Pulmonology: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0613. Online ahead of print.ABSTRACTThe field of pulmonology saw significant advances in 2023. The publications highlighted in this article address advances and changes in practice related to asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, pleural disorders, and sleep-disordered breathing. One article reviews data examining the efficacy of vaccination against respiratory syncytial virus, a respiratory viral illness that has had devastating effects globally. Four studies evaluate the role of various therapies in COPD, including dupilumab, ensifen...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Aram Karkar Sana Khan Rebecca O'Leary Albina Tyker Michael Unger Source Type: research
Impact of sex on severe asthma: a cross-sectional retrospective analysis of UK primary and specialist care
Conclusions
Females had increased symptoms and were more likely to be obese despite higher FEV1% predicted and lower type 2 biomarkers with consistent and clinically important differences across both datasets. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Loewenthal, L., Busby, J., McDowell, R., Brown, T., Burhan, H., Chaudhuri, R., Dennison, P., Dodd, J. W., Doe, S., Faruqi, S., Gore, R., Idris, E., Jackson, D. J., Patel, M., Pantin, T., Pavord, I., Pfeffer, P. E., Price, D. B., Rupani, H., Siddiqui, S., Tags: Thorax Asthma Source Type: research
Use of inhaled corticosteroids and the risk of hospitalisation for pneumonia in children with asthma: a nationwide cohort study
Conclusions
In this nationwide cohort study, we found no evidence of an association between ICS use and the risk of hospitalisation for pneumonia among children with asthma, as compared with no use. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Sielinou Kamgang, K.-H., Rhedin, S. A., Almqvist, C., Wintzell, V. Tags: Open access, Thorax Asthma Source Type: research
Unravelling the obesity-asthma connection in childhood and adolescence: does body shape matter?
Given the concurrent worldwide epidemics of childhood obesity and asthma, it is perhaps not surprising that the two have been inextricably linked in the minds of many. Indeed, there is good evidence to suggest that adiposity in childhood is associated with an increased risk of developing asthma.1 2 Several longitudinal studies conducted in population-based cohorts have demonstrated that childhood obesity precedes incident asthma. One such study, from Taiwan, found that adiposity gain before age 6 years was good at predicting childhood-onset asthma, while adiposity gain during the prepubertal period was best at predicting y...
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Morgan, A. D. Tags: Thorax Editorial Source Type: research
Impacts of sex and gender on severe asthma
For decades, the unwritten rule for asthma management was ‘Keep it Simple’, with clinicians largely trying to apply a one-size-fits-all stepwise approach to hundreds of millions of people across the globe. More recently, our broader understanding, increasing array of targeted therapies, and relatively stagnant outcomes have led to a greater acknowledgement of the complexity that needs to be addressed.1 However, despite progress, our therapeutic pathways do not account for some basic patient characteristics such as sex. The impacts of sex and gender on asthma pathogenesis, prevalence and manifestation throughout...
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Wang, K. C. W., Blakey, J. D. Tags: Thorax Editorial Source Type: research
Does ICS treatment increase the risk of pneumonia in asthma?
Patients with asthma have an increased risk of being hospitalised for pneumonia. For example, in a study based on the Respiratory Health In Northern Europe data set, Ekbom et al found that adults with asthma had a more than three times higher risk (HR (3.35 (95% CI 1.97 to 5.02)) of hospitalisation for pneumonia than non-asthmatics.1 Kankaanranta et al also found a high incidence of pneumonia in people with asthma when using data from the National Finnish Register of Health Care.2 In that study, the incidence of pneumonia was higher in those with more severe asthma than in the group with non-severe disease. Likewise, Ekbom...
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Janson, C. Tags: Thorax Editorial Source Type: research
Greenhouse gas emissions associated with suboptimal asthma care in the UK: the SABINA healthCARe-Based envirONmental cost of treatment (CARBON) study
Conclusions
These findings suggest that addressing the high burden of poorly controlled asthma, including curbing high SABA use and its associated risk of exacerbations, may significantly alleviate asthma care-related carbon emissions. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Wilkinson, A. J. K., Maslova, E., Janson, C., Radhakrishnan, V., Quint, J. K., Budgen, N., Tran, T. N., Xu, Y., Menzies-Gow, A., Bell, J. P. Tags: Open access, Press releases, Thorax Asthma Source Type: research
Body composition and respiratory outcomes in children: a population-based prospective cohort study
Conclusion
Adolescents with higher total and abdominal fat indices may have impaired lung function, while those with a higher lean mass during childhood and adolescence may have better small airway function. Public health measures should focus on a healthy body composition in adolescents to minimise respiratory morbidity. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Wu, T., Santos, S., Quezada-Pinedo, H. G., Vernooij, M. W., Jaddoe, V. W. V., Klein, S., Duijts, L., Oei, E. H. G. Tags: Thorax Respiratory epidemiology Source Type: research
The Association of Infant Urinary Adrenal Steroids with the Risk of Childhood Asthma Development
Adrenal steroids play important roles in early life development. However, our understanding of the effects of perinatal adrenal steroids on the development of childhood asthma is incomplete. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 15, 2024 Category: Allergy & Immunology Authors: Kedir N Turi, Yajing Li, Yaomin Xu, Tebeb Gebretsadik, Christian Rosas-Salazar, Derek A Wiggins, Chris McKennan, Dawn Newcomb, James E Gern, Tina V Hartert Tags: Original Article Source Type: research
CAP Update: The first 5 years
Ann Allergy Asthma Immunol. 2024 Apr 12:S1081-1206(24)00218-7. doi: 10.1016/j.anai.2024.04.010. Online ahead of print.NO ABSTRACTPMID:38615736 | DOI:10.1016/j.anai.2024.04.010 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 14, 2024 Category: Allergy & Immunology Authors: Mitchell R Lester Michael R Nelson Brianna E Wilkins Rayn é C Harrison Theodore M Freeman Source Type: research
8-Iso-prostaglandin F2 α as a biomarker of T2-low airway inflammation and remodeling in adult asthma
CONCLUSION: Urinary 8-iso-prostaglandin F2a concentrations are a potential biomarker for phenotyping severe asthma, particularly non-eosinophilic asthma, offering oxidative stress-induced epithelial inflammation/remodeling as an additional target in asthma management.PMID:38615737 | DOI:10.1016/j.anai.2024.04.007 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 14, 2024 Category: Allergy & Immunology Authors: Seong-Dae Woo Hee Sun Park Eun-Mi Yang Ga-Young Ban Hae-Sim Park Source Type: research
Protracted Anaphylaxis and Cytokine Release Syndrome Six Days Following Rituximab Desensitization
Ann Allergy Asthma Immunol. 2024 Apr 12:S1081-1206(24)00219-9. doi: 10.1016/j.anai.2024.04.011. Online ahead of print.NO ABSTRACTPMID:38615738 | DOI:10.1016/j.anai.2024.04.011 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 14, 2024 Category: Allergy & Immunology Authors: Kelsey A Finkel Heejin Jung Haejin Kim David T Coleman Source Type: research
Urticarial Vasculitis - A Rare Clinical Presentation Of Hodgkin's Lymphoma
Ann Allergy Asthma Immunol. 2024 Apr 12:S1081-1206(24)00217-5. doi: 10.1016/j.anai.2024.04.006. Online ahead of print.NO ABSTRACTPMID:38615739 | DOI:10.1016/j.anai.2024.04.006 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 14, 2024 Category: Allergy & Immunology Authors: Chase P Rupprecht Pranay Maniar Alexandra E Conway Chih- Yu Fang Sarah A Taylor-Black Source Type: research
Early-life house dust mite aeroallergen exposure augments cigarette smoke-induced myeloid inflammation and emphysema in mice
CONCLUSIONS: Early-life allergic airways disease worsened emphysematous lung pathology in CS-exposed mice and markedly alters the lung transcriptome.PMID:38614991 | DOI:10.1186/s12931-024-02774-6 (Source: Cell Research)
Source: Cell Research - April 13, 2024 Category: Cytology Authors: Nok Him Fung Quynh Anh Nguyen Catherine Owczarek Nick Wilson Nadeem Elahee Doomun David De Souza Kylie Quinn Stavros Selemidis Jonathan McQualter Ross Vlahos Hao Wang Steven Bozinovski Source Type: research
Early-life house dust mite aeroallergen exposure augments cigarette smoke-induced myeloid inflammation and emphysema in mice
Longitudinal studies have identified childhood asthma as a risk factor for obstructive pulmonary disease (COPD) and asthma-COPD overlap (ACO) where persistent airflow limitation can develop more aggressively. ... (Source: Respiratory Research)
Source: Respiratory Research - April 13, 2024 Category: Respiratory Medicine Authors: Nok Him Fung, Quynh Anh Nguyen, Catherine Owczarek, Nick Wilson, Nadeem Elahee Doomun, David De Souza, Kylie Quinn, Stavros Selemidis, Jonathan McQualter, Ross Vlahos, Hao Wang and Steven Bozinovski Tags: Research Source Type: research
