessive Distal Renal Tubular Acidosis; Autosomal Dominant Polycystic Kidney Disease; Autosomal Recessive Polycystic Kidney Disease; Bartter Syndrome; BK Nephropathy; C3 Glomerulopathy With Monoclonal Gammopathy; C3 Glomerulopathy; Calciphylaxis; Crystalglobulinaemia; Crystal-storing Histiocytosis; Cystinosis; Cystinuria; Dense Deposit Disease; Dent Disease; Den...
Source: ClinicalTrials.gov - October 4, 2023 Category: Research Source Type: clinical trials
